AU2011306065B2 - Manufacture of tablets from energy-applied powder blend - Google Patents

Manufacture of tablets from energy-applied powder blend Download PDF

Info

Publication number: AU2011306065B2
Authority: AU; Australia
Prior art keywords: tablets; tablet; powder blend; energy; binder
Prior art date: 2010-09-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU2011306065A

Other languages

English (en)

Other versions

AU2011306065A1 (en

Inventor

Frank J. Bunick

Leo B. Kriksunov

Joseph R. Luber

Harry S. Sowden

Christopher E. Szymczak

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kenvue Brands LLC

Original Assignee

McNeil PPC Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-22

Filing date

2011-03-21

Publication date

2015-03-19

2010-09-22 Priority claimed from US12/887,544 external-priority patent/US8871263B2/en

2011-03-21 Application filed by McNeil PPC Inc filed Critical McNeil PPC Inc

2011-03-21 Priority claimed from US13/052,200 external-priority patent/US20110319492A1/en

2013-02-28 Publication of AU2011306065A1 publication Critical patent/AU2011306065A1/en

2015-03-19 Application granted granted Critical

2015-03-19 Publication of AU2011306065B2 publication Critical patent/AU2011306065B2/en

Status Ceased legal-status Critical Current

2031-03-21 Anticipated expiration legal-status Critical

Links

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230000002035 prolonged effect Effects 0.000 description 1
150000005599 propionic acid derivatives Chemical class 0.000 description 1
229960000786 propylhexedrine Drugs 0.000 description 1
JCRIVQIOJSSCQD-UHFFFAOYSA-N propylhexedrine Chemical compound CNC(C)CC1CCCCC1 JCRIVQIOJSSCQD-UHFFFAOYSA-N 0.000 description 1
229940126409 proton pump inhibitor Drugs 0.000 description 1
239000000612 proton pump inhibitor Substances 0.000 description 1
ZPMNHBXQOOVQJL-UHFFFAOYSA-N prucalopride Chemical compound C1CN(CCCOC)CCC1NC(=O)C1=CC(Cl)=C(N)C2=C1OCC2 ZPMNHBXQOOVQJL-UHFFFAOYSA-N 0.000 description 1
229960003863 prucalopride Drugs 0.000 description 1
235000019423 pullulan Nutrition 0.000 description 1
239000010453 quartz Substances 0.000 description 1
229960004157 rabeprazole Drugs 0.000 description 1
YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
229960002281 racecadotril Drugs 0.000 description 1
108700040249 racecadotril Proteins 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
229960000672 rosuvastatin Drugs 0.000 description 1
BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 description 1
235000013533 rum Nutrition 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
239000012176 shellac wax Substances 0.000 description 1
235000020046 sherry Nutrition 0.000 description 1
238000005029 sieve analysis Methods 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
208000019116 sleep disease Diseases 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
235000019385 spermaceti wax Nutrition 0.000 description 1
238000009987 spinning Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000008143 stimulant laxative Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
150000003445 sucroses Chemical class 0.000 description 1
229950005175 sudoxicam Drugs 0.000 description 1
229960000894 sulindac Drugs 0.000 description 1
MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
229960004492 suprofen Drugs 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
235000013616 tea Nutrition 0.000 description 1
229950002757 teoclate Drugs 0.000 description 1
238000010998 test method Methods 0.000 description 1
238000012360 testing method Methods 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
239000000892 thaumatin Substances 0.000 description 1
235000010436 thaumatin Nutrition 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
229960003785 thonzylamine Drugs 0.000 description 1
229930003799 tocopherol Natural products 0.000 description 1
239000011732 tocopherol Substances 0.000 description 1
235000019149 tocopherols Nutrition 0.000 description 1
229960001017 tolmetin Drugs 0.000 description 1
UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
229960001128 triprolidine Drugs 0.000 description 1
CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000005418 vegetable material Substances 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
239000011800 void material Substances 0.000 description 1
235000020234 walnut Nutrition 0.000 description 1
229920003176 water-insoluble polymer Polymers 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
235000015041 whisky Nutrition 0.000 description 1
235000014101 wine Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000005019 zein Substances 0.000 description 1
229940093612 zein Drugs 0.000 description 1
229960001475 zolpidem Drugs 0.000 description 1
ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 description 1
QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/027—Particular press methods or systems
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/34—Heating or cooling presses or parts thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Mechanical Engineering (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Medicinal Preparation (AREA)

AU2011306065A 2010-09-22 2011-03-21 Manufacture of tablets from energy-applied powder blend Ceased AU2011306065B2 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US12/887,544 US8871263B2 (en)	2009-09-24	2010-09-22	Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder
US12/887,552 US9610224B2 (en)	2009-09-24	2010-09-22	Manufacture of tablet in a die utilizing powder blend containing water-containing material
US12/887,552		2010-09-22
US12/887,544		2010-09-22
US13/052,200 US20110319492A1 (en)	2010-06-24	2011-03-21	Manufacture of tablets from energy-applied powder blend
US13/052,200		2011-03-21
PCT/US2011/029161 WO2012039790A1 (fr)	2010-09-22	2011-03-21	Fabrication de comprimés à partir d'un mélange pulvérulent auquel de l'énergie est appliquée

Publications (2)

Publication Number	Publication Date
AU2011306065A1 AU2011306065A1 (en)	2013-02-28
AU2011306065B2 true AU2011306065B2 (en)	2015-03-19

Family

ID=44140931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2011306065A Ceased AU2011306065B2 (en)	2010-09-22	2011-03-21	Manufacture of tablets from energy-applied powder blend

Country Status (9)

Country	Link
EP (1)	EP2618813A1 (fr)
KR (1)	KR20130106399A (fr)
CN (1)	CN103124552A (fr)
AU (1)	AU2011306065B2 (fr)
BR (1)	BR112013006689A2 (fr)
CA (1)	CA2810837A1 (fr)
MX (1)	MX2013003288A (fr)
RU (1)	RU2013118252A (fr)
WO (1)	WO2012039790A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2015105992A1 (fr) *	2014-01-10	2015-07-16	Mcneil-Ppc, Inc.	Procédé pour fabriquer un comprimé par radiofréquence et particules revêtues à perte
US20180147153A1 (en) *	2016-11-28	2018-05-31	Johnson & Johnson Consumer Inc.	Process for making a coated dosage form
US10493026B2 (en) *	2017-03-20	2019-12-03	Johnson & Johnson Consumer Inc.	Process for making tablet using radiofrequency and lossy coated particles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090060983A1 (en) *	2007-08-30	2009-03-05	Bunick Frank J	Method And Composition For Making An Orally Disintegrating Dosage Form

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4268465A (en) *	1978-01-27	1981-05-19	Massachusetts Institute Of Technology	Method of accelerating the cooling of polymeric articles
JPS5967006A (ja) *	1982-10-08	1984-04-16	Hitachi Ltd	タブレツト成形機
US4851226A (en)	1987-11-16	1989-07-25	Mcneil Consumer Products Company	Chewable medicament tablet containing means for taste masking
US4906478A (en)	1988-12-12	1990-03-06	Valentine Enterprises, Inc.	Simethicone/calcium silicate composition
EP0416791A2 (fr) *	1989-09-08	1991-03-13	General Motors Corporation	Procédé et appareil de moulage par compression avec chauffage diÀ©lectrique
US5178878A (en)	1989-10-02	1993-01-12	Cima Labs, Inc.	Effervescent dosage form with microparticles
US5223264A (en)	1989-10-02	1993-06-29	Cima Labs, Inc.	Pediatric effervescent dosage form
US5275822A (en)	1989-10-19	1994-01-04	Valentine Enterprises, Inc.	Defoaming composition
US5075114A (en)	1990-05-23	1991-12-24	Mcneil-Ppc, Inc.	Taste masking and sustained release coatings for pharmaceuticals
CA2068402C (fr)	1991-06-14	1998-09-22	Michael R. Hoy	Enrobage pour masquer le gout pouvant etre utilise dans des comprimes pharmaceutiques croquables
US5464632C1 (en)	1991-07-22	2001-02-20	Prographarm Lab	Rapidly disintegratable multiparticular tablet
DE19531277A1 (de)	1995-08-25	1997-02-27	Basf Ag	Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren
ATE260646T1 (de) *	1996-04-16	2004-03-15	Novartis Consumer Health Sa	Schnell zerfallende orale dosierungsform
CN1191824C (zh)	1996-06-17	2005-03-09	詹森药业有限公司	双面凸的迅速崩解剂型
US5939091A (en) *	1997-05-20	1999-08-17	Warner Lambert Company	Method for making fast-melt tablets
US6103260A (en)	1997-07-17	2000-08-15	Mcneil-Ppc, Inc.	Simethicone/anhydrous calcium phosphate compositions
HUP0101282A3 (en)	1998-03-16	2005-03-29	Yamanouchi Pharma Tech Inc	Tablets quickly disintegrating in the oral cavity and process for producing the same
DE19812688A1 (de)	1998-03-23	1999-09-30	Basf Ag	Verfahren zur Herstellung von festen Dosierungsformen
US6767200B2 (en)	2001-09-28	2004-07-27	Mcneil-Ppc, Inc.	Systems, methods and apparatuses for manufacturing dosage forms
US7807197B2 (en)	2002-09-28	2010-10-05	Mcneil-Ppc, Inc.	Composite dosage forms having an inlaid portion
WO2004100857A2 (fr) *	2003-05-07	2004-11-25	Akina, Inc.	Granules a teneur elevee en plastique, destines a la fabrication de comprimes a dissolution rapide

2011
- 2011-03-21 CA CA2810837A patent/CA2810837A1/fr not_active Abandoned
- 2011-03-21 CN CN2011800459163A patent/CN103124552A/zh active Pending
- 2011-03-21 AU AU2011306065A patent/AU2011306065B2/en not_active Ceased
- 2011-03-21 RU RU2013118252/15A patent/RU2013118252A/ru not_active Application Discontinuation
- 2011-03-21 EP EP11710981.9A patent/EP2618813A1/fr not_active Withdrawn
- 2011-03-21 BR BR112013006689A patent/BR112013006689A2/pt not_active IP Right Cessation
- 2011-03-21 WO PCT/US2011/029161 patent/WO2012039790A1/fr not_active Ceased
- 2011-03-21 MX MX2013003288A patent/MX2013003288A/es not_active Application Discontinuation
- 2011-03-21 KR KR1020137009871A patent/KR20130106399A/ko not_active Withdrawn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20090060983A1 (en) *	2007-08-30	2009-03-05	Bunick Frank J	Method And Composition For Making An Orally Disintegrating Dosage Form

Also Published As

Publication number	Publication date
AU2011306065A1 (en)	2013-02-28
CN103124552A (zh)	2013-05-29
MX2013003288A (es)	2013-05-22
RU2013118252A (ru)	2014-10-27
EP2618813A1 (fr)	2013-07-31
WO2012039790A1 (fr)	2012-03-29
BR112013006689A2 (pt)	2016-06-07
KR20130106399A (ko)	2013-09-27
CA2810837A1 (fr)	2012-03-29

Legal Events

Date	Code	Title	Description
2015-07-16	FGA	Letters patent sealed or granted (standard patent)
2016-10-20	MK14	Patent ceased section 143(a) (annual fees not paid) or expired

Publication	Publication Date	Title
EP2480201B1 (fr)	2017-08-23	Fabrication de comprimé dans une matrice à l'aide de mélange pulvérulent contenant une matière contenant de l'eau
AU2011306063B2 (en)	2015-03-12	Multi-layered orally disintegrating tablet and the manufacture thereof
US20170035656A1 (en)	2017-02-09	Multi-layered orally disintegrating tablet and the manufacture thereof
US20110319492A1 (en)	2011-12-29	Manufacture of tablets from energy-applied powder blend
US9511028B2 (en)	2016-12-06	Orally disintegrating tablet
WO2012039788A1 (fr)	2012-03-29	Comprimé orodispersible multicouche et sa fabrication
AU2011306065B2 (en)	2015-03-19	Manufacture of tablets from energy-applied powder blend
HK1185564A (en)	2014-02-21	Manufacture of tablets from energy-applied powder blend
HK1171964B (en)	2015-07-17	Manufacture of tablet in a die utilizing powder blend containing water-containing material
HK1171986B (en)	2016-03-24	Machine for the manufacture of dosage forms utilizing radiofrequency energy
HK1174262B (en)	2016-03-24	Manufacture of tablet in a die utilizing radiofrequency energy and meltable binder