AU2370801A - Non peptide tachykinin receptor antagonists - Google Patents

Non peptide tachykinin receptor antagonists Download PDF

Info

Publication number: AU2370801A
Authority: AU; Australia
Prior art keywords: phenyl; ylmethyl; indol; alkyl; benzofuran
Prior art date: 1999-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU23708/01A

Other languages

English (en)

Inventor

Hubert Dr. Barth

David Christopher Horwell

Russell Andrew Lewthwaite

Martin Clive Pritchard

Jennifer Raphy

Bernd Schiefermayr

Klaus Steiner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-22

Filing date

2000-12-21

Publication date

2001-07-03

2000-02-22 Priority claimed from EP00103665A external-priority patent/EP1127875A1/fr

2000-12-21 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2001-07-03 Publication of AU2370801A publication Critical patent/AU2370801A/en

Status Abandoned legal-status Critical Current

Links

239000002462 tachykinin receptor antagonist Substances 0.000 title description 6
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150000001875 compounds Chemical class 0.000 claims description 89
-1 CF 3 Inorganic materials 0.000 claims description 60
125000000217 alkyl group Chemical group 0.000 claims description 58
238000000034 method Methods 0.000 claims description 40
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 34
238000002360 preparation method Methods 0.000 claims description 27
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 21
229910052739 hydrogen Inorganic materials 0.000 claims description 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
229910052757 nitrogen Inorganic materials 0.000 claims description 20
125000003545 alkoxy group Chemical group 0.000 claims description 19
229910052736 halogen Inorganic materials 0.000 claims description 19
150000002367 halogens Chemical class 0.000 claims description 19
230000008569 process Effects 0.000 claims description 19
125000002541 furyl group Chemical group 0.000 claims description 18
125000001544 thienyl group Chemical group 0.000 claims description 18
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 17
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125000004076 pyridyl group Chemical group 0.000 claims description 16
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208000026935 allergic disease Diseases 0.000 claims description 15
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 14
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125000004432 carbon atom Chemical group C* 0.000 claims description 11
YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims description 11
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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 7
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 7
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VNUIZIRGAROHHL-UHFFFAOYSA-N 2-(1-benzofuran-2-ylmethylcarbamoylamino)-2-(1h-indol-3-ylmethyl)-3-methoxy-n-(1-phenylethyl)propanamide Chemical compound C=1NC2=CC=CC=C2C=1CC(COC)(NC(=O)NCC=1OC2=CC=CC=C2C=1)C(=O)NC(C)C1=CC=CC=C1 VNUIZIRGAROHHL-UHFFFAOYSA-N 0.000 claims description 5
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125000001424 substituent group Chemical group 0.000 claims description 4
RQEUFEKYXDPUSK-ZETCQYMHSA-N (1S)-1-phenylethanamine Chemical compound C[C@H](N)C1=CC=CC=C1 RQEUFEKYXDPUSK-ZETCQYMHSA-N 0.000 claims description 3
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125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 3
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UKYTZQPDSUAZSQ-IFUPQEAVSA-N (2s)-2-(1-benzofuran-2-ylmethylamino)-2-[(dimethylamino)methyl]-3-(1h-indol-3-yl)propanoic acid;dihydrochloride Chemical compound Cl.Cl.C1=CC=C2OC(CN[C@@](CC=3C4=CC=CC=C4NC=3)(CN(C)C)C(O)=O)=CC2=C1 UKYTZQPDSUAZSQ-IFUPQEAVSA-N 0.000 claims description 2
125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims description 2
QWPVLMCETGYBKC-UHFFFAOYSA-N n-(1-phenylethyl)propanamide Chemical compound CCC(=O)NC(C)C1=CC=CC=C1 QWPVLMCETGYBKC-UHFFFAOYSA-N 0.000 claims description 2
125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 claims 1
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Classifications

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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Endocrinology (AREA)
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AU23708/01A 1999-12-22 2000-12-21 Non peptide tachykinin receptor antagonists Abandoned AU2370801A (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US17154099P	1999-12-22	1999-12-22
US60171540		1999-12-22
EP00103665A EP1127875A1 (fr)	2000-02-22	2000-02-22	Procédé de préparation de l'ester méthylique de l'alpha-diméthylaminométhyl-tryptophane
EP00103665		2000-02-22
PCT/EP2000/013349 WO2001046176A2 (fr)	1999-12-22	2000-12-21	Antagonistes de recepteur de tachykinine non peptidique

Publications (1)

Publication Number	Publication Date
AU2370801A true AU2370801A (en)	2001-07-03

Family

ID=26070578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU23708/01A Abandoned AU2370801A (en)	1999-12-22	2000-12-21	Non peptide tachykinin receptor antagonists

Country Status (18)

Country	Link
EP (1)	EP1244653A1 (fr)
JP (1)	JP2003518111A (fr)
KR (1)	KR20020062364A (fr)
CN (1)	CN1413206A (fr)
AP (1)	AP2002002556A0 (fr)
AU (1)	AU2370801A (fr)
BG (1)	BG106804A (fr)
BR (1)	BR0016626A (fr)
CA (1)	CA2399584A1 (fr)
IL (1)	IL150203A0 (fr)
IS (1)	IS6395A (fr)
MA (1)	MA26854A1 (fr)
MX (1)	MXPA02006282A (fr)
NO (1)	NO20022942L (fr)
OA (1)	OA12129A (fr)
PL (1)	PL357650A1 (fr)
SK (1)	SK8862002A3 (fr)
WO (1)	WO2001046176A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2117538A1 (fr)	2007-01-24	2009-11-18	Glaxo Group Limited	Compositions pharmaceutiques contenant du 2-méthoxy-5- (5-trifluorométhyl-tétrazol-i-yl-benzyl) - (2s-phényl-pipéridin-3s-yl-)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU687754B2 (en) *	1990-08-31	1998-03-05	Warner-Lambert Company	Tachykinin antagonists
CA2355137A1 (fr) *	1998-12-18	2000-06-29	Martyn Clive Pritchard	Antagonistes des recepteurs nk1 non peptidiques

2000
- 2000-12-21 CN CN00817549A patent/CN1413206A/zh active Pending
- 2000-12-21 PL PL00357650A patent/PL357650A1/xx not_active Application Discontinuation
- 2000-12-21 EP EP00987477A patent/EP1244653A1/fr not_active Withdrawn
- 2000-12-21 MX MXPA02006282A patent/MXPA02006282A/es unknown
- 2000-12-21 WO PCT/EP2000/013349 patent/WO2001046176A2/fr not_active Ceased
- 2000-12-21 KR KR1020027008007A patent/KR20020062364A/ko not_active Withdrawn
- 2000-12-21 BR BR0016626-0A patent/BR0016626A/pt not_active Application Discontinuation
- 2000-12-21 OA OA1200200196A patent/OA12129A/en unknown
- 2000-12-21 CA CA002399584A patent/CA2399584A1/fr not_active Abandoned
- 2000-12-21 AU AU23708/01A patent/AU2370801A/en not_active Abandoned
- 2000-12-21 AP APAP/P/2002/002556A patent/AP2002002556A0/en unknown
- 2000-12-21 IL IL15020300A patent/IL150203A0/xx unknown
- 2000-12-21 JP JP2001547086A patent/JP2003518111A/ja active Pending
- 2000-12-21 SK SK886-2002A patent/SK8862002A3/sk unknown
2002
- 2002-05-24 IS IS6395A patent/IS6395A/is unknown
- 2002-06-10 BG BG106804A patent/BG106804A/xx unknown
- 2002-06-14 MA MA26689A patent/MA26854A1/fr unknown
- 2002-06-19 NO NO20022942A patent/NO20022942L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20022942D0 (no)	2002-06-19
BR0016626A (pt)	2002-11-05
IL150203A0 (en)	2002-12-01
CA2399584A1 (fr)	2001-06-28
KR20020062364A (ko)	2002-07-25
MA26854A1 (fr)	2004-12-20
PL357650A1 (en)	2004-07-26
OA12129A (en)	2006-05-05
MXPA02006282A (es)	2004-09-06
CN1413206A (zh)	2003-04-23
JP2003518111A (ja)	2003-06-03
BG106804A (en)	2003-03-31
IS6395A (is)	2002-05-24
EP1244653A1 (fr)	2002-10-02
SK8862002A3 (en)	2002-11-06
WO2001046176A3 (fr)	2002-07-04
AP2002002556A0 (en)	2002-06-30
NO20022942L (no)	2002-06-19
WO2001046176A2 (fr)	2001-06-28

Legal Events

Date	Code	Title	Description
2003-08-21	MK1	Application lapsed section 142(2)(a) - no request for examination in relevant period

Publication	Publication Date	Title
AU698239B2 (en)	1998-10-29	Tachykinin antagonists
JP3529381B2 (ja)	2004-05-24	エンドテリン変換酵素阻害剤
JP2008531677A (ja)	2008-08-14	ペプチド様化合物及び生物活性誘導体の製造
EP1717226B1 (fr)	2009-01-21	Dérivés de la amide du octan 5-amino-4-hydroxy-8-(1h-indol-5-yl) en tant que inhibiteurs du rénin pour le traitement de la hypertension
RU2185375C2 (ru)	2002-07-20	Ациламиноалкениленамидные производные, способы их получения и фармацевтическая композиция на их основе
AU2008320718A1 (en)	2009-05-07	Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof
NO325605B1 (no)	2008-06-23	1-aryl-2-acylaminoetanforbindelser, fremgangsmate for fremstilling derav og farmasoytiske sammensetninger omfattende forbindelsene.
KR20120099457A (ko)	2012-09-10	디아실글리세롤 아실트랜스퍼라제의 억제제
WO2003093234A1 (fr)	2003-11-13	Ligands des recepteurs de la melanocortine
US20070142638A1 (en)	2007-06-21	Ornithine derivatives as prostaglandin e2 agonists or antagonists
JP2002533338A (ja)	2002-10-08	非ペプチドｎｋ１レセプターアンタゴニスト
KR20000052921A (ko)	2000-08-25	뉴로키닌 길항제로서의 피페라지노 유도체
AU2370801A (en)	2001-07-03	Non peptide tachykinin receptor antagonists
WO2006056815A1 (fr)	2006-06-01	Amides d'acide indole-2-carboxylique
HK1021372B (en)	2003-06-20	Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists
FR2665702A1 (fr)	1992-02-14	Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.