AU725547B2 - Multi-functional chimeric hematopoietic receptor agonists - Google Patents

Multi-functional chimeric hematopoietic receptor agonists Download PDF

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Publication number: AU725547B2
Authority: AU; Australia
Prior art keywords: xaa; leu; ser; ala; arg
Prior art date: 1996-10-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU51652/98A

Other languages

English (en)

Other versions

AU5165298A (en

Inventor

Yiqing Feng

John P. Mckearn

Charles A. Mcwherter

John C. Minnerly

Nancy I. Minster

Nicholas R Staten

Philip R. Streeter

Neena L. Summers

Susan L. Woulfe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-23

Publication date

2000-10-12

1997-10-23 Application filed by GD Searle LLC filed Critical GD Searle LLC

1998-05-15 Publication of AU5165298A publication Critical patent/AU5165298A/en

2000-10-12 Application granted granted Critical

2000-10-12 Publication of AU725547B2 publication Critical patent/AU725547B2/en

2017-10-23 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AU51652/98A 1996-10-25 1997-10-23 Multi-functional chimeric hematopoietic receptor agonists Ceased AU725547B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2962996P	1996-10-25	1996-10-25
US60/029629		1996-10-25
PCT/US1997/020037 WO1998017810A2 (fr)	1996-10-25	1997-10-23	Agonistes recepteurs hematopoietiques chimeriques multifonctionnels

Publications (2)

Publication Number	Publication Date
AU5165298A AU5165298A (en)	1998-05-15
AU725547B2 true AU725547B2 (en)	2000-10-12

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ID=21850035

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU51652/98A Ceased AU725547B2 (en)	1996-10-25	1997-10-23	Multi-functional chimeric hematopoietic receptor agonists

Country Status (17)

Country	Link
EP (1)	EP0935663A2 (fr)
JP (1)	JP2001504689A (fr)
KR (1)	KR100497423B1 (fr)
AR (1)	AR010041A1 (fr)
AU (1)	AU725547B2 (fr)
BR (1)	BR9713668A (fr)
CA (1)	CA2268742A1 (fr)
CZ (1)	CZ295843B6 (fr)
IL (1)	IL129565A0 (fr)
NO (1)	NO991948L (fr)
NZ (1)	NZ335382A (fr)
PL (1)	PL333023A1 (fr)
RO (1)	RO120919B1 (fr)
RU (2)	RU2245887C2 (fr)
TW (2)	TW591035B (fr)
WO (1)	WO1998017810A2 (fr)
ZA (1)	ZA979607B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5581476A (en)	1993-01-28	1996-12-03	Amgen Inc.	Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) *	1997-03-31	2002-09-26	Genentech, Inc.	Secreted and transmembrane polypeptides and nucleic acids encoding the same
CA2284127A1 (fr) *	1997-04-11	1998-10-22	G.D. Searle & Co.	Proteines chimeriques contenant le ligand flt3
BR9905867A (pt) *	1998-11-06	2001-01-23	Bio Sidus S A	Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (fr) *	2001-06-12	2002-12-19	Smithkline Beecham Corporation	Procede d'identification de composes modulant les activites du gene 1 de reponse primaire a l'epo, eprg1
PL371781A1 (en)	2001-07-11	2005-06-27	Maxygen Holdings, Ltd.	G-csf conjugates
DE602004023956D1 (de)	2003-08-18	2009-12-17	Univ California	Polypeptid-display-bibliotheken und verfahren zur herstellung und verwendung davon
EP1888119B1 (fr)	2005-06-01	2011-03-09	Maxygen, Inc.	Polypeptides g-csf pegyles et procedes de production correspondants
US7550433B2 (en) *	2005-06-03	2009-06-23	Affymax, Inc.	Erythropoietin receptor peptide formulations and uses
EP2535346B1 (fr)	2005-08-31	2017-08-02	The Regents of The University of California	Bibliothèques cellulaires de séquences peptidiques (CliPS) et procédés d'utilisation de celles-ci
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1997
- 1997-10-23 NZ NZ335382A patent/NZ335382A/xx unknown
- 1997-10-23 CA CA002268742A patent/CA2268742A1/fr not_active Abandoned
- 1997-10-23 AU AU51652/98A patent/AU725547B2/en not_active Ceased
- 1997-10-23 CZ CZ19991323A patent/CZ295843B6/cs not_active IP Right Cessation
- 1997-10-23 IL IL12956597A patent/IL129565A0/xx unknown
- 1997-10-23 WO PCT/US1997/020037 patent/WO1998017810A2/fr not_active Ceased
- 1997-10-23 BR BR9713668-9A patent/BR9713668A/pt not_active Application Discontinuation
- 1997-10-23 EP EP97946495A patent/EP0935663A2/fr not_active Withdrawn
- 1997-10-23 PL PL97333023A patent/PL333023A1/xx unknown
- 1997-10-23 KR KR10-1999-7003635A patent/KR100497423B1/ko not_active Expired - Fee Related
- 1997-10-23 RO RO99-00480A patent/RO120919B1/ro unknown
- 1997-10-23 JP JP51975498A patent/JP2001504689A/ja not_active Abandoned
- 1997-10-23 RU RU99111071/13A patent/RU2245887C2/ru not_active IP Right Cessation
- 1997-10-27 TW TW086116018A patent/TW591035B/zh not_active IP Right Cessation
- 1997-10-27 ZA ZA979607A patent/ZA979607B/xx unknown
- 1997-10-27 TW TW093111460A patent/TW200413407A/zh unknown
- 1997-10-28 AR ARP970104979A patent/AR010041A1/es unknown
1999
- 1999-04-23 NO NO991948A patent/NO991948L/no not_active Application Discontinuation
2005
- 2005-02-24 RU RU2005105360/13A patent/RU2005105360A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO991948D0 (no)	1999-04-23
TW591035B (en)	2004-06-11
CZ132399A3 (cs)	1999-12-15
WO1998017810A3 (fr)	1998-10-15
NZ335382A (en)	2001-03-30
IL129565A0 (en)	2000-02-29
RU2005105360A (ru)	2006-08-10
BR9713668A (pt)	2000-03-08
PL333023A1 (en)	1999-11-08
WO1998017810A2 (fr)	1998-04-30
RU2245887C2 (ru)	2005-02-10
AU5165298A (en)	1998-05-15
TW200413407A (en)	2004-08-01
CZ295843B6 (cs)	2005-11-16
AR010041A1 (es)	2000-05-17
NO991948L (no)	1999-06-23
RO120919B1 (ro)	2006-09-29
JP2001504689A (ja)	2001-04-10
KR20000052812A (ko)	2000-08-25
KR100497423B1 (ko)	2005-07-07
EP0935663A2 (fr)	1999-08-18
CA2268742A1 (fr)	1998-04-30
ZA979607B (en)	1999-04-28

Legal Events

Date	Code	Title	Description
2001-02-08	FGA	Letters patent sealed or granted (standard patent)

Publication	Publication Date	Title
AU725547B2 (en)	2000-10-12	Multi-functional chimeric hematopoietic receptor agonists
US6730303B1 (en)	2004-05-04	Fused G-CSF and IL-3 proteins and uses thereof
US6660257B1 (en)	2003-12-09	Circular permuteins of flt3 ligand
AU705083B2 (en)	1999-05-13	Multi-functional hematopoietic receptor agonists
AU717733B2 (en)	2000-03-30	Novel G-CSF receptor agonists
US6358505B1 (en)	2002-03-19	G-CSF receptor agonists
WO1997012985A9 (fr)	1997-05-29	Agonistes multifonctionnels des recepteurs hematopoietiques
US6967092B1 (en)	2005-11-22	Multi-functional chimeric hematopoietic receptor agonists
NZ337911A (en)	2001-04-27	flt3 ligand chimeric proteins
AU722759B2 (en)	2000-08-10	Novel C-MPL receptor agonists
MXPA99003877A (en)	1999-10-14	Multi-functional chimeric hematopoietic receptor agonists
AU703627B2 (en)	1999-03-25	Interleuken-3 (IL-3) receptor agonists
CZ346799A3 (cs)	2000-03-15	Chimérické proteiny jako flt3 ligandy