BE1003113A5 - Procede de preparation de derives de nucleosides. - Google Patents

Procede de preparation de derives de nucleosides. Download PDF

Info

Publication number
BE1003113A5
BE1003113A5 BE9000544A BE9000544A BE1003113A5 BE 1003113 A5 BE1003113 A5 BE 1003113A5 BE 9000544 A BE9000544 A BE 9000544A BE 9000544 A BE9000544 A BE 9000544A BE 1003113 A5 BE1003113 A5 BE 1003113A5
Authority
BE
Belgium
Prior art keywords
preparation
dideoxynucleosides
nucleoside derivatives
derivatives
didehydro
Prior art date
Application number
BE9000544A
Other languages
English (en)
Inventor
Yusuke Amino
Hisao Iwagami
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of BE1003113A5 publication Critical patent/BE1003113A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Des dérivés de 2',3'-didéshydro-2',3'-didésoxynucléosides qui sont des intermédiaires pour la synthèse de 2',3'-didésoxynucléosides utiles comme médicaments tels que des agent antiviraux, entre autres, sont obtenus par un nouveau procédé de préparation de dérivés de 2',3'-didéshydro-2',3'-didésoxynucléosides avec une haute pureté et un rendement élevé. Le procédé de l'invention est aussi un procédé général pour convertir les 1,2-diols en oléfines.
BE9000544A 1989-05-26 1990-05-23 Procede de preparation de derives de nucleosides. BE1003113A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1134186A JPH02311491A (ja) 1989-05-26 1989-05-26 ヌクレオシド誘導体の製造方法

Publications (1)

Publication Number Publication Date
BE1003113A5 true BE1003113A5 (fr) 1991-11-26

Family

ID=15122451

Family Applications (1)

Application Number Title Priority Date Filing Date
BE9000544A BE1003113A5 (fr) 1989-05-26 1990-05-23 Procede de preparation de derives de nucleosides.

Country Status (4)

Country Link
US (1) US5106962A (fr)
JP (1) JPH02311491A (fr)
BE (1) BE1003113A5 (fr)
FR (1) FR2647450B1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
CN100408552C (zh) * 2003-01-09 2008-08-06 味之素株式会社 谷氨酸衍生物和焦谷氨酸衍生物的制造方法和新型的制造用中间体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3280104A (en) * 1964-04-13 1966-10-18 Syntex Corp 2', 3'-dideoxyribonucleoside and 2', 3'-dideoxyribonucleotide derivatives

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 106, no. 21, 17 octobre 1984, pages 6217-6220, American Chemical Society; R. MAIDAN et al.: "Application of multielectron charge relays in chemical and photochemical debromination processes. The role of induced disproportionation of N,N'-dioctyl-4,4'-bipyridinium radical cation in two-phase systems" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 28, no. 4, avril 1963, pages 936-941, American Chemical Society; J.J. FOX et al.: "Nucleosides. XVI. Further studies of anhydronucleosides" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 1, 11 janvier 1974, pages 30-38, American Chemical Society; T.C. JAIN et al.: "Reactions of 2-acyloxyisobutyryl halides with nucleosides. IV. A facile synthesis of 2',3'-unsaturated nucleosides using chromous acetate" *
JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 9, 27 avril 1979, pages 1404-1409, American Chemical Society; T. ADACHI et al.: "Synthetic electrochemical studies on nucleosides. 1. Novel method for the synthesis of 2',3'-unsaturated nucleosides via electrolysis" *
TETRAHEDRON LETTERS, vol. 25, no. 4, 1984, pages 367-370, Pergamon Press Ltd, GB; M.J. ROBINS et al.: "A mild conversion of vicinal diols to alkenes. Efficient transformation of ribonucleosides into 2'-ene and 2',3'-dideoxynucleosides" *

Also Published As

Publication number Publication date
FR2647450A1 (fr) 1990-11-30
US5106962A (en) 1992-04-21
JPH02311491A (ja) 1990-12-27
FR2647450B1 (fr) 1994-10-21

Similar Documents

Publication Publication Date Title
EP0322854B1 (fr) Cyclobutanes contenant un groupe purinyle
US5015743A (en) Difluoro antivirals and intermediate therefor
US5539116A (en) Method and compositions for the synthesis of BCH-189 and related compounds
US4762823A (en) Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
RU96122244A (ru) Способ диастереоселективного синтеза аналогов нуклеозидов
FR2374334A1 (fr) Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation
CN1285843A (zh) 化合物
EP0216357A2 (fr) Composés phosphoramidites et leur procédé de préparation
US20080176813A1 (en) Carbocyclic nucleosides and process for obtaining such
EP0334250A2 (fr) Composés dérivés d'oxétanocine et procédé pour leur production
EP0152965A3 (en) Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxy-menthyl)-purines and certain derivatives
BE1003113A5 (fr) Procede de preparation de derives de nucleosides.
US5336764A (en) 2'-fluorofuranosyl derivatives and novel method of preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
IE872124L (en) Pyrimidine derivatives
JPH0680688A (ja) ４’−メチルヌクレオシド誘導体
FR2402644A1 (fr) Nouveaux nitroethylcyclopentanes utiles comme intermediaires pour la synthese des prostaglandines, et leur procede de preparation
KR0173319B1 (ko) 데옥시뉴클레오시드의 제조방법
Marquez et al. Psicoplanocin A. A synthetic carbocyclic nucleoside with the combined structural features of neplanocin A and psicofuranine
Hossain et al. New synthesis of 2′, 3′-dideoxy-2′, 3′-didehydro-3′-C-substituted thymidines
US5574021A (en) Methods of treatment using 2',3'-dideoxy-2',2'-difluoronucleosides
US5478928A (en) 2',3'-dideoxy-4'-thioribonucleosides and synthetic precursors thereof
FR2398064A1 (fr) Nouveau procede de preparation de la 5,6-diamino-uracile a partir de la 5-nitroso-6-amino-uracile
Berque et al. Enantioselective Synthesis of a C1-C9 Moiety of Tylonolide, Tylosin Aglycon
JPH06263793A (ja) ピラノース型ヌクレオシド誘導体
Nitta et al. PHOTOCHEMICAL CYCLOADDITION OF BENZOPHENONE WITH 1, 5-DIMETHYL-6-METHYLENETRICYCLO [3.2. 1.02, 7] OCT-3-EN-8-ONE AND A RELATED ALCOHOL: A STRIKING SUBSTITUENT EFFECT ON THE PRODUCT COMPOSITION

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AJINOMOTO CO., INC.

Effective date: 19940531