AU2005299816B2 - Triazoles useful as inhibitors of protein kinases - Google Patents

Triazoles useful as inhibitors of protein kinases Download PDF

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Publication number
AU2005299816B2
AU2005299816B2 AU2005299816A AU2005299816A AU2005299816B2 AU 2005299816 B2 AU2005299816 B2 AU 2005299816B2 AU 2005299816 A AU2005299816 A AU 2005299816A AU 2005299816 A AU2005299816 A AU 2005299816A AU 2005299816 B2 AU2005299816 B2 AU 2005299816B2
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agent
aliphatic
treating
disease
disorders
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AU2005299816A2 (en
AU2005299816A1 (en
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Michael J. Arnost
Robert J. Davies
Cornelia J. Forster
Jian Wang
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Endocrinology (AREA)
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AU2005299816A 2004-10-21 2005-10-21 Triazoles useful as inhibitors of protein kinases Ceased AU2005299816B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62127004P 2004-10-21 2004-10-21
US60/621,270 2004-10-21
PCT/US2005/037830 WO2006047256A1 (en) 2004-10-21 2005-10-21 Triazoles useful as inhibitors of protein kinases

Publications (3)

Publication Number Publication Date
AU2005299816A2 AU2005299816A2 (en) 2006-05-04
AU2005299816A1 AU2005299816A1 (en) 2006-05-04
AU2005299816B2 true AU2005299816B2 (en) 2011-09-01

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AU2005299816A Ceased AU2005299816B2 (en) 2004-10-21 2005-10-21 Triazoles useful as inhibitors of protein kinases

Country Status (26)

Country Link
US (1) US7645775B2 (de)
EP (1) EP1811998B1 (de)
JP (1) JP5085330B2 (de)
KR (1) KR20070085407A (de)
CN (1) CN101072556A (de)
AR (1) AR054088A1 (de)
AT (1) ATE485042T1 (de)
AU (1) AU2005299816B2 (de)
BR (1) BRPI0517435A (de)
CA (1) CA2584752A1 (de)
CY (1) CY1111197T1 (de)
DE (1) DE602005024293D1 (de)
DK (1) DK1811998T3 (de)
ES (1) ES2352453T3 (de)
HR (1) HRP20100715T1 (de)
IL (1) IL182664A0 (de)
MX (1) MX2007004841A (de)
NO (1) NO20072567L (de)
NZ (1) NZ555088A (de)
PL (1) PL1811998T3 (de)
PT (1) PT1811998E (de)
RU (1) RU2393155C2 (de)
SI (1) SI1811998T1 (de)
TW (1) TW200630090A (de)
WO (1) WO2006047256A1 (de)
ZA (1) ZA200703950B (de)

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AU2016259396B2 (en) * 2006-12-29 2018-11-08 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as Axl inhibitors
JP2010514810A (ja) 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
AU2007342005A1 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as Axl inhibitors
AU2014200824B2 (en) * 2006-12-29 2016-12-15 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as Axl inhibitors
ES2404668T3 (es) 2006-12-29 2013-05-28 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl
EP2114954B1 (de) 2006-12-29 2013-02-13 Rigel Pharmaceuticals, Inc. Durch bicyclisches aryl bzw. bicyclisches heteroaryl substituierte triazole, die sich als axl-inihibitoren eignen
JP2011500625A (ja) 2007-10-18 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリ置換された１，２，４−トリアゾール
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
MY152486A (en) 2008-03-19 2014-10-15 Janssen Pharmaceutica Nv Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators
WO2009135944A1 (en) 2008-05-09 2009-11-12 Janssen Pharmaceutica Nv Trisubstituted pyrazoles as acetylcholine receptor modulators
US8431594B2 (en) 2008-07-09 2013-04-30 Rigel Pharmaceuticals, Inc. Bridged bicyclic heteroaryl substituted triazoles useful as AXL inhibitors
CA2749195C (en) 2009-01-15 2017-03-07 Rigel Pharmaceuticals, Inc. Protein kinase c inhibitors and uses thereof
RU2555326C2 (ru) 2009-01-16 2015-07-10 Риджел Фармасьютикалз, Инк. ИНГИБИТОРЫ Axl ДЛЯ ПРИМЕНЕНИЯ В КОМБИНИРОВАННОЙ ТЕРАПИИ ДЛЯ ПРЕДОТВРАЩЕНИЯ, УСТРАНЕНИЯ ИЛИ ЛЕЧЕНИЯ МЕТАСТAЗИРУЮЩЕГО РАКА
AR081383A1 (es) 2010-05-11 2012-08-29 Sanofi Aventis N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central.
TW201206939A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted phenyl cycloalkyl pyrrolidine (piperidine) spirolactams and amides, preparation and therapeutic use thereof
TW201202251A (en) 2010-05-11 2012-01-16 Sanofi Aventis Substituted N-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof
JP5784110B2 (ja) 2010-05-11 2015-09-24 サノフイ 置換されたｎ−ヘテロアリールテトラヒドロ−イソキノリン誘導体、その製造及び治療上の使用
JP2013529198A (ja) 2010-05-11 2013-07-18 サノフイ 置換されたｎ−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用
EP2569303A1 (de) 2010-05-11 2013-03-20 Sanofi Substituierte n-alkyl- und n-acyl-tetrahydroisochinolinderivate, ihre zubereitung und therapeutische verwendung
CN102787092B (zh) * 2011-05-17 2018-01-09 李晖 培养基、细胞培养用试剂盒及细胞培养方法
CA2900892A1 (en) 2013-03-05 2014-09-12 F. Hoffmann-La Roche Ag Antiviral compounds
CA2988306A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
CN112142747B (zh) * 2019-06-28 2024-03-01 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用

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RU2340611C2 (ru) * 2000-09-15 2008-12-10 Вертекс Фармасьютикалз Инкорпорейтед Производные пиразола, используемые в качестве ингибиторов протеинкиназы
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