BE867702A - Nouveaux amino-acides fluores - Google Patents

Nouveaux amino-acides fluores

Info

Publication number
BE867702A
BE867702A BE188232A BE188232A BE867702A BE 867702 A BE867702 A BE 867702A BE 188232 A BE188232 A BE 188232A BE 188232 A BE188232 A BE 188232A BE 867702 A BE867702 A BE 867702A
Authority
BE
Belgium
Prior art keywords
amino acids
new fluorine
fluorine amino
new
acids
Prior art date
Application number
BE188232A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BE867702A publication Critical patent/BE867702A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BE188232A 1977-06-01 1978-06-01 Nouveaux amino-acides fluores BE867702A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/802,391 US4325961A (en) 1977-06-01 1977-06-01 Fluorinated amino acids

Publications (1)

Publication Number Publication Date
BE867702A true BE867702A (fr) 1978-12-01

Family

ID=25183569

Family Applications (1)

Application Number Title Priority Date Filing Date
BE188232A BE867702A (fr) 1977-06-01 1978-06-01 Nouveaux amino-acides fluores

Country Status (4)

Country Link
US (1) US4325961A (fr)
BE (1) BE867702A (fr)
PH (1) PH16587A (fr)
ZA (1) ZA783121B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347374A (en) 1980-07-21 1982-08-31 Merck & Co., Inc. Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431821A (en) * 1977-06-01 1984-02-14 Merck & Co., Inc. Fluorinated tryptamines
US4866206A (en) * 1977-07-11 1989-09-12 Merrell Dow France Et Cie 2-Halomethyl derivatives of 2-amino acids
US5614557A (en) * 1977-07-11 1997-03-25 Marion Merrell Et Compagnie C/O Merrell Pharmaceuticals Inc. Method of controlling tumor growth rate
US4438270A (en) 1977-07-11 1984-03-20 Merrell Toraude Et Compagnie α-Halomethyl derivatives of α-amino acids
US4413141A (en) * 1977-07-11 1983-11-01 Merrell Toraude Et Compagnie 2-(Difluoromethyl)-2,5-diaminopentanoic acid
US4560795A (en) * 1979-04-10 1985-12-24 Merrell Dow France et Cie. α-Halomethyl derivatives of α-amino acids
GB2083030B (en) * 1980-08-23 1984-03-07 Merrell Toraude & Co Fluorinated pentene diamine derivatives
US4447443A (en) * 1982-11-15 1984-05-08 Merck & Co., Inc. Anti-inflammatory/analgesic combination of α-fluoromethylhistidine and a selected non-steroidal anti-inflammatory drug (NSAID)
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4522823A (en) * 1984-01-05 1985-06-11 Merck & Co., Inc. Orexigenic use of α-fluoromethyl-histidine
CA1309557C (fr) 1985-06-18 1992-10-27 Robert N. Young Antagonistes de leucotrienes
US4760091A (en) * 1985-10-01 1988-07-26 The Dow Chemical Company Method of controlling phytopathogenic fungus
US5196450A (en) * 1985-12-19 1993-03-23 Merrell Dow Pharmaceuticals Inc. Method of inhibiting protozoal growth
ATE90076T1 (de) 1986-03-27 1993-06-15 Merck Frosst Canada Inc Tetrahydrocarbazole ester.
US5428033A (en) 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5030645A (en) * 1990-10-15 1991-07-09 Merck & Co., Inc. Method of treating asthma using (S)-α-fluoromethyl-histidine and esters thereof
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
AU2002245505A1 (en) * 2001-02-27 2002-09-12 Trustees Of Tufts College Non-racemic hexafluoreleucine, and methods of making and using it
CN101041674A (zh) * 2002-04-30 2007-09-26 埃默里大学 肿瘤成像化合物
CA2612187C (fr) * 2005-06-23 2013-05-07 Emory University Synthese stereo-selective d'analogues d'acides amines pour l'imagerie des tumeurs
EP1893244A4 (fr) * 2005-06-23 2009-06-24 Univ Emory Agents pour l'imagerie
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US12162902B2 (en) * 2018-12-06 2024-12-10 Sail Biomedicines Decarboxylase inhibitors for treating Parkinson's disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3046300A (en) * 1960-10-21 1962-07-24 Merck & Co Inc alpha-trifluoromethyloxyphenylalanines
US3395176A (en) * 1964-03-06 1968-07-30 Merck & Co Inc Alpha-hydroxymethylphenylalanine compounds
JPS5025465B1 (fr) * 1970-12-29 1975-08-23
US4004996A (en) * 1974-12-23 1977-01-25 Merck & Co., Inc. Fluorination of organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347374A (en) 1980-07-21 1982-08-31 Merck & Co., Inc. Acid addition salts of N-trityl-α-fluoromethylhistidine enantiomer derivatives

Also Published As

Publication number Publication date
ZA783121B (en) 1979-07-25
PH16587A (en) 1983-11-22
US4325961A (en) 1982-04-20

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERCK & CO. INC.

Effective date: 19870630