AU2024257450A1 - Regulatable controlled expression of a transgene in primates - Google Patents
Regulatable controlled expression of a transgene in primatesInfo
- Publication number
- AU2024257450A1 AU2024257450A1 AU2024257450A AU2024257450A AU2024257450A1 AU 2024257450 A1 AU2024257450 A1 AU 2024257450A1 AU 2024257450 A AU2024257450 A AU 2024257450A AU 2024257450 A AU2024257450 A AU 2024257450A AU 2024257450 A1 AU2024257450 A1 AU 2024257450A1
- Authority
- AU
- Australia
- Prior art keywords
- antibody
- inducer
- administered
- artemisinin
- transgene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363459853P | 2023-04-17 | 2023-04-17 | |
| US202363459850P | 2023-04-17 | 2023-04-17 | |
| US63/459,853 | 2023-04-17 | ||
| US63/459,850 | 2023-04-17 | ||
| PCT/US2024/024837 WO2024220449A2 (fr) | 2023-04-17 | 2024-04-17 | Expression régulable et contrôlable d'un transgène chez des primates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2024257450A1 true AU2024257450A1 (en) | 2025-11-27 |
Family
ID=93153477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2024257450A Pending AU2024257450A1 (en) | 2023-04-17 | 2024-04-17 | Regulatable controlled expression of a transgene in primates |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4698662A2 (fr) |
| KR (1) | KR20260013512A (fr) |
| CN (1) | CN121311595A (fr) |
| AU (1) | AU2024257450A1 (fr) |
| IL (1) | IL323984A (fr) |
| MX (1) | MX2025012417A (fr) |
| WO (1) | WO2024220449A2 (fr) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
| MX2010003371A (es) * | 2007-09-28 | 2010-05-05 | Intrexon Corp | Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos. |
| EP3568474A1 (fr) * | 2017-01-10 | 2019-11-20 | Intrexon Corporation | Modulation de l'expression de polypeptides par l'intermédiaire de nouveaux systèmes d'expression de commutateurs géniques |
| GB201900741D0 (en) * | 2019-01-18 | 2019-03-06 | Synpromics Ltd | Liver-specifc inducible prometers and methods of use thereof |
-
2024
- 2024-04-17 EP EP24793343.5A patent/EP4698662A2/fr active Pending
- 2024-04-17 CN CN202480039554.4A patent/CN121311595A/zh active Pending
- 2024-04-17 KR KR1020257037899A patent/KR20260013512A/ko active Pending
- 2024-04-17 WO PCT/US2024/024837 patent/WO2024220449A2/fr not_active Ceased
- 2024-04-17 AU AU2024257450A patent/AU2024257450A1/en active Pending
-
2025
- 2025-10-15 IL IL323984A patent/IL323984A/en unknown
- 2025-10-16 MX MX2025012417A patent/MX2025012417A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024220449A9 (fr) | 2025-04-03 |
| CN121311595A (zh) | 2026-01-09 |
| WO2024220449A2 (fr) | 2024-10-24 |
| EP4698662A2 (fr) | 2026-02-25 |
| MX2025012417A (es) | 2026-01-07 |
| WO2024220449A3 (fr) | 2025-01-16 |
| IL323984A (en) | 2025-12-01 |
| KR20260013512A (ko) | 2026-01-28 |
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