BE862365A - Preparation de gamma-lactones d'acides 7 zeta (alcoxycarbonyl)-6zeta-alkyl/halogeno-3-oxo-17alpha-pregn-4-ene-21-carboxyliques, des acides, sels et esters correspondant a leur utilisation - Google Patents

Preparation de gamma-lactones d'acides 7 zeta (alcoxycarbonyl)-6zeta-alkyl/halogeno-3-oxo-17alpha-pregn-4-ene-21-carboxyliques, des acides, sels et esters correspondant a leur utilisation

Info

Publication number
BE862365A
BE862365A BE183884A BE183884A BE862365A BE 862365 A BE862365 A BE 862365A BE 183884 A BE183884 A BE 183884A BE 183884 A BE183884 A BE 183884A BE 862365 A BE862365 A BE 862365A
Authority
BE
Belgium
Prior art keywords
acids
6zeta
lactons
alcoxycarbonyl
17alpha
Prior art date
Application number
BE183884A
Other languages
English (en)
French (fr)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BE862365A publication Critical patent/BE862365A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
BE183884A 1976-12-27 1977-12-27 Preparation de gamma-lactones d'acides 7 zeta (alcoxycarbonyl)-6zeta-alkyl/halogeno-3-oxo-17alpha-pregn-4-ene-21-carboxyliques, des acides, sels et esters correspondant a leur utilisation BE862365A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
BE862365A true BE862365A (fr) 1978-06-27

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
BE183884A BE862365A (fr) 1976-12-27 1977-12-27 Preparation de gamma-lactones d'acides 7 zeta (alcoxycarbonyl)-6zeta-alkyl/halogeno-3-oxo-17alpha-pregn-4-ene-21-carboxyliques, des acides, sels et esters correspondant a leur utilisation

Country Status (19)

Country Link
US (1) US4069219A (da)
JP (1) JPS5382767A (da)
AU (1) AU518862B2 (da)
BE (1) BE862365A (da)
CA (1) CA1099702A (da)
CH (6) CH637403A5 (da)
DE (1) DE2758279A1 (da)
DK (1) DK577377A (da)
FI (1) FI773936A7 (da)
FR (1) FR2375253A1 (da)
GB (1) GB1575986A (da)
IE (1) IE46128B1 (da)
IL (1) IL53692A (da)
NL (1) NL7714428A (da)
NO (2) NO774464L (da)
NZ (1) NZ186119A (da)
PT (1) PT67455B (da)
SE (1) SE7714764L (da)
ZA (1) ZA777684B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CN100384866C (zh) * 1995-12-11 2008-04-30 G·D·瑟尔公司 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
EP1490390A2 (en) * 2002-03-22 2004-12-29 Pharmacia Corporation C-17 spirolactonization and 6,7 oxidation of steroids
AU2003213807A1 (en) * 2002-11-06 2004-06-03 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
TWI280133B (en) * 2002-11-07 2007-05-01 Upjohn Co Process for preparing C-7 substituted steroids
SI1746101T2 (sl) 2005-07-21 2014-09-30 Bayer Pharma Aktiengesellschaft Postopek za pripravo 3-okso-pregn-4-en-21,17-karbolaktonov z oksidacijo 17-(3-hidroksipropil)-3,17-dihidroksiandrostanov brez uporabe kovine
EA016411B1 (ru) 2005-07-21 2012-04-30 Байер Фарма Акциенгезельшафт Способ получения 3-оксо-прегн-4-ен-21,17-карболактонов с помощью окисления 17-(3-гидроксипропил)-3,17-дигидроксиандростанов без использования металла

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
PT67455A (en) 1978-01-01
IE46128L (en) 1978-06-27
CH637405A5 (de) 1983-07-29
JPS5382767A (en) 1978-07-21
CH637404A5 (de) 1983-07-29
CA1099702A (en) 1981-04-21
IL53692A0 (en) 1978-03-10
NO774464L (no) 1978-06-28
PT67455B (en) 1979-05-25
NL7714428A (nl) 1978-06-29
CH638536A5 (de) 1983-09-30
GB1575986A (en) 1980-10-01
DK577377A (da) 1978-06-28
AU3201277A (en) 1979-06-28
SE7714764L (sv) 1978-06-28
NZ186119A (en) 1979-08-31
CH635595A5 (de) 1983-04-15
NO820059L (no) 1978-06-28
US4069219A (en) 1978-01-17
IE46128B1 (en) 1983-02-23
ZA777684B (en) 1979-08-29
AU518862B2 (en) 1981-10-22
FI773936A7 (fi) 1978-06-28
FR2375253A1 (fr) 1978-07-21
FR2375253B1 (da) 1981-04-30
IL53692A (en) 1982-07-30
DE2758279A1 (de) 1978-06-29
CH637403A5 (de) 1983-07-29
CH637408A5 (de) 1983-07-29

Similar Documents

Publication Publication Date Title
BE865995A (fr) Preparation d'esters silylalkyliques d'acides phosphores
BE865468A (fr) Derives d'acetamide utiles notamment en therapeutique
BE868417A (fr) Derives d'acide 1,2,3-thiadiazole-5-carboxylique leur procede de preparation et leur utilisation
BE851725A (fr) Nouveaux esters d'acides androstadiene-17-carboxyliques
IT1093261B (it) Tcopolieteres teramidi stabili all'idrolisi
BE862365A (fr) Preparation de gamma-lactones d'acides 7 zeta (alcoxycarbonyl)-6zeta-alkyl/halogeno-3-oxo-17alpha-pregn-4-ene-21-carboxyliques, des acides, sels et esters correspondant a leur utilisation
BE856278A (fr) Nouveaux derives d'acide penicillanique et leur utilisation therapeutique
BE891609A (fr) Preparation d'acides carboxyliques
BE856041A (fr) Procede de preparation de fluorures d'acides perfluoro-alcoxypropioniques
PT67352B (fr) Procedes pour la preparation d'acides thiazolidinacarboxidiques et acides en rapportes
BE863112A (fr) Solutions aqueuses concentrees de sels d'acides acetylacetylaminoarylsulfoniques
FR2276283A1 (fr) Preparation d'acides carboxyliques, notamment d'a-ceto-acides
BE795474A (fr) Sels alcalins d'acides polyester-carboxyliques, et leur preparation
FR2353556A1 (fr) Derives de l'acide clavulanique, leur procede de preparation et leur application en therapeutique
RO70295A (ro) Procedeu de preparare a esterului izobutilic al acidului 2,6-dimetil-3-metoxicarbonil-4-(2'-nitrofenil)-1,4-dihidropiridin-5-carboxilic
FR2276818A1 (fr) Bestatine, ses sels d'addition d'acides et esters et leur application pharmacologique
BE859290A (fr) Preparation d'acides alpha-cetocarboxyliques aliphatiques et heterocycliques
AU4168978A (en) Salts of alpha-isocyanocarboxylic acids
FR2353544A1 (fr) Esters benzyliques et esters apparentes d'acides 6,11-dihydrodibenz(b,e)oxepine-acetiques, leur procede de preparation et leur application therapeutique
BE816682A (fr) Preparation de sels d'amines et d'anhydrides d'acides carboxyliques
BE869794A (fr) Acides aminoalkylene-phosphoniques et leurs sels, leur preparation et leur emploi
FR2286646A1 (fr) Derives de l'acide 2-naphtyl-butyrique a activite therapeutique
BE856044A (fr) Derives optiquement actifs d'acide benzoxazolylpropionique, leur procede de preparation et leur utilisation
BE857101A (fr) Sels d'acides dicarboxyliques et de diamines presentant un indice de coloration ameliore
FR2335493A1 (fr) Sels de derives du 2,4-diaminoazobenzene et d'acides alkylarenesulfoniques, leur preparation et leur utilisation comme colorants

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: G.D. SEARLE & CO.

Effective date: 19851231