|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
ATE272114T1
(de)
*
|
1998-01-23 |
2004-08-15 |
Immunex Corp |
Rezeptoren für il-18
|
|
US6927044B2
(en)
*
|
1998-09-25 |
2005-08-09 |
Regeneron Pharmaceuticals, Inc. |
IL-1 receptor based cytokine traps
|
|
US7083950B2
(en)
*
|
1998-09-25 |
2006-08-01 |
Regeneron Pharmaceuticals, Inc. |
High affinity fusion proteins and therapeutic and diagnostic methods for use
|
|
US7083949B2
(en)
|
1998-09-25 |
2006-08-01 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
|
US20040120891A1
(en)
*
|
1998-12-21 |
2004-06-24 |
Craig Hill |
Compounds for intracellular delivery of therapeutic moieties to nerve cells
|
|
US20040220103A1
(en)
*
|
1999-04-19 |
2004-11-04 |
Immunex Corporation |
Soluble tumor necrosis factor receptor treatment of medical disorders
|
|
WO2001092340A2
(en)
|
2000-05-26 |
2001-12-06 |
Immunex Corporation |
Use of interleukin-4 antagonists and compositions thereof
|
|
US7446183B2
(en)
|
2000-06-16 |
2008-11-04 |
Asterion Limited |
Fusion protein comprising growth hormone and growth hormone receptor
|
|
EP2177616B1
(en)
*
|
2000-08-08 |
2012-02-29 |
ZymoGenetics, Inc. |
Soluble zcytor 11 cytokine receptors
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US20050112616A1
(en)
*
|
2001-12-10 |
2005-05-26 |
William Lee |
Functionalized materials and libraries thereof
|
|
US7795213B2
(en)
*
|
2001-12-13 |
2010-09-14 |
Posco |
Methods of contacting β amyloid protein with VEGF
|
|
US6846520B2
(en)
*
|
2002-01-17 |
2005-01-25 |
Canon Kabushiki Kaisha |
Epoxy resin composition, surface treatment method, liquid-jet recording head and liquid-jet recording apparatus
|
|
JP2005525404A
(ja)
*
|
2002-05-01 |
2005-08-25 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Hiv感染およびaidsを処置するためにサイトカインアンタゴニストを使用する方法
|
|
US20040223966A1
(en)
*
|
2002-10-25 |
2004-11-11 |
Wolfman Neil M. |
ActRIIB fusion polypeptides and uses therefor
|
|
EP1578397B1
(en)
*
|
2002-11-15 |
2012-12-26 |
Genmab A/S |
Human monoclonal antibodies against cd25
|
|
US6919012B1
(en)
|
2003-03-25 |
2005-07-19 |
Olimex Group, Inc. |
Method of making a composite article comprising a ceramic coating
|
|
DK1606318T3
(da)
|
2003-03-26 |
2009-11-02 |
Apogenix Gmbh |
Forbedrede Fc-fusionsproteiner
|
|
WO2004100987A2
(en)
*
|
2003-05-06 |
2004-11-25 |
Regeneron Pharmaceuticals, Inc. |
Methods of using il-1 antagonists to treat neointimal hyperplasia
|
|
WO2004098596A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
Composition comprising roflumilast and il-1 trap
|
|
BRPI0411248A
(pt)
*
|
2003-06-11 |
2006-07-25 |
Wyeth Corp |
método para produzir um polipeptìdeo
|
|
HUE029951T2
(en)
*
|
2003-07-28 |
2017-04-28 |
Genentech Inc |
Reduction of Protein A Dissolution in Protein A Affinity Chromatography
|
|
CA2536936A1
(en)
*
|
2003-09-05 |
2005-03-17 |
National Research Council Of Canada |
E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains
|
|
NZ547588A
(en)
|
2003-11-07 |
2009-05-31 |
Immunex Corp |
Antibodies that bind interleukin-4 receptor
|
|
EP1723173B1
(en)
*
|
2004-02-27 |
2008-05-14 |
Regeneron Pharmaceuticals, Inc. |
Il-4/il-13 specific polypeptides and therapeutic uses thereof
|
|
AU2005249570B2
(en)
|
2004-06-04 |
2011-06-16 |
Regeneron Pharmaceuticals, Inc. |
Methods of using IL-1 antagonists to treat autoinflammatory disease
|
|
EP3489257A1
(en)
|
2004-07-23 |
2019-05-29 |
Acceleron Pharma Inc. |
Actrii receptor polypeptides, methods and compositions
|
|
AU2005277357B2
(en)
*
|
2004-08-17 |
2011-08-04 |
Regeneron Pharmaceuticals, Inc. |
IL-1 antagonist formulations
|
|
EP1630232B1
(en)
*
|
2004-08-27 |
2008-07-02 |
CONARIS research institute AG |
Optimized nucleotide sequences encoding sgp130
|
|
US7786261B2
(en)
*
|
2004-09-02 |
2010-08-31 |
National Research Council Of Canada |
Coiled-coil fusion proteins comprising cell receptor domains
|
|
CN101094688B
(zh)
*
|
2004-09-13 |
2013-05-01 |
建新公司 |
多聚构建体
|
|
MX2007004374A
(es)
*
|
2004-10-12 |
2008-01-29 |
Amprotein Corp |
Proteina quimerica.
|
|
EA015706B1
(ru)
|
2004-10-22 |
2011-10-31 |
Займоджинетикс, Инк. |
Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела
|
|
JP2008527981A
(ja)
*
|
2005-01-25 |
2008-07-31 |
アポロ ライフ サイエンシズ リミテッド |
治療目的および診断目的のためにパラメーターにより選択されたgm−csf、il−3、il−4、il−5、ならびにそのキメラ
|
|
HUE034109T2
(en)
*
|
2005-03-25 |
2018-01-29 |
Regeneron Pharma |
VEGF antagonist formulations
|
|
US7732167B2
(en)
*
|
2005-06-17 |
2010-06-08 |
Regeneron Pharmaceuticals, Inc. |
Interferon-α/β binding fusion proteins and therapeutic uses thereof
|
|
US7608430B2
(en)
*
|
2005-07-08 |
2009-10-27 |
Regeneron Pharmaceuticals, Inc. |
Interferon-γ antagonists and therapeutic uses thereof
|
|
EP2295080A3
(en)
|
2005-07-25 |
2011-06-22 |
Emergent Product Development Seattle, LLC |
B-cell reduction using CD37-specific and CD20-specific binding molecules
|
|
US7666622B2
(en)
*
|
2005-10-19 |
2010-02-23 |
Regeneron Pharmaceuticals, Inc. |
Monomeric self-associating fusion polypeptides and therapeutic uses thereof
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
WO2007061981A2
(en)
|
2005-11-21 |
2007-05-31 |
Lumera Corporation |
Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
|
|
CN101370511B
(zh)
*
|
2005-11-23 |
2015-07-01 |
阿塞勒隆制药公司 |
Activin-ActRIIa拮抗剂及其促进骨骼生长的应用
|
|
US8128933B2
(en)
|
2005-11-23 |
2012-03-06 |
Acceleron Pharma, Inc. |
Method of promoting bone growth by an anti-activin B antibody
|
|
EP2781222B1
(en)
*
|
2005-11-23 |
2017-08-02 |
Acceleron Pharma, Inc. |
Activin-actriia antagonists in use for promoting bone growth
|
|
US7463358B2
(en)
|
2005-12-06 |
2008-12-09 |
Lumera Corporation |
Highly stable surface plasmon resonance plates, microarrays, and methods
|
|
WO2007110205A2
(en)
|
2006-03-24 |
2007-10-04 |
Merck Patent Gmbh |
Engineered heterodimeric protein domains
|
|
CN105837690A
(zh)
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
SI2944306T1
(sl)
|
2006-06-16 |
2021-04-30 |
Regeneron Pharmaceuticals, Inc. |
Formulacije antagonista VEGF, primerne za intravitrealno dajanje
|
|
ES2352561T3
(es)
*
|
2006-06-30 |
2011-02-21 |
Conaris Research Institute Ag |
Dímeros de sgp 130fc mejorados.
|
|
US8106004B2
(en)
*
|
2006-07-28 |
2012-01-31 |
Children's Memorial Hospital |
Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
|
|
AU2007279205B2
(en)
|
2006-07-28 |
2013-09-26 |
Children's Memorial Hospital |
Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
|
|
US7632490B2
(en)
*
|
2006-10-20 |
2009-12-15 |
Regeneron Pharmaceuticals, Inc. |
Use of IL-1 antagonists to treat gout
|
|
MX2009004051A
(es)
*
|
2006-10-20 |
2009-05-11 |
Regeneron Pharma |
Uso de antagonistas de il-1 para tratar gota y pseudo gota.
|
|
US8895016B2
(en)
|
2006-12-18 |
2014-11-25 |
Acceleron Pharma, Inc. |
Antagonists of activin-actriia and uses for increasing red blood cell levels
|
|
JP5272735B2
(ja)
*
|
2007-01-30 |
2013-08-28 |
国立大学法人 新潟大学 |
生物学的製剤
|
|
CA2677007A1
(en)
|
2007-02-01 |
2008-08-07 |
Acceleron Pharma Inc. |
Activin-actriia antagonists and uses for treating or preventing breast cancer
|
|
TW201803890A
(zh)
|
2007-02-02 |
2018-02-01 |
艾瑟勒朗法瑪公司 |
衍生自ActRIIB的變體與其用途
|
|
EP2481415B1
(en)
|
2007-02-09 |
2019-09-11 |
Acceleron Pharma Inc. |
Pharmaceutical compositions comprising Activin-ActRIIA antagonists
|
|
US8501678B2
(en)
|
2007-03-06 |
2013-08-06 |
Atara Biotherapeutics, Inc. |
Variant activin receptor polypeptides and uses thereof
|
|
US7947646B2
(en)
|
2007-03-06 |
2011-05-24 |
Amgen Inc. |
Variant activin receptor polypeptides
|
|
EP2574671B1
(en)
|
2007-03-19 |
2016-02-03 |
National Research Council Of Canada |
Antagonists of ligands and uses thereof
|
|
WO2009010539A2
(en)
*
|
2007-07-19 |
2009-01-22 |
Ablynx. N.V. |
Receptor for interleukin-6 (il-6) from macaca fascicularis
|
|
JP2010539236A
(ja)
|
2007-09-18 |
2010-12-16 |
アクセルロン ファーマ, インコーポレイテッド |
アクチビン−ActRIIa拮抗薬およびFSH分泌を低減または阻害するための使用
|
|
JP2011502163A
(ja)
*
|
2007-10-31 |
2011-01-20 |
ザ スクリプス リサーチ インスティテュート |
持続性ウイルス感染を治療するための併用療法
|
|
US8004669B1
(en)
|
2007-12-18 |
2011-08-23 |
Plexera Llc |
SPR apparatus with a high performance fluid delivery system
|
|
WO2010031168A1
(en)
*
|
2008-09-17 |
2010-03-25 |
National Research Council Of Canada |
HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY
|
|
PT2132228E
(pt)
|
2008-04-11 |
2011-10-11 |
Emergent Product Dev Seattle |
Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
|
|
TWI626945B
(zh)
|
2008-08-14 |
2018-06-21 |
艾瑟勒朗法瑪公司 |
使用gdf阱以增加紅血球水平
|
|
US8216997B2
(en)
|
2008-08-14 |
2012-07-10 |
Acceleron Pharma, Inc. |
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
|
|
NZ627111A
(en)
|
2008-11-26 |
2015-10-30 |
Amgen Inc |
Variants of activin iib receptor polypeptides and uses thereof
|
|
JP5912078B2
(ja)
|
2009-06-08 |
2016-04-27 |
アクセルロン ファーマ, インコーポレイテッド |
熱発生性脂肪細胞を増加させるための方法
|
|
EP3290439B1
(en)
|
2009-06-12 |
2020-09-02 |
Acceleron Pharma Inc. |
Truncated actriib-fc fusion proteins
|
|
EP3332796A1
(en)
|
2009-11-17 |
2018-06-13 |
Acceleron Pharma Inc. |
Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
|
|
KR20130132824A
(ko)
|
2010-11-08 |
2013-12-05 |
악셀레론 파마 인코포레이티드 |
Actriia 결합제 및 이의 용도
|
|
CN103492416A
(zh)
|
2011-04-15 |
2014-01-01 |
默克专利股份公司 |
用于癌症中使用的抗il-1r1抑制剂
|
|
JO3283B1
(ar)
|
2011-04-26 |
2018-09-16 |
Sanofi Sa |
تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
|
|
BR112014015003A2
(pt)
|
2011-12-19 |
2019-09-24 |
Amgen Inc |
composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
|
|
US10195249B2
(en)
|
2012-11-02 |
2019-02-05 |
Celgene Corporation |
Activin-ActRII antagonists and uses for treating bone and other disorders
|
|
EP2928916B1
(en)
*
|
2012-12-10 |
2019-03-13 |
Vib Vzw |
Novel interleukin-33 inhibitors
|
|
SG11201505960VA
(en)
|
2013-02-01 |
2015-08-28 |
Santa Maria Biotherapeutics Inc |
Administration of an anti-activin-a compound to a subject
|
|
EP4050019A1
(en)
|
2013-02-15 |
2022-08-31 |
R-Pharm International, LLC |
Il-1beta inhibitor composition and use thereof
|
|
US12180264B2
(en)
|
2014-03-24 |
2024-12-31 |
R-Pharm Overseas, Inc. |
IL1-R1 derived inhibitor of IL-1β and use thereof
|
|
MA40008A
(fr)
|
2014-06-13 |
2021-05-05 |
Acceleron Pharma Inc |
Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
|
|
WO2016008975A1
(en)
|
2014-07-18 |
2016-01-21 |
Sanofi |
Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
|
|
MA41052A
(fr)
|
2014-10-09 |
2017-08-15 |
Celgene Corp |
Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
|
|
RS65665B1
(sr)
|
2014-12-01 |
2024-07-31 |
Ferring Bv |
Selektivne kompozicije inhibitora il-6-trans-signalizacije
|
|
EP3226888B1
(en)
|
2014-12-01 |
2021-04-21 |
Ferring B.V. |
Administration of a selective il-6-trans-signalling inhibitor
|
|
TWI730949B
(zh)
|
2014-12-03 |
2021-06-21 |
美商西建公司 |
活化素-actrii拮抗劑及治療貧血之用途
|
|
GB201503453D0
(en)
|
2015-03-01 |
2015-04-15 |
Jain Arjun |
Endothelin-1"sponge"
|
|
WO2016183222A1
(en)
*
|
2015-05-12 |
2016-11-17 |
Regeneron Pharmaceuticals, Inc. |
Multimeric protein purity determination
|
|
KR102784293B1
(ko)
|
2015-09-21 |
2025-03-20 |
압테보 리서치 앤드 디벨롭먼트 엘엘씨 |
Cd3 결합 폴리펩타이드
|
|
AU2017336546C1
(en)
|
2016-09-27 |
2025-05-29 |
Epicentrx, Inc. |
Immunomodulatory fusion proteins
|
|
CA3059731A1
(en)
*
|
2017-04-21 |
2018-10-25 |
Kindred Biosciences, Inc. |
Il4/il13 receptor molecule for veterinary use
|
|
KR102757384B1
(ko)
|
2017-09-27 |
2025-01-20 |
에피센트알엑스, 인코포레이티드 |
면역조절 융합 단백질
|
|
TWI823906B
(zh)
|
2018-03-09 |
2023-12-01 |
美商艾吉納斯公司 |
抗-cd73 抗體及其使用方法
|
|
MX2021000644A
(es)
|
2018-07-18 |
2021-08-19 |
Manzanita Pharmaceuticals Inc |
Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
|
|
CN110950965B
(zh)
*
|
2018-09-26 |
2021-10-15 |
重庆精准生物技术有限公司 |
抗人cd123的嵌合抗原受体及其应用
|
|
TW202607038A
(zh)
|
2020-10-19 |
2026-02-16 |
美商碩騰服務公司 |
犬及貓抑瘤素M受體β之抗體及其用途
|