AU4065593A - Novel tricyclic thiazolo and thiazino derivatives and anti-viral medicaments containing them - Google Patents

Novel tricyclic thiazolo and thiazino derivatives and anti-viral medicaments containing them

Info

Publication number
AU4065593A
AU4065593A AU40655/93A AU4065593A AU4065593A AU 4065593 A AU4065593 A AU 4065593A AU 40655/93 A AU40655/93 A AU 40655/93A AU 4065593 A AU4065593 A AU 4065593A AU 4065593 A AU4065593 A AU 4065593A
Authority
AU
Australia
Prior art keywords
atoms
thiazino
derivatives
alkyl
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU40655/93A
Inventor
Bernhard Konig
Ulrike Leser
Alfred Mertens
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU4065593A publication Critical patent/AU4065593A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to tricyclic thiazolo and thiazino derivatives of formula (I) in which A is a carbocyclic or heterocyclic ring, X may be an oxygen or sulphur atom or the group =NH, =N-C1?-C6? alkyl or =S(O)2?, R is an aliphatic radical with 1-9 C atoms, which may be substituted by phenyl, or a carbocyclic ring with 7-15 C atoms or a heterocyclic ring system, R?1 is a hydrogen atom, an aliphatic radical with 1-6 C atoms or C1?-C6? alkoxy, C1?-C6? alkylmercapto, C1?-C6? alkylsulphinyl, C1?-C6? alkylsulphonyl, amino, C1?-C6? alkylamino, di-C1?-C6? alkylamino, sulphonamido, C1?-C6? alkoxycarbonyl, carboxy, halogen, hydroxy, nitro, cyano, azido, phenyl or benzyloxy, R?2, R?3, R?4 and R?5 may be hydrogen, C1?-C6? alkyl, C1?-C6? hydroxyalkyl, cyano, carboxy or C1?-C6? alkoxycarbonyl and R?2 and R?4 are a further bond between the C atoms to which they are bonded, R?6 is hydrogen or C1?-C6? alkyl, n is 0, 1 or 2 and m is 0 or 1, and their tautomers, enantiomers, diastereomers or physiological acceptable salts. The invention also relates to medicaments containing compounds of formula (I), especially for the treatment of viral infections.
AU40655/93A 1992-05-10 1993-05-07 Novel tricyclic thiazolo and thiazino derivatives and anti-viral medicaments containing them Abandoned AU4065593A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4214830A DE4214830A1 (en) 1992-05-10 1992-05-10 New tricyclic thiazolo and thiazino derivatives and medicaments containing them
DE4214830 1992-05-10

Publications (1)

Publication Number Publication Date
AU4065593A true AU4065593A (en) 1993-12-13

Family

ID=6458213

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40655/93A Abandoned AU4065593A (en) 1992-05-10 1993-05-07 Novel tricyclic thiazolo and thiazino derivatives and anti-viral medicaments containing them

Country Status (7)

Country Link
EP (1) EP0640088B1 (en)
JP (1) JPH08500090A (en)
AT (1) ATE143964T1 (en)
AU (1) AU4065593A (en)
CA (1) CA2134200A1 (en)
DE (2) DE4214830A1 (en)
WO (1) WO1993023407A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007059125A2 (en) * 2005-11-15 2007-05-24 Bristol-Myers Squibb Company Hiv integrase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA986932A (en) * 1970-08-27 1976-04-06 Shigeho Inaba Process for preparing quinazoline derivatives
DE4103177A1 (en) * 1991-02-02 1992-08-06 Boehringer Mannheim Gmbh THIAZOLO- (2,3-A) ISOINDOL DERIVATIVES AND MEDICAMENTS CONTAINING THEREOF
IL102764A0 (en) * 1991-08-16 1993-01-31 Merck & Co Inc Quinazoline derivatives,and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE143964T1 (en) 1996-10-15
EP0640088B1 (en) 1996-10-09
DE4214830A1 (en) 1993-11-11
WO1993023407A1 (en) 1993-11-25
CA2134200A1 (en) 1993-11-25
DE59304138D1 (en) 1996-11-14
JPH08500090A (en) 1996-01-09
EP0640088A1 (en) 1995-03-01

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