BE657005A - - Google Patents

Description

  

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  "New drug combinations intended for the reconstitution of the intestinal flora"
We know the importance of the reseeding of the intestinal flora after treatment with antibiotics, which is always more or less deeply degraded under the influence of these drugs.



   Dehydrated cultures are generally used for this purpose.

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 dramas or freeze-dried from different bacillus one of the roles is; to allow the intestinal environment to secrete the vitamins - in particular of the B group - essential for the balanced assessment of the body,
The new drugs forming the subject of the present application for a Special Medicines Patent have been characterized by the fact that they comprise, alongside living cultures, suitably dehydrated, of the various bacilli that one wishes to re-introduce into the intestinal environment, a large amount of Sorbitol.



   The presence of this exerts a considerable influence by allowing a much faster assimilation, as soon as they are formed, of the vitamins than the bacilli nc'-. so many intrusions secrete, thereby assuring a much higher rate of assimilation.



   . It is remarkable that the mildly acteric-static action of Sorbitol exerts no harmful influence on the development of the crops once reintroduced into the favorable environment.



   The bacilli which can be used without inconvenience in the presence of sorbitol should preferably be live and originate from antibiotic resistant strains. Among those which are likely to be used with the best results, mention may be made of: Bacillus Subtilis, Saccharomyces, bacillus lactis, bacillus aoidophilus, streptococci such as lactic bacilli such as sureptococcus lactis, streptococcus thermophilus, as well as as bacillum bulgaricus, escherichia coli
The quantities of live germs which can be used vary according to the species used from 1 million to 100 billion or even more, per unit dose.

   It should be noted, however, that the quantities corresponding to the optimum activity
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 outé 8 motl are ;. generally less than. those used during employment proved san.sSorbitol, because of the better rate of assimilation of vitamins xzacs, -; u group B secreted by bacteria.

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     : The amount of Sorbitol required can be up to 2.5 g per dose. Nevertheless, the absorption of too large quantities is liable to provoke the phenomena of diarrhea. The addition of 0.25 g of Sorbitol per dose always avoids this risk and is generally sufficient to allow almost complete absorption of the vitamins secreted in the intestinal environment.



   The medicaments according to the invention can be produced in all the usual pharmaceutical forms, that is to say capsules, drinkable ampoules, lyophilized preparations, or even tablets, in the presence of pharmaceutically acceptable excipients.



   To illustrate the present Special Medicines Patent application, exemplary embodiments of medicaments according to the invention are given below, without however the details provided being able to be interpreted restrictively as regards the general scope of the invention. The invention, in particular with regard to the nature of the seeds, the dosage and the dosage.



    EXAMPLE 1 - Gelatin capsules
Lyophilized culture of live, antibiotic-resistant lactobacillus acidophilus containing at least 1 billion germs
Sorbitol 0.25 g
Excipient QS for one capsule
Dosage: 2 to 4 capsules per day or more, EXAMPLE 2 - Drinkable ampoules
Antibiotic-resistant Bacillus Subtilis living 50 billion germs
Sorbitol 0.50 g
Excipient QS for a drinkable ampoule of '10 ml Dosage: 1 to 2 ampoules per day or more

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The medicaments according to the invention can be administered in all conventional ways and be added to foods, in particular for pediatric use.

   A particularly interesting particular embodiment is the preparation, an example of which is given below, in which Sorbitol is added to a yoghurt enriched with living germs.



    EXAMPLE 3 - Special yoghurt
Yogurt enriched with live antibiotic-resistant bacillus bulgarious 100 g containing at least 100 million live germs
Sorbitol Bone? 5 g
QS fragrance
Dosage! 1 to 2 per day
This embodiment of the products according to the invention is particularly suitable for flavoring, in particular with natural fruit extracts.

 

Claims (1)

ABSTRACT The medicaments according to the invention are characterized by the fact that they combine in the same presentation: 1) antibiotic-resistant and living bacteria which multiply in the intestine, thus restoring the intestinal flora which produces vitamins, especially those of group B 2) Sorbitol which allows the vitamins synthesized by the reseeded intestinal flora to cross the intestinal barrier and be absorbed in a very increased proportion. The medicaments according to the invention are characterized by a more rapid and more vigorous action thus making it possible to rapidly correct the deficiency disorders which frequently appear, in particular following antibiotic therapy. @