BE2015C026I2 - 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens - Google Patents

2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Info

Publication number
BE2015C026I2
BE2015C026I2 BE2015C026C BE2015C026C BE2015C026I2 BE 2015C026 I2 BE2015C026 I2 BE 2015C026I2 BE 2015C026 C BE2015C026 C BE 2015C026C BE 2015C026 C BE2015C026 C BE 2015C026C BE 2015C026 I2 BE2015C026 I2 BE 2015C026I2
Authority
BE
Belgium
Prior art keywords
aminoethoxy
estrogens
benzyl
phenyl
indole
Prior art date
Application number
BE2015C026C
Other languages
French (fr)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2015C026(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BE2015C026I2 publication Critical patent/BE2015C026I2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to new formulations containing one or more estrogens and 2- phenyl- 1-[4- (2-aminoethoxy)benzyl]-Indole compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have general structures (I) or (II).
BE2015C026C 1998-05-15 2015-04-28 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens BE2015C026I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens
EP99921834A EP1076558B1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Publications (1)

Publication Number Publication Date
BE2015C026I2 true BE2015C026I2 (en) 2018-08-24

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2015C026C BE2015C026I2 (en) 1998-05-15 2015-04-28 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Country Status (41)

Country Link
EP (1) EP1076558B1 (en)
JP (3) JP2002515431A (en)
KR (1) KR100620772B1 (en)
CN (1) CN1230163C (en)
AP (1) AP1424A (en)
AR (1) AR020074A1 (en)
AT (1) ATE245026T1 (en)
AU (1) AU760378B2 (en)
BE (1) BE2015C026I2 (en)
BG (1) BG64783B1 (en)
BR (1) BR9911040A (en)
CA (1) CA2329530A1 (en)
CU (1) CU23241B7 (en)
CY (1) CY2015020I1 (en)
CZ (1) CZ299334B6 (en)
DE (1) DE69909616T2 (en)
DK (1) DK1076558T3 (en)
EA (1) EA005932B1 (en)
EE (1) EE04262B1 (en)
ES (1) ES2203131T3 (en)
FR (1) FR15C0035I2 (en)
GE (1) GEP20033079B (en)
HR (1) HRP20000778B1 (en)
HU (2) HU226587B1 (en)
ID (1) ID26890A (en)
IL (1) IL139130A (en)
IN (1) IN192220B (en)
LT (1) LTC1076558I2 (en)
LU (1) LU92699I2 (en)
NO (2) NO328129B1 (en)
NZ (1) NZ508200A (en)
OA (1) OA11552A (en)
PL (1) PL194750B1 (en)
PT (1) PT1076558E (en)
SI (1) SI1076558T1 (en)
SK (1) SK284666B6 (en)
TR (1) TR200003377T2 (en)
TW (1) TW565554B (en)
UA (1) UA66861C2 (en)
WO (1) WO1999059581A1 (en)
ZA (1) ZA200006959B (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA005932B1 (en) * 1998-05-15 2005-08-25 Уайт 2-phenyl-1[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
CA2376158C (en) 1999-07-06 2011-03-15 Endorecherche, Inc. Use of selective estrogen receptor modulators in the manufacture of medicaments for treating and/or suppressing weight gain
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
WO2002003989A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
AU2001271785A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of statins, estrogenic agents and optionally estrogens
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AU2001273125A1 (en) * 2000-07-06 2002-01-21 American Home Products Corporation Combinations of bisphosphonates, estrogenic agents and optionally estrogens
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AU2001271784A1 (en) * 2000-07-06 2002-01-21 Wyeth Therapy for prosthesis-related bone degeneration
DE10117441A1 (en) * 2001-04-03 2002-10-10 Schering Ag 1-indolyl derivatives, their use in the manufacture of medicaments, a process for the preparation of 1-indolyl derivatives and pharmaceutical preparations containing 1-indolyl derivatives
JP2005504032A (en) 2001-07-31 2005-02-10 ファイザー・プロダクツ・インク Pharmaceutical compositions, kits and methods comprising estrogen agonist / antagonist, estrogen and progestin combinations
KR100470274B1 (en) 2002-11-08 2005-02-05 진 장 Method of phase transition of amorphous material using a cap layer
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (en) * 2005-01-07 2007-03-09 Sanofi Aventis Sa N- (HETEROARYL) -1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
HUE025471T2 (en) 2008-04-16 2016-03-29 Karobio Ab Novel estrogen receptor ligands
AR072297A1 (en) * 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (en) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 New synthetic method of bazedoxifene
CN103709090A (en) * 2014-01-16 2014-04-09 江苏万特制药有限公司 Preparation method of bazedoxifene acetate and key intermediate thereof
CN103739540B (en) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 A kind of preparation method of bazedoxifene acetate intermediate
CN105669518B (en) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 The preparation method of bazedoxifene acetate and its A crystal form
BR112020011668A2 (en) 2017-12-15 2020-11-17 Bristol-Myers Squibb Company substituted indole ether compounds
IT201800006562A1 (en) * 2018-06-21 2019-12-21 PROCEDURE AND USEFUL INTERMEDIATES FOR THE PREPARATION OF INDOLES
EP4122925A4 (en) * 2020-03-17 2024-04-17 Medshine Discovery Inc. PROTEOLYSIS REGULATOR AND METHOD OF USE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (en) * 1994-07-27 1996-03-14 Schering Ag 2-phenylindoles, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of medicaments
PT802183E (en) * 1996-04-19 2002-03-28 American Home Prod ESTROGENIC AGENTS
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
WO1998001443A1 (en) * 1996-07-09 1998-01-15 Smithkline Beecham S.P.A. Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
PT1025077E (en) * 1997-10-15 2007-05-31 Wyeth Corp Novel aryloxy-alkyl-dialkylamines
JP2001520997A (en) * 1997-10-28 2001-11-06 メルク エンド カムパニー インコーポレーテッド Gonadotropin-releasing hormone antagonist
ID24568A (en) * 1997-11-06 2000-07-27 American Home Prod ORAL CONTRACEPTION THAT CONTAINS ANTI-ESTROGEN PLUS PROGESTIN
EA005932B1 (en) * 1998-05-15 2005-08-25 Уайт 2-phenyl-1[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Also Published As

Publication number Publication date
AR020074A1 (en) 2002-04-10
WO1999059581A1 (en) 1999-11-25
LTC1076558I2 (en) 2016-11-10
HRP20000778A2 (en) 2001-06-30
JP2014159472A (en) 2014-09-04
NZ508200A (en) 2003-09-26
CU23241B7 (en) 2007-10-17
JP5872624B2 (en) 2016-03-01
DE69909616D1 (en) 2003-08-21
KR100620772B1 (en) 2006-09-13
AU3894499A (en) 1999-12-06
IL139130A0 (en) 2001-11-25
KR20010043641A (en) 2001-05-25
DE69909616T2 (en) 2004-06-17
SI1076558T1 (en) 2003-10-31
CN1230163C (en) 2005-12-07
IL139130A (en) 2005-11-20
OA11552A (en) 2004-06-07
SK17202000A3 (en) 2001-07-10
HUP0103096A3 (en) 2002-11-28
TW565554B (en) 2003-12-11
AP2000001970A0 (en) 2000-12-31
HK1031691A1 (en) 2001-06-22
EE200000652A (en) 2002-04-15
BR9911040A (en) 2001-02-13
ZA200006959B (en) 2001-11-27
NO20005770L (en) 2001-01-12
AU760378B2 (en) 2003-05-15
CA2329530A1 (en) 1999-11-25
PL345268A1 (en) 2001-12-03
CZ20004254A3 (en) 2001-12-12
PT1076558E (en) 2003-11-28
BG104930A (en) 2001-07-31
LU92699I2 (en) 2015-06-24
FR15C0035I2 (en) 2015-08-28
UA66861C2 (en) 2004-06-15
SK284666B6 (en) 2005-08-04
IN192220B (en) 2004-03-20
DK1076558T3 (en) 2003-11-03
HU226587B1 (en) 2009-04-28
EP1076558B1 (en) 2003-07-16
HUP0103096A2 (en) 2002-05-29
EP1076558A1 (en) 2001-02-21
JP5607871B2 (en) 2014-10-15
NO2015015I1 (en) 2015-06-02
FR15C0035I1 (en) 2015-06-26
EA005932B1 (en) 2005-08-25
CN1326347A (en) 2001-12-12
ATE245026T1 (en) 2003-08-15
AP1424A (en) 2005-06-06
BG64783B1 (en) 2006-04-28
PL194750B1 (en) 2007-06-29
NO20005770D0 (en) 2000-11-14
ID26890A (en) 2001-02-15
CY2015020I1 (en) 2020-05-29
EA200001193A1 (en) 2001-12-24
EE04262B1 (en) 2004-04-15
JP2002515431A (en) 2002-05-28
JP2009019042A (en) 2009-01-29
NO328129B1 (en) 2009-12-14
NO2015015I2 (en) 2015-06-02
CZ299334B6 (en) 2008-06-25
GEP20033079B (en) 2003-10-27
HRP20000778B1 (en) 2004-10-31
HUS1500023I1 (en) 2017-03-28
ES2203131T3 (en) 2004-04-01
TR200003377T2 (en) 2001-03-21

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