BE846340A - Analogues de prostaglandines et leur preparation - Google Patents

Analogues de prostaglandines et leur preparation

Info

Publication number
BE846340A
BE846340A BE170736A BE170736A BE846340A BE 846340 A BE846340 A BE 846340A BE 170736 A BE170736 A BE 170736A BE 170736 A BE170736 A BE 170736A BE 846340 A BE846340 A BE 846340A
Authority
BE
Belgium
Prior art keywords
preparation
prostaglandin analogues
prostaglandin
analogues
Prior art date
Application number
BE170736A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE846340A publication Critical patent/BE846340A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
BE170736A 1975-09-17 1976-09-17 Analogues de prostaglandines et leur preparation BE846340A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/614,242 US4016184A (en) 1975-09-17 1975-09-17 9-Deoxy-9,10-didehydro-PGD1 compounds

Publications (1)

Publication Number Publication Date
BE846340A true BE846340A (fr) 1977-03-17

Family

ID=24460426

Family Applications (1)

Application Number Title Priority Date Filing Date
BE170736A BE846340A (fr) 1975-09-17 1976-09-17 Analogues de prostaglandines et leur preparation

Country Status (2)

Country Link
US (22) US4016184A (fr)
BE (1) BE846340A (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201873A (en) * 1975-09-17 1980-05-06 The Upjohn Company 9-Deoxy-9,10-didehydro-PGD2 analogs
US4209639A (en) * 1975-09-22 1980-06-24 American Cyanamid Company 13-Thia-prostaglandins
US4138590A (en) * 1977-01-13 1979-02-06 American Home Products Corporation Prostaglandin derivatives
US4220796A (en) 1979-05-01 1980-09-02 The Upjohn Company 9-Deoxy-9-methylene-5,6-didehydro-PGF1 compounds
US4401824A (en) * 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins
DE3375914D1 (en) * 1982-10-07 1988-04-14 Teijin Ltd Novel 5-membered cyclic compounds, process for the production thereof, and pharmaceutical use thereof
CA1241324A (fr) 1984-03-08 1988-08-30 Paul A. Aristoff Derives d'interphenylene carbacycline
US4888358A (en) * 1988-08-25 1989-12-19 Syntex (U.S.A.) Inc. 13,14-dihydroprostaglandin C-type derivatives
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5011856A (en) * 1990-03-12 1991-04-30 Allergan, Inc. Use of prostaglandin F3 α as an ocular hypotensive agent
US5238961A (en) * 1990-06-14 1993-08-24 Allergan, Inc. Pgf 1-alcohols and their use as ocular hypotensives
US6022897A (en) * 1995-04-25 2000-02-08 The Salk Institute For Biological Studies Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
FR2804070B1 (fr) 2000-01-26 2002-09-20 Inoplast Sa Ouvrant de vehicule automobile en materiau plastique et vehicule automobile equipe d'un tel ouvrant
CA2406628C (fr) * 2000-04-24 2010-10-05 Shell Canada Limited Procede de traitement d'une formation contenant des hydrocarbures
US8287640B2 (en) * 2008-09-29 2012-10-16 Clearwater International, Llc Stable foamed cement slurry compositions and methods for making and using same
CA2768154C (fr) 2009-07-13 2018-02-13 Irix Pharmaceuticals Synthese de prostanoides
KR102311896B1 (ko) 2013-09-30 2021-10-14 패턴 에이피아이 서비시즈 인코포레이티드 복분해를 사용하는 프로스타글란딘 및 프로스타글란딘 중간체의 합성 경로

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959346A (en) * 1969-03-14 1976-05-25 The Upjohn Company Racemic prostaglandins of the 2-series and analogs thereof
JPS503362B1 (fr) * 1970-06-10 1975-02-04
JPS4830848A (fr) * 1971-08-23 1973-04-23
BE794516A (fr) * 1972-01-26 1973-05-16 Wisconsin Alumni Res Found Nouvelles prostaglandines et leur procede de preparation
DE2317019A1 (de) * 1972-04-27 1973-11-08 Upjohn Co Neue 4,5-didehydro-prostaglandine
JPS5432773B2 (fr) * 1972-05-09 1979-10-16
US3862979A (en) * 1972-06-15 1975-01-28 Erba Carlo Spa 9-desoxy-prosta-5,9(10),13-trienoic acid derivatives
US3933899A (en) * 1972-10-30 1976-01-20 The Upjohn Company PGE2 -oxa-phenylene compounds
US3914282A (en) * 1973-01-16 1975-10-21 Upjohn Co Prostaglandin E{HD 1{B , F{HD 1{B , and A{HD 1 {B analogs
US3962293A (en) * 1973-07-20 1976-06-08 The Upjohn Company 13,14-Dihydro-16-fluoro prostaglandin F1
US3932463A (en) * 1974-06-03 1976-01-13 American Cyanamid Company 11-Deoxy-13-dihydro-prostaglandin-9-ketals
US3933904A (en) * 1974-09-13 1976-01-20 American Home Products Corporation 11,15-Dihydroxy-9,13-prostadienoic acid
US3954844A (en) * 1975-01-03 1976-05-04 G. D. Searle & Co. (5Z,13E,15S)-15-Hydroxy-11-oxoprosta-5,9.13-trien-1-oic acid and esters
US4026909A (en) * 1975-07-14 1977-05-31 The Upjohn Company Cis-13-PGF2.sub.α analogs

Also Published As

Publication number Publication date
US4069390A (en) 1978-01-17
US4083865A (en) 1978-04-11
US4069389A (en) 1978-01-17
US4118415A (en) 1978-10-03
US4124615A (en) 1978-11-07
US4094891A (en) 1978-06-13
US4083859A (en) 1978-04-11
US4087615A (en) 1978-05-02
US4082782A (en) 1978-04-04
US4120880A (en) 1978-10-17
US4117005A (en) 1978-09-26
US4119672A (en) 1978-10-10
US4066836A (en) 1978-01-03
US4122098A (en) 1978-10-24
US4120879A (en) 1978-10-17
US4122099A (en) 1978-10-24
US4070538A (en) 1978-01-24
US4108878A (en) 1978-08-22
US4082784A (en) 1978-04-04
US4082794A (en) 1978-04-04
US4086259A (en) 1978-04-25
US4016184A (en) 1977-04-05

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UPJOHN CY

Effective date: 19860930