AU2014361800B2 - Methods to treat lymphoplasmacytic lymphoma - Google Patents
Methods to treat lymphoplasmacytic lymphoma Download PDFInfo
- Publication number
- AU2014361800B2 AU2014361800B2 AU2014361800A AU2014361800A AU2014361800B2 AU 2014361800 B2 AU2014361800 B2 AU 2014361800B2 AU 2014361800 A AU2014361800 A AU 2014361800A AU 2014361800 A AU2014361800 A AU 2014361800A AU 2014361800 B2 AU2014361800 B2 AU 2014361800B2
- Authority
- AU
- Australia
- Prior art keywords
- certain embodiments
- optionally substituted
- alkyl
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CCc1c(C)c(*)cc(C)c1* Chemical compound CCc1c(C)c(*)cc(C)c1* 0.000 description 13
- QWQFGTOJXBOYJO-HYXAFXHYSA-N C/C=C(/C(N1)=O)\SC1=C Chemical compound C/C=C(/C(N1)=O)\SC1=C QWQFGTOJXBOYJO-HYXAFXHYSA-N 0.000 description 1
- LELWDBPLERONSZ-UHFFFAOYSA-N CC(C)(c1cc(NC(c2ccc(C)c(NC(c3cc(-c4ccc[s]4)cnc3)=O)c2)=O)ccc1)C#N Chemical compound CC(C)(c1cc(NC(c2ccc(C)c(NC(c3cc(-c4ccc[s]4)cnc3)=O)c2)=O)ccc1)C#N LELWDBPLERONSZ-UHFFFAOYSA-N 0.000 description 1
- VTLICYGJCMMIFP-UHFFFAOYSA-N CC(C)NS(C=C)=O Chemical compound CC(C)NS(C=C)=O VTLICYGJCMMIFP-UHFFFAOYSA-N 0.000 description 1
- JXZUHDMMANYKMX-UHFFFAOYSA-N CC[n]1cnc(C)c1 Chemical compound CC[n]1cnc(C)c1 JXZUHDMMANYKMX-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- UVEDQUMYFTWIPC-UHFFFAOYSA-N CNc1n[o]cc1 Chemical compound CNc1n[o]cc1 UVEDQUMYFTWIPC-UHFFFAOYSA-N 0.000 description 1
- OKDRSASIWHFWNJ-UHFFFAOYSA-N Cc(c(NC(c1cc(-c2ccc[s]2)cnc1)=O)c1)ccc1NC(c1ccc(CN2CCNCC2)c(C(F)(F)F)c1)=O Chemical compound Cc(c(NC(c1cc(-c2ccc[s]2)cnc1)=O)c1)ccc1NC(c1ccc(CN2CCNCC2)c(C(F)(F)F)c1)=O OKDRSASIWHFWNJ-UHFFFAOYSA-N 0.000 description 1
- ZMCYVXSHOPYEIG-UHFFFAOYSA-N Cc(ccc(C(Nc1ccc(CN2CCNCC2)c(C(F)(F)F)c1)=O)c1)c1NC(c1cc(-c2c[o]nc2)cnc1)=O Chemical compound Cc(ccc(C(Nc1ccc(CN2CCNCC2)c(C(F)(F)F)c1)=O)c1)c1NC(c1cc(-c2c[o]nc2)cnc1)=O ZMCYVXSHOPYEIG-UHFFFAOYSA-N 0.000 description 1
- CDCHBOQVXIGZHA-UHFFFAOYSA-N O=C1NCC=C1 Chemical compound O=C1NCC=C1 CDCHBOQVXIGZHA-UHFFFAOYSA-N 0.000 description 1
- UFWIBTONFRDIAS-UHFFFAOYSA-N c1cc2ccccc2cc1 Chemical compound c1cc2ccccc2cc1 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915684P | 2013-12-13 | 2013-12-13 | |
| US61/915,684 | 2013-12-13 | ||
| US201462036917P | 2014-08-13 | 2014-08-13 | |
| US62/036,917 | 2014-08-13 | ||
| PCT/US2014/070167 WO2015089481A2 (en) | 2013-12-13 | 2014-12-12 | Methods to treat lymphoplasmacytic lymphoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014361800A1 AU2014361800A1 (en) | 2016-06-09 |
| AU2014361800B2 true AU2014361800B2 (en) | 2020-05-07 |
Family
ID=53371973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014361800A Ceased AU2014361800B2 (en) | 2013-12-13 | 2014-12-12 | Methods to treat lymphoplasmacytic lymphoma |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9908872B2 (2) |
| EP (1) | EP3079682A4 (2) |
| JP (1) | JP6878004B2 (2) |
| AU (1) | AU2014361800B2 (2) |
| CA (1) | CA2932353A1 (2) |
| WO (1) | WO2015089481A2 (2) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2932353A1 (en) | 2013-12-13 | 2015-06-18 | Steven P. Treon | Methods to treat lymphoplasmacytic lymphoma |
| EP3079683A4 (en) | 2013-12-13 | 2017-12-20 | Dana-Farber Cancer Institute, Inc. | Methods to treat lymphoplasmacytic lymphoma |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
| JP7458147B2 (ja) | 2016-01-13 | 2024-03-29 | ストラ エンソ オーユーイー | ２，５－フランジカルボン酸ならびにその中間体および誘導体の製造方法 |
| US11319299B2 (en) | 2016-03-01 | 2022-05-03 | Propellon Therapeutics Inc. | Substituted carboxamides as inhibitors of WDR5 protein-protein binding |
| JP2019507179A (ja) | 2016-03-01 | 2019-03-14 | プロペロン セラピューティックス インコーポレイテッド | Ｗｄｒ５タンパク質−タンパク質結合の阻害剤 |
| AU2017363313B2 (en) * | 2016-11-22 | 2021-06-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of interleukin-1 receptor-associated kinases and uses thereof |
| WO2018102366A1 (en) * | 2016-11-30 | 2018-06-07 | Ariad Pharmaceuticals, Inc. | Anilinopyrimidines as haematopoietic progenitor kinase 1 (hpk1) inhibitors |
| CA3068305A1 (en) * | 2017-06-29 | 2019-01-03 | Rigel Pharmaceuticals, Inc. | Kinase inhibitors and methods for making and using |
| US11542251B2 (en) | 2018-02-14 | 2023-01-03 | Dana-Farber Cancer Institute, Inc. | IRAK degraders and uses thereof |
| CN108707147A (zh) * | 2018-06-20 | 2018-10-26 | 桑文军 | 一种新型微管蛋白抑制剂及其在抗肿瘤药物中的应用 |
| CN117285467A (zh) | 2018-07-31 | 2023-12-26 | 罗索肿瘤学公司 | 喷雾干燥的分散体和制剂 |
| US11203591B2 (en) | 2018-10-31 | 2021-12-21 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds |
| WO2020092528A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| IL315677A (en) | 2022-03-23 | 2024-11-01 | Rigel Pharmaceuticals Inc | Pyrimid-2-yl-pyrazole compounds as irak inhibitors |
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| WO2000018738A1 (en) * | 1998-09-25 | 2000-04-06 | Astrazeneca Ab | Benzamide derivatives and their use as cytokine inhibitors |
| US6821965B1 (en) * | 1998-08-04 | 2004-11-23 | Asterzeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
| WO2006003378A1 (en) * | 2004-07-01 | 2006-01-12 | Astrazeneca Ab | Azine-carboxamides as anti-cancer agent |
| WO2006067445A2 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Csf-1r kinase inhibitors |
| WO2006067446A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| US20070072862A1 (en) * | 2005-08-15 | 2007-03-29 | Dimauro Erin F | Bis-aryl amide compounds and methods of use |
| US20080269215A1 (en) * | 2005-11-14 | 2008-10-30 | Genentech Inc. | Bisamide Inhibitors of Hedgehog Signaling |
| WO2013050261A1 (en) * | 2011-10-03 | 2013-04-11 | Syngenta Participations Ag | Insecticidal 2-methoxybenzamide derivatives |
| CN103405429A (zh) * | 2013-08-22 | 2013-11-27 | 中国药科大学 | 一类vegfr-2抑制剂及其用途 |
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| ATE269295T1 (de) | 1998-04-17 | 2004-07-15 | Parker Hughes Inst | Btk inhibitoren und verfahren zur identifizierung und verwendung |
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| CA2932353A1 (en) | 2013-12-13 | 2015-06-18 | Steven P. Treon | Methods to treat lymphoplasmacytic lymphoma |
| EP3715346B1 (en) | 2014-10-22 | 2024-01-03 | Dana-Farber Cancer Institute, Inc. | Thiazolyl-containing compounds for treating proliferative diseases |
-
2014
- 2014-12-12 CA CA2932353A patent/CA2932353A1/en active Pending
- 2014-12-12 EP EP14869351.8A patent/EP3079682A4/en active Pending
- 2014-12-12 US US15/104,005 patent/US9908872B2/en active Active
- 2014-12-12 JP JP2016539167A patent/JP6878004B2/ja active Active
- 2014-12-12 AU AU2014361800A patent/AU2014361800B2/en not_active Ceased
- 2014-12-12 WO PCT/US2014/070167 patent/WO2015089481A2/en not_active Ceased
-
2018
- 2018-02-23 US US15/904,143 patent/US10597387B2/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821965B1 (en) * | 1998-08-04 | 2004-11-23 | Asterzeneca Ab | Amidobenzamide derivatives which are useful as cytokine inhibitors |
| WO2000018738A1 (en) * | 1998-09-25 | 2000-04-06 | Astrazeneca Ab | Benzamide derivatives and their use as cytokine inhibitors |
| WO2006003378A1 (en) * | 2004-07-01 | 2006-01-12 | Astrazeneca Ab | Azine-carboxamides as anti-cancer agent |
| WO2006067445A2 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Csf-1r kinase inhibitors |
| WO2006067446A1 (en) * | 2004-12-22 | 2006-06-29 | Astrazeneca Ab | Pyridine carboxamide derivatives for use as anticancer agents |
| US20070072862A1 (en) * | 2005-08-15 | 2007-03-29 | Dimauro Erin F | Bis-aryl amide compounds and methods of use |
| US20080269215A1 (en) * | 2005-11-14 | 2008-10-30 | Genentech Inc. | Bisamide Inhibitors of Hedgehog Signaling |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3079682A2 (en) | 2016-10-19 |
| CA2932353A1 (en) | 2015-06-18 |
| US9908872B2 (en) | 2018-03-06 |
| US20160311807A1 (en) | 2016-10-27 |
| US10597387B2 (en) | 2020-03-24 |
| JP6878004B2 (ja) | 2021-05-26 |
| JP2017504595A (ja) | 2017-02-09 |
| WO2015089481A2 (en) | 2015-06-18 |
| WO2015089481A3 (en) | 2015-10-29 |
| US20180186780A1 (en) | 2018-07-05 |
| AU2014361800A1 (en) | 2016-06-09 |
| EP3079682A4 (en) | 2017-08-30 |
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