AU4061085A - Composition useful for obtaining vaccines containing particles carrying the surface antigene of hepatitis b virus and the receptor of polymerized human serum albumin, animal cells capable of producing such particles and method for the obtention thereof - Google Patents

Composition useful for obtaining vaccines containing particles carrying the surface antigene of hepatitis b virus and the receptor of polymerized human serum albumin, animal cells capable of producing such particles and method for the obtention thereof

Info

Publication number
AU4061085A
AU4061085A AU40610/85A AU4061085A AU4061085A AU 4061085 A AU4061085 A AU 4061085A AU 40610/85 A AU40610/85 A AU 40610/85A AU 4061085 A AU4061085 A AU 4061085A AU 4061085 A AU4061085 A AU 4061085A
Authority
AU
Australia
Prior art keywords
particles
hepatitis
receptor
antigene
obtention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU40610/85A
Other versions
AU598181B2 (en
Inventor
Yves Malpiece
Marie-Louise Michel
Elaine Sobczak
Rolf E. Streeck
Pierre Tiollais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GROUPEMENT DE GENIE GENETIQUE
Centre National de la Recherche Scientifique
Institut National de la Santé et de la Recherche Médicale
Institut Pasteur
Original Assignee
GROUPEMENT DE GENIE GENETIQUE
Centre National de la Recherche Scientifique
Institut National de la Santé et de la Recherche Médicale
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GROUPEMENT DE GENIE GENETIQUE, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut Pasteur filed Critical GROUPEMENT DE GENIE GENETIQUE
Publication of AU4061085A publication Critical patent/AU4061085A/en
Application granted granted Critical
Publication of AU598181B2 publication Critical patent/AU598181B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compsn. for vaccine prodn. comprises (or contains) polypeptide particles which are practically spherical (at least those having immunogenic and immunological characteristics of hepatitis B surface antigen) with diam. 18-25 (pref. 20-22)nm and density allowing sepn. in a density region 1.2-1.22 g/ml in a CsCl gradient. The compsn. is totally free of Dane particles and of envelope antigen (including core antigen), and the particles also contain a receptor for polymerised human albumin. Also new are (1) vectors for transforming eucaryotic cells contg. a DNA sequence coding for the S and pre-S regions of HBV under direct control of an exogenous promoter which is very efficient for expression in the intended animal host cells and (2) animal cell lines transformed with these vectors.
AU40610/85A 1984-03-07 1985-03-07 Composition useful for obtaining vaccines containing particles carrying the surface antigene of hepatitis b virus and the receptor of polymerized human serum albumin, animal cells capable of producing such particles and method for the obtention thereof Expired AU598181B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8403564A FR2560890B1 (en) 1984-03-07 1984-03-07 COMPOSITION USEFUL FOR THE MANUFACTURE OF VACCINES CONTAINING PARTICLES CARRYING THE SURFACE ANTIGEN OF HEPATITIS B VIRUS AND THE POLYMERIZED HUMAN SERUM ALBUMIN RECEPTOR, ANIMAL CELLS CAPABLE OF PRODUCING SUCH PARTICLES
FR8403564 1984-03-07

Publications (2)

Publication Number Publication Date
AU4061085A true AU4061085A (en) 1985-09-24
AU598181B2 AU598181B2 (en) 1990-06-21

Family

ID=9301807

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40610/85A Expired AU598181B2 (en) 1984-03-07 1985-03-07 Composition useful for obtaining vaccines containing particles carrying the surface antigene of hepatitis b virus and the receptor of polymerized human serum albumin, animal cells capable of producing such particles and method for the obtention thereof

Country Status (10)

Country Link
EP (2) EP0732104A1 (en)
JP (1) JPH08839B2 (en)
KR (1) KR930003609B1 (en)
AT (1) ATE141168T1 (en)
AU (1) AU598181B2 (en)
CA (1) CA1262532A (en)
DE (1) DE3588117T2 (en)
FR (1) FR2560890B1 (en)
SU (1) SU1625332A3 (en)
WO (1) WO1985003876A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619753B2 (en) * 1987-06-22 1992-02-06 Medeva Holdings B.V. Hepatitis b surface antigen vaccine

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79740A0 (en) * 1986-08-17 1986-11-30 Yeda Res & Dev Hepatitis vaccine
FR2608052B1 (en) * 1986-12-10 1990-04-13 Pasteur Vaccins PROCESS FOR THE PREPARATION OF A HEPATITIS B VACCINE AND VACCINE OBTAINED
IL86832A (en) 1987-06-22 2002-09-12 Medeva Holdings Bv Recombinant dna molecule including the nucleotide sequence of part of the hbv pre-s1 coding region, an immunogenic particle containing plurality of monomers of a peptide containing pre-s1 epitope and pharmaceutical compositions containing the same
EP0304578B1 (en) * 1987-06-22 2001-10-24 Medeva Holdings Bv Peptide comprising hepatitis B surface antigen
EP0328123A1 (en) * 1988-02-09 1989-08-16 Eugene Tech International, Inc. Heterogeneous, pre-S rich hepatitis B surface antigen
EP0491077A1 (en) * 1990-12-19 1992-06-24 Medeva Holdings B.V. A composition used as a therapeutic agent against chronic viral hepatic diseases
FR2711670B1 (en) 1993-10-22 1996-01-12 Pasteur Institut Nucleotide vector, composition containing it and vaccine for immunization against hepatitis.
RU2135209C1 (en) * 1998-07-17 1999-08-27 Акционерное общество закрытого типа НПК "Комбиотех Лтд" Pharmaceutical composition for viral hepatitis b prophylaxis
JP4085231B2 (en) * 2000-02-28 2008-05-14 株式会社ビークル Protein hollow nanoparticles, substance carrier using the same, and method for introducing substance into cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113712A (en) * 1976-03-08 1978-09-12 The Green Cross Corporation HBsAG Particle composed of single polypeptide subunits and the preparation procedure
CA1100037A (en) * 1977-03-11 1981-04-28 Chung-Mei Ling Hb.sub.c ag coated on solid phase
YU44186B (en) * 1978-12-22 1990-04-30 Biogen Nv Process for obtaining recombinant dnk molecules
JPS5610119A (en) * 1979-07-05 1981-02-02 Alpha Therapeutic Corp Manufacture of b type hepatitis infection preventive vaccine
EP0038765B1 (en) * 1980-04-22 1987-09-02 Institut Pasteur Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine
FR2480780B1 (en) * 1980-04-22 1985-12-06 Pasteur Institut PROCESS FOR THE TRANSFORMATION OF CELLS, ESPECIALLY EUKARYOTES, BY CIRCULAR DNA SUCH AS THAT OF HEPATITIS B VIRUS AND PREPARATIONS CONTAINING THE EXPRESSION PRODUCTS OF SAID DNA
ZW18282A1 (en) * 1981-08-31 1983-03-23 Genentech Inc Preparation of polypeptides in vertebrate cell culture
JPS5936698A (en) * 1982-08-20 1984-02-28 Science & Tech Agency Recombinant dna recombined with gene of virus of hepatitis b, transformed animal cell, and preparation of protein of virus of hepatitis b
US4847080A (en) * 1984-03-07 1989-07-11 New York Blood Center, Inc. Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipide vesicle carriers
AU579148B2 (en) * 1984-03-09 1988-11-17 Scripps Clinic And Research Foundation Synthetic hepatitis b virus vaccine including both t cell and b cell determinants
NL8401066A (en) * 1984-04-04 1985-11-01 Stichting Centraal Lab PROCESS FOR PREPARING PREPARATIONS INCREASING HUMORAL AND CELLULAR IMMUNE ACTIVITY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619753B2 (en) * 1987-06-22 1992-02-06 Medeva Holdings B.V. Hepatitis b surface antigen vaccine

Also Published As

Publication number Publication date
SU1625332A3 (en) 1991-01-30
FR2560890B1 (en) 1987-10-16
JPH08839B2 (en) 1996-01-10
FR2560890A1 (en) 1985-09-13
EP0732104A1 (en) 1996-09-18
KR850700214A (en) 1985-12-26
KR930003609B1 (en) 1993-05-08
WO1985003876A1 (en) 1985-09-12
ATE141168T1 (en) 1996-08-15
AU598181B2 (en) 1990-06-21
DE3588117D1 (en) 1996-09-19
DE3588117T2 (en) 1997-03-20
JPS61500971A (en) 1986-05-15
EP0156712A1 (en) 1985-10-02
CA1262532A (en) 1989-10-31
EP0156712B1 (en) 1996-08-14

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