BE860169A - Thymosine alpha1 - Google Patents

Thymosine alpha1

Info

Publication number: BE860169A
Authority: BE; Belgium
Prior art keywords: thymosin alpha1; alpha1; thymosin
Prior art date: 1976-10-28

Application number

BE182108A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Univ Texas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-28

Filing date

1977-10-27

Publication date

1978-04-27

1977-10-27 Application filed by Hoffmann La Roche, Univ Texas filed Critical Hoffmann La Roche

1978-04-27 Publication of BE860169A publication Critical patent/BE860169A/fr

Links

108010078233 Thymalfasin Proteins 0.000 title 1
102400000800 Thymosin alpha-1 Human genes 0.000 title 1
NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 title 1
229960004231 thymalfasin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/18—Thymus derived hormone or factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BE182108A 1976-10-28 1977-10-27 Thymosine alpha1 BE860169A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US73663876A	1976-10-28	1976-10-28

Publications (1)

Publication Number	Publication Date
BE860169A true BE860169A (fr)	1978-04-27

Family

ID=24960663

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE182108A BE860169A (fr)	1976-10-28	1977-10-27	Thymosine alpha1

Country Status (4)

Country	Link
US (1)	US4079127A (fr)
BE (1)	BE860169A (fr)
HU (1)	HU172798B (fr)
ZA (1)	ZA775976B (fr)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4116951A (en) *	1977-04-22	1978-09-26	Hoffmann-La Roche Inc.	[Asn2 ]-thymosin α1 and analogs thereof
US4680276A (en) *	1977-05-25	1987-07-14	Institut National De La Sante Et De La Recherche Medicale	Metal polypeptides
US4264571A (en) *	1979-01-22	1981-04-28	George Washington University	Radioimmunoassay of thymosin α1
US4297276A (en) *	1979-03-23	1981-10-27	Hoffman-La Roche Inc.	Thymosin beta 3 and beta 4
US4261886A (en) *	1980-03-13	1981-04-14	Ortho Pharmaceutical Corporation	Peptides having thymopoietin-like activity
DE2919592A1 (de) *	1979-05-15	1981-01-15	Max Planck Gesellschaft	Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
EP0033384B1 (fr) *	1980-01-18	1984-02-15	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Médicaments contenant des fragments de thymosine-alpha-1, leur activité immunostimulante, et fragments de thymosine-alpha-1
JPS56138154A (en) *	1980-02-28	1981-10-28	Genentech Inc	Desacetylthymosin-alpha-1 and manufacture
US4361673A (en) *	1980-09-19	1982-11-30	American Home Products Corporation	Polypeptide compositions
SE448605B (sv) *	1980-10-27	1987-03-09	Vtoroi Mo G Med I Imen	Terapeutiskt preparat for reglering av t-immunsystemet och forfarande for framstellning derav
JPS57110196A (en) *	1980-10-30	1982-07-08	Hoffmann La Roche	Preparation of thimocin alpha 1
US4444757A (en) *	1981-11-16	1984-04-24	Research Corporation	Use of thymosin as an anti-diabetes and anti-hypertensive disease agent
US4427783A (en)	1981-12-14	1984-01-24	Hoffmann-La Roche Inc.	Immunoassay of thymosin α1
US4388234A (en) *	1981-12-28	1983-06-14	Hoffmann-La Roche Inc.	Peptide isolation
DE3230151A1 (de) *	1982-08-13	1984-02-16	Hoechst Ag, 6230 Frankfurt	Neues polypeptid mit wirkung auf das immunsystem, verfahren zu seiner isolierung und reinigung, seine verwendung, dieses enthaltende mittel sowie seine spaltprodukte, deren verwendung und diese enthaltende mittel
US4517119A (en) *	1983-04-04	1985-05-14	Hoffmann-La Roche Inc.	Synthesis of thymosin α1
US4504415A (en) *	1983-04-04	1985-03-12	Hoffman-La Roche Inc.	Synthesis of thymosin α1 and desacetyl thymosin α1
US4543340A (en) *	1983-04-07	1985-09-24	George Washington University	Radioimmunoassay of thymosin β4
US4614731A (en) *	1983-09-15	1986-09-30	Hoffmann-La Roche Inc.	Peptide having immunopotentiating activity similar to thymosin alpha1
US4621135A (en) *	1983-12-08	1986-11-04	Yeda Research & Development Company, Ltd.	Novel THF compositions
US4983387A (en) *	1986-05-19	1991-01-08	Viral Technologies Inc.	HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus
US4777239A (en) *	1986-07-10	1988-10-11	The Board Of Trustees Of The Leland Stanford Junior University	Diagnostic peptides of human papilloma virus
US5728680A (en)	1987-12-30	1998-03-17	Cytoven J.V.	Methods for normalizing numbers of lymphocytes
US5807830A (en) *	1987-12-30	1998-09-15	Cytoven J.V.	Method for treatment of purulent inflammatory diseases
US5811399A (en) *	1988-12-14	1998-09-22	Cytran, Inc.	Pharmaceutical dipeptide compositions and methods of use thereof: immunodepressants
US5770576A (en) *	1989-08-30	1998-06-23	Cytran, Inc.	Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity
WO1992013546A1 (fr) *	1991-02-04	1992-08-20	George Washington University	Peptide mb-40 augmentant la production d'interleukine-1 et modulant la reponse immunitaire associee a l'age
US5273963A (en) *	1991-03-29	1993-12-28	The George Washington University	Compositions and methods for treating small cell and nonsmall cell lung cancers
US6066622A (en) *	1991-10-28	2000-05-23	Cytran, Inc.	Immunomodulating peptides and methods of use
US6100380A (en) *	1991-10-28	2000-08-08	Cytran, Inc.	Immunomodulating peptides and methods of use
WO1995011688A1 (fr) *	1992-02-06	1995-05-04	Sciclone Pharmaceuticals	Methode de traitement de porteurs de l'hepatite b presentant un etat pathologique minime
US5308833A (en) *	1992-02-06	1994-05-03	Sciclone Pharmaceuticals	Method for treating hepatitis B carriers with minimal disease
CN1058500C (zh) *	1993-02-03	2000-11-15	施塞克龙药品公司	胸腺素α－1衍生物
WO1994020063A2 (fr) *	1993-03-04	1994-09-15	Cytoven International N.V.	Tryptophane pharmaceutique contenant des compositions dipeptidiques et modes d'utilisation
US6200952B1 (en)	1993-06-02	2001-03-13	Sciclone Pharmaceuticals, Inc.	Combination therapy method for treating chronic hepatitis B
AU7964194A (en) *	1993-10-07	1995-05-01	George Washington University Medical Center, The	Method of treating septic shock using thymosin-alpha1
TW252045B (fr) *	1993-10-07	1995-07-21	Allan L Goldstein
AU685413B2 (en) *	1993-11-05	1998-01-22	Board Of Governors Of Wayne State University, The	Method and composition for treatment of patients having decompensated liver disease
US6262230B1 (en)	1994-01-28	2001-07-17	Sciclone Pharmaceuticals Inc.	Analogs of thymosin α1
JP3853384B2 (ja) *	1994-09-09	2006-12-06	株式会社三菱化学ヤトロン	抗サイモシンα１モノクローナル抗体産生ハイブリドーマ
US5632983A (en)	1994-11-17	1997-05-27	University Of South Florida	Method for treating secondary immunodeficiency
WO1998035696A1 (fr) *	1997-02-18	1998-08-20	Sciclone Pharmaceuticals, Inc.	Utilisation de thymosine alpha 1 pour la fabrication d'un medicament destine a favoriser le developpement de cellules souches
MXPA03003638A (es)	2000-10-27	2004-01-26	Immuno Rx Inc	Inmunoterapia con vacuna para pacientes inmunosuprimidos.
US20070025958A1 (en)	2000-10-27	2007-02-01	Hadden John W	Vaccine immunotherapy
US20070154399A1 (en) *	2000-10-27	2007-07-05	Hadden John W	Immunotherapy for immune suppressed patients
DE60224435T2 (de) *	2001-10-26	2009-01-02	Rhode Island Hospital	Thymosin-augmentation bei genetischer immunisierung
UA78726C2 (en) *	2001-11-01	2007-04-25	Sciclone Pharmaceuticals Inc	Pharmaceutical composition of thymosin alpha 1 conjugated with polyethylene glycol, method for production, and method for treatment
UA77999C2 (en) *	2001-12-10	2007-02-15		Thymosin-alpha 1 for treatment of malignant glioblastoma
WO2004048971A1 (fr) *	2002-11-25	2004-06-10	Sciclone Pharmaceuticals, Inc.	Procedes de protection contre des dommages dus a un rayonnement, faisant appel a la thymosine alpha
EP1613340B1 (fr)	2003-03-28	2010-05-12	SciClone Pharmaceuticals, Inc.	Traitement d'infections par i aspergillus /i a l'aide de thymosine alpha 1
US20100311656A1 (en) *	2003-04-23	2010-12-09	Sciclone Pharmaceuticals, Inc.	Treatment or prevention of respiratory viral infections with alpha thymosin peptides
CN1822850A (zh) *	2003-07-18	2006-08-23	雷根内克斯生物制药有限公司	由放射线照射引起的损伤的治疗或预防
WO2005115341A2 (fr) *	2004-05-27	2005-12-08	Advanced Bionutrition Corporation	Microparticules pour administration orale
ITRM20060583A1 (it) *	2006-10-27	2008-04-28	Francesco Bistoni	Uso della timosina alfa 1 per la preparazione di un medicamento per la prevenzione e la cura delle allergie
RU2327475C1 (ru) *	2006-11-28	2008-06-27	Общество с ограниченной ответственностью Научно-производственное предприятие "ЭргоБио"	Способ получения иммуноактивных полипептидов/пептидов, обладающих иммунокорригирующими свойствами
ES2653887T3 (es)	2007-11-28	2018-02-09	Irx Therapeutics, Inc.	Procedimiento para aumentar el efecto inmunológico
CN102458470B (zh) *	2009-05-08	2016-01-20	赛生制药有限公司	作为疫苗增强剂的α胸腺素肽
JP5797190B2 (ja)	2009-05-15	2015-10-21	アイアールエックスセーラピューティクス，インコーポレイテッド	ワクチン免疫療法
CN107050430B (zh)	2009-12-08	2021-10-15	伊尔克斯治疗有限公司	逆转朗格汉斯细胞免疫抑制的方法
US20130296223A1 (en)	2012-03-30	2013-11-07	Sciclone Pharmaceuticals, Inc.	Use of thymosin alpha for the treatment of sepsis
GB201621732D0 (en) *	2016-12-20	2017-02-01	Agricultural Research Council	A multi-epitope dna vaccine for heartwater

1977
- 1977-02-08 US US05/766,638 patent/US4079127A/en not_active Expired - Lifetime
- 1977-10-05 ZA ZA00775976A patent/ZA775976B/xx unknown
- 1977-10-26 HU HU77HO00002021A patent/HU172798B/hu unknown
- 1977-10-27 BE BE182108A patent/BE860169A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA775976B (en)	1978-06-28
US4079127A (en)	1978-03-14
HU172798B (hu)	1978-12-28

Legal Events

Date

Code

Title

Description

1997-01-01

RE20

Patent expired

Owner name: F. HOFFMANN-LA ROCHE A.G.

Effective date: 19971027

Owner name: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTE