BE873895A - Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyle - Google Patents
Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyleInfo
- Publication number
- BE873895A BE873895A BE0/193234A BE193234A BE873895A BE 873895 A BE873895 A BE 873895A BE 0/193234 A BE0/193234 A BE 0/193234A BE 193234 A BE193234 A BE 193234A BE 873895 A BE873895 A BE 873895A
- Authority
- BE
- Belgium
- Prior art keywords
- aminobenzoyl
- glutamates
- dialkyl
- preparing
- dialkyl glutamates
- Prior art date
Links
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/875,051 US4136101A (en) | 1978-02-03 | 1978-02-03 | Process for preparing dialkyl (p-aminobenzoyl) glutamates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE873895A true BE873895A (fr) | 1979-08-02 |
Family
ID=25365117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/193234A BE873895A (fr) | 1978-02-03 | 1979-02-02 | Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyle |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4136101A (fr) |
| JP (1) | JPS54115337A (fr) |
| AU (1) | AU4230878A (fr) |
| BE (1) | BE873895A (fr) |
| DE (1) | DE2900326A1 (fr) |
| FR (1) | FR2416218A1 (fr) |
| GB (1) | GB2013659A (fr) |
| NL (1) | NL7812587A (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5190041A (en) * | 1989-08-11 | 1993-03-02 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
| US5101814A (en) * | 1989-08-11 | 1992-04-07 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
| US5166149A (en) * | 1989-09-08 | 1992-11-24 | Chemex Pharmaceuticals, Inc. | Methotrexate compositions and methods of treatment using same |
| US5066828A (en) * | 1990-04-12 | 1991-11-19 | Merrell Dow Pharmaceuticals Inc. | Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases |
| US5382582A (en) * | 1993-03-26 | 1995-01-17 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| US5698556A (en) * | 1995-06-07 | 1997-12-16 | Chan; Carcy L. | Methotrexate analogs and methods of using same |
| ES2312179T3 (es) | 1996-12-06 | 2009-02-16 | Amgen Inc. | Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1. |
| WO2004060911A2 (fr) * | 2002-12-30 | 2004-07-22 | Amgen Inc. | Polytherapie a facteurs costimulants |
| US6921667B2 (en) | 2003-03-07 | 2005-07-26 | Prometheus Laboratories, Inc. | Methods for direct detection of individual methotrexate metabolites |
| US7582282B2 (en) | 2003-08-29 | 2009-09-01 | Prometheus Laboratories Inc. | Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics |
| US20080312201A1 (en) * | 2004-09-10 | 2008-12-18 | Patrick Fogarty | Reduced Toxicity Methotrexate Formulations and Methods for Using the Same |
| US20060286571A1 (en) | 2005-04-28 | 2006-12-21 | Prometheus Laboratories, Inc. | Methods of predicting methotrexate efficacy and toxicity |
| NZ592293A (en) | 2005-11-28 | 2012-10-26 | Verrow Pharmaceuticals Inc | Compositions comprising an oligosaccharide such as a cyclodextrin for reducing the nephrotoxicity of other drugs |
| CN102014919B (zh) | 2008-03-03 | 2015-02-25 | 托斯克公司 | 减少毒性的甲氨蝶呤佐剂及其使用方法 |
| WO2012037068A1 (fr) | 2010-09-13 | 2012-03-22 | De Novo Diagnostics, Inc. | Méthodes de surveillance de thérapie par méthotrexate |
| EP2646442B1 (fr) | 2010-12-03 | 2015-11-11 | Kocak Farma Ilac Ve Kimya San. A.S | Nouveau procédé pour la préparation d'agents antifolique comportant un squelette de acide glutamique comme structure partielle |
| TR201113223A2 (tr) | 2011-12-29 | 2012-06-21 | Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. | Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem. |
| EP3749314A4 (fr) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | Méthotrexate alpha-polyglutamaté et utilisations associées |
| JP7462950B2 (ja) | 2018-02-14 | 2024-04-08 | エル．イー．エー．エフ． ホールディングス グループ エルエルシー | ガンマポリグルタミン酸化メトトレキセートおよびその使用 |
| CN113735735A (zh) * | 2021-03-03 | 2021-12-03 | 浙江致新医药科技有限公司 | 一种甲氨化反应的制备方法 |
| CN113461689B (zh) * | 2021-06-30 | 2023-03-31 | 浙江浙北药业有限公司 | 一种甲氨蝶呤化合物的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892801A (en) * | 1974-09-11 | 1975-07-01 | American Cyanamid Co | Method for preparing alkali salts of p-methylaminobenzoylglutamic acid |
-
1978
- 1978-02-03 US US05/875,051 patent/US4136101A/en not_active Expired - Lifetime
- 1978-12-07 AU AU42308/78A patent/AU4230878A/en active Pending
- 1978-12-27 NL NL7812587A patent/NL7812587A/xx not_active Application Discontinuation
-
1979
- 1979-01-05 DE DE19792900326 patent/DE2900326A1/de not_active Withdrawn
- 1979-01-09 GB GB7900821A patent/GB2013659A/en not_active Withdrawn
- 1979-01-30 FR FR7902346A patent/FR2416218A1/fr not_active Withdrawn
- 1979-02-02 BE BE0/193234A patent/BE873895A/fr unknown
- 1979-02-03 JP JP1099779A patent/JPS54115337A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE2900326A1 (de) | 1979-08-09 |
| AU4230878A (en) | 1979-08-09 |
| JPS54115337A (en) | 1979-09-07 |
| GB2013659A (en) | 1979-08-15 |
| FR2416218A1 (fr) | 1979-08-31 |
| US4136101A (en) | 1979-01-23 |
| NL7812587A (nl) | 1979-08-07 |
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