BE2014C041I2 - - Google Patents

Download PDF

Info

Publication number
BE2014C041I2
BE2014C041I2 BE2014C041C BE2014C041C BE2014C041I2 BE 2014C041 I2 BE2014C041 I2 BE 2014C041I2 BE 2014C041 C BE2014C041 C BE 2014C041C BE 2014C041 C BE2014C041 C BE 2014C041C BE 2014C041 I2 BE2014C041 I2 BE 2014C041I2
Authority
BE
Belgium
Application number
BE2014C041C
Other languages
French (fr)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29582046&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2014C041(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BE2014C041I2 publication Critical patent/BE2014C041I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BE2014C041C 2002-05-20 2014-07-09 BE2014C041I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/151,436 US6515117B2 (en) 1999-10-12 2002-05-20 C-aryl glucoside SGLT2 inhibitors and method
PCT/US2003/015591 WO2003099836A1 (en) 2002-05-20 2003-05-15 C-aryl glucoside sglt2 inhibitors and method

Publications (1)

Publication Number Publication Date
BE2014C041I2 true BE2014C041I2 (en) 2022-08-09

Family

ID=29582046

Family Applications (2)

Application Number Title Priority Date Filing Date
BE2013C025C BE2013C025I2 (en) 2002-05-20 2013-04-09
BE2014C041C BE2014C041I2 (en) 2002-05-20 2014-07-09

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE2013C025C BE2013C025I2 (en) 2002-05-20 2013-04-09

Country Status (39)

Country Link
US (1) US6515117B2 (en)
EP (1) EP1506211B1 (en)
JP (4) JP5090621B2 (en)
KR (1) KR101021752B1 (en)
CN (5) CN101092409A (en)
AR (1) AR040032A1 (en)
AT (1) ATE353334T1 (en)
AU (1) AU2003237886B2 (en)
BE (2) BE2013C025I2 (en)
BR (2) BR122017015091B8 (en)
CA (1) CA2486539C (en)
CY (3) CY1106465T1 (en)
DE (1) DE60311649T2 (en)
DK (1) DK1506211T3 (en)
ES (1) ES2280759T3 (en)
FR (2) FR13C0022I2 (en)
GE (1) GEP20084403B (en)
HK (1) HK1205120A1 (en)
HR (1) HRP20041084B1 (en)
IL (1) IL165119A0 (en)
IN (1) IN2004DE03573A (en)
IS (1) IS7529A (en)
LT (1) LTC1506211I2 (en)
LU (2) LU92182I2 (en)
ME (2) ME00091B (en)
MX (1) MX249731B (en)
MY (1) MY142499A (en)
NO (4) NO329107B1 (en)
NZ (1) NZ536605A (en)
PE (1) PE20040760A1 (en)
PL (1) PL210304B1 (en)
PT (1) PT1506211E (en)
RS (1) RS51469B (en)
RU (4) RU2337916C2 (en)
SI (1) SI1506211T1 (en)
TW (1) TWI310770B (en)
UA (1) UA77306C2 (en)
WO (1) WO2003099836A1 (en)
ZA (1) ZA200409295B (en)

Families Citing this family (352)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (en) * 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 Fastening element
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
FR2809310B1 (en) * 2000-05-26 2004-02-13 Centre Nat Rech Scient USE OF BIGUANIDE DERIVATIVES FOR MANUFACTURING A MEDICINAL PRODUCT HAVING A HEALING EFFECT
WO2002043731A2 (en) 2000-11-30 2002-06-06 University Of Florida Treatments for neurogenetic disorders, impulse control disorders, and wound healing
EE05643B1 (en) * 2001-02-24 2013-04-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and use as medicaments
US6936590B2 (en) * 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
JP4590159B2 (en) * 2001-04-04 2010-12-01 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド Combination therapy comprising a glucose reabsorption inhibitor and a PPAR modulator
ES2258141T3 (en) * 2001-04-11 2006-08-16 Bristol-Myers Squibb Company C-ARILO GLUCOSIDE AMINO ACIDS COMPLEX FOR DIABETES TREATMENT AND PROCEDURE.
US20030087843A1 (en) * 2001-09-05 2003-05-08 Washburn William N. O-pyrazole glucoside SGLT2 inhibitors and method of use
TWI254635B (en) * 2002-08-05 2006-05-11 Yamanouchi Pharma Co Ltd Azulene derivative and salt thereof
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
CA2500873C (en) * 2002-10-04 2012-01-17 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same
DE10258007B4 (en) * 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatic fluoroglycoside derivatives, medicaments containing these compounds and methods for the preparation of these medicaments
AU2003299966A1 (en) * 2003-01-03 2004-08-10 Bristol-Myers Squibb Company Methods of producing c-aryl glucoside sglt2 inhibitors
EP1457206A1 (en) * 2003-03-13 2004-09-15 Fournier Laboratories Ireland Limited Combined use of a fibrate and orlistat for the treatment of obesity
CN1802366B (en) 2003-03-14 2010-12-22 安斯泰来制药有限公司 C-glycoside derivatives and their salts
JP2004300102A (en) * 2003-03-31 2004-10-28 Kissei Pharmaceut Co Ltd Condensed heterocyclic derivative, pharmaceutical composition containing the same and its pharmaceutical application
AU2004261660A1 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted fused heterocyclic C-glycosides
TW200524951A (en) * 2003-08-01 2005-08-01 Janssen Pharmaceutica Nv Substituted benzimidazole-, benztriazole-, and benzimidazolone-O-glucosides
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
RS20060320A (en) * 2003-08-01 2008-08-07 Janssen Pharmaceutica N.V., Substituted indazole-o-glucosides
MXPA06001274A (en) * 2003-08-01 2006-04-11 Tanabe Seiyaku Co NEW COMPOUNDS THAT HAVE INHIBITORY ACTIVITY AGAINST SODIUM-DEPENDENT CARRIER.
EP1680131A4 (en) * 2003-08-01 2009-05-27 Janssen Pharmaceutica Nv Substituted indole-o-glucosides
US7371759B2 (en) * 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7420059B2 (en) * 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
RU2387663C2 (en) * 2004-03-04 2010-04-27 Киссеи Фармасьютикал Ко., Лтд. Condensed heterocyclic derivatives medical compositions containing them and their medical application
EP2360165A3 (en) * 2004-03-16 2012-01-04 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
CA2568640C (en) 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US7393836B2 (en) 2004-07-06 2008-07-01 Boehringer Ingelheim International Gmbh D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
DE102004034690A1 (en) * 2004-07-17 2006-02-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methylidene-D-xylopyranosyl and oxo-D-xylopyranosyl-substituted phenyls, medicaments containing these compounds, their use and processes for their preparation
TW200606129A (en) * 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
EP1773800A1 (en) * 2004-07-27 2007-04-18 Boehringer Ingelheim International GmbH D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof
AR051446A1 (en) 2004-09-23 2007-01-17 Bristol Myers Squibb Co C-ARYL GLUCOSIDS AS SELECTIVE INHIBITORS OF GLUCOSE CONVEYORS (SGLT2)
JP5046370B2 (en) * 2004-09-29 2012-10-10 キッセイ薬品工業株式会社 1- (β-D-glycopyranosyl) -3-substituted nitrogen-containing heterocyclic compound, pharmaceutical composition containing the same, and pharmaceutical use thereof
DE102004048388A1 (en) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg D-pyranosyl-substituted phenyls, pharmaceutical compositions containing them, their use and processes for their preparation
US20060089325A1 (en) * 2004-10-13 2006-04-27 Sanjay Bhanot Antisense modulation of PTP1B expression
DE102004054054A1 (en) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines
WO2006064033A2 (en) * 2004-12-16 2006-06-22 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
MY147375A (en) * 2005-01-31 2012-11-30 Mitsubishi Tanabe Pharma Corp Indole derivatives
AR053329A1 (en) * 2005-01-31 2007-05-02 Tanabe Seiyaku Co INDOL DERIVATIVES USEFUL AS INHIBITORS OF GLUCOSE CONVEYORS DEPENDENT ON SODIUM (SGLT)
EP1846410B1 (en) * 2005-02-10 2009-01-21 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
WO2006089872A1 (en) * 2005-02-23 2006-08-31 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ( (hetero)arylethynyl-benzyd-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
ATE453656T1 (en) * 2005-04-15 2010-01-15 Boehringer Ingelheim Int GLUCOPYRANOSYL-SUBSTITUTED (HETEROARYLOXY-BENZYL)-BENZENE DERIVATIVES AS SGLT INHIBITORS
US7723309B2 (en) * 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
UA91546C2 (en) * 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Crystalline form of 1-chloro-4-(я-d-glucopyranos-1-yl)-2-[4-((s)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7772191B2 (en) * 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
WO2007000445A1 (en) * 2005-06-29 2007-01-04 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200726755A (en) * 2005-07-07 2007-07-16 Astellas Pharma Inc A crystalline choline salt of an azulene derivative
ES2346347T3 (en) * 2005-07-27 2010-10-14 Boehringer Ingelheim International Gmbh DERIVATIVES OF ((HETERO) CICLOALQUILETINIL-BENCIL) -BENZENE AND ITS USE AS INHIBITORS OF THE SODIUM DEPENDENT GLUCOSE COTRANSPORTADOR (SGLT).
JP2009502959A (en) * 2005-07-28 2009-01-29 ブリストル−マイヤーズ スクイブ カンパニー Substituted tetrahydro-1H-pyrido [4,3, B] indoles as serotonin receptor agonists and antagonists
DE102005035891A1 (en) 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals
US7795436B2 (en) * 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
ATE484499T1 (en) * 2005-08-30 2010-10-15 Boehringer Ingelheim Int GLUCOPYRANOSYL-SUBSTITUTED BENZYL DERIVATIVES, MEDICATIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PRODUCTION METHOD THEREOF
CN101238112A (en) * 2005-09-08 2008-08-06 贝林格尔·英格海姆国际有限公司 Crystal form of 1-chloro-4-(β-D-glucopyranose-1-yl)-2-(4-ethynyl-benzyl)-benzene, its preparation method and its use in the preparation of medicaments
AR056195A1 (en) * 2005-09-15 2007-09-26 Boehringer Ingelheim Int PROCEDURES TO PREPARE DERIVATIVES OF (ETINIL-BENCIL) -BENZENE REPLACED GLUCOPYRANOSIL AND INTERMEDIATE COMPOUNDS OF THE SAME
JP5094416B2 (en) * 2005-12-28 2012-12-12 武田薬品工業株式会社 Diabetes treatment
AU2007216452A1 (en) 2006-02-15 2007-08-23 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
PE20080697A1 (en) * 2006-05-03 2008-08-05 Boehringer Ingelheim Int BENZONITRILE DERIVATIVES SUBSTITUTED WITH GLUCOPYRANOSIL, PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS OF THIS TYPE, THEIR USE AND PROCEDURE FOR THEIR MANUFACTURE
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CN102838599A (en) 2006-05-04 2012-12-26 贝林格尔.英格海姆国际有限公司 Polymorphs
PE20080251A1 (en) 2006-05-04 2008-04-25 Boehringer Ingelheim Int USES OF DPP IV INHIBITORS
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
DE102006028862A1 (en) 2006-06-23 2007-12-27 Merck Patent Gmbh 3-amino-imidazo [1,2-a] pyridine
US7919598B2 (en) 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
US7795291B2 (en) 2006-07-07 2010-09-14 Bristol-Myers Squibb Company Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
TWI432446B (en) 2006-07-27 2014-04-01 Chugai Pharmaceutical Co Ltd Fused ring spiroketal derivative and use thereof as anti-diabetic drug
TWI403516B (en) 2006-07-27 2013-08-01 Chugai Pharmaceutical Co Ltd To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes
TWI418556B (en) * 2006-07-27 2013-12-11 Mitsubishi Tanabe Pharma Corp Indole derivatives
CA2656847A1 (en) 2006-08-15 2008-02-21 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as sglt inhibitors and process for their manufacture
EA015964B1 (en) * 2006-09-07 2012-01-30 Глаксосмитклайн Байолоджикалс С.А. Vaccine
TWI499414B (en) 2006-09-29 2015-09-11 Lexicon Pharmaceuticals Inc Inhibitors of sodium glucose co-transporter 2 and methods of their use
US20080194575A1 (en) * 2006-10-04 2008-08-14 Naiara Beraza Treatment for non-alcoholic-steatohepatitis
CN101522699A (en) 2006-10-13 2009-09-02 中外制药株式会社 Thioglucose spiroketal derivative and use thereof as therapeutic agent for diabetes
EP2086991A1 (en) 2006-10-27 2009-08-12 Boehringer Ingelheim International GmbH CRYSTALLINE FORM OF 4-(ß-D-GLUCOPYRANOS-1-YL)-1-METHYL-2-[4-((S)-TETRAHYDROFURAN-3-YLOXY)-BENZYL]-BENZENE, A METHOD FOR ITS PREPARATION AND THE USE THEREOF FOR PREPARING MEDICAMENTS
JP5298025B2 (en) * 2006-12-04 2013-09-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Thienyl-containing glycopyranosyl derivatives as antidiabetic agents
UY30730A1 (en) * 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp CRYSTAL FORM OF HEMIHYDRATE 1- (B (BETA) -D-GLUCOPYRANOSIL) -4-METHYL-3- [5- (4-FLUOROPHENYL) -2-TIENYLMETHYL] BENZENE
CN101657471B (en) 2006-12-06 2013-07-03 史密丝克莱恩比彻姆公司 Bicyclic compounds and their use as antidiabetic agents
MX2009006444A (en) * 2006-12-21 2009-06-26 Astellas Pharma Inc Method for producing c-glycoside derivative and synthetic intermediate thereof.
DE102007008420A1 (en) 2007-02-21 2008-08-28 Merck Patent Gmbh benzimidazole derivatives
US7846945B2 (en) * 2007-03-08 2010-12-07 Lexicon Pharmaceuticals, Inc. Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use
TW200904454A (en) * 2007-03-22 2009-02-01 Bristol Myers Squibb Co Methods for treating obesity employing an SGLT2 inhibitor and compositions thereof
AU2014201239B2 (en) * 2007-03-22 2016-03-10 Astrazeneca Ab Pharmaceutical formulations containing dapagliflozin propylene glycol hydrate
AR065809A1 (en) * 2007-03-22 2009-07-01 Bristol Myers Squibb Co PHARMACEUTICAL FORMULATIONS CONTAINING AN SGLT2 INHIBITOR
PE20090696A1 (en) 2007-04-20 2009-06-20 Bristol Myers Squibb Co CRYSTALLINE FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING THEM
MX2009013293A (en) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders.
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2375800T3 (en) * 2007-07-26 2012-03-06 Lexicon Pharmaceuticals, Inc. METHODS AND USEFUL COMPOUNDS FOR THE PREPARATION OF SODIUM-GLUCOSE COTRANSPORTADOR 2 INHIBITORS.
PE20090938A1 (en) * 2007-08-16 2009-08-08 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION INCLUDING A BENZENE DERIVATIVE SUBSTITUTED WITH GLUCOPYRANOSIL
PE20090603A1 (en) * 2007-08-16 2009-06-11 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION INCLUDING A SGLT2 INHIBITOR AND A DPP IV INHIBITOR
AU2008290582B2 (en) * 2007-08-17 2014-08-14 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
WO2009026537A1 (en) * 2007-08-23 2009-02-26 Theracos, Inc. Benzylbenzene derivatives and methods of use
CN101801371B (en) * 2007-09-10 2012-11-28 詹森药业有限公司 Process for the preparation of compounds useful as SGLT inhibitors
DE102007048716A1 (en) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo [1,2-a] pyrimidine derivatives
JP5498392B2 (en) * 2007-11-30 2014-05-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 1,5-Dihydro-pyrazolo [3,4-D] pyrimidin-4-one derivatives and their use as PDE9A modulators for the treatment of CNS disorders
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
CN104387354A (en) * 2007-12-27 2015-03-04 阿斯利康公司 Crystal structures and preparation methods of SGLT2 inhibitors
CL2008003653A1 (en) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Use of a glucopyranosyl-derived sglt inhibitor and a selected dppiv inhibitor to treat diabetes; and pharmaceutical composition.
ES2541141T3 (en) * 2008-01-31 2015-07-16 Astellas Pharma Inc. Pharmaceutical composition for the treatment of fatty liver diseases
CN101503399B (en) * 2008-02-04 2012-06-27 白鹭医药技术（上海）有限公司 C-aryl glucoside SGLT2 inhibitor
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
PE20091730A1 (en) 2008-04-03 2009-12-10 Boehringer Ingelheim Int FORMULATIONS INVOLVING A DPP4 INHIBITOR
DE102008017590A1 (en) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
WO2009143021A1 (en) * 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating and preventing kidney stones employing an sglt2 inhibitor and composition containing same
BRPI0913129A2 (en) 2008-05-22 2016-01-05 Bristol Myers Squibb Co method for treating hyperuricemia employing an sglt2 inhibitor and composition containing the same
WO2009143010A1 (en) * 2008-05-22 2009-11-26 Bristol-Myers Squibb Company Method for treating hyponatremia employing an sglt2 inhibitor and composition containing same
PE20100156A1 (en) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int NAFLD TREATMENT
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010009243A1 (en) * 2008-07-15 2010-01-21 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
UY32030A (en) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "TREATMENT FOR DIABETES IN INAPPROPRIATE PATIENTS FOR THERAPY WITH METFORMIN"
KR20200118243A (en) 2008-08-06 2020-10-14 베링거 인겔하임 인터내셔날 게엠베하 Treatment for diabetes in patients inappropriate for metformin therapy
MX370599B (en) * 2008-08-15 2019-12-18 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases.
PT2324002T (en) * 2008-08-22 2016-11-09 Theracos Sub Llc Processes for the preparation of sglt2 inhibitors
MX2011002166A (en) * 2008-08-28 2011-04-07 Pfizer Dioxa-bicyclo[3.2.1.]octane-2,3,4-triol derivatives.
CN102143965A (en) 2008-09-08 2011-08-03 贝林格尔.英格海姆国际有限公司 Pyrazolopyrimidines and their use for the treatment of CNS disorders
BRPI0919288A2 (en) 2008-09-10 2015-12-15 Boehring Ingelheim Internat Gmbh combination therapy for treatment of diabetes and related conditions.
CN102159561A (en) * 2008-09-19 2011-08-17 诺瓦提斯公司 Glycoside derivatives and uses thereof
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
WO2010045656A2 (en) * 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
EA022310B1 (en) 2008-12-23 2015-12-30 Бёрингер Ингельхайм Интернациональ Гмбх SALT FORMS OF ORGANIC COMPOUND
AR074990A1 (en) 2009-01-07 2011-03-02 Boehringer Ingelheim Int TREATMENT OF DIABETES IN PATIENTS WITH AN INAPPROPRIATE GLUCEMIC CONTROL THROUGH METFORMIN THERAPY
UY32427A (en) 2009-02-13 2010-09-30 Boheringer Ingelheim Internat Gmbh PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL FORM, PROCEDURE FOR PREPARATION, METHODS OF TREATMENT AND USES OF THE SAME
MY161472A (en) 2009-02-13 2017-04-14 Boehringer Ingelheim Int Sglt-2 inhibitor for treating type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance or hyperglycemia
MX345494B (en) * 2009-02-13 2017-02-02 Boehringer Ingelheim Int Gmbh * Pharmaceutical composition comprising glucopyranosyl diphenylmethane derivatives, pharmaceutical dosage form thereof, process for their preparation and uses thereof for improved glycemic control in a patient.
PL2395983T3 (en) * 2009-02-13 2020-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprisng a sglt2 inhibitor, a dpp-iv inhibitor and optionally a further antidiabetic agent and uses thereof
CA2752212C (en) * 2009-02-23 2016-08-16 Taisho Pharmaceutical Co., Ltd. 4-isopropylphenyl glucitol compounds as sglt1 inhibitors
EP2226076A1 (en) 2009-02-25 2010-09-08 Henning Vollert Plant Extract for the Prophylaxis and Treatment of Hyperglycemic Diseases
PT2414363E (en) * 2009-03-31 2014-02-26 Boehringer Ingelheim Int 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators
EP2435033A1 (en) * 2009-05-27 2012-04-04 Bristol-Myers Squibb Company Methods for treating type 2 diabetes in patients resistant to previous treatment with other anti-diabetic drugs employing an sglt2 inhibitor and compositions thereof
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
KR101532412B1 (en) 2009-07-10 2015-06-29 얀센 파마슈티카 엔.브이. Crystallization method of 1- (β-D-glucopyranosyl) -4-methyl-3- (5- (4-fluorophenyl) -2-thienylmethyl) benzene
AR077859A1 (en) * 2009-08-12 2011-09-28 Boehringer Ingelheim Int COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS
HUE029381T2 (en) * 2009-09-30 2017-02-28 Boehringer Ingelheim Int A method for preparing a crystalline form of 1-chloro-4- (beta-D-glucopyranos-1-yl) -2- [4 - ((S) -tetrahydrofuran-3-yloxy) benzyl] benzene.
BR112012007085B8 (en) 2009-09-30 2021-05-25 Boehringer Ingelheim Int processes for the preparation of glycopyranosyl substituted benzyl-benzene derivatives
US10610489B2 (en) * 2009-10-02 2020-04-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof
SG10201500258WA (en) * 2009-10-14 2015-03-30 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
US8163704B2 (en) * 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
NZ599945A (en) 2009-11-02 2014-05-30 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
ES2689107T3 (en) 2009-11-13 2018-11-08 Astrazeneca Ab Bilayer tablet formulations
CN104825417A (en) 2009-11-13 2015-08-12 阿斯利康(瑞典)有限公司 Immediate release tablet formulations
EP2501685A1 (en) 2009-11-16 2012-09-26 Mellitech [1,5]-diazocin derivatives
NZ599298A (en) 2009-11-27 2014-11-28 Boehringer Ingelheim Int Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
WO2011070592A2 (en) 2009-12-09 2011-06-16 Panacea Biotec Ltd. Novel sugar derivatives
CN102134226B (en) * 2010-01-26 2013-06-12 天津药物研究院 Phenyl C-glucoside derivatives, preparation method and use thereof
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
US20140088027A1 (en) * 2010-03-30 2014-03-27 Boehringer Ingelheim International Gmbh Pharmaceutical composition comprising an sglt2 inhibitor and a ppar- gamma agonist and uses thereof
WO2011138421A1 (en) 2010-05-05 2011-11-10 Boehringer Ingelheim International Gmbh Combination therapy
JP5596799B2 (en) 2010-05-11 2014-09-24 田辺三菱製薬株式会社 Canagliflozin-containing tablets
LT2568988T (en) 2010-05-11 2016-09-12 Janssen Pharmaceutica, N.V. Pharmaceutical formulations comprising 1-(beta-d-glucopyranosyl)-2-thienylmethylbenzene derivatives as inhibitors of sglt
WO2011153712A1 (en) 2010-06-12 2011-12-15 Theracos, Inc. Crystalline form of benzylbenzene sglt2 inhibitor
NZ603319A (en) 2010-06-24 2015-04-24 Boehringer Ingelheim Int Diabetes therapy
UA110347C2 (en) 2010-08-12 2015-12-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх DERIVATIVES OF 6-CYCLOALKYL-1,5-DIHYDROPYRAZOLE $ 3,4-d] PYRIMIDIN-4-ONE AND THEIR USE AS PDE9A INHIBITORS
WO2012025857A1 (en) 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors
AU2011295837B2 (en) 2010-09-03 2015-06-18 Astrazeneca Uk Limited Drug formulations using water soluble antioxidants
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012041898A1 (en) 2010-09-29 2012-04-05 Celon Pharma Sp. Z O.O. Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes
CN102453026A (en) 2010-10-27 2012-05-16 上海艾力斯医药科技有限公司 C-aryl glucoside derivative, preparation method and application thereof
US20120283169A1 (en) 2010-11-08 2012-11-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
AR083878A1 (en) 2010-11-15 2013-03-27 Boehringer Ingelheim Int VASOPROTECTORA AND CARDIOPROTECTORA ANTIDIABETIC THERAPY, LINAGLIPTINA, TREATMENT METHOD
IL295438B2 (en) * 2011-01-05 2026-05-01 Lexicon Pharmaceuticals Inc Compositions comprising and methods of using inhibitors of sodium-glucose cotransporters 1 and 2
EP2670397B1 (en) 2011-02-01 2020-05-13 Bristol-Myers Squibb Company Pharmaceutical formulations including an amine compound
US20130035281A1 (en) * 2011-02-09 2013-02-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
WO2012109996A1 (en) 2011-02-18 2012-08-23 上海璎黎科技有限公司 Aryl glycoside compound, preparation method and use thereof
UY33937A (en) 2011-03-07 2012-09-28 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITIONS CONTAINING DPP-4 AND / OR SGLT-2 AND METFORMIN INHIBITORS
CN102167715B (en) * 2011-03-07 2013-04-24 上海惠斯生物科技有限公司 Eutectic preparation method of sodium-glucose cotransporter 2 bulk pharmaceutical chemicals
AU2012241897C1 (en) 2011-04-13 2017-05-11 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
JP2014512399A (en) * 2011-04-25 2014-05-22 ベイジン・プレリュード・ファーム・サイ・アンド・テック・カンパニー・リミテッド Sodium-dependent glucose transport protein inhibitor and preparation method and use thereof
TWI542596B (en) 2011-05-09 2016-07-21 健生藥品公司 (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxyl L-proline and citric acid cocrystals of methyl)tetrahydro-2H-piperan-3,4,5-triol
JP5844888B2 (en) * 2011-05-26 2016-01-20 テーエフシム Aryl, heteroaryl, O-aryl and O-heteroarylcarbasaccharide families
CA2837232A1 (en) * 2011-06-03 2012-12-06 Ratiopharm Gmbh Pharmaceutical composition comprising dapagliflozin and cyclodextrin
ES2448398T3 (en) 2011-06-03 2014-03-13 Ratiopharm Gmbh Pharmaceutical composition comprising dapagliflozin and cyclodextrin
EA201301354A1 (en) 2011-06-03 2014-05-30 Бёрингер Ингельхайм Интернациональ Гмбх SGLT-2 INHIBITORS DESIGNED FOR THE TREATMENT OF METABOLIC DISORDERS IN PATIENTS TREATED BY NEUROLEPTICS
WO2013000275A1 (en) 2011-06-25 2013-01-03 山东轩竹医药科技有限公司 C-glycoside derivatives
US20130035298A1 (en) 2011-07-08 2013-02-07 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CA2841552C (en) 2011-07-15 2020-06-23 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
EP2755722B1 (en) 2011-09-13 2017-05-24 Panacea Biotec Ltd. Novel sglt inhibitors
BR112014010574A2 (en) * 2011-10-31 2017-05-02 Scinopharm Taiwan Ltd crystalline and non-crystalline forms of sglt2 inhibitors
EP2597090A1 (en) 2011-11-28 2013-05-29 Sandoz AG Crystalline dapagliflozin hydrate
SI2794626T1 (en) 2011-12-22 2018-02-28 Glycomimetics, Inc. E-selectin antagonist compounds
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
WO2013152476A1 (en) 2012-04-10 2013-10-17 Theracos, Inc. Process for the preparation of benzylbenzene sglt2 inhibitors
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
EP3685839A1 (en) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin for use in the treatment of albuminuria and kidney related diseases
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
CN103450214B (en) * 2012-05-29 2016-04-06 广东东阳光药业有限公司 Glucopyranosyl derivatives, its preparation method and in application pharmaceutically
EP2679229B1 (en) 2012-06-30 2019-02-27 BioActive Food GmbH Composition for the treatment of hyperglycemic diseases
JP6198013B2 (en) * 2012-08-30 2017-09-20 大正製薬株式会社 Combination of SGLT2 inhibitor and antihypertensive drug
LT2928476T (en) 2012-12-07 2018-05-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
CN103910769B (en) 2012-12-31 2018-10-02 上海璎黎药业有限公司 The compound of glucosan derivative and proline, crystal, preparation method and application
EP2774619B1 (en) 2013-03-04 2016-05-18 BioActive Food GmbH Composition for the treatment of hyperglycaemic diseases
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
PT3466431T (en) 2013-03-14 2024-01-26 Msd Int Gmbh Crystalline forms and methods for preparing sglt2 inhibitors
JP2016514671A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists and uses thereof
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
JP2016514670A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists in combination with other drugs
EP4245765A3 (en) 2013-04-04 2024-03-20 Boehringer Ingelheim Vetmedica GmbH Treatment of metabolic disorders in equine animals
US20140303097A1 (en) 2013-04-05 2014-10-09 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
HRP20190101T1 (en) 2013-04-05 2019-03-08 Boehringer Ingelheim International Gmbh THERAPEUTIC USES OF EMPAGLIFLOZINE
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CA2812519A1 (en) 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
KR102309654B1 (en) 2013-04-18 2021-10-08 베링거 인겔하임 인터내셔날 게엠베하 Pharmaceutical composition, methods for treating and uses thereof
EP2991999B1 (en) 2013-04-29 2019-05-08 Mapi Pharma Limited Dapagliflozin lactose co-crystal
EA201592263A1 (en) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. ULTRASCULAR AGONISTS OF GUANYLACYCLASE C, METHOD OF THEIR RECEIVING AND USING
US20160214953A1 (en) 2013-09-23 2016-07-28 Sun Pharmaceutical Industries Limited Process for the preparation of dapagliflozin
EP3049397A1 (en) 2013-09-27 2016-08-03 Sun Pharmaceutical Industries Ltd Process for the purification of dapagliflozin
US9394329B2 (en) 2013-09-27 2016-07-19 Sunshine Lake Pharma Co., Ltd. Glucopyranosyl derivatives and their uses in medicine
CN105611920B (en) 2013-10-12 2021-07-16 泰拉科斯萨普有限责任公司 Preparation of hydroxy-diphenylmethane derivatives
EP3063116A1 (en) 2013-10-31 2016-09-07 Sun Pharmaceutical Industries Ltd Process for the preparation of 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene
ES2969764T3 (en) 2013-12-17 2024-05-22 Boehringer Ingelheim Vetmedica Gmbh An SGLT-2 inhibitor for use in the treatment of a metabolic disorder in feline animals
WO2015101916A1 (en) 2013-12-30 2015-07-09 Mylan Laboratories Ltd. Process for the preparation of empagliflozin
CN104761522B (en) * 2014-01-03 2017-02-15 山东轩竹医药科技有限公司 C-Glycoside Derivatives of Optically Pure Benzyl-4-Chlorophenyl
US9315438B2 (en) 2014-01-03 2016-04-19 Xuanzhu Pharma Co., Ltd Optically pure benzyl-4-chlorophenyl-C-glucoside derivative
CN103739581B (en) * 2014-01-23 2016-11-23 中国药科大学 C-aryl glucoside SGLT2 inhibitor
CN115282284A (en) 2014-01-23 2022-11-04 勃林格殷格翰动物保健有限公司 Treatment of metabolic disorders in canines
CN104829572B (en) * 2014-02-10 2019-01-04 江苏豪森药业集团有限公司 Dapagliflozin novel crystal forms and preparation method thereof
IN2014MU00626A (en) * 2014-02-21 2015-09-25 Cadila Healthcare Ltd
US20170056365A1 (en) 2014-02-28 2017-03-02 Sun Pharmaceutical Industries Limited Dapagliflozin compositions
ES2950384T3 (en) 2014-02-28 2023-10-09 Boehringer Ingelheim Int Medical use of a DPP-4 inhibitor
IN2014CH01141A (en) 2014-03-06 2015-09-11 Msn Lab Private Ltd
ES2811261T3 (en) 2014-04-01 2021-03-11 Boehringer Ingelheim Vetmedica Gmbh Treatment of metabolic disorders in equine animals
CN105001213B (en) 2014-04-14 2020-08-28 上海迪诺医药科技有限公司 C-aryl glycoside derivative, pharmaceutical composition, preparation method and application thereof
ES2900843T3 (en) * 2014-05-16 2022-03-18 Astrazeneca Ab Method for suppressing glucagon secretion of an sglt2 inhibitor
EP2944311A1 (en) 2014-05-16 2015-11-18 BioActive Food GmbH Combination of biologically active substances for treating hyperglycemic diseases
WO2015198227A1 (en) 2014-06-23 2015-12-30 Sun Pharmaceutical Industries Limited Co-crystal of dapagliflozin with citric acid
HUE068152T2 (en) 2014-09-25 2024-12-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals
JP2017528499A (en) 2014-09-25 2017-09-28 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Combination drug of omega-3 fatty acid and SGLT-2 inhibitor for treating liver diseases
CN104327027B (en) * 2014-10-14 2017-04-05 中国药科大学 One class novel C aryl glucoside SGLT2 inhibitor
CN104478839A (en) * 2014-11-24 2015-04-01 苏州乔纳森新材料科技有限公司 Synthesis method of dapagliflozin
CN104496952B (en) * 2014-11-28 2017-04-19 深圳翰宇药业股份有限公司 Synthesis method of dapagliflozin
HUE045542T2 (en) 2014-12-03 2019-12-30 Glycomimetics Inc Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
CN105753910A (en) * 2014-12-16 2016-07-13 康普药业股份有限公司 Preparation method of canagliflozin intermediate
CN104529970A (en) * 2015-01-08 2015-04-22 江苏联环药业股份有限公司 Method for preparing Dapagliflozin
CN104478959A (en) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 Compound with nitrile group biphenyl double-glucoside structure and preparation method and application thereof
CN104478966A (en) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 O-galactoside derivative with aniline thiazolyl and preparation method and application thereof
CN104478957A (en) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 Derivative containing nitrile-based benzene and bis-O-glucoside, preparation method thereof and application
CN104530149A (en) * 2015-01-14 2015-04-22 佛山市赛维斯医药科技有限公司 Halogen-substituted phenyl group double-O-glucoside derivant, and preparation method and application thereof
CN104478968A (en) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 O-galactoside derivative with thiazolyl and preparation method and application thereof
CN104497070A (en) * 2015-01-15 2015-04-08 佛山市赛维斯医药科技有限公司 Compound with trifluoromethyl-S-glucoside and application
CN104478963A (en) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 Compound containing nitrile-based benzene S-glucoside structure and application of compound
CN104478965A (en) * 2015-01-15 2015-04-01 佛山市赛维斯医药科技有限公司 Alkoxy phenyl S-glucoside derivative and preparation method and application thereof
EP3256482B1 (en) 2015-02-09 2019-11-27 Indoco Remedies Limited Process for the preparation of sglt inhibitor compounds
HK1249847A1 (en) 2015-03-09 2018-11-16 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
WO2016161995A1 (en) 2015-04-08 2016-10-13 Zentiva, K.S. Solid forms of amorphous dapagliflozin
US10556877B2 (en) 2015-05-05 2020-02-11 Glenmark Life Sciences Limited Process for preparation of dapagliflozin
CN106317068A (en) * 2015-06-23 2017-01-11 中国科学院上海药物研究所 C, O-spiro aryl glycoside compound and preparation and application thereof
CN104961715B (en) * 2015-07-10 2017-08-22 浙江美诺华药物化学有限公司 A kind of preparation method of Dapagliflozin
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
ES2896101T3 (en) 2015-09-15 2022-02-23 Laurus Labs Ltd SGLT2 inhibitor co-crystals, process for their preparation and pharmaceutical compositions thereof
CZ2015729A3 (en) 2015-10-13 2017-04-26 Zentiva, K.S. Preparation of intermediates for the synthesis of Canagliflozin and Dapagliflozin
EP3362055B1 (en) 2015-10-15 2023-01-18 Boehringer Ingelheim International GmbH Sglt-2 inhibitor for use in the treatment of a metabolic myopathy
CN105218329B (en) * 2015-10-15 2017-05-03 上海应用技术学院 Intermediate of liflozin analogues and preparation method of intermediate
US9845303B2 (en) 2015-10-19 2017-12-19 Cadila Healthcare Limited Process for the preparation of dapagliflozin
CN106892929B (en) * 2015-12-17 2020-01-14 上海艾力斯医药科技有限公司 Spiroketal derivative and preparation method and application thereof
CN105693669A (en) * 2015-12-28 2016-06-22 南昌大学 Antidiabetic compound and preparation method and application thereof
UA122083C2 (en) * 2016-01-04 2020-09-10 Че Іль Фармасьютікал Ко., Лтд. C-GLYCOSIDE DERIVATIVES CONTAINING A CONDENSED PHENYLING RING OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF PREPARATION
WO2017118945A1 (en) 2016-01-08 2017-07-13 Lupin Limited Premix of dapagliflozin and process for the preparation thereof
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US9834533B2 (en) * 2016-02-19 2017-12-05 Scinopharm Taiwan, Ltd. Process for preparing SGLT2 inhibitors and intermediates thereof
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US20190110994A1 (en) 2016-03-31 2019-04-18 Lupin Limited Pharmaceutical composition of dapagliflozin
CN107304194A (en) * 2016-04-20 2017-10-31 扬子江药业集团上海海尼药业有限公司 The method for preparing Dapagliflozin
EP3466939B1 (en) * 2016-05-24 2021-02-24 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. New dapagliflozin crystal form and preparation method and use thereof
WO2017203229A1 (en) 2016-05-27 2017-11-30 Cipla Limited Dapagliflozin premixes
WO2017211979A1 (en) 2016-06-10 2017-12-14 Boehringer Ingelheim International Gmbh Combinations of linagliptin and metformin
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
WO2018029611A1 (en) * 2016-08-09 2018-02-15 Laurus Labs Limited Novel processes for preparation of dapagliflozin or its solvates or co-crystals thereof
WO2018029264A1 (en) 2016-08-10 2018-02-15 Amneal Pharmaceuticals Company Gmbh Process for preparation of dapagliflozin and intermediates thereof
CA3037850A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
EA201990951A1 (en) 2016-10-19 2019-11-29 COMBINATIONS CONTAINING SSAO / VAP-1 INHIBITOR AND SGLT2 INHIBITOR, AND THEIR APPLICATION
CA3039745A1 (en) 2016-11-10 2018-05-17 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
KR20180058510A (en) 2016-11-24 2018-06-01 한미약품 주식회사 Pharmaceutical formulation comprising dapagliflozin l-proline
CN108218928B (en) * 2016-12-13 2020-06-30 华润双鹤药业股份有限公司 Bicyclic derivatives of glucoside, preparation method and application thereof
WO2018142422A1 (en) * 2017-02-02 2018-08-09 Indoco Remedies Limited Process for the preparation of dapagliflozin
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
WO2018167589A1 (en) 2017-03-16 2018-09-20 Inventia Healthcare Private Limited Pharmaceutical composition comprising dapagliflozin
KR20200036808A (en) 2017-04-03 2020-04-07 코히러스 바이오사이언시스, 인크. PPARγ agonist for the treatment of advanced nuclear paralysis
WO2018207111A1 (en) 2017-05-09 2018-11-15 Piramal Enterprises Limited A process for the preparation of sglt2 inhibitors and intermediates thereof
AR112015A1 (en) 2017-06-09 2019-09-11 Novo Nordisk As SOLID COMPOSITIONS FOR ORAL ADMINISTRATION
KR101943382B1 (en) 2017-09-19 2019-01-29 오토텔릭바이오 주식회사 A pharmaceutical composition comprising SGLT-2 inhibitor and angiotensin receptor blocker
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
MY210547A (en) * 2017-11-30 2025-09-30 Idorsia Pharmaceuticals Ltd Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
US11707474B2 (en) 2018-03-05 2023-07-25 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
CN111989103A (en) 2018-04-17 2020-11-24 勃林格殷格翰国际有限公司 Pharmaceutical compositions, methods of treatment and uses thereof
KR102204439B1 (en) 2018-05-14 2021-01-18 에이치케이이노엔 주식회사 Pharmaceutical Composition comprising SGLT-2 inhibitor and DPP-IV inhibitor
WO2020001812A1 (en) 2018-06-25 2020-01-02 Pharmathen S.A. A novel process for the preparation of sglt-2 inhibitors
WO2020016335A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
WO2020039394A1 (en) 2018-08-24 2020-02-27 Novartis Ag New drug combinations
KR102131359B1 (en) 2018-09-07 2020-07-07 오토텔릭바이오 주식회사 A pharmaceutical composition with an improved stability
WO2020089025A1 (en) 2018-10-29 2020-05-07 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
SG11202102440SA (en) 2018-10-29 2021-04-29 Boehringer Ingelheim Int Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof
CN109705075B (en) * 2018-12-13 2022-12-23 苏中药业集团股份有限公司 Purification method of dapagliflozin
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
EP3771480A1 (en) 2019-08-01 2021-02-03 Lexicon Pharmaceuticals, Inc. Continuous process for preparing the crystalline form ii of sotagliflozin
JOP20200098A1 (en) 2019-08-30 2021-02-28 Astrazeneca Ab Methods of treating heart failure with reduced ejection fraction with dapagliflozin
CN114727624A (en) 2019-11-28 2022-07-08 勃林格殷格翰动物保健有限公司 Use of SGLT-2 inhibitors in weaning of non-human mammals
KR20220143732A (en) 2020-02-17 2022-10-25 베링거잉겔하임베트메디카게엠베하 Use of SGLT-2 inhibitors to prevent and/or treat heart disease in felines
EP4106732A1 (en) 2020-02-21 2022-12-28 Zaklady Farmaceutyczne Polpharma S.A. Pharmaceutical composition comprising dapagliflozin
WO2021176096A1 (en) 2020-03-05 2021-09-10 Krka, D.D., Novo Mesto Pharmaceutical composition comprising sglt2 inhibitor
CN115209894B (en) 2020-03-06 2025-05-02 弗特克斯药品有限公司 Methods for treating APOL-1-dependent focal segmental glomerulosclerosis
WO2021214023A1 (en) 2020-04-22 2021-10-28 Bayer Aktiengesellschaft Combination of finerenone and a sglt2 inhibitor for the treatment and/or prevention of cardiovascular and/or renal diseases
US20230165856A1 (en) 2020-04-29 2023-06-01 Astrazeneca Ab Dapagliflozin and ambrisentan for the prevention and treatment of covid-19
CN115867538A (en) 2020-06-05 2023-03-28 新梅斯托克公司 Preparation of highly pure amorphous dapagliflozin
WO2021260617A1 (en) * 2020-06-25 2021-12-30 Hikal Limited An improved process for preparation of dapagliflozin propanediol monohydrate
CR20230083A (en) 2020-07-10 2023-05-16 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease
AU2021202643B2 (en) 2020-07-27 2023-02-02 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
PT4188389T (en) 2020-07-27 2025-10-07 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
WO2022051316A1 (en) 2020-09-03 2022-03-10 Coherus Biosciences, Inc. Fixed dose combinations of chs-131 and a sglt-2 inhibitor
WO2022067724A1 (en) 2020-09-30 2022-04-07 北京睿创康泰医药研究院有限公司 Sglt-2 inhibitor sarcosine co-crystal, preparation method therefor and use thereof
TR202019589A2 (en) 2020-12-03 2022-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi FILM COATED TABLET FORMULATION CONTAINING DAPAGLYFLOZIN AND METFORMIN HYDROCHLORIDE
TR202019592A2 (en) 2020-12-03 2022-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Solid pharmaceutical formulations of amorphous dapagliflozin
TR202019590A2 (en) 2020-12-03 2022-06-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A PROCESS FOR FORMULATIONS OF DAPAGLYFLOZIN AND METFORMIN HYDROCHLORIDE
WO2022119543A1 (en) 2020-12-03 2022-06-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi A process for tablet formulations comprising amorphous dapagliflozin and metformin hydrochloride
WO2022208172A1 (en) 2021-04-01 2022-10-06 Astrazeneca Uk Limited Systems and methods for managing prediabetes with a gliflozin sodium-glucose cotransport 2 inhibitor pharmaceutical composition
EP4079296A1 (en) 2021-04-21 2022-10-26 Sanovel Ilac Sanayi Ve Ticaret A.S. A bilayer tablet formulation comprising amorphous dapagliflozin and metformin
MX2024001184A (en) 2021-07-28 2024-02-27 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of cardiac diseases in non-human mammals excluding felines, in particular canines.
EP4376819A1 (en) 2021-07-28 2024-06-05 Boehringer Ingelheim Vetmedica GmbH Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals
MX2024001185A (en) 2021-07-28 2024-02-27 Boehringer Ingelheim Vetmedica Gmbh Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals.
CN113773194B (en) 2021-08-16 2023-05-02 浙江奥翔药业股份有限公司 Preparation method of 5-bromo-2-chloro-benzoic acid as synthesis raw material of hypoglycemic agent
IL314031A (en) 2021-12-30 2024-09-01 Newamsterdam Pharma B V Materials and methods for improved phosphotransferases
EP4212150A1 (en) 2022-01-13 2023-07-19 Sanovel Ilac Sanayi Ve Ticaret A.S. A bilayer tablet composition comprising amorphous dapagliflozin and metformin
CN118510504A (en) 2022-01-26 2024-08-16 阿斯利康(瑞典)有限公司 Dapagliflozin for use in the treatment of pre-diabetes or in reducing the risk of developing type 2 diabetes
EP4531810A1 (en) 2022-05-25 2025-04-09 Boehringer Ingelheim Vetmedica GmbH Aqueous pharmaceutical compositions comprising sglt-2 inhibitors
US20260069559A1 (en) 2022-06-07 2026-03-12 Astrazeneca Ab Combinations of rxfp1 modulators and sglt2 inhibitors
KR102490653B1 (en) * 2022-08-03 2023-01-20 진양제약주식회사 Pharmaceutical composition comprising dapagliflozin and glimepiride
KR20240028315A (en) 2022-08-24 2024-03-05 주식회사 제뉴원사이언스 Combination preparation comprising dapagliflozin, sitagliptin and metformin
JP2026505367A (en) 2023-02-08 2026-02-13 アストラゼネカ・アクチエボラーグ A combination of zibotentan and dapagliflozin for the treatment of hyperproteinuric chronic kidney disease
US20240307628A1 (en) 2023-03-06 2024-09-19 Boehringer Ingelheim Vetmedica Gmbh Systems and methods for delivery of liquid pharmaceutical compositions in particular comprising one or more sglt-2 inhibitor(s)
EP4431088A1 (en) 2023-03-06 2024-09-18 Galenicum Health S.L.U. Pharmaceutical compositions comprising dapagliflozin and metformin
EP4427742A1 (en) 2023-03-06 2024-09-11 Galenicum Health S.L.U. Pharmaceutical compositions comprising dapagliflozin and metformin
WO2024210557A1 (en) 2023-04-05 2024-10-10 한미약품 주식회사 Combination formulation comprising sacubitril-valsartan and sglt-2 inhibitor having improved stability and dissolution rate
EP4701626A1 (en) 2023-04-24 2026-03-04 NewAmsterdam Pharma B.V. Amorphous obicetrapib and sglt2 inhibitor combination
KR20260019532A (en) 2023-05-24 2026-02-10 베링거잉겔하임베트메디카게엠베하 Combination treatment and/or prevention of renal disease and/or hypertension in non-human mammals comprising one or more SGLT-2 inhibitors and telmisartan
WO2024240632A1 (en) 2023-05-24 2024-11-28 Boehringer Ingelheim Vetmedica Gmbh Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan
EP4487910A1 (en) * 2023-07-06 2025-01-08 Zaklady Farmaceutyczne Polpharma S.A. Process for the preparation of dapagliflozin
WO2025069009A1 (en) 2023-09-29 2025-04-03 Graviton Bioscience Bv Rock2 inhibitors in the treatment of obesity
EP4556001A1 (en) 2023-11-14 2025-05-21 Sanovel Ilac Sanayi ve Ticaret A.S. A bilayer tablet composition comprising dapagliflozin and metformin
WO2025125513A1 (en) 2023-12-15 2025-06-19 AstraZeneca Ireland Limited Sglt2 inhibitors and baxdrostat for treating chronic kidney disease and hypertension
WO2025133907A1 (en) 2023-12-18 2025-06-26 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of microvascular angina
WO2025160910A1 (en) * 2024-02-01 2025-08-07 New Wish Biotechnology Wuxi Co., Ltd. Indazole compound and pharmaceutical composition, preparation method and use thereof
WO2025163559A1 (en) 2024-02-01 2025-08-07 Astrazeneca Ab Combination of zibotentan and dapagliflozin for use for the treatment of hypertension
CN118908926A (en) * 2024-07-24 2024-11-08 安徽海康药业股份有限公司 Dapagliflozin Net synthesis method
WO2026078068A1 (en) 2024-10-09 2026-04-16 Astrazeneca Ab Combination of zibotentan and dapagliflozin for the treatment of chronic kidney disease and liver fibrosis
WO2026093542A1 (en) 2024-11-01 2026-05-07 Astrazeneca Ab Glp1r agonist and sglt-2 inhibitor combination therapy

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03133746A (en) * 1989-10-19 1991-06-06 Taiyo Kagaku Kogyo Kk Self-supporting bag and its manufacturing method
CA2102591C (en) 1992-11-12 2000-12-26 Kenji Tsujihara Hypoglycemic agent
EP0671953A4 (en) * 1992-11-13 1996-01-10 Univ Ohio State Res Found ANALOGS OF N- (4-HYDROXYPHENYL) RETINAMIDE-O-GLUCURONIDE ARYLAMIDE.
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
JP2814950B2 (en) 1994-05-11 1998-10-27 田辺製薬株式会社 Hypoglycemic agent
US5830873A (en) 1994-05-11 1998-11-03 Tanabe Seiyaku Co., Ltd. Propiophenone derivative and a process for preparing the same
JP3006513B2 (en) 1995-11-07 2000-02-07 田辺製薬株式会社 Pharmaceutical composition
JP3059088B2 (en) 1995-11-07 2000-07-04 田辺製薬株式会社 Propiophenone derivatives and their production
JP3034192B2 (en) 1995-11-07 2000-04-17 田辺製薬株式会社 Propiophenone derivatives and their production
TW406086B (en) 1996-12-26 2000-09-21 Tanabe Seiyaku Co Propiophenone derivatives and process for preparing the same
AU6024998A (en) 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
JPH10245391A (en) 1997-03-03 1998-09-14 Dainippon Ink & Chem Inc A therapeutic agent for diabetes containing a 7-glycosyloxybenzopyran derivative as an active ingredient
CA2286315C (en) * 1997-04-04 2007-03-06 Yoshitomi Pharmaceutical Industries Ltd. 2-aminopropane-1,3-diol compound, pharmaceutical use thereof and synthetic intermediates therefor
JP3451000B2 (en) 1997-10-20 2003-09-29 新日本製鐵株式会社 Method of forming insulating film on grain-oriented silicon steel sheet
DE19806803A1 (en) * 1998-02-18 1999-11-25 Hermann Koepsell Transporter for saccharide-coupled cytostatics in tumor cells
GB9811427D0 (en) * 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
US6486299B1 (en) * 1998-09-28 2002-11-26 Curagen Corporation Genes and proteins predictive and therapeutic for stroke, hypertension, diabetes and obesity
AUPP823099A0 (en) * 1999-01-18 1999-02-11 Alchemia Pty Ltd Protecting groups for carbohydrate synthesis
PH12000002657B1 (en) * 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) * 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
ES2258141T3 (en) * 2001-04-11 2006-08-16 Bristol-Myers Squibb Company C-ARILO GLUCOSIDE AMINO ACIDS COMPLEX FOR DIABETES TREATMENT AND PROCEDURE.

Also Published As

Publication number Publication date
NO2022041I1 (en) 2022-10-03
BRPI0311323B8 (en) 2021-05-25
CY2013013I1 (en) 2015-11-04
BR122017015091B8 (en) 2021-07-27
ATE353334T1 (en) 2007-02-15
AR040032A1 (en) 2005-03-09
RS51469B (en) 2011-04-30
CA2486539A1 (en) 2003-12-04
PL373369A1 (en) 2005-08-22
LTPA2013008I1 (en) 2013-05-27
RU2008122558A (en) 2009-12-20
RU2489151C3 (en) 2019-11-28
US6515117B2 (en) 2003-02-04
JP5090621B2 (en) 2012-12-05
HRP20041084B1 (en) 2008-06-30
JP5584738B2 (en) 2014-09-03
RU2337916C2 (en) 2008-11-10
PE20040760A1 (en) 2004-11-20
NZ536605A (en) 2007-05-31
RU2643764C2 (en) 2018-02-05
CN101092409A (en) 2007-12-26
SI1506211T1 (en) 2007-10-31
BR0311323A (en) 2005-03-15
FR13C0022I1 (en) 2014-02-03
AU2003237886B2 (en) 2009-02-05
RU2013115635A (en) 2014-10-20
RU2643764C9 (en) 2021-12-15
NO329107B1 (en) 2010-08-23
CY2014025I1 (en) 2015-11-04
DE60311649D1 (en) 2007-03-22
BRPI0311323B1 (en) 2017-09-26
EP1506211A4 (en) 2005-08-17
IL165119A0 (en) 2005-12-18
LU92182I9 (en) 2019-01-04
LTC1506211I2 (en) 2023-02-10
MX249731B (en) 2007-10-01
AU2003237886A1 (en) 2003-12-12
FR13C0022I2 (en) 2014-03-07
CY2013013I2 (en) 2015-11-04
RS99204A (en) 2006-12-15
TWI310770B (en) 2009-06-11
UA77306C2 (en) 2006-11-15
EP1506211A1 (en) 2005-02-16
TW200404813A (en) 2004-04-01
RU2017131447A (en) 2019-03-07
ES2280759T3 (en) 2007-09-16
LU92182I2 (en) 2013-06-17
NO20044915L (en) 2004-12-16
ME00091B (en) 2010-10-10
US20020137903A1 (en) 2002-09-26
CN101628905B (en) 2012-03-21
MEP13008A (en) 2010-06-10
JP2012207037A (en) 2012-10-25
ZA200409295B (en) 2006-02-22
LU92496I2 (en) 2014-09-10
CY2014025I2 (en) 2015-11-04
CA2486539C (en) 2012-03-13
CN102627676B (en) 2014-08-20
PL210304B1 (en) 2011-12-30
JP5604568B2 (en) 2014-10-08
HK1068214A1 (en) 2005-04-22
HK1205120A1 (en) 2015-12-11
KR20050004161A (en) 2005-01-12
RU2489151C2 (en) 2013-08-10
CY1106465T1 (en) 2012-01-25
NO2013007I2 (en) 2013-04-12
PT1506211E (en) 2007-04-30
FR14C0054I1 (en) 2014-08-08
JP2009275050A (en) 2009-11-26
BR122017015091B1 (en) 2018-05-15
IN2004DE03573A (en) 2005-04-01
WO2003099836A1 (en) 2003-12-04
JP5340077B2 (en) 2013-11-13
RU2017131447A3 (en) 2021-01-14
EP1506211B1 (en) 2007-02-07
RU2746132C1 (en) 2021-04-07
CN104230866A (en) 2014-12-24
CN100534997C (en) 2009-09-02
HRP20041084A2 (en) 2005-06-30
RU2004137489A (en) 2005-06-27
CN102627676A (en) 2012-08-08
BE2013C025I2 (en) 2022-09-29
JP2005531588A (en) 2005-10-20
NO2014017I1 (en) 2014-07-09
NO2013007I1 (en) 2013-04-29
RU2746132C3 (en) 2021-08-02
CN101628905A (en) 2010-01-20
MY142499A (en) 2010-11-30
DK1506211T3 (en) 2007-04-10
DE60311649T2 (en) 2007-11-22
CN1653075A (en) 2005-08-10
GEP20084403B (en) 2008-06-25
IS7529A (en) 2004-11-16
JP2014028807A (en) 2014-02-13
KR101021752B1 (en) 2011-03-15
MXPA04011371A (en) 2005-02-14

Similar Documents

Publication Publication Date Title
BE2019C510I2 (en)
BE2018C021I2 (en)
BE2017C049I2 (en)
BE2016C069I2 (en)
BE2016C013I2 (en)
BE2018C018I2 (en)
BE2015C017I2 (en)
BE2014C030I2 (en)
BE2014C016I2 (en)
BE2014C015I2 (en)
BE2013C063I2 (en)
BE2013C039I2 (en)
BE2013C025I2 (en)
BE2011C038I2 (en)
BE2015C069I2 (en)
JP2003178163A5 (en)
JP2003231159A5 (en)
JP2003224084A5 (en)
HU0202118D0 (en)
AU2001284561A1 (en)
AU2001255621A1 (en)
AU2001279772A1 (en)
AU2001283830A1 (en)
HU0202924D0 (en)
AU2001279159A1 (en)