BE2016C024I2 - - Google Patents

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Publication number
BE2016C024I2
BE2016C024I2 BE2016C024C BE2016C024C BE2016C024I2 BE 2016C024 I2 BE2016C024 I2 BE 2016C024I2 BE 2016C024 C BE2016C024 C BE 2016C024C BE 2016C024 C BE2016C024 C BE 2016C024C BE 2016C024 I2 BE2016C024 I2 BE 2016C024I2
Authority
BE
Belgium
Prior art keywords
factor viii
inhibitory antibodies
amino acid
modified factor
loci
Prior art date
Application number
BE2016C024C
Other languages
French (fr)
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Publication of BE2016C024I2 publication Critical patent/BE2016C024I2/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/10—Factor VIII, AHF; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glass Compositions (AREA)
  • Fish Paste Products (AREA)
  • Steroid Compounds (AREA)

Abstract

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more of the specific loci. The modified factor VIII is not inhibited by inhibitory antibodies against the A2 or C2 domain epitopes. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory antibodies.
BE2016C024C 2000-03-10 2016-05-02 BE2016C024I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/523,656 US6458563B1 (en) 1996-06-26 2000-03-10 Modified factor VIII
PCT/US2001/005076 WO2001068109A1 (en) 2000-03-10 2001-02-16 Modified factor viii

Publications (1)

Publication Number Publication Date
BE2016C024I2 true BE2016C024I2 (en) 2020-01-30

Family

ID=24085870

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2016C024C BE2016C024I2 (en) 2000-03-10 2016-05-02

Country Status (35)

Country Link
US (3) US6458563B1 (en)
EP (1) EP1280540B1 (en)
JP (1) JP4044337B2 (en)
KR (1) KR100485525B1 (en)
CN (1) CN1191360C (en)
AT (1) ATE391512T1 (en)
AU (2) AU3841601A (en)
BE (1) BE2016C024I2 (en)
BR (2) BRPI0109131B8 (en)
CA (1) CA2400295C (en)
CY (2) CY1108179T1 (en)
CZ (1) CZ298250B6 (en)
DE (1) DE60133541T2 (en)
DK (1) DK1280540T3 (en)
EE (1) EE05075B1 (en)
ES (1) ES2304379T3 (en)
FR (1) FR16C0016I2 (en)
HU (2) HU227804B1 (en)
IL (2) IL151371A0 (en)
LT (1) LTC1280540I2 (en)
LU (1) LU93049I2 (en)
ME (1) MEP8209A (en)
MX (1) MXPA02008798A (en)
NL (1) NL300808I2 (en)
NO (2) NO331935B1 (en)
NZ (1) NZ520799A (en)
PL (1) PL202936B1 (en)
PT (1) PT1280540E (en)
RS (1) RS50364B (en)
RU (1) RU2285724C2 (en)
SI (1) SI1280540T1 (en)
SK (1) SK286205B6 (en)
UA (1) UA75064C2 (en)
WO (1) WO2001068109A1 (en)
ZA (1) ZA200206810B (en)

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* Cited by examiner, † Cited by third party
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EP1280540A4 (en) 2004-11-03
JP4044337B2 (en) 2008-02-06
BRPI0109131B1 (en) 2020-08-25
HUS1600020I1 (en) 2016-06-28
LU93049I2 (en) 2016-06-27
WO2001068109A1 (en) 2001-09-20
DE60133541T2 (en) 2009-05-07
NO2016007I2 (en) 2016-05-10
IL151371A (en) 2010-12-30
ME00601B (en) 2011-12-20
US7012132B2 (en) 2006-03-14
IL151371A0 (en) 2003-04-10
EP1280540A1 (en) 2003-02-05
SK286205B6 (en) 2008-05-06
NO2016007I1 (en) 2016-05-10
BR122013026957A8 (en) 2017-02-21
JP2003526358A (en) 2003-09-09
CZ20023346A3 (en) 2003-01-15
ES2304379T3 (en) 2008-10-16
BR0109131A (en) 2004-12-07
ATE391512T1 (en) 2008-04-15
US20030068785A1 (en) 2003-04-10
CY2016011I1 (en) 2016-10-05
HU227804B1 (en) 2012-03-28
CA2400295A1 (en) 2001-09-20
FR16C0016I2 (en) 2018-11-02
NO331935B1 (en) 2012-05-07
SK14392002A3 (en) 2003-06-03
NO20024296L (en) 2002-11-08
KR20020081426A (en) 2002-10-26
CN1416348A (en) 2003-05-07
US20050079584A1 (en) 2005-04-14
ZA200206810B (en) 2003-11-26
AU3841601A (en) 2001-09-24
DK1280540T3 (en) 2008-07-14
BRPI0109131B8 (en) 2021-07-06
MEP8209A (en) 2011-12-20
PT1280540E (en) 2008-06-09
MXPA02008798A (en) 2003-04-25
CY2016011I2 (en) 2016-10-05
YU68002A (en) 2005-11-28
SI1280540T1 (en) 2008-08-31
US7122634B2 (en) 2006-10-17
US6458563B1 (en) 2002-10-01
NL300808I1 (en) 2016-05-18
AU2001238416B2 (en) 2004-09-02
HUP0300586A2 (en) 2003-06-28
NZ520799A (en) 2004-06-25
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RU2285724C2 (en) 2006-10-20
EE05075B1 (en) 2008-10-15
CN1191360C (en) 2005-03-02
UA75064C2 (en) 2006-03-15
KR100485525B1 (en) 2005-04-28
HK1051004A1 (en) 2003-07-18
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LTC1280540I2 (en) 2020-05-25
NL300808I2 (en) 2020-12-21
CZ298250B6 (en) 2007-08-01
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RS50364B (en) 2009-11-10
CY1108179T1 (en) 2014-02-12
FR16C0016I1 (en) 2016-04-29
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