BE795735A - Nouvelles ethylenediamines substituees a activite cardiovasculaire - Google Patents

Nouvelles ethylenediamines substituees a activite cardiovasculaire

Info

Publication number
BE795735A
BE795735A BE795735DA BE795735A BE 795735 A BE795735 A BE 795735A BE 795735D A BE795735D A BE 795735DA BE 795735 A BE795735 A BE 795735A
Authority
BE
Belgium
Prior art keywords
ethylenediamines
substitutes
new
cardiovascular activity
cardiovascular
Prior art date
Application number
Other languages
English (en)
Inventor
R Y Mauvernay
N Bush
J Simond
A Monteil
J Moleyre
Original Assignee
Cerm Cent Europ Rech Mauvernay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE795735A publication Critical patent/BE795735A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
BE795735D 1972-03-06 Nouvelles ethylenediamines substituees a activite cardiovasculaire BE795735A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7207647A FR2174655B1 (fr) 1972-03-06 1972-03-06

Publications (1)

Publication Number Publication Date
BE795735A true BE795735A (fr) 1973-06-18

Family

ID=9094658

Family Applications (1)

Application Number Title Priority Date Filing Date
BE795735D BE795735A (fr) 1972-03-06 Nouvelles ethylenediamines substituees a activite cardiovasculaire

Country Status (12)

Country Link
US (2) US3962238A (fr)
JP (1) JPS4899127A (fr)
BE (1) BE795735A (fr)
CA (2) CA1015360A (fr)
CH (1) CH556815A (fr)
DE (1) DE2310918C3 (fr)
ES (1) ES412203A1 (fr)
FR (1) FR2174655B1 (fr)
GB (1) GB1377327A (fr)
IL (1) IL41619A (fr)
NL (1) NL153190C (fr)
ZA (1) ZA731411B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2378024A1 (fr) * 1977-01-25 1978-08-18 Cerm Cent Europ Rech Mauvernay Nouvelle propylamine substituee, obtention et application
FR2472567A1 (fr) 1979-12-28 1981-07-03 Cerm Cent Europ Rech Mauvernay Ethers de 1- (2-propynyloxy)-2-amino-3-propanol, leur preparation et leur application en therapeutique
WO1983002274A1 (fr) * 1981-12-28 1983-07-07 Carter Wallace Synthese de l'hydrochlorure de 1-(3-isobutoxy-2-(phenylbenzyl)-amino)-propyl-pyrrolydino
US4405585A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary aminoether alcohols
US4405811A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Severely sterically hindered tertiary amino compounds
US4508692A (en) * 1982-01-18 1985-04-02 Exxon Research & Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with strongly basic tertiary amino compounds
US4762934A (en) * 1982-01-18 1988-08-09 Exxon Research And Engineering Company Diaminoether compositions
US4405583A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 using di-severely sterically hindered secondary aminoethers
US4483833A (en) * 1982-01-18 1984-11-20 Exxon Research & Engineering Co. Process for selective removal of H2 S from mixtures containing H22 with heterocyclic tertiary aminoalkanols
US4405582A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 using diaminoether solutions
US4417075A (en) * 1982-01-18 1983-11-22 Exxon Research And Engineering Co. Di-(Secondary and tertiaryalkylaminoalkoxy)alkanes
US4405580A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for selective removal of H2 S from mixtures containing H22 with tertiary amino azabicyclic alcohols
US4471138A (en) * 1982-01-18 1984-09-11 Exxon Research And Engineering Co. Severely sterically hindered secondary aminoether alcohols
US4405581A (en) * 1982-01-18 1983-09-20 Exxon Research And Engineering Co. Process for the selective removal of hydrogen sulfide from gaseous mixtures with severely sterically hindered secondary amino compounds
DK156396C (da) * 1983-09-27 1990-01-08 Cerm Cent Europ Rech Mauvernay 2-(n-pyrrolidino)-3-isobutoxy-n-substituerede phenyl-n-benzyl-propylamin-forbindelser og farmaceutiske midler indeholdende disse
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
AU568704B2 (en) * 1983-11-11 1988-01-07 Akzo N.V. Ether of n-propanolamine derivative
US4727072A (en) * 1986-02-12 1988-02-23 Mcneilab, Inc. 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
US4758563A (en) * 1986-02-12 1988-07-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyamines, cardiovascular compositions and use
DE3726633A1 (de) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh Neue 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3726632A1 (de) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-diamino-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US4888335A (en) 1988-07-25 1989-12-19 Mcneilab, Inc. 3-alkoxy-2-aminopropyl heterocyclic amines and their use as cardiovascular agents
US5185362A (en) * 1988-09-14 1993-02-09 Mcneilab, Inc. Diphenylamine cardiovascular agents, compositions and use
EA200500234A1 (ru) 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
SG141430A1 (en) * 2003-05-30 2008-04-28 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
CA2574958A1 (fr) * 2004-07-26 2006-02-09 Cotherix, Inc. Traitement de l'hypertension pulmonaire au moyen d'iloprost inhale avec une formulation de microparticules
ES2328384T3 (es) * 2004-11-23 2009-11-12 Warner-Lambert Company Llc Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (fr) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
WO2007050783A2 (fr) 2005-10-26 2007-05-03 Asahi Kasei Pharma Corporation Fasudil en polytherapies pour traiter l'hypertension arterielle pulmonaire
BRPI0618379A2 (pt) * 2005-11-08 2011-08-30 Ranbaxy Lab Ltd processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
AR059838A1 (es) * 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
AU2007274724B2 (en) * 2006-07-14 2012-07-26 Ranbaxy Laboratories Limited Polymorphic forms of an HMG-CoA reductase inhibitor and uses thereof
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8748648B2 (en) 2007-09-06 2014-06-10 Nektar Therapeutics Oligomer-calcium channel blocker conjugates
WO2012037665A1 (fr) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Oxyde nitrique libérant un ester d'acide aminé pour le traitement de l'hypertension pulmonaire et autres états respiratoires
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
WO2016098128A1 (fr) 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Procédé de préparation de bépridil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH268689A (de) * 1947-07-01 1950-05-31 Spojene Farmaceuticke Z Narodn Verfahren zur Darstellung eines biologisch wirksamen Phenyläthylendiaminderivates.
US2600301A (en) * 1948-06-04 1952-06-10 Smith Kline French Lab N-substituted-beta halo-ethyl amines
NL101813C (fr) * 1955-04-09
GB1219609A (en) * 1968-07-19 1971-01-20 Koninklijke Pharma Fab Nv Diphenylmethoxyethylamino derivatives

Also Published As

Publication number Publication date
IL41619A (en) 1976-05-31
USRE30577E (en) 1981-04-14
NL153190B (nl) 1977-05-16
ZA731411B (en) 1974-04-24
DE2310918A1 (de) 1973-09-20
JPS4899127A (fr) 1973-12-15
DE2310918B2 (de) 1979-10-25
US3962238A (en) 1976-06-08
ES412203A1 (es) 1975-12-01
FR2174655A1 (fr) 1973-10-19
CA1015360A (fr) 1977-08-09
DE2310918C3 (de) 1980-07-03
FR2174655B1 (fr) 1975-08-01
NL153190C (nl) 1980-12-15
NL7303117A (fr) 1973-09-10
CA1048027A (fr) 1979-02-06
GB1377327A (en) 1974-12-11
IL41619A0 (en) 1973-04-30
CH556815A (fr) 1974-12-13

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