BE2016C024I2 - - Google Patents
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- Publication number
- BE2016C024I2 BE2016C024I2 BE2016C024C BE2016C024C BE2016C024I2 BE 2016C024 I2 BE2016C024 I2 BE 2016C024I2 BE 2016C024 C BE2016C024 C BE 2016C024C BE 2016C024 C BE2016C024 C BE 2016C024C BE 2016C024 I2 BE2016C024 I2 BE 2016C024I2
- Authority
- BE
- Belgium
- Prior art keywords
- factor viii
- inhibitory antibodies
- amino acid
- modified factor
- loci
- Prior art date
Links
- 102000001690 Factor VIII Human genes 0.000 abstract 4
- 108010054218 Factor VIII Proteins 0.000 abstract 4
- 229960000301 factor viii Drugs 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 102000002110 C2 domains Human genes 0.000 abstract 1
- 108050009459 C2 domains Proteins 0.000 abstract 1
- 208000031220 Hemophilia Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 102000057593 human F8 Human genes 0.000 abstract 1
- 229960000900 human factor viii Drugs 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Glass Compositions (AREA)
- Fish Paste Products (AREA)
- Steroid Compounds (AREA)
Abstract
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII is not inhibited by inhibitory antibodies against the A2 or C2 domain epitopes. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/523,656 US6458563B1 (en) | 1996-06-26 | 2000-03-10 | Modified factor VIII |
| PCT/US2001/005076 WO2001068109A1 (en) | 2000-03-10 | 2001-02-16 | Modified factor viii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2016C024I2 true BE2016C024I2 (en) | 2020-01-30 |
Family
ID=24085870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2016C024C BE2016C024I2 (en) | 2000-03-10 | 2016-05-02 |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6458563B1 (en) |
| EP (1) | EP1280540B1 (en) |
| JP (1) | JP4044337B2 (en) |
| KR (1) | KR100485525B1 (en) |
| CN (1) | CN1191360C (en) |
| AT (1) | ATE391512T1 (en) |
| AU (2) | AU3841601A (en) |
| BE (1) | BE2016C024I2 (en) |
| BR (2) | BRPI0109131B8 (en) |
| CA (1) | CA2400295C (en) |
| CY (2) | CY1108179T1 (en) |
| CZ (1) | CZ298250B6 (en) |
| DE (1) | DE60133541T2 (en) |
| DK (1) | DK1280540T3 (en) |
| EE (1) | EE05075B1 (en) |
| ES (1) | ES2304379T3 (en) |
| FR (1) | FR16C0016I2 (en) |
| HU (2) | HU227804B1 (en) |
| IL (2) | IL151371A0 (en) |
| LT (1) | LTC1280540I2 (en) |
| LU (1) | LU93049I2 (en) |
| ME (1) | ME00601B (en) |
| MX (1) | MXPA02008798A (en) |
| NL (1) | NL300808I2 (en) |
| NO (2) | NO331935B1 (en) |
| NZ (1) | NZ520799A (en) |
| PL (1) | PL202936B1 (en) |
| PT (1) | PT1280540E (en) |
| RS (1) | RS50364B (en) |
| RU (1) | RU2285724C2 (en) |
| SI (1) | SI1280540T1 (en) |
| SK (1) | SK286205B6 (en) |
| UA (1) | UA75064C2 (en) |
| WO (1) | WO2001068109A1 (en) |
| ZA (1) | ZA200206810B (en) |
Families Citing this family (99)
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|---|---|---|---|---|
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