ATE99936T1 - Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren. - Google Patents

Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.

Info

Publication number: ATE99936T1
Authority: AT; Austria
Prior art keywords: serum; triglyzeride; mammmals; pharmaceuticals; lowering
Prior art date: 1988-10-21

Application number

AT89870154T

Other languages

English (en)

Inventor

Karl H Beyer Jr

Original Assignee

Karl H Beyer Jr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-21

Filing date

1989-10-20

Publication date

1994-01-15

1989-10-20 Application filed by Karl H Beyer Jr filed Critical Karl H Beyer Jr

1994-01-15 Application granted granted Critical

1994-01-15 Publication of ATE99936T1 publication Critical patent/ATE99936T1/de

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 3
239000003814 drug Substances 0.000 title abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical class C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
210000002966 serum Anatomy 0.000 title 1
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
-1 bromo, iodo Chemical group 0.000 abstract 2
125000001153 fluoro group Chemical group F* 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT89870154T 1988-10-21 1989-10-20 Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren. ATE99936T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/260,947 US4920123A (en)	1988-10-21	1988-10-21	Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
EP89870154A EP0370987B1 (de)	1988-10-21	1989-10-20	Pyrazin-Derivate als Arneimittel zur Kontrolle und/oder Senkung des Serum Triglyzerid- und/oder- Cholesterolspiegels in Säugetieren

Publications (1)

Publication Number	Publication Date
ATE99936T1 true ATE99936T1 (de)	1994-01-15

Family

ID=22991313

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89870154T ATE99936T1 (de)	1988-10-21	1989-10-20	Pyrazin-derivate als arneimittel zur kontrolle und/oder senkung des serum triglyzeridund/oder- cholesterolspiegels in saeugetieren.

Country Status (9)

Country	Link
US (1)	US4920123A (de)
EP (1)	EP0370987B1 (de)
JP (1)	JP2840089B2 (de)
KR (1)	KR900005981A (de)
AT (1)	ATE99936T1 (de)
AU (1)	AU616313B2 (de)
CA (1)	CA2001171C (de)
DE (2)	DE370987T1 (de)
ZA (1)	ZA897966B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5110817A (en) *	1988-10-21	1992-05-05	Beyer Jr Karl H	Method for controlling and/or lowering serum triglyceride and/or cholesterol levels in mammals
US5268181A (en) *	1989-04-13	1993-12-07	Upsher-Smith Laboratories, Inc.	Method of using niacin to control nocturnal cholesterol synthesis
US5622985A (en) *	1990-06-11	1997-04-22	Bristol-Myers Squibb Company	Method for preventing a second heart attack employing an HMG CoA reductase inhibitor
US6676967B1 (en) *	1993-09-20	2004-01-13	Kos Pharmaceuticals, Inc.	Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6129930A (en)	1993-09-20	2000-10-10	Bova; David J.	Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6080428A (en)	1993-09-20	2000-06-27	Bova; David J.	Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6746691B2 (en)	1993-09-20	2004-06-08	Kos Pharmaceuticals, Inc.	Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US20060263428A1 (en) *	1993-09-20	2006-11-23	Eugenio Cefali	Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
US6818229B1 (en)	1993-09-20	2004-11-16	Kos Pharmaceuticals, Inc.	Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6369103B1 (en) *	1994-01-18	2002-04-09	Bristol-Myers Squibb Company	Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
US5801177A (en) *	1995-12-14	1998-09-01	Beyer, Jr.; Karl H.	Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin-dependent diabetic patients
DE19622222A1 (de) *	1996-06-03	1997-12-04	Hoechst Ag	Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide
GT199800127A (es) *	1997-08-29	2000-02-01		Combinaciones terapeuticas.
EP2292576B1 (de)	2004-08-24	2014-05-07	The UAB Research Foundation	Retinoide zur Verwendung in der Behandlung von Krebs und zur Senkung des Serumtriglycerid-Spiegels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3274191A (en) *	1963-11-15	1966-09-20	Merck & Co Inc	N-(3-aminopyrazinoyl) benzamidines and process for preparing
US4594349A (en) *	1982-01-04	1986-06-10	Beyer Jr Karl H	Hyperuretic agents
US4604394A (en) *	1984-10-01	1986-08-05	Merck & Co., Inc.	Antiarrhythmic compositions and method
GB8712368D0 (en) *	1987-05-26	1987-07-01	Erba Farmitalia	Pyrazine n-oxide derivatives

1988
- 1988-10-21 US US07/260,947 patent/US4920123A/en not_active Expired - Lifetime
1989
- 1989-10-17 AU AU42909/89A patent/AU616313B2/en not_active Expired
- 1989-10-19 JP JP1272755A patent/JP2840089B2/ja not_active Expired - Fee Related
- 1989-10-20 CA CA002001171A patent/CA2001171C/en not_active Expired - Lifetime
- 1989-10-20 DE DE198989870154T patent/DE370987T1/de active Pending
- 1989-10-20 EP EP89870154A patent/EP0370987B1/de not_active Expired - Lifetime
- 1989-10-20 KR KR1019890015107A patent/KR900005981A/ko not_active Withdrawn
- 1989-10-20 DE DE89870154T patent/DE68912284T2/de not_active Expired - Lifetime
- 1989-10-20 AT AT89870154T patent/ATE99936T1/de not_active IP Right Cessation
- 1989-10-20 ZA ZA897966A patent/ZA897966B/xx unknown

Also Published As

Publication number	Publication date
JPH02237923A (ja)	1990-09-20
ZA897966B (en)	1990-08-29
DE68912284D1 (de)	1994-02-24
CA2001171C (en)	1999-12-21
DE370987T1 (de)	1991-09-05
EP0370987A3 (en)	1990-12-19
JP2840089B2 (ja)	1998-12-24
CA2001171A1 (en)	1990-04-21
AU616313B2 (en)	1991-10-24
AU4290989A (en)	1990-04-26
EP0370987A2 (de)	1990-05-30
KR900005981A (ko)	1990-05-07
EP0370987B1 (de)	1994-01-12
DE68912284T2 (de)	1994-04-28
US4920123A (en)	1990-04-24

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Legal Events

Date	Code	Title	Description
1994-11-15	UEP	Publication of translation of european patent specification
1996-07-15	REN	Ceased due to non-payment of the annual fee