BE860315A - Trans-5a-aryl-decahydrobenzazepines a activite analgesique - Google Patents

Trans-5a-aryl-decahydrobenzazepines a activite analgesique

Info

Publication number
BE860315A
BE860315A BE1008484A BE1008484A BE860315A BE 860315 A BE860315 A BE 860315A BE 1008484 A BE1008484 A BE 1008484A BE 1008484 A BE1008484 A BE 1008484A BE 860315 A BE860315 A BE 860315A
Authority
BE
Belgium
Prior art keywords
decahydrobenzazepines
trans
aryl
analgesic activity
analgesic
Prior art date
Application number
BE1008484A
Other languages
English (en)
Inventor
D M Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BE860315A publication Critical patent/BE860315A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
BE1008484A 1976-11-02 1977-10-28 Trans-5a-aryl-decahydrobenzazepines a activite analgesique BE860315A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/737,959 US4141894A (en) 1976-11-02 1976-11-02 Trans-5a-aryl-decahydrobenzazepines

Publications (1)

Publication Number Publication Date
BE860315A true BE860315A (fr) 1978-04-28

Family

ID=24965985

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1008484A BE860315A (fr) 1976-11-02 1977-10-28 Trans-5a-aryl-decahydrobenzazepines a activite analgesique

Country Status (26)

Country Link
US (1) US4141894A (fr)
JP (1) JPS5356683A (fr)
AR (1) AR221835A1 (fr)
AT (1) AT358046B (fr)
AU (1) AU510911B2 (fr)
BE (1) BE860315A (fr)
BG (1) BG28417A3 (fr)
CA (2) CA1096861A (fr)
DD (1) DD133797A5 (fr)
DE (1) DE2748468A1 (fr)
DK (1) DK485177A (fr)
ES (1) ES463782A1 (fr)
FR (1) FR2369268A1 (fr)
GB (1) GB1585296A (fr)
GR (1) GR70052B (fr)
IE (1) IE45899B1 (fr)
IL (1) IL53235A0 (fr)
NL (1) NL7712052A (fr)
PH (1) PH13506A (fr)
PL (1) PL108916B1 (fr)
PT (1) PT67195B (fr)
RO (1) RO72899B (fr)
SE (1) SE7712219L (fr)
SU (1) SU843743A3 (fr)
YU (1) YU257577A (fr)
ZA (1) ZA776498B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080021152A (ko) * 2000-07-06 2008-03-06 다이이찌 산쿄 가부시키가이샤 히드로피리딘 유도체 산부가염
FR3062850B1 (fr) * 2017-02-10 2020-01-31 Guerbet Procede de preparation monotope de composes organo-iodes
FR3084668A1 (fr) 2018-08-02 2020-02-07 Guerbet Procede de preparation monotope de composes organo-iodes intermediaires a la synthese du ioversol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT330179B (de) * 1972-07-20 1976-06-25 Du Pont Verfahren zur herstellung von neuen 4a-aryl- transdecahydroisochinolinderivaten sowie deren optischen isomeren
US4001247A (en) * 1974-06-07 1977-01-04 Eli Lilly And Company 1-ethyl 3a-(substituted-phenyl) decahydroisoquinoline
US4001248A (en) * 1974-06-07 1977-01-04 Eli Lilly And Company N-cycloalkylmethyl decahydroisoquinolines

Also Published As

Publication number Publication date
ATA782277A (de) 1980-01-15
PH13506A (en) 1980-06-03
GB1585296A (en) 1981-02-25
ES463782A1 (es) 1978-12-16
IL53235A0 (en) 1977-12-30
DE2748468A1 (de) 1978-05-03
NL7712052A (nl) 1978-05-05
SE7712219L (sv) 1978-05-03
FR2369268A1 (fr) 1978-05-26
JPS5356683A (en) 1978-05-23
AR221835A1 (es) 1981-03-31
SU843743A3 (ru) 1981-06-30
FR2369268B1 (fr) 1980-05-16
YU257577A (en) 1983-01-21
IE45899L (en) 1978-05-02
ZA776498B (en) 1979-06-27
AT358046B (de) 1980-08-11
DD133797A5 (de) 1979-01-24
PL201883A1 (pl) 1979-01-29
RO72899B (fr) 1981-03-22
US4141894A (en) 1979-02-27
IE45899B1 (en) 1982-12-29
BG28417A3 (en) 1980-04-15
PT67195A (en) 1977-11-01
AU510911B2 (en) 1980-07-17
GR70052B (fr) 1982-07-26
CA1096861A (fr) 1981-03-03
CA1102319A (fr) 1981-06-02
AU3023377A (en) 1979-05-10
PL108916B1 (en) 1980-05-31
PT67195B (en) 1979-03-23
DK485177A (da) 1978-05-03

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