ATE98644T1 - 3-beta-(3,4-disubstituiertes succinimido)azetidinone. - Google Patents
3-beta-(3,4-disubstituiertes succinimido)azetidinone.Info
- Publication number
- ATE98644T1 ATE98644T1 AT87306089T AT87306089T ATE98644T1 AT E98644 T1 ATE98644 T1 AT E98644T1 AT 87306089 T AT87306089 T AT 87306089T AT 87306089 T AT87306089 T AT 87306089T AT E98644 T1 ATE98644 T1 AT E98644T1
- Authority
- AT
- Austria
- Prior art keywords
- disubstituted
- beta
- azetidinones
- succinimido
- chiral
- Prior art date
Links
- HCXJFMDOHDNDCC-UHFFFAOYSA-N 5-$l^{1}-oxidanyl-3,4-dihydropyrrol-2-one Chemical class O=C1CCC(=O)[N]1 HCXJFMDOHDNDCC-UHFFFAOYSA-N 0.000 title abstract 2
- BQPAOWVNIXJERC-UHFFFAOYSA-N 2-(2,5-dioxopyrrolidin-1-yl)acetyl chloride Chemical class ClC(=O)CN1C(=O)CCC1=O BQPAOWVNIXJERC-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006352 cycloaddition reaction Methods 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 229940124586 β-lactam antibiotics Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/884,124 US4734498A (en) | 1986-07-10 | 1986-07-10 | 3β-succinimidoazetidinones as chiral intermediates |
| EP87306089A EP0252744B1 (de) | 1986-07-10 | 1987-07-09 | 3-Beta-(3,4-disubstituiertes succinimido)azetidinone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE98644T1 true ATE98644T1 (de) | 1994-01-15 |
Family
ID=25384007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87306089T ATE98644T1 (de) | 1986-07-10 | 1987-07-09 | 3-beta-(3,4-disubstituiertes succinimido)azetidinone. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4734498A (de) |
| EP (1) | EP0252744B1 (de) |
| JP (1) | JP2510600B2 (de) |
| KR (1) | KR950013767B1 (de) |
| AT (1) | ATE98644T1 (de) |
| CA (1) | CA1320209C (de) |
| DE (1) | DE3788463T2 (de) |
| ES (1) | ES2061503T3 (de) |
| HU (1) | HU197896B (de) |
| IE (1) | IE61494B1 (de) |
| IL (1) | IL83121A (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0715235Y2 (ja) * | 1989-01-31 | 1995-04-10 | 鐘淵化学工業株式会社 | 画像読み取り装置に於けるセンサ素子の位置決め装置 |
| US5159073A (en) * | 1990-09-13 | 1992-10-27 | Eli Lilly And Company | Intermediates to 1-carbacephalosporins and process for preparation thereof |
| IL99380A (en) * | 1990-09-13 | 1997-01-10 | Lilly Co Eli | Process for the preparation of acid addition salt of 3-amino-4-arylethyl-2-oxoazetidine acetic acid derivatives and n-beta-methyl acrylic acid ester intermediate therefor |
| US5225553A (en) * | 1990-09-13 | 1993-07-06 | Eli Lilly And Company | Intermediates to 1-carbacephalosporins and process for preparation thereof |
| US5175256A (en) * | 1990-09-28 | 1992-12-29 | Neorx Corporation | Protein labeling reagents |
| US5599336A (en) * | 1992-07-02 | 1997-02-04 | The Procter & Gamble Company | Absorbent hydrogel fines in absorbent structures |
| EP0939632B1 (de) | 1996-02-23 | 2005-10-05 | Eli Lilly And Company | Non-peptidische vasopressin via antagonisten |
| JP2000247934A (ja) * | 1999-02-23 | 2000-09-12 | Toray Ind Inc | 高光学純度アミノ酸ベンジルエステルの製造法 |
| US6706916B1 (en) | 1999-02-23 | 2004-03-16 | Toray Fine Chemicals Co., Ltd. | Optically active amino acid derivatives and processes for the preparation of the same |
| JP4524841B2 (ja) * | 1999-03-02 | 2010-08-18 | 東レ・ファインケミカル株式会社 | 光学活性アミノ酸エステル酒石酸アミドおよびその製造法 |
| AU2002342045C1 (en) * | 2001-10-12 | 2009-07-30 | Azevan Pharmaceuticals, Inc. | Beta-lactamyl vasopressin Vla antagonists |
| AU2006227199A1 (en) | 2005-03-22 | 2006-09-28 | Azevan Pharmaceuticals, Inc. | Beta-lactamylalkanoic acids for treating premenstrual disorders |
| DK1910346T3 (da) | 2005-07-19 | 2019-05-27 | Azevan Pharmaceuticals Inc | Beta-lactamyl fenylalanin, cystein og serin vasopressin antagonist |
| WO2008034032A2 (en) * | 2006-09-14 | 2008-03-20 | Azevan Pharmaceuticals, Inc. | Beta-lactam cannabinoid receptor modulators |
| KR100932221B1 (ko) * | 2007-11-07 | 2009-12-16 | 강원대학교산학협력단 | 베타락탐 올리고머 및 이의 제조방법 |
| EP2587919B1 (de) | 2010-07-01 | 2017-12-13 | Azevan Pharmaceuticals, Inc. | Verfahren zur behandlung posttraumatischer belastungsstörungen |
| SG11201608064WA (en) | 2014-03-28 | 2016-10-28 | Azevan Pharmaceuticals Inc | Compositions and methods for treating neurodegenerative diseases |
| KR102790657B1 (ko) | 2017-09-15 | 2025-04-02 | 아제반 파마슈티칼스, 인코퍼레이티드 | 뇌 손상을 치료하기 위한 조성물 및 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665171A (en) * | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
-
1986
- 1986-07-10 US US06/884,124 patent/US4734498A/en not_active Expired - Fee Related
-
1987
- 1987-07-08 IL IL83121A patent/IL83121A/xx unknown
- 1987-07-08 CA CA000541557A patent/CA1320209C/en not_active Expired - Fee Related
- 1987-07-09 JP JP62172044A patent/JP2510600B2/ja not_active Expired - Lifetime
- 1987-07-09 EP EP87306089A patent/EP0252744B1/de not_active Expired - Lifetime
- 1987-07-09 DE DE87306089T patent/DE3788463T2/de not_active Expired - Fee Related
- 1987-07-09 KR KR1019870007337A patent/KR950013767B1/ko not_active Expired - Fee Related
- 1987-07-09 ES ES87306089T patent/ES2061503T3/es not_active Expired - Lifetime
- 1987-07-09 HU HU873097A patent/HU197896B/hu not_active IP Right Cessation
- 1987-07-09 IE IE184187A patent/IE61494B1/en not_active IP Right Cessation
- 1987-07-09 AT AT87306089T patent/ATE98644T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE871841L (en) | 1988-01-10 |
| HUT44536A (en) | 1988-03-28 |
| IL83121A (en) | 1992-09-06 |
| DE3788463T2 (de) | 1994-04-28 |
| HU197896B (en) | 1989-06-28 |
| CA1320209C (en) | 1993-07-13 |
| KR950013767B1 (ko) | 1995-11-15 |
| IE61494B1 (en) | 1994-11-02 |
| DE3788463D1 (de) | 1994-01-27 |
| EP0252744A2 (de) | 1988-01-13 |
| JP2510600B2 (ja) | 1996-06-26 |
| EP0252744B1 (de) | 1993-12-15 |
| KR880001638A (ko) | 1988-04-25 |
| EP0252744A3 (en) | 1989-12-13 |
| US4734498A (en) | 1988-03-29 |
| ES2061503T3 (es) | 1994-12-16 |
| JPS6323858A (ja) | 1988-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |