BE843691A - Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine) - Google Patents

Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine)

Info

Publication number
BE843691A
BE843691A BE168562A BE168562A BE843691A BE 843691 A BE843691 A BE 843691A BE 168562 A BE168562 A BE 168562A BE 168562 A BE168562 A BE 168562A BE 843691 A BE843691 A BE 843691A
Authority
BE
Belgium
Prior art keywords
lofepramino
chlorhydrate
dibenz
azepinyl
acetophenone
Prior art date
Application number
BE168562A
Other languages
English (en)
Inventor
E Eriksoo
S S Kelfve
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE843691A publication Critical patent/BE843691A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE168562A 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine) BE843691A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28145/75A GB1497306A (en) 1975-07-03 1975-07-03 Preparation of lofepramine and its hydrochloride

Publications (1)

Publication Number Publication Date
BE843691A true BE843691A (fr) 1977-01-03

Family

ID=10270996

Family Applications (1)

Application Number Title Priority Date Filing Date
BE168562A BE843691A (fr) 1975-07-03 1976-07-01 Procede pour la preparation de chlorhydrate de4' -chloro-23-(10,11-dihydro-5h)dibenz(b,f) azepinyl-(5)-propyl -methylamino - acetophenone (ou chlorhydrate de lofepramine)

Country Status (10)

Country Link
US (1) US4172074A (fr)
JP (1) JPS6014030B2 (fr)
BE (1) BE843691A (fr)
CA (1) CA1079274A (fr)
CH (1) CH618686A5 (fr)
DE (1) DE2628558A1 (fr)
FR (1) FR2316234A1 (fr)
GB (1) GB1497306A (fr)
IE (1) IE43255B1 (fr)
SE (1) SE7607565L (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108119A1 (de) * 1991-03-13 1992-09-17 Jellalabad Ltd Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten
CA2200761C (fr) * 1994-10-05 2008-02-26 Cari Loder Traitement de la sclerose en plaques (ms) et d'autres maladies demyelinisantes utilisant la lofepramine en combinaison avec l-phenylalanine, tyrosine ou tryptophane et eventuellement un compose de la vitamine b12
GB2308065B (en) * 1994-10-05 1999-01-13 Cari Loder Treatment of multiple sclerosis (MS) and other demyelinating conditions
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
WO2006038084A1 (fr) * 2004-10-01 2006-04-13 Neurocure Ltd Utilisation de compositions pharmaceutiques de lofepramine pour le traitement du thada, du syndrome de fatigue chronique, de la fibromyalgie et de la depression
EP2317316A3 (fr) 2005-07-08 2011-06-15 Braincells, Inc. Procédés permettant d'identifier l'agent et les conditions qui modulent la neurogénèse
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2382975A3 (fr) 2006-05-09 2012-02-29 Braincells, Inc. Neurogénèse par modulation d'angiotensine
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (fr) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation de la neurogenèse par des ligands mélatoninergiques
AU2008204800A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
EP2288345B1 (fr) 2008-04-18 2015-06-10 University College Dublin National University Of Ireland, Dublin Produits psycho-pharmaceutiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1177525A (en) * 1967-04-13 1970-01-14 Leo Ab New Heterocyclic Aminoketones of Therapeutic Interest

Also Published As

Publication number Publication date
US4172074A (en) 1979-10-23
DE2628558C2 (fr) 1989-11-16
CH618686A5 (fr) 1980-08-15
GB1497306A (en) 1978-01-05
IE43255B1 (en) 1981-01-14
FR2316234A1 (fr) 1977-01-28
DE2628558A1 (de) 1977-01-20
FR2316234B1 (fr) 1979-06-08
JPS527982A (en) 1977-01-21
SE7607565L (sv) 1977-01-04
IE43255L (en) 1977-01-03
JPS6014030B2 (ja) 1985-04-11
CA1079274A (fr) 1980-06-10

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Legal Events

Date Code Title Description
CN Change of patent owner's name
RE20 Patent expired

Owner name: PHARMACIA BIOSYSTEMS A.B.

Effective date: 19960701