BE834754R - ADJUVANT AGENTS FORMED BY N-ACYL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS - Google Patents

ADJUVANT AGENTS FORMED BY N-ACYL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS

Info

Publication number
BE834754R
BE834754R BE161150A BE161150A BE834754R BE 834754 R BE834754 R BE 834754R BE 161150 A BE161150 A BE 161150A BE 161150 A BE161150 A BE 161150A BE 834754 R BE834754 R BE 834754R
Authority
BE
Belgium
Prior art keywords
adjuvant agents
acyl
compositions
acid derivatives
vaccines containing
Prior art date
Application number
BE161150A
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/516,991 external-priority patent/US4186194A/en
Application filed filed Critical
Application granted granted Critical
Publication of BE834754R publication Critical patent/BE834754R/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BE161150A 1974-10-22 1975-10-22 ADJUVANT AGENTS FORMED BY N-ACYL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS BE834754R (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/516,991 US4186194A (en) 1973-10-23 1974-10-22 Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Publications (1)

Publication Number Publication Date
BE834754R true BE834754R (en) 1976-02-16

Family

ID=24057920

Family Applications (2)

Application Number Title Priority Date Filing Date
BE161150A BE834754R (en) 1974-10-22 1975-10-22 ADJUVANT AGENTS FORMED BY N-ACYL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS
BE161149A BE834753R (en) 1974-10-22 1975-10-22 ADJUVANT AGENTS FORMED BY N-ACL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE161149A BE834753R (en) 1974-10-22 1975-10-22 ADJUVANT AGENTS FORMED BY N-ACL-MURAMIC ACID DERIVATIVES AND COMPOSITIONS OF VACCINES CONTAINING SUCH ADJUVANT AGENTS

Country Status (3)

Country Link
BE (2) BE834754R (en)
FR (1) FR2288527A2 (en)
ZA (2) ZA756661B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310514A (en) 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4315913A (en) 1980-06-09 1982-02-16 Merck & Co. Inc. Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
US4368190A (en) 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4461761A (en) * 1978-06-05 1984-07-24 Agence Nationale De Valorisation De La Recherche (Anvar) Oligomers of compounds of the muramyl-peptide type and medicaments containing them

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397844A (en) * 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
FR2529463B1 (en) * 1982-07-05 1986-01-10 Centre Nat Rech Scient METHOD AND DEVICE FOR THE ENCAPSULATION IN ERYTHROCYTES OF AT LEAST ONE BIOLOGICALLY ACTIVE SUBSTANCE, IN PARTICULAR ALLOSTERIC EFFECTORS OF HEMOGLOBIN AND ERYTHROCYTES OBTAINED THEREBY
FR2533827A1 (en) * 1982-09-30 1984-04-06 Anvar Composition possessing immunoregulatory properties, in particular of non-specific immunological adjuvants, based on muramyl peptide and an aluminium derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (en) * 1971-11-19 1975-02-07 Anvar
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4461761A (en) * 1978-06-05 1984-07-24 Agence Nationale De Valorisation De La Recherche (Anvar) Oligomers of compounds of the muramyl-peptide type and medicaments containing them
US4368190A (en) 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4310514A (en) 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4315913A (en) 1980-06-09 1982-02-16 Merck & Co. Inc. Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation

Also Published As

Publication number Publication date
ZA756661B (en) 1976-11-24
BE834753R (en) 1976-02-16
ZA756660B (en) 1976-11-24
FR2288527A2 (en) 1976-05-21
FR2288527B2 (en) 1979-09-14

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE

Effective date: 19901031