AU4331700A - Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives - Google Patents

Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives

Info

Publication number: AU4331700A
Authority: AU; Australia
Prior art keywords: taxol; cholesterol; vitamin; acid derivatives; tumor activity
Prior art date: 1999-04-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU43317/00A

Other languages

English (en)

Inventor

Marc Fariss

J. Doyle Smith

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Virginia Commonwealth University

Washington State University Research Foundation

Original Assignee

University of Washington

Virginia Commonwealth University

Washington State University Research Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-07

Filing date

2000-04-07

Publication date

2000-10-23

2000-04-07 Application filed by University of Washington, Virginia Commonwealth University, Washington State University Research Foundation filed Critical University of Washington

2000-10-23 Publication of AU4331700A publication Critical patent/AU4331700A/en

Status Abandoned legal-status Critical Current

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
229930012538 Paclitaxel Natural products 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title 1
235000012000 cholesterol Nutrition 0.000 title 1
229960001592 paclitaxel Drugs 0.000 title 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AU43317/00A 1999-04-07 2000-04-07 Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives Abandoned AU4331700A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12804799P	1999-04-07	1999-04-07
US60128047		1999-04-07
PCT/US2000/009141 WO2000059492A2 (fr)	1999-04-07	2000-04-07	Activite anti-tumeur de derives de vitamine e, de cholesterol, de taxol et d'acide betulinique

Publications (1)

Publication Number	Publication Date
AU4331700A true AU4331700A (en)	2000-10-23

Family

ID=22433345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU43317/00A Abandoned AU4331700A (en)	1999-04-07	2000-04-07	Anti-tumor activity of vitamin e, cholesterol, taxol and betulinic acid derivatives

Country Status (4)

Country	Link
EP (1)	EP1189607A2 (fr)
AU (1)	AU4331700A (fr)
CA (1)	CA2366807A1 (fr)
WO (1)	WO2000059492A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001284946B2 (en) *	2000-08-18	2007-02-01	Advanced Life Sciences Inc.	Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5869535A (en)	1995-03-21	1999-02-09	The Board Of Trustees Of The University Of Illinois	Method and composition for selectively inhibiting melanoma
JP2004538304A (ja) *	2001-07-27	2004-12-24	ユニバーシティーオブロチェスター	アンドロゲンレセプターのビタミンｅ阻害および前立腺癌細胞中の前立腺特異的抗原の発現
RU2328273C2 (ru) *	2001-12-19	2008-07-10	Рисерч Дивелопмент Фаундейшн	Липосомальная доставка соединений, основанных на витамине е
US7365221B2 (en)	2002-09-26	2008-04-29	Panacos Pharmaceuticals, Inc.	Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
US20040102421A1 (en) *	2002-11-21	2004-05-27	Children's Hospital Research Center At Oakland	Tocopherol and tocotrienol anti-inflammatory medicaments
CN101160132A (zh)	2005-04-12	2008-04-09	帕纳克斯医药公司	3-o-(3′,3′-二甲基琥珀酰基)桦木酸二-n-甲基-d-葡萄糖胺的多晶形物
JP2012506426A (ja) *	2008-10-23	2012-03-15	ダボスライフサイエンスピーティーイー．リミテッド	癌を予防するためのトコトリエノール組成物の使用
US8969303B2 (en)	2010-02-05	2015-03-03	First Tech International Limited	Tocotrienol esters
US20250345454A1 (en) *	2024-05-09	2025-11-13	Peptinovo Biopharma Inc.	Chemotherapeutic paclitaxel based micellular nanoparticles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5610180A (en) *	1988-01-29	1997-03-11	Virginia Commonwealth University	Ionizable congeners of aromatic and aliphatic alcohols as anti-leukemia agents
WO1994005282A1 (fr) *	1992-09-04	1994-03-17	The Scripps Research Institute	Derives de taxol hydrosolubles

2000
- 2000-04-07 EP EP00923141A patent/EP1189607A2/fr not_active Withdrawn
- 2000-04-07 CA CA002366807A patent/CA2366807A1/fr not_active Abandoned
- 2000-04-07 WO PCT/US2000/009141 patent/WO2000059492A2/fr not_active Ceased
- 2000-04-07 AU AU43317/00A patent/AU4331700A/en not_active Abandoned

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2001284946B2 (en) *	2000-08-18	2007-02-01	Advanced Life Sciences Inc.	Prodrugs of betulinic acid derivatives for the treatment of cancer and HIV

Also Published As

Publication number	Publication date
WO2000059492A2 (fr)	2000-10-12
WO2000059492A3 (fr)	2002-01-24
EP1189607A2 (fr)	2002-03-27
CA2366807A1 (fr)	2000-10-12

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Legal Events

Date	Code	Title	Description
2002-03-07	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase