BE801079A - 2-(heteroaryl-methyl)-5,9 beta-dialcoyl-6,7-benzomorphanes et leurs sels d'addition avec des acides - Google Patents

2-(heteroaryl-methyl)-5,9 beta-dialcoyl-6,7-benzomorphanes et leurs sels d'addition avec des acides

Info

Publication number: BE801079A
Authority: BE; Belgium
Prior art keywords: dialcoyl; benzomorphanes; heteroaryl; beta; acids
Prior art date: 1972-06-19

Application number

BE132406A

Other languages

English (en)

French (fr)

Original Assignee

Boehringer Sohn Ingelheim

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-06-19

Filing date

1973-06-18

Publication date

1973-12-18

1973-06-18 Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim

1973-12-18 Publication of BE801079A publication Critical patent/BE801079A/xx

Links

239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical class 0.000 title 1
150000003839 salts Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)

BE132406A 1972-06-19 1973-06-18 2-(heteroaryl-methyl)-5,9 beta-dialcoyl-6,7-benzomorphanes et leurs sels d'addition avec des acides BE801079A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2229695A DE2229695A1 (de)	1972-06-19	1972-06-19	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
BE801079A true BE801079A (fr)	1973-12-18

Family

ID=5848060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE132406A BE801079A (fr)	1972-06-19	1973-06-18	2-(heteroaryl-methyl)-5,9 beta-dialcoyl-6,7-benzomorphanes et leurs sels d'addition avec des acides

Country Status (13)

Country	Link
US (1)	US3931194A (mo)
JP (1)	JPS5711908B2 (mo)
AT (6)	AT325218B (mo)
BE (1)	BE801079A (mo)
CH (9)	CH582698A5 (mo)
DE (1)	DE2229695A1 (mo)
DK (1)	DK136904C (mo)
ES (8)	ES416037A1 (mo)
FR (1)	FR2189056B1 (mo)
GB (1)	GB1433817A (mo)
NL (1)	NL7308483A (mo)
NO (1)	NO137694C (mo)
SE (1)	SE405121B (mo)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2437610A1 (de) *	1974-08-05	1976-02-26	Boehringer Sohn Ingelheim	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
JPS63177704A (ja) *	1987-01-16	1988-07-21	松山株式会社	農作業機連結装置
US8329897B2 (en)	2007-07-26	2012-12-11	Vitae Pharmaceuticals, Inc.	Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
EP2220048B1 (en) *	2007-11-16	2017-01-25	Boehringer Ingelheim International GmbH	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5490014B2 (ja)	2007-12-11	2014-05-14	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
EP2252601B1 (en)	2008-01-24	2012-12-19	Vitae Pharmaceuticals, Inc.	Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
ATE531696T1 (de) *	2008-02-12	2011-11-15	Boehringer Ingelheim Int	Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung
EP2254872A2 (en)	2008-02-15	2010-12-01	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5538365B2 (ja)	2008-05-01	2014-07-02	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
CA2722427A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001058A1 (es)	2008-05-01	2010-09-10	Vitae Pharmaceuticals Inc	Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras.
WO2009138386A2 (en)	2008-05-13	2009-11-19	Boehringer Ingelheim International Gmbh	Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
JP5777030B2 (ja)	2008-07-25	2015-09-09	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
RU2539979C2 (ru)	2008-07-25	2015-01-27	Вайтаи Фармасьютиклз, Инк.	Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
MA33216B1 (fr)	2009-04-30	2012-04-02	Boehringer Ingelheim Int	Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (en)	2009-06-11	2012-04-18	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
TWI531571B (zh) *	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (en)	2010-06-16	2016-09-14	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
JP2014524438A (ja)	2011-08-17	2014-09-22	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	インデノピリジン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1281227A (fr) *	1958-09-22	1962-01-12	Smith Kline French Lab	Perfectionnements apportés aux procédés pour la préparation de dérivés d'aralcoylbenzomorphane
BE582575A (mo) *	1958-09-22
CS166804B2 (mo) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
SE392895B (sv) *	1971-08-24	1977-04-25	Sumitomo Chemical Co	Forfarande for framstellning av bensomorfanderivat och deras salter

1972
- 1972-06-19 DE DE2229695A patent/DE2229695A1/de not_active Withdrawn
1973
- 1973-06-05 US US05/367,114 patent/US3931194A/en not_active Expired - Lifetime
- 1973-06-06 AT AT494373A patent/AT325218B/de not_active IP Right Cessation
- 1973-06-06 AT AT489774*7A patent/AT328628B/de not_active IP Right Cessation
- 1973-06-06 AT AT489874*7A patent/AT329199B/de not_active IP Right Cessation
- 1973-06-06 AT AT490074*7A patent/AT328629B/de not_active IP Right Cessation
- 1973-06-06 AT AT489974*7A patent/AT329200B/de not_active IP Right Cessation
- 1973-06-06 AT AT489474*7A patent/AT328627B/de not_active IP Right Cessation
- 1973-06-14 CH CH1041376A patent/CH582698A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041276A patent/CH589648A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041076A patent/CH583230A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1040876A patent/CH583228A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041476A patent/CH589649A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH864373A patent/CH583227A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041576A patent/CH583231A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1040976A patent/CH583229A5/xx not_active IP Right Cessation
- 1973-06-14 CH CH1041176A patent/CH582697A5/xx not_active IP Right Cessation
- 1973-06-18 GB GB2886973A patent/GB1433817A/en not_active Expired
- 1973-06-18 SE SE7308564A patent/SE405121B/xx unknown
- 1973-06-18 ES ES416037A patent/ES416037A1/es not_active Expired
- 1973-06-18 BE BE132406A patent/BE801079A/xx unknown
- 1973-06-18 DK DK336173A patent/DK136904C/da active
- 1973-06-18 NO NO2518/73A patent/NO137694C/no unknown
- 1973-06-18 JP JP6863473A patent/JPS5711908B2/ja not_active Expired
- 1973-06-19 NL NL7308483A patent/NL7308483A/xx not_active Application Discontinuation
- 1973-06-19 FR FR7322249A patent/FR2189056B1/fr not_active Expired
1974
- 1974-10-30 ES ES431514A patent/ES431514A1/es not_active Expired
- 1974-10-30 ES ES431511A patent/ES431511A1/es not_active Expired
- 1974-10-30 ES ES0431516A patent/ES431516A1/es not_active Expired
- 1974-10-30 ES ES431512A patent/ES431512A1/es not_active Expired
- 1974-10-30 ES ES431515A patent/ES431515A1/es not_active Expired
- 1974-10-30 ES ES431510A patent/ES431510A1/es not_active Expired
- 1974-10-30 ES ES431513A patent/ES431513A1/es not_active Expired

Also Published As

Publication number	Publication date
ATA489474A (de)	1975-06-15
CH582697A5 (mo)	1976-12-15
AT329199B (de)	1976-04-26
CH589649A5 (mo)	1977-07-15
AT325218B (de)	1975-10-10
CH583228A5 (mo)	1976-12-31
JPS4961170A (mo)	1974-06-13
FR2189056A1 (mo)	1974-01-25
CH583230A5 (mo)	1976-12-31
DE2229695A1 (de)	1974-01-31
ES431514A1 (es)	1976-11-01
ES431511A1 (es)	1976-11-01
ES431512A1 (es)	1976-11-01
ES431515A1 (es)	1976-11-01
ES431516A1 (es)	1976-11-16
GB1433817A (en)	1976-04-28
CH583231A5 (mo)	1976-12-31
ATA489974A (de)	1975-07-15
AT328627B (de)	1976-03-25
AT328628B (de)	1976-03-25
NL7308483A (mo)	1973-12-21
US3931194A (en)	1976-01-06
NO137694C (no)	1978-04-05
ES431510A1 (es)	1976-11-01
DK136904C (da)	1978-06-26
ATA489874A (de)	1975-07-15
CH583227A5 (mo)	1976-12-31
FR2189056B1 (mo)	1976-10-22
AU5704673A (en)	1974-12-19
CH582698A5 (mo)	1976-12-15
ATA490074A (de)	1975-06-15
ES431513A1 (es)	1976-11-01
NO137694B (no)	1977-12-27
AT329200B (de)	1976-04-26
AT328629B (de)	1976-03-25
CH589648A5 (mo)	1977-07-15
DK136904B (da)	1977-12-12
SE405121B (sv)	1978-11-20
ES416037A1 (es)	1976-02-16
JPS5711908B2 (mo)	1982-03-08
ATA489774A (de)	1975-06-15
CH583229A5 (mo)	1976-12-31

Publication	Publication Date	Title
NO136839C (no)	1977-11-16	1,2,4-triazolderivater med fungicid virkning
FR3548M (fr)	1965-09-20	Thioxanthenesulfamides substitués, et leurs sels d'addition avec des acides.
CH555315A (fr)	1974-10-31	Procede de preparation d'alkyl- et cycloalkylthiophenylalkylaminoalkanols et leurs sels.
DK136067C (da)	1978-01-09	Herbicidt virksomme tetrahydro-1,3,5-triazin-2,6-dioner
BE779582A (fr)	1972-08-18	N-(furylmethyl)-morphinanes, leurs sels d'addition avec des acides et procedes pour les fabriquer
BE786028A (fr)	1973-01-08	2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
DK130969B (da)	1975-05-12	1-Aminosulfonyl-2-aminobenzimidazoler med fungicid virkning.
BE779058A (fr)	1972-08-07	2-(furylmethyl)6,7-benzomorphanes, leurs sels d'addition avec des acides et leurs procedes de fabrication
DK130970B (da)	1975-05-12	1-Acyl-3-aminosulfonyl-2-imino-benzimidazoliner med fungicid virkning.
DK139911B (da)	1979-05-14	6-Amino-s-triazindioner med herbicid virkning.
BE796086A (fr)	1973-08-28	Tube d'injection de vapeur.
GB1406882A (en)	1975-09-17	Benzoic acid derivatives and benzisptjoaup'e 1.1 dopxode derovatoves
DK133776C (da)	1976-12-06	Herbicidt aktive n,n'-tetrasubstituerede urinstoffer
NL148481B (nl)	1976-02-16	Looftrekker.
BE806392A (fr)	1974-02-15	Coprecipites d'aspirine/the
CH546330A (de)	1974-02-28	Viehstallung.
CH548733A (de)	1974-05-15	Viehselbsttraenkebecken.
BE804928A (fr)	1974-01-16	Terpolymeres de styrene, d'un nitrile et d'un acide
DK138640B (da)	1978-10-09	Cyclopropancarboxylsyrederivater med insekticid virkning.
SU418225A1 (mo)	1974-03-05
DK132219B (da)	1975-11-10	Herbicidt virksomme 3-aryl-2-halogen-thiopropionsyrederivater.
NO136210C (no)	1977-08-03	Cellulosesubstrat med forbedret v}tstyrke.
CH556661A (fr)	1974-12-13	Distributeur d'essuie-mains.
BE804446A (fr)	1974-03-04	Solutions concentrees d'ethylauramine
BE788329A (fr)	1973-03-01	1-phenyl-2-amino-imidazolines-(2), leurs sels d'addition avec des acides et procedes pour les fabriquer