AU2024259993A1 - Cdk2 inhibitors and methods of using same - Google Patents
Cdk2 inhibitors and methods of using sameInfo
- Publication number
- AU2024259993A1 AU2024259993A1 AU2024259993A AU2024259993A AU2024259993A1 AU 2024259993 A1 AU2024259993 A1 AU 2024259993A1 AU 2024259993 A AU2024259993 A AU 2024259993A AU 2024259993 A AU2024259993 A AU 2024259993A AU 2024259993 A1 AU2024259993 A1 AU 2024259993A1
- Authority
- AU
- Australia
- Prior art keywords
- heterocyclyl
- cycloalkyl
- compound
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2023090329 | 2023-04-24 | ||
| CNPCT/CN2023/090329 | 2023-04-24 | ||
| US202363501034P | 2023-05-09 | 2023-05-09 | |
| US63/501,034 | 2023-05-09 | ||
| CNPCT/CN2023/127659 | 2023-10-30 | ||
| CN2023127659 | 2023-10-30 | ||
| US202363615863P | 2023-12-29 | 2023-12-29 | |
| US63/615,863 | 2023-12-29 | ||
| PCT/CN2024/089320 WO2024222678A1 (en) | 2023-04-24 | 2024-04-23 | Cdk2 inhibitors and methods of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2024259993A1 true AU2024259993A1 (en) | 2025-11-06 |
Family
ID=93255543
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2024259993A Pending AU2024259993A1 (en) | 2023-04-24 | 2024-04-23 | Cdk2 inhibitors and methods of using same |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP4702015A1 (de) |
| KR (1) | KR20260039645A (de) |
| CN (1) | CN121443596A (de) |
| AU (1) | AU2024259993A1 (de) |
| IL (1) | IL324169A (de) |
| WO (1) | WO2024222678A1 (de) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201016676A (en) * | 2008-10-03 | 2010-05-01 | Astrazeneca Ab | Heterocyclic derivatives and methods of use thereof |
| PL3060562T3 (pl) * | 2013-10-21 | 2022-01-10 | Genosco | Podstawione związki pirymidynowe i ich zastosowanie jako inhibitory syk |
| WO2018226739A1 (en) * | 2017-06-06 | 2018-12-13 | Signalrx Pharmaceuticals, Inc. | Thienopyranones and furanopyranones as checkpoint inhibitors and modulatiors of anti-tumor immunity |
| US20210101881A1 (en) * | 2018-02-12 | 2021-04-08 | Ancureall Pharmaceutical (Shanghai) Co., Ltd. | Pyrimidine compound, preparation method thereof and medical use thereof |
-
2024
- 2024-04-23 EP EP24796058.6A patent/EP4702015A1/de active Pending
- 2024-04-23 KR KR1020257039144A patent/KR20260039645A/ko active Pending
- 2024-04-23 AU AU2024259993A patent/AU2024259993A1/en active Pending
- 2024-04-23 CN CN202480042008.6A patent/CN121443596A/zh active Pending
- 2024-04-23 WO PCT/CN2024/089320 patent/WO2024222678A1/en not_active Ceased
-
2025
- 2025-10-23 IL IL324169A patent/IL324169A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024222678A1 (en) | 2024-10-31 |
| CN121443596A (zh) | 2026-01-30 |
| IL324169A (en) | 2025-12-01 |
| KR20260039645A (ko) | 2026-03-20 |
| EP4702015A1 (de) | 2026-03-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110724143B (zh) | 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用 | |
| AU2012204982B2 (en) | 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors | |
| KR102662358B1 (ko) | Egfr 돌연변이 키나아제 활성을 조절하기 위한 화합물 및 조성물 | |
| TWI551595B (zh) | 2,4-disubstituted benzene-1,5-diamine derivatives and their use, Its preparation of pharmaceutical compositions and pharmaceutical compositions | |
| JP2019522055A (ja) | Ｆｇｆｒ阻害剤として使用される複素環式化合物 | |
| JP2013535491A (ja) | フタラジノンケトン誘導体、その製造法および医薬用途 | |
| TW202024037A (zh) | 用於治療特定白血病之化合物 | |
| KR20150126391A (ko) | 신규 피리미딘 및 피리딘 화합물 및 이들의 용도 | |
| EP3380475A1 (de) | Octahydropyrrolo [3,4-c | |
| AU2024245104A1 (en) | Compound acting as wrn helicase inhibitor | |
| CA3015166C (en) | 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds | |
| WO2021099832A2 (en) | Adenosine receptor antagonist compounds | |
| WO2015066697A1 (en) | Fused morpholinopyrimidines and methods of use thereof | |
| CA3231988A1 (en) | Azaindazole macrocycle compound and use thereof | |
| EP4702015A1 (de) | Cdk2-inhibitoren und verfahren zur verwendung davon | |
| WO2011082271A2 (en) | Substituted triazolo-pyrimidine compounds | |
| TWI894448B (zh) | Ctla-4小分子降解劑及其應用 | |
| JP6977038B2 (ja) | Ｇｓｋ−３阻害剤 | |
| CN114075196B (zh) | 一类芳香环并内酰胺类化合物、其制备方法和用途 | |
| CA3223874A1 (en) | Pyrimidine compounds for use as map4k1 inhibitors | |
| WO2024067820A1 (en) | Tricyclic compounds as cdk inhibitors and methods of using same | |
| TW202604908A (zh) | 雜環化合物及其作為ｒｅｔ抑制劑的用途 | |
| WO2023033740A1 (en) | Compounds useful in modulation of ahr signalling | |
| EP4698531A1 (de) | Pyrrolopyrazinverbindungen, herstellung davon und therapeutische verwendungen davon | |
| FR3025200A1 (fr) | Derives de n-aryl-tricyclopyrimidine-2-amine polyethers macrocycliques |