BE853227A - 11ALPHA-AMINO, DELTA 4 OR DELTA 5 PREGNANES AND ANDROSTANES WITH DISUBSTITUTED GROUP - Google Patents

11ALPHA-AMINO, DELTA 4 OR DELTA 5 PREGNANES AND ANDROSTANES WITH DISUBSTITUTED GROUP

Info

Publication number
BE853227A
BE853227A BE176410A BE176410A BE853227A BE 853227 A BE853227 A BE 853227A BE 176410 A BE176410 A BE 176410A BE 176410 A BE176410 A BE 176410A BE 853227 A BE853227 A BE 853227A
Authority
BE
Belgium
Prior art keywords
delta
11alpha
androstanes
pregnanes
amino
Prior art date
Application number
BE176410A
Other languages
French (fr)
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of BE853227A publication Critical patent/BE853227A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE176410A 1976-04-05 1977-04-04 11ALPHA-AMINO, DELTA 4 OR DELTA 5 PREGNANES AND ANDROSTANES WITH DISUBSTITUTED GROUP BE853227A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB13707/76A GB1581234A (en) 1976-04-05 1976-04-05 11a - amino - 3a - hydroxysteroids

Publications (1)

Publication Number Publication Date
BE853227A true BE853227A (en) 1977-10-04

Family

ID=10027931

Family Applications (1)

Application Number Title Priority Date Filing Date
BE176410A BE853227A (en) 1976-04-05 1977-04-04 11ALPHA-AMINO, DELTA 4 OR DELTA 5 PREGNANES AND ANDROSTANES WITH DISUBSTITUTED GROUP

Country Status (19)

Country Link
JP (1) JPS52142056A (en)
AU (1) AU517206B2 (en)
BE (1) BE853227A (en)
DE (1) DE2715078A1 (en)
DK (1) DK148677A (en)
ES (1) ES457507A1 (en)
FI (1) FI771046A7 (en)
FR (2) FR2347382A1 (en)
GB (1) GB1581234A (en)
IE (1) IE45276B1 (en)
IL (1) IL51816A (en)
IT (1) IT1073232B (en)
LU (1) LU77064A1 (en)
NL (1) NL7703667A (en)
NO (1) NO771197L (en)
NZ (1) NZ183775A (en)
PL (1) PL197186A1 (en)
SE (1) SE7703929L (en)
ZA (1) ZA772029B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059637A1 (en) * 1981-03-02 1982-09-08 Glaxo Group Limited 11Alpha-amino-3 Beta-hydroxy-androstanes
US4352798A (en) * 1980-07-16 1982-10-05 Glaxo Group Limited 11 α-Amino-androstanes
US4353898A (en) * 1980-07-16 1982-10-12 Glaxo Group Limited 11α-Amino-androstanes

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3260539D1 (en) * 1981-05-29 1984-09-13 Glaxo Group Ltd 11-alpha-amino-androstanes
DE3260462D1 (en) * 1981-05-29 1984-08-30 Glaxo Group Ltd 11-alpha-amino-androstanes
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
FR2910002B1 (en) * 2006-12-13 2009-01-30 Sanofi Aventis Sa NOVEL METHOD FOR THE DIASTEREOSELECTIVE OBTAINING OF A PRIMARY CHIRAL AMINE ON A STEROID
JP2010037243A (en) * 2008-08-04 2010-02-18 Mitsubishi Rayon Co Ltd Method for producing norbornene lactone monomer
CN119192266A (en) 2011-10-14 2024-12-27 萨奇治疗股份有限公司 3,3-disubstituted 19-norpregnane compounds, compositions, and uses thereof
SG10201606063RA (en) 2012-01-23 2016-09-29 Sage Therapeutics Inc Neuroactive steroid formulations and methods of treating cns disorders
MX2015002252A (en) 2012-08-21 2015-07-21 Sage Therapeutics Inc Methods of treating epilepsy or status epilepticus.
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
ES2807264T3 (en) 2013-04-17 2021-02-22 Sage Therapeutics Inc 19-nor neuroactive steroids for treatment methods
JP6470258B2 (en) 2013-04-17 2019-02-13 セージ セラピューティクス， インコーポレイテッド 19-nor C 3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
WO2015010054A2 (en) 2013-07-19 2015-01-22 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
ES2848823T3 (en) 2013-08-23 2021-08-12 Sage Therapeutics Inc Neuroactive steroids, compositions and uses thereof
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (en) 2014-09-08 2017-06-16 Sage Therapeutics Inc Neuroactive steroids and formulations, and their uses
US10577390B2 (en) 2014-10-16 2020-03-03 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
ME03809B (en) 2014-10-16 2021-04-20 Sage Therapeutics Inc COMPOSITIONS AND METHODS OF TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
WO2016082789A1 (en) * 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
WO2016123056A1 (en) 2015-01-26 2016-08-04 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
HK1258616A1 (en) 2016-03-08 2019-11-15 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
MA45599A (en) 2016-07-11 2019-05-15 Sage Therapeutics Inc NEUROACTIVE STEROIDS SUBSTITUTED FOR C17, C20 AND C21 AND THEIR USE PROCEDURES
US20190233465A1 (en) 2016-07-11 2019-08-01 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
CN111741965B (en) * 2017-12-22 2024-06-25 萨奇治疗股份有限公司 Compositions and methods for treating central nervous system diseases
IL283629B2 (en) 2018-12-05 2026-03-01 Sage Therapeutics Inc Neuroactive steroids and their methods of use
CR20240234A (en) 2019-05-31 2024-07-09 Sage Therapeutics Inc NEUROACTIVE STEROIDS AND THEIR COMPOSITIONS (Divisional 2021-629)
US20230257415A1 (en) * 2019-06-27 2023-08-17 Sage Therapeutics, Inc. Compounds for treating cns disorders
AU2020304673A1 (en) * 2019-06-27 2022-01-20 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
JP7787635B2 (en) 2019-06-27 2025-12-17 セージ セラピューティクス， エルエルシー Compositions and methods for treating CNS disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2982775A (en) * 1957-05-06 1961-05-02 Schering Corp 11-oximino-, amino- and acylaminosteroids

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352798A (en) * 1980-07-16 1982-10-05 Glaxo Group Limited 11 α-Amino-androstanes
US4353898A (en) * 1980-07-16 1982-10-12 Glaxo Group Limited 11α-Amino-androstanes
EP0059637A1 (en) * 1981-03-02 1982-09-08 Glaxo Group Limited 11Alpha-amino-3 Beta-hydroxy-androstanes

Also Published As

Publication number Publication date
IT1073232B (en) 1985-04-13
GB1581234A (en) 1980-12-10
DE2715078A1 (en) 1977-10-13
DK148677A (en) 1977-10-06
LU77064A1 (en) 1979-01-18
ZA772029B (en) 1978-11-29
ES457507A1 (en) 1978-03-16
JPS52142056A (en) 1977-11-26
FR2347382B1 (en) 1982-01-08
IL51816A0 (en) 1977-06-30
NL7703667A (en) 1977-10-07
IE45276L (en) 1977-10-05
PL197186A1 (en) 1979-06-18
FR2485020A1 (en) 1981-12-24
AU2394277A (en) 1978-10-12
IE45276B1 (en) 1982-07-28
FI771046A7 (en) 1977-10-06
IL51816A (en) 1981-09-13
NZ183775A (en) 1979-12-11
AU517206B2 (en) 1981-07-16
SE7703929L (en) 1978-10-27
FR2347382A1 (en) 1977-11-04
NO771197L (en) 1977-10-06

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO LABORATORIES LTD

Effective date: 19840404