AU751433B2 - Anti-(helicobacter) vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method - Google Patents
Anti-(helicobacter) vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method Download PDFInfo
- Publication number
- AU751433B2 AU751433B2 AU72768/98A AU7276898A AU751433B2 AU 751433 B2 AU751433 B2 AU 751433B2 AU 72768/98 A AU72768/98 A AU 72768/98A AU 7276898 A AU7276898 A AU 7276898A AU 751433 B2 AU751433 B2 AU 751433B2
- Authority
- AU
- Australia
- Prior art keywords
- helicobacter
- route
- immunogenic agent
- use according
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 241000589989 Helicobacter Species 0.000 title claims description 102
- 238000000034 method Methods 0.000 title claims description 82
- 230000009885 systemic effect Effects 0.000 title claims description 35
- 239000000203 mixture Substances 0.000 title claims description 17
- 238000002649 immunization Methods 0.000 title description 39
- 230000003053 immunization Effects 0.000 title description 38
- 229960005486 vaccine Drugs 0.000 title description 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 109
- 108010046334 Urease Proteins 0.000 claims description 101
- 239000003795 chemical substances by application Substances 0.000 claims description 70
- 241000699670 Mus sp. Species 0.000 claims description 66
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 64
- 230000002163 immunogen Effects 0.000 claims description 63
- 229920001184 polypeptide Polymers 0.000 claims description 61
- 239000002671 adjuvant Substances 0.000 claims description 44
- 230000028993 immune response Effects 0.000 claims description 39
- 239000013598 vector Substances 0.000 claims description 38
- 108020004414 DNA Proteins 0.000 claims description 32
- 238000002360 preparation method Methods 0.000 claims description 31
- 102000053602 DNA Human genes 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 27
- 238000002965 ELISA Methods 0.000 claims description 25
- 238000007920 subcutaneous administration Methods 0.000 claims description 25
- 241000124008 Mammalia Species 0.000 claims description 24
- 238000007918 intramuscular administration Methods 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 23
- 241000894006 Bacteria Species 0.000 claims description 22
- HIHOWBSBBDRPDW-PTHRTHQKSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate Chemical compound C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HIHOWBSBBDRPDW-PTHRTHQKSA-N 0.000 claims description 20
- 230000006698 induction Effects 0.000 claims description 20
- 239000002502 liposome Substances 0.000 claims description 19
- 108010049048 Cholera Toxin Proteins 0.000 claims description 18
- 102000009016 Cholera Toxin Human genes 0.000 claims description 18
- 241000894007 species Species 0.000 claims description 17
- 150000002632 lipids Chemical class 0.000 claims description 16
- 206010019375 Helicobacter infections Diseases 0.000 claims description 15
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 14
- 229940037003 alum Drugs 0.000 claims description 14
- 230000001737 promoting effect Effects 0.000 claims description 13
- 239000004202 carbamide Substances 0.000 claims description 11
- 239000013592 cell lysate Substances 0.000 claims description 11
- 239000003053 toxin Substances 0.000 claims description 10
- 231100000765 toxin Toxicity 0.000 claims description 10
- 241000588724 Escherichia coli Species 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 238000007911 parenteral administration Methods 0.000 claims description 7
- 239000004005 microsphere Substances 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 5
- 101710146739 Enterotoxin Proteins 0.000 claims description 4
- 241000288906 Primates Species 0.000 claims description 4
- 239000000147 enterotoxin Substances 0.000 claims description 4
- 231100000655 enterotoxin Toxicity 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 241000193163 Clostridioides difficile Species 0.000 claims description 3
- 108010028921 Lipopeptides Proteins 0.000 claims description 3
- 108010081690 Pertussis Toxin Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 241000590002 Helicobacter pylori Species 0.000 claims 4
- 229940037467 helicobacter pylori Drugs 0.000 claims 4
- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 claims 1
- 230000004044 response Effects 0.000 description 43
- 241000282693 Cercopithecidae Species 0.000 description 39
- 239000000427 antigen Substances 0.000 description 24
- 108091007433 antigens Proteins 0.000 description 24
- 102000036639 antigens Human genes 0.000 description 24
- 230000001580 bacterial effect Effects 0.000 description 24
- 230000000694 effects Effects 0.000 description 24
- 238000002474 experimental method Methods 0.000 description 22
- 238000012360 testing method Methods 0.000 description 22
- 208000015181 infectious disease Diseases 0.000 description 18
- 210000002784 stomach Anatomy 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 14
- 101150026046 iga gene Proteins 0.000 description 14
- 230000002496 gastric effect Effects 0.000 description 13
- 230000001681 protective effect Effects 0.000 description 13
- 210000004705 lumbosacral region Anatomy 0.000 description 11
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 208000007882 Gastritis Diseases 0.000 description 9
- 239000002953 phosphate buffered saline Substances 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 9
- 230000037452 priming Effects 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 108090000695 Cytokines Proteins 0.000 description 7
- 102000004127 Cytokines Human genes 0.000 description 7
- 238000001574 biopsy Methods 0.000 description 7
- 239000000872 buffer Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 210000004400 mucous membrane Anatomy 0.000 description 7
- 239000013642 negative control Substances 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 230000009467 reduction Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 108700012359 toxins Proteins 0.000 description 7
- 238000002255 vaccination Methods 0.000 description 7
- 108010006591 Apoenzymes Proteins 0.000 description 6
- 241000282560 Macaca mulatta Species 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000000069 prophylactic effect Effects 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 5
- 210000004962 mammalian cell Anatomy 0.000 description 5
- 230000035772 mutation Effects 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- PSLWZOIUBRXAQW-UHFFFAOYSA-M dimethyl(dioctadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC PSLWZOIUBRXAQW-UHFFFAOYSA-M 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 239000006166 lysate Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- 241000590017 Helicobacter felis Species 0.000 description 3
- 208000028861 Helicobacter pylori infectious disease Diseases 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- 102000000588 Interleukin-2 Human genes 0.000 description 3
- 102000003992 Peroxidases Human genes 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 150000001413 amino acids Chemical group 0.000 description 3
- -1 another molecule Substances 0.000 description 3
- 230000005875 antibody response Effects 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000001332 colony forming effect Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 101150028842 ctxA gene Proteins 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229940035032 monophosphoryl lipid a Drugs 0.000 description 3
- 238000010172 mouse model Methods 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000003079 salivary gland Anatomy 0.000 description 3
- 238000010561 standard procedure Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 241000272478 Aquila Species 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000003098 Ganglion Cysts Diseases 0.000 description 2
- 241001495142 Helicobacter heilmannii Species 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 241001644525 Nastus productus Species 0.000 description 2
- 238000011887 Necropsy Methods 0.000 description 2
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 2
- 241000607762 Shigella flexneri Species 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 210000004241 Th2 cell Anatomy 0.000 description 2
- 241000607626 Vibrio cholerae Species 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 208000000718 duodenal ulcer Diseases 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 210000002443 helper t lymphocyte Anatomy 0.000 description 2
- 230000008348 humoral response Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000001926 lymphatic effect Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000000663 muscle cell Anatomy 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 238000007388 punch biopsy Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 229940063673 spermidine Drugs 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 229940118696 vibrio cholerae Drugs 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- OPCHFPHZPIURNA-MFERNQICSA-N (2s)-2,5-bis(3-aminopropylamino)-n-[2-(dioctadecylamino)acetyl]pentanamide Chemical compound CCCCCCCCCCCCCCCCCCN(CC(=O)NC(=O)[C@H](CCCNCCCN)NCCCN)CCCCCCCCCCCCCCCCCC OPCHFPHZPIURNA-MFERNQICSA-N 0.000 description 1
- UGXDVELKRYZPDM-XLXQKPBQSA-N (4r)-4-[[(2s,3r)-2-[[(2r)-2-[(2r,3r,4r,5r)-2-acetamido-4,5,6-trihydroxy-1-oxohexan-3-yl]oxypropanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoic acid Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](C)O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O UGXDVELKRYZPDM-XLXQKPBQSA-N 0.000 description 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 description 1
- QHZLMUACJMDIAE-UHFFFAOYSA-N 1-monopalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 description 1
- RYOFERRMXDATKG-YEUCEMRASA-N 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium Chemical compound CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC RYOFERRMXDATKG-YEUCEMRASA-N 0.000 description 1
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 1
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- VDCRFBBZFHHYGT-IOSLPCCCSA-N 2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3h-purine-6,8-dione Chemical compound O=C1N(CC=C)C=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VDCRFBBZFHHYGT-IOSLPCCCSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 208000004300 Atrophic Gastritis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241000178270 Canarypox virus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 102100036912 Desmin Human genes 0.000 description 1
- 108010044052 Desmin Proteins 0.000 description 1
- 108010069091 Dystrophin Proteins 0.000 description 1
- 241000272184 Falconiformes Species 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 208000036495 Gastritis atrophic Diseases 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 description 1
- 108010026389 Gramicidin Proteins 0.000 description 1
- 241000590006 Helicobacter mustelae Species 0.000 description 1
- 101000718525 Homo sapiens Alpha-galactosidase A Proteins 0.000 description 1
- 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241000282567 Macaca fascicularis Species 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001092142 Molina Species 0.000 description 1
- 206010065764 Mucosal infection Diseases 0.000 description 1
- 101100476480 Mus musculus S100a8 gene Proteins 0.000 description 1
- 102000003505 Myosin Human genes 0.000 description 1
- 108060008487 Myosin Proteins 0.000 description 1
- 108700024476 N-acetylmuramyl-alanylglutamine methyl ester Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 241001454523 Quillaja saponaria Species 0.000 description 1
- 235000009001 Quillaja saponaria Nutrition 0.000 description 1
- 101150090155 R gene Proteins 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000714474 Rous sarcoma virus Species 0.000 description 1
- 101150019179 SAF1 gene Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241001222774 Salmonella enterica subsp. enterica serovar Minnesota Species 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000194026 Streptococcus gordonii Species 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 108010059722 Viral Fusion Proteins Proteins 0.000 description 1
- 101100286925 Zea mays IN2-1 gene Proteins 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000240 adjuvant effect Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 229940047712 aluminum hydroxyphosphate Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 229960003150 bupivacaine Drugs 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 229960005084 calcitriol Drugs 0.000 description 1
- 235000020964 calcitriol Nutrition 0.000 description 1
- 239000011612 calcitriol Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 208000016644 chronic atrophic gastritis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 239000007382 columbia agar Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 210000005045 desmin Anatomy 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 108010007093 dispase Proteins 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002185 fusiogenic effect Effects 0.000 description 1
- 230000000799 fusogenic effect Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- IUAYMJGZBVDSGL-XNNAEKOYSA-N gramicidin S Chemical compound C([C@@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N[C@H](CC=2C=CC=CC=2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(C)C)C(=O)N1)C(C)C)=O)CC(C)C)C(C)C)C1=CC=CC=C1 IUAYMJGZBVDSGL-XNNAEKOYSA-N 0.000 description 1
- 229950009774 gramicidin s Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 102000050459 human LTF Human genes 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229940117681 interleukin-12 Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- 101150027374 irgA gene Proteins 0.000 description 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007108 local immune response Effects 0.000 description 1
- 229950005634 loxoribine Drugs 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- OXSVRXKURHXDIV-OTVXWGLQSA-N methyl (2r)-2-[[(2s)-2-[2-[(2s,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoylamino]propanoyl]amino]-5-amino-5-oxopentanoate Chemical compound NC(=O)CC[C@H](C(=O)OC)NC(=O)[C@H](C)NC(=O)C(C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O OXSVRXKURHXDIV-OTVXWGLQSA-N 0.000 description 1
- JMUHBNWAORSSBD-WKYWBUFDSA-N mifamurtide Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCC)COP(O)(=O)OCCNC(=O)[C@H](C)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O JMUHBNWAORSSBD-WKYWBUFDSA-N 0.000 description 1
- 229960005225 mifamurtide Drugs 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical class NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 108700026215 vpr Genes Proteins 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9705609 | 1997-04-30 | ||
| FR9705609A FR2762788B1 (fr) | 1997-04-30 | 1997-04-30 | Composition vaccinale anti-helicobacter pour usage par voie systemique sous-diaphragmatique |
| FR9715731 | 1997-12-08 | ||
| FR9715731 | 1997-12-08 | ||
| PCT/US1998/008890 WO1998048835A1 (fr) | 1997-04-30 | 1998-04-30 | Vaccin anti-helicobacter administrable par voie generale sous-diaphragmatique, et procede combine d'immunisation par les muqueuses/parenterale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU7276898A AU7276898A (en) | 1998-11-24 |
| AU751433B2 true AU751433B2 (en) | 2002-08-15 |
Family
ID=26233514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU72768/98A Ceased AU751433B2 (en) | 1997-04-30 | 1998-04-30 | Anti-(helicobacter) vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1017417A1 (fr) |
| JP (1) | JP2002512619A (fr) |
| KR (1) | KR20010020366A (fr) |
| CN (1) | CN1254292A (fr) |
| AU (1) | AU751433B2 (fr) |
| BR (1) | BR9809426A (fr) |
| CA (1) | CA2289253A1 (fr) |
| HU (1) | HUP0003388A3 (fr) |
| NO (1) | NO995290L (fr) |
| WO (1) | WO1998048835A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0029919D0 (en) * | 2000-12-07 | 2001-01-24 | Chiron Spa | Helicobacter pylori prime & boost vaccination |
| ES2569907T3 (es) | 2008-06-27 | 2016-05-13 | Zoetis Services Llc | Composiciones adyuvantes novedosas |
| UA130246C2 (uk) | 2013-09-19 | 2025-12-31 | Зоетіс Сервісіз Ллс | Ад'ювант на основі олії |
| CN115317600A (zh) | 2015-01-16 | 2022-11-11 | 硕腾服务有限责任公司 | 口蹄疫疫苗 |
| CN108743929B (zh) * | 2018-06-14 | 2021-07-27 | 四川大学 | 一种用作尿素清除剂的脲酶凝胶微球的制备方法和用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018150A1 (fr) * | 1992-03-02 | 1993-09-16 | Biocine S.P.A. | Proteines d'helicobacter pylori utiles pour des vaccins et des diagnostics |
| WO1995033482A1 (fr) * | 1994-06-08 | 1995-12-14 | Csl Limited | Traitement et prevention d'infections causees par les bacteries du genre helicobacter |
| WO1996038475A1 (fr) * | 1995-06-01 | 1996-12-05 | Astra Aktiebolag | Antigenes d'helicobacter pylori et compositions de vaccins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5679769A (en) * | 1994-03-15 | 1997-10-21 | Sloan-Kettering Institute For Cancer Research | Synthesis of asparagine-linked glycopeptides on a polymeric solid support |
| US5610060A (en) * | 1994-06-24 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Isolated Helicobacter hepaticus |
| SK165197A3 (en) * | 1995-06-07 | 1999-01-11 | Astra Ab | Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics |
-
1998
- 1998-04-30 CA CA002289253A patent/CA2289253A1/fr not_active Abandoned
- 1998-04-30 KR KR1019997009988A patent/KR20010020366A/ko not_active Ceased
- 1998-04-30 EP EP98920126A patent/EP1017417A1/fr not_active Withdrawn
- 1998-04-30 AU AU72768/98A patent/AU751433B2/en not_active Ceased
- 1998-04-30 HU HU0003388A patent/HUP0003388A3/hu unknown
- 1998-04-30 CN CN98804722A patent/CN1254292A/zh active Pending
- 1998-04-30 JP JP54744198A patent/JP2002512619A/ja active Pending
- 1998-04-30 WO PCT/US1998/008890 patent/WO1998048835A1/fr not_active Ceased
- 1998-04-30 BR BR9809426-2A patent/BR9809426A/pt not_active Application Discontinuation
-
1999
- 1999-10-29 NO NO995290A patent/NO995290L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993018150A1 (fr) * | 1992-03-02 | 1993-09-16 | Biocine S.P.A. | Proteines d'helicobacter pylori utiles pour des vaccins et des diagnostics |
| WO1995033482A1 (fr) * | 1994-06-08 | 1995-12-14 | Csl Limited | Traitement et prevention d'infections causees par les bacteries du genre helicobacter |
| WO1996038475A1 (fr) * | 1995-06-01 | 1996-12-05 | Astra Aktiebolag | Antigenes d'helicobacter pylori et compositions de vaccins |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2289253A1 (fr) | 1998-11-05 |
| NO995290L (no) | 1999-12-29 |
| KR20010020366A (ko) | 2001-03-15 |
| HUP0003388A3 (en) | 2001-06-28 |
| HUP0003388A2 (hu) | 2001-02-28 |
| CN1254292A (zh) | 2000-05-24 |
| EP1017417A1 (fr) | 2000-07-12 |
| WO1998048835A1 (fr) | 1998-11-05 |
| JP2002512619A (ja) | 2002-04-23 |
| AU7276898A (en) | 1998-11-24 |
| NO995290D0 (no) | 1999-10-29 |
| BR9809426A (pt) | 2000-06-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Corthésy-Theulaz et al. | Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice | |
| EP0771214B1 (fr) | Traitement et prevention d'infections causees par les bacteries du genre helicobacter | |
| JP5745731B2 (ja) | サルモネラワクチン | |
| EP1229928A2 (fr) | Utilisation de vecteurs de salmonella a des fins de vaccination contre l'infection par helicobacter | |
| AU750379B2 (en) | Anti-helicobacter vaccine composition comprising a Th1 adjuvant | |
| US6762295B2 (en) | Protective helicobacter antigens | |
| JPH11509200A (ja) | 粘膜アジュバントとしてのクロストリジウム・ディフィシール(Clostridium Difficile)トキシン | |
| AU751433B2 (en) | Anti-(helicobacter) vaccine composition for use by the subdiaphragmatic systemic route, and combined mucosal/parenteral immunization method | |
| US9119803B2 (en) | Carious tooth vaccine and preparation method | |
| US20040033240A1 (en) | Immunological combinations for prophylaxis and therapy of helicobacter pylori infection | |
| WO1995027508A1 (fr) | Composition utilisable pour induire une reponse immunitaire | |
| Medaglini et al. | Recombinant Gram-positive bacteria as vehicles of vaccine antigens | |
| MXPA99009915A (es) | Composicion de vacuna anti-helicobacter para usomediante la ruta sistematica sub-diafragmatica, ymetodo de inmunizacion mucosal/parenteral combinado | |
| CZ361799A3 (cs) | Použití imunogenní látky odvozené od bakterie rodu Helicobacter a způsob prevence nebo léčby infekcí způsobených těmito bakteriemi | |
| JPH11240844A (ja) | 肺炎球菌抗原の経口投与 | |
| JP2009078995A (ja) | 歯周病用免疫ワクチン | |
| FR2762788A1 (fr) | Composition vaccinale anti-helicobacter pour usage par voie systemique sous-diaphragmatique | |
| AU702878B2 (en) | Treatment and prevention of helicobacter infection | |
| JP2023516397A (ja) | タンパク質抗原を発現するように操作される生チフス菌ベクターおよびその使用方法 | |
| Kotloff et al. | Vaccine Strategies Against Helicobacter Pylori | |
| FR2762787A1 (fr) | Composition vaccinale anti-helicobacter comprenant un adjuvant de type th1 | |
| AU2249900A (en) | Composition for inducing a mucosal immune response | |
| WO1998049318A1 (fr) | Composition vaccinale anti-helicobacter a base d'adn |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |