BE867594A - N-cyano-n'-2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines - Google Patents

N-cyano-n'-2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines

Info

Publication number
BE867594A
BE867594A BE188137A BE188137A BE867594A BE 867594 A BE867594 A BE 867594A BE 188137 A BE188137 A BE 188137A BE 188137 A BE188137 A BE 188137A BE 867594 A BE867594 A BE 867594A
Authority
BE
Belgium
Prior art keywords
alkynylguanidines
methylthio
imidazolyl
cyano
ethyl
Prior art date
Application number
BE188137A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE867594A publication Critical patent/BE867594A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE188137A 1977-06-03 1978-05-29 N-cyano-n'-2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines BE867594A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03

Publications (1)

Publication Number Publication Date
BE867594A true BE867594A (fr) 1978-11-29

Family

ID=25185323

Family Applications (1)

Application Number Title Priority Date Filing Date
BE188137A BE867594A (fr) 1977-06-03 1978-05-29 N-cyano-n'-2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines

Country Status (8)

Country Link
US (2) US4158013A (fr)
JP (2) JPS595581B2 (fr)
AT (1) AT363955B (fr)
AU (1) AU516144B2 (fr)
BE (1) BE867594A (fr)
HU (1) HU182645B (fr)
SU (1) SU900809A3 (fr)
ZA (1) ZA783141B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
JPS5533416A (en) * 1978-08-31 1980-03-08 Sogo Yatsukou Kk Production of hexamethyene bis-dicyandiamide
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
ES521588A0 (es) * 1983-03-30 1984-08-16 Ferrer Int Procedimiento de obtencion de nuevas n-ciano-formamidinas.
US4588719A (en) * 1984-04-27 1986-05-13 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2697727A (en) * 1953-04-28 1954-12-21 American Cyanamid Co Method of preparing s-alkyl cyanopseudothioureas
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1399283A (en) * 1972-04-20 1975-07-02 Smith Kline French Lab Pharmaceutical compositions
US3897555A (en) * 1972-05-22 1975-07-29 Smithkline Corp Pharmaceutical compositions and method of inhibiting gastric acid secretion
BE804144A (fr) 1972-09-05 1974-02-28 Smith Kline French Lab Cyanoguanidines
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
GB1553070A (en) * 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
GB1578219A (en) * 1975-12-01 1980-11-05 Smith Kline French Lab Isothioureas
DK168277A (da) 1977-02-22 1978-08-23 Smithkline Corp Fremgangsmaade til fremstilling af 4-substituerede imidazolforbindelser

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239908A (en) * 1979-12-10 1980-12-16 G.D. Searle & Co. N-aralkenyl-N'-cyano-N"-(heterocyclylthioalkyl)-guanidines
US4431802A (en) * 1979-12-10 1984-02-14 G. D. Searle & Co. N-Heterocyclyl-N-cyano-N-(heterocyclythioalkyl)-guanidines

Also Published As

Publication number Publication date
JPS55157559A (en) 1980-12-08
AT363955B (de) 1981-09-10
AU516144B2 (en) 1981-05-21
ATA404378A (de) 1981-02-15
JPS5737589B2 (fr) 1982-08-10
US4158013A (en) 1979-06-12
US4157347A (en) 1979-06-05
AU3681678A (en) 1979-12-06
JPS595581B2 (ja) 1984-02-06
HU182645B (en) 1984-02-28
ZA783141B (en) 1979-06-27
JPS55157562A (en) 1980-12-08
SU900809A3 (ru) 1982-01-23

Similar Documents

Publication Publication Date Title
SE7803626L (sv) Hydantoin
DK559777A (da) Neglebelaegningspraeparat
AR218674A1 (es) Revestimiento retrorreflector
AT378967B (de) Beschichtungsmassen
DK504278A (da) Belaegningsmiddel
IT1132296B (it) Dispositivo di rivestimento elettrolitico
IT1097828B (it) Dispositivo per l'essiccazione di nastri
BE867594A (fr) N-cyano-n'-2-(4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines
IL51513A0 (en) N-(4-benzyloxyphenyl)-n'-methyl-n'-methoxyurea
TR20474A (tr) Kaplanmis duesuek fitoksisiteli pestisid
BR8107590A (pt) Revestimento conformavel
IT7852208A0 (it) Procedimento per il rivestimento senza solventi
IT7950946A0 (it) Procedimento per rivestire organopo lisilossano reticolato
IT7969069A0 (it) Procedimento per la finitura dicatene di cerniere lampo
SE7801406L (sv) Beleggning
FI800163A7 (fi) Spirokinolylhydantoiner
IT1133006B (it) Procedimento di depurazione dell'antibiotico spectinomicina
FI781737A7 (fi) N-cyano-n'-(2-(4-metyl-5-imidazolyl) metyltio)etyl)-n''-alkynylguanidiner och foerfarande foer deras framstaellning
ATA94482A (de) Schieinspannvorrichtung
LU81026A1 (fr) N-cyano-n'-(2-((4-methyl-5-imidazolyl)methylthio)ethyl)-n"-alkynylguanidines
DK145171C (da) Herbicid indeholdende et n-phenyl-n'-methyl-n'-methoxy-urinstofderivat
FR2534058B1 (fr) Revetement projetable antineutronique
IT1095105B (it) Balestrina perfezionata per il sostegno di nastro scorrevole
IT7867484A0 (it) Induttanza di regolazione
PL203592A1 (pl) Powloka antykorozyjna

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19850529

RR Patent reestablished after lapse

Free format text: 860210 *BRISTOL-MYERS CY

RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19870531