AU769879B2 - Method for producing in vivo proteins chemically diversified by incorporating non-standard amino acids - Google Patents

Method for producing in vivo proteins chemically diversified by incorporating non-standard amino acids Download PDF

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Publication number
AU769879B2
AU769879B2 AU63473/99A AU6347399A AU769879B2 AU 769879 B2 AU769879 B2 AU 769879B2 AU 63473/99 A AU63473/99 A AU 63473/99A AU 6347399 A AU6347399 A AU 6347399A AU 769879 B2 AU769879 B2 AU 769879B2
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AU
Australia
Prior art keywords
protein
amino acid
cells
cell
unconventional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU63473/99A
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English (en)
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AU6347399A (en
Inventor
Volker Doring
Philippe Marliere
Henning Mootz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
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Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of AU6347399A publication Critical patent/AU6347399A/en
Application granted granted Critical
Publication of AU769879B2 publication Critical patent/AU769879B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Ecology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
AU63473/99A 1998-10-28 1999-10-28 Method for producing in vivo proteins chemically diversified by incorporating non-standard amino acids Ceased AU769879B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9813533A FR2785291B1 (fr) 1998-10-28 1998-10-28 Procede de production in vivo de proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels
FR98/13533 1998-10-28
PCT/FR1999/002628 WO2000024922A1 (fr) 1998-10-28 1999-10-28 Procede de production in vivo de proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels

Publications (2)

Publication Number Publication Date
AU6347399A AU6347399A (en) 2000-05-15
AU769879B2 true AU769879B2 (en) 2004-02-05

Family

ID=9532101

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63473/99A Ceased AU769879B2 (en) 1998-10-28 1999-10-28 Method for producing in vivo proteins chemically diversified by incorporating non-standard amino acids

Country Status (10)

Country Link
US (1) US7736899B1 (de)
EP (1) EP1124983B1 (de)
JP (1) JP4427902B2 (de)
AT (1) ATE451469T1 (de)
AU (1) AU769879B2 (de)
CA (1) CA2347993A1 (de)
DE (1) DE69941789D1 (de)
FR (1) FR2785291B1 (de)
NZ (1) NZ511932A (de)
WO (1) WO2000024922A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524646B2 (en) 2001-04-19 2009-04-28 Institut Pasteur Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2808284B1 (fr) * 2000-04-28 2004-11-19 Pasteur Institut Souches mutantes capables de produire des proteines chimiquement diversifiees par incorporation d'acides amines non conventionnels
EP1251175B1 (de) * 2001-04-19 2006-11-08 Institut Pasteur Methode für die Erweiterung der chemischen Zusammensetzung von Proteinen produziert in vivo unter Verwendung von mutierten Aminoacyl-tRNA-Synthetasen ohne Korrekturfunktion
US20040214314A1 (en) 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
US7288382B2 (en) 2002-03-14 2007-10-30 The Board Of Trustees Od The Leland Stanford Junior University Methods for structural analysis of proteins
WO2012027533A1 (en) * 2010-08-25 2012-03-01 Gt Life Sciences, Inc. Selectable markers and related methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
166 *
LEMEIGNON ET AL., J. MOL. BIOLOGY, VOL.231(2) MAY'93 PP.161- *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524646B2 (en) 2001-04-19 2009-04-28 Institut Pasteur Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases

Also Published As

Publication number Publication date
US7736899B1 (en) 2010-06-15
JP4427902B2 (ja) 2010-03-10
JP2002528090A (ja) 2002-09-03
NZ511932A (en) 2004-02-27
AU6347399A (en) 2000-05-15
ATE451469T1 (de) 2009-12-15
WO2000024922A1 (fr) 2000-05-04
DE69941789D1 (de) 2010-01-21
CA2347993A1 (fr) 2000-05-04
EP1124983B1 (de) 2009-12-09
EP1124983A1 (de) 2001-08-22
FR2785291B1 (fr) 2003-03-07
FR2785291A1 (fr) 2000-05-05

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