AU620803B2 - 1,2,4-trioxane derivatives - Google Patents

1,2,4-trioxane derivatives Download PDF

Info

Publication number
AU620803B2
AU620803B2 AU14012/88A AU1401288A AU620803B2 AU 620803 B2 AU620803 B2 AU 620803B2 AU 14012/88 A AU14012/88 A AU 14012/88A AU 1401288 A AU1401288 A AU 1401288A AU 620803 B2 AU620803 B2 AU 620803B2
Authority
AU
Australia
Prior art keywords
groups
group
pharmaceutical composition
composition according
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU14012/88A
Other languages
English (en)
Other versions
AU1401288A (en
Inventor
Charles W. Jefford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of AU1401288A publication Critical patent/AU1401288A/en
Application granted granted Critical
Publication of AU620803B2 publication Critical patent/AU620803B2/en
Assigned to OXACO S.A reassignment OXACO S.A Alteration of Name(s) in Register under S187 Assignors: JEFFORD, CHARLES W.
Assigned to PHARMA MAR S.A. reassignment PHARMA MAR S.A. Alteration of Name(s) in Register under S187 Assignors: OXACO S.A
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C07D323/04—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Catching Or Destruction (AREA)
  • Steering Devices For Bicycles And Motorcycles (AREA)
  • Soil Working Implements (AREA)
AU14012/88A 1987-04-03 1988-03-30 1,2,4-trioxane derivatives Ceased AU620803B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1311/87A CH672734A5 (2) 1987-04-03 1987-04-03
CH1311/87 1987-04-03

Publications (2)

Publication Number Publication Date
AU1401288A AU1401288A (en) 1988-10-06
AU620803B2 true AU620803B2 (en) 1992-02-27

Family

ID=4207470

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14012/88A Ceased AU620803B2 (en) 1987-04-03 1988-03-30 1,2,4-trioxane derivatives

Country Status (15)

Country Link
EP (1) EP0286316B1 (2)
JP (1) JP2690012B2 (2)
AT (1) ATE72564T1 (2)
AU (1) AU620803B2 (2)
CA (1) CA1340897C (2)
CH (1) CH672734A5 (2)
DE (1) DE3868339D1 (2)
DK (1) DK179588A (2)
ES (1) ES2035276T3 (2)
GR (1) GR3004578T3 (2)
IE (1) IE61609B1 (2)
IL (1) IL85914A (2)
NZ (1) NZ224077A (2)
OA (1) OA08726A (2)
ZA (1) ZA882247B (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809367D0 (en) * 1988-04-20 1988-05-25 Jefford C W Pharmaceutical compositions
US5559145A (en) * 1988-06-01 1996-09-24 Oxaco S.A. 1,2,4-trioxane derivatives
EP0376737A3 (en) * 1988-12-29 1991-09-25 Oxaco S.A. Cleavage of 1,2,4-trioxanes
GB9217765D0 (en) * 1992-08-21 1992-10-07 Oxaco Sa Oxygenated heterocyclic compounds
GB9622427D0 (en) * 1996-10-28 1997-01-08 Pharma Mar Sa Antimalarial drugs
CN104031060B (zh) * 2013-03-05 2016-08-03 中国科学院上海有机化学研究所 青蒿素简化类似物及其制备方法和用途
GB2517199A (en) 2013-08-15 2015-02-18 Charles William Jefford Adjuvants in anti-cancer chemotherapy

Also Published As

Publication number Publication date
NZ224077A (en) 1990-11-27
IE880995L (en) 1988-10-03
CA1340897C (en) 2000-02-15
ZA882247B (en) 1988-09-21
EP0286316A1 (en) 1988-10-12
IE61609B1 (en) 1994-11-16
IL85914A (en) 1996-06-18
CH672734A5 (2) 1989-12-29
JPS646268A (en) 1989-01-10
DK179588A (da) 1988-10-04
OA08726A (en) 1989-03-31
JP2690012B2 (ja) 1997-12-10
ATE72564T1 (de) 1992-02-15
AU1401288A (en) 1988-10-06
EP0286316B1 (en) 1992-02-12
GR3004578T3 (2) 1993-04-28
DE3868339D1 (de) 1992-03-26
IL85914A0 (en) 1988-09-30
DK179588D0 (da) 1988-03-30
ES2035276T3 (es) 1993-04-16

Similar Documents

Publication Publication Date Title
Perry et al. Antiviral and antitumor agents from a New Zealand sponge, Mycale sp. 2. Structures and solution conformations of mycalamides A and B
Jung et al. Antitumor activity of novel deoxoartemisinin monomers, dimers, and trimer
Cimino et al. Unprecedented alkaloid skeleton from the Mediterranean sponge Reniera sarai: X-ray structure of an acetate derivative of sarain-A
EP0514276A1 (fr) Nouveaux dérivés du thiopyranopyrrole et leur préparation
CA2317112A1 (en) C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumour activities
Noite et al. New examples of acyclic and cyclic C-15 acetogenins from laurencia pinnatifida. Reassignment of the absolute configuration for E and Z pinnatifidienyne.
Anagnostaki et al. “Common synthetic scaffolds” in the synthesis of structurally diverse natural products
Kuehne et al. Syntheses and biological evaluation of vinblastine congeners
Acton et al. Synthesis and antimalarial activity of some 9-substituted artemisinin derivatives
EP0286316B1 (en) 1,2,4-trioxane derivatives
US5559145A (en) 1,2,4-trioxane derivatives
Hufford et al. 13C‐and 1H‐NMR. Assignments for colchicine derivatives
JP2017502039A (ja) 放射性標識のための方法および試薬
US6136847A (en) Water-soluble trioxanes as potent and safe antimalarial agents
FR2800374A1 (fr) Nouveaux derives de 9-(3,5-dimethoxyphenyl)-5,8,8a,9- tetrahydrofuro[3',4':6,7]naphto[2,3-d] [1,3]dioxol-6(5ah)- one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
JPH0343497A (ja) 多環式エーテルの製造法、多環式エーテル、匂い特性を授与するか、改善するか、向上させるか、もしくは変性させる方法、および異性体多環式エーテル混合物
Trost et al. New synthetic methods. Rational synthesis of 7, 8-diazatetracyclo [3.3. 0.02. 403.6] oct-7-ene
US5817692A (en) Endoperoxides useful as antiparasitic agents
Chen et al. The photochemistry of taxol: synthesis of a novel pentacyclic taxol isomer
EP0011057B1 (fr) Procédé de synthèse de la vincadifformine et des dérivés apparentés à celle-ci, produits intermédiaires obtenus pendant cette synthèse et procédé pour leur préparation
WO1993008195A1 (en) Cyclic peroxyacetal compounds
CA2174892A1 (fr) Composes cyclohexaniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HUP0302905A2 (hu) Triazolo-epotilon-analógok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
Hashem et al. Photochemical transformations of 2 (5 H)-furanones. A review
US5106840A (en) Method of preparing n-oxo-tetrahydro-beta-carbolines

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: PHARMA MAR S.A.

Free format text: FORMER OWNER WAS: OXACO S.A.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired