AU1502995A - Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administraiton - Google Patents

Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administraiton

Info

Publication number
AU1502995A
AU1502995A AU15029/95A AU1502995A AU1502995A AU 1502995 A AU1502995 A AU 1502995A AU 15029/95 A AU15029/95 A AU 15029/95A AU 1502995 A AU1502995 A AU 1502995A AU 1502995 A AU1502995 A AU 1502995A
Authority
AU
Australia
Prior art keywords
trimetazidine
pharmaceutical compositions
prolonged release
administraiton
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU15029/95A
Other versions
AU684893B2 (en
Inventor
Alain Cuine
Bruno Huet De Barochez
Patrick Genty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Publication of AU1502995A publication Critical patent/AU1502995A/en
Application granted granted Critical
Publication of AU684893B2 publication Critical patent/AU684893B2/en
Assigned to LES LABORATOIRES SERVIER reassignment LES LABORATOIRES SERVIER Alteration of Name(s) in Register under S187 Assignors: ADIR ET COMPAGNIE
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compsn. for prolonged liberation of trimetazidine (II) or its salts, uses a polymer insoluble in water and a plasticiser to control liberation.
AU15029/95A 1994-03-24 1995-03-22 Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administraiton Expired AU684893B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9403434A FR2717687B1 (en) 1994-03-24 1994-03-24 Pharmaceutical compositions for the sustained release of trimetazidine after oral administration.
FR9403434 1994-03-24

Publications (2)

Publication Number Publication Date
AU1502995A true AU1502995A (en) 1995-10-05
AU684893B2 AU684893B2 (en) 1998-01-08

Family

ID=9461361

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15029/95A Expired AU684893B2 (en) 1994-03-24 1995-03-22 Pharmaceutical compositions permitting the prolonged release of trimetazidine after oral administraiton

Country Status (15)

Country Link
EP (1) EP0673649B1 (en)
JP (1) JP3017040B2 (en)
CN (1) CN1056057C (en)
AT (1) ATE216583T1 (en)
AU (1) AU684893B2 (en)
CA (1) CA2145248C (en)
DE (1) DE69526467T2 (en)
DK (1) DK0673649T3 (en)
ES (1) ES2176296T3 (en)
FI (1) FI116881B (en)
FR (1) FR2717687B1 (en)
NO (1) NO306450B1 (en)
NZ (1) NZ270791A (en)
PT (1) PT673649E (en)
ZA (1) ZA952418B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030227B1 (en) * 2012-02-03 2018-07-31 Ле Лаборатуар Сервье MINI GRANULES FOR THE PROLONGED SHOULDING OF TRIMETHAZIDINE, METHOD OF THEIR RECEIVING AND APPLICATION
WO2019241495A1 (en) * 2018-06-14 2019-12-19 Ming Fang Pharmaceutical composition and method for acute on chronic liver failure

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2802424B1 (en) * 1999-12-17 2002-02-15 Adir MATRIX TABLET FOR THE EXTENDED RELEASE OF TRIMETAZIDINE AFTER ORAL ADMINISTRATION
DE60042972D1 (en) * 2000-10-05 2009-10-29 Usv Ltd Delayed-release drug-containing trimetazidine and method of preparation
FR2818549B1 (en) * 2000-12-26 2003-02-07 Servier Lab SOLID THERMOFORMABLE PHARMACEUTICAL COMPOSITION FOR THE CONTROLLED RELEASE OF TRIMETAZIDINE
EP1448173A2 (en) * 2001-11-21 2004-08-25 Themis Laboratories Private Limited A process for manufacture of a sustained release pharmaceutical composition containing microbeads of trimetazidine dihydrochloride
FR2885807B1 (en) * 2005-05-18 2008-05-16 Mg Pharma SOLID PHARMACEUTICAL COMPOSITION WITH PROLONGED RELEASE OF 1- (2,3,4-TRIMETHOXYBENZYL) PIPERAZINE, AND PREPARATION METHOD
WO2007116243A2 (en) * 2006-04-10 2007-10-18 Mintails Limited Method for treating fibromyalgia and related conditions
EP2200591A2 (en) 2007-09-11 2010-06-30 Ranbaxy Laboratories Limited Controlled release pharmaceutical dosage forms of trimetazidine
JP2012515757A (en) 2009-01-20 2012-07-12 マイクロ ラブス リミテッド Trimetazidine controlled release solid pharmaceutical composition and method for producing the same
PL2391353T3 (en) * 2009-01-30 2016-09-30 Pharmaceutical compositions of trimetazidine
TR201001902A2 (en) 2010-03-12 2011-04-21 Ali̇ Rai̇f İlaç Sanayi̇ Ve Ti̇caret A.Ş. Trimetazidine tablets with extended release
ES2508490T3 (en) 2010-05-04 2014-10-16 Sanovel Ilaç Sanayi Ve Ticaret Anonim Sirketi Formulation of trimetazidine with different release profiles
EP2386302A1 (en) 2010-05-11 2011-11-16 Ranbaxy Laboratories Limited A controlled release pharmaceutical dosage form of trimetazidine and processes for the preparation thereof
BG1345U1 (en) * 2010-05-20 2010-08-31 "Адифарм" Ад Modified-release pharmaceutical formulation
EP2491930A1 (en) 2011-02-25 2012-08-29 Deva Holding Anonim Sirketi Pharmaceutical combination of betahistine and trimetazidine
CN102133195A (en) * 2011-03-17 2011-07-27 王国栋 Trimetazidine dihydrochloride sustained control release pellet and preparation method thereof
CN102319225B (en) * 2011-09-23 2013-04-03 广州白云山光华制药股份有限公司 Trimetazidine hydrochloride sustained release tablet and preparation method thereof
CN102764261A (en) * 2012-07-30 2012-11-07 沈阳药科大学 Oral composition controlling release of trimetazidine dihydrochloride and preparation method of oral composition
CN103565751A (en) * 2013-10-17 2014-02-12 广州帝奇医药技术有限公司 Long-acting sustained-release pellet and preparation method thereof
CN110237053A (en) * 2019-07-26 2019-09-17 湖北欣泽霏药业有限公司 A kind of trimetazidine hydrochloride sustained-release pellet and preparation method thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2490963B1 (en) * 1980-09-30 1986-04-18 Science Union & Cie NOVEL THERAPEUTIC COMPOSITION WITH ANTI-ISCHEMIC ACTION CONTAINING TRIMETHOXY 2, 3, 4-BENZYL 1-PIPERAZINE
EP0187703B1 (en) * 1985-01-11 1992-08-05 Teijin Limited Sustained release preparation
JPH0625055B2 (en) * 1985-03-18 1994-04-06 日本ケミフア株式会社 Persistent tablets
US5260066A (en) * 1992-01-16 1993-11-09 Srchem Incorporated Cryogel bandage containing therapeutic agent
US5417983A (en) * 1992-02-19 1995-05-23 Sagami Chemical Research Center Drug release controlling material responsive to changes in temperature

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030227B1 (en) * 2012-02-03 2018-07-31 Ле Лаборатуар Сервье MINI GRANULES FOR THE PROLONGED SHOULDING OF TRIMETHAZIDINE, METHOD OF THEIR RECEIVING AND APPLICATION
WO2019241495A1 (en) * 2018-06-14 2019-12-19 Ming Fang Pharmaceutical composition and method for acute on chronic liver failure

Also Published As

Publication number Publication date
FI951357L (en) 1995-09-25
CN1124140A (en) 1996-06-12
CA2145248A1 (en) 1995-09-25
PT673649E (en) 2002-08-30
DE69526467T2 (en) 2002-12-05
EP0673649B1 (en) 2002-04-24
NO951110L (en) 1995-09-25
FR2717687A1 (en) 1995-09-29
JPH07258086A (en) 1995-10-09
CN1056057C (en) 2000-09-06
FR2717687B1 (en) 1996-06-14
FI951357A0 (en) 1995-03-22
CA2145248C (en) 2004-01-06
DK0673649T3 (en) 2002-08-05
FI116881B (en) 2006-03-31
NO951110D0 (en) 1995-03-23
DE69526467D1 (en) 2002-05-29
ZA952418B (en) 1995-12-18
ATE216583T1 (en) 2002-05-15
EP0673649A1 (en) 1995-09-27
NZ270791A (en) 1996-07-26
ES2176296T3 (en) 2002-12-01
AU684893B2 (en) 1998-01-08
JP3017040B2 (en) 2000-03-06
NO306450B1 (en) 1999-11-08

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: LES LABORATOIRES SERVIER

Free format text: FORMER OWNER WAS: ADIR ET COMPAGNIE