BE879666A - Nouvelles cephalosporines, leur preparation et compositions les contenant - Google Patents

Nouvelles cephalosporines, leur preparation et compositions les contenant Download PDF

Info

Publication number
BE879666A
BE879666A BE0/197842A BE197842A BE879666A BE 879666 A BE879666 A BE 879666A BE 0/197842 A BE0/197842 A BE 0/197842A BE 197842 A BE197842 A BE 197842A BE 879666 A BE879666 A BE 879666A
Authority
BE
Belgium
Prior art keywords
emi
preparation
compositions containing
novel cephalosporins
cephalosporins
Prior art date
Application number
BE0/197842A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE879666A publication Critical patent/BE879666A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Description


   <EMI ID=1.1> 

  
compositions les contenant   <EMI ID=2.1> 

  
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pénicillines. Dans certaines circonstances, 

  
souhaitable d'utiliser une céphalosporine qui fasse

  
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large spectre. - '  <EMI ID=8.1>   <EMI ID=9.1> 

  

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antibiotiques type des céphalosporines dans les-

  
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éventuellement substitué susmentionné est un radical

  
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Quant ja;rla position 3, elle porte, parmi de nombreux . dès radicaux mono- 

  
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est  oqu 

  
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-aucun <EMI ID=21.1> 

  
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activité tout particulièrement avantageuse (décrite plus en détail dans la suite du présent mémoire). contre toute

  
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 par rapport au groupe car, Dans présent 

  
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structure comme suit : 

  

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les conformes invention sont des isomères 

  
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portée de l'invention s'étend aussi bien aux 

  
 <EMI ID=42.1> 

  
Les composés suivant l'invention font 

  
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solubles (par exemple des sels métaux alcalins, 

  
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M MOI, 

  
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-carbone auquel ils sont attachés. 

  
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exemple, on peut nient chlorures 

  
 <EMI ID=78.1>  <EMI ID=79.1>  . les réactifs en solution ou suspension. effectue  avantageusement la réaction utilisant  <EMI ID=80.1> 

  
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milieu non. aqueux qui comprend, préférence, -on 

  
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tant l'anion voulu,

  
+se des composés formule

  
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Pour 'utilisation titre matières 

  
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On peut préparer les acides de formule

  
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(dans laquelle possède les signifierons, précitées ; 

  
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que 

  
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 <EMI ID=140.1>   <EMI ID=141.1>  peuvent se préparer par acylation des composés

  
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thiourée. 

  
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une, minute. 

  
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les,- les séchés 

  
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 <EMI ID=173.1>  <EMI ID=174.1> 

  
 <EMI ID=175.1>   <EMI ID=176.1>  <EMI ID=177.1> 

  
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 <EMI ID=180.1> 

  
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 <EMI ID=182.1>   <EMI ID=183.1> 

  
exiger des doses quotidiennes supérieures. 

  
Les antibiotiques conformes présente

  
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 <EMI ID=185.1> 

  
tiques, par exemple des pénicillines d'autres . &#65533;e&#65533;s&#65533;.&#65533;.os&#65533;aa&#65533;&#65533;z&#65533;es. 

  
La composition qui suit, illustre façon..

  
 <EMI ID=186.1> 

  
 <EMI ID=187.1> 

  
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Claims (1)

  1. <EMI ID=196.1> <EMI ID=197.1>
    <EMI ID=198.1>
    <EMI ID=199.1>
    <EMI ID=200.1>
    <EMI ID=201.1> <EMI ID=202.1>
    <EMI ID=203.1> <EMI ID=204.1>
    <EMI ID=205.1>
    <EMI ID=206.1>
    <EMI ID=207.1> <EMI ID=208.1>
BE0/197842A 1978-10-27 1979-10-26 Nouvelles cephalosporines, leur preparation et compositions les contenant BE879666A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7842164 1978-10-27

Publications (1)

Publication Number Publication Date
BE879666A true BE879666A (fr) 1980-04-28

Family

ID=10500627

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/197842A BE879666A (fr) 1978-10-27 1979-10-26 Nouvelles cephalosporines, leur preparation et compositions les contenant

Country Status (4)

Country Link
JP (1) JPS5559197A (fr)
AU (1) AU529338B2 (fr)
BE (1) BE879666A (fr)
ZA (1) ZA795738B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS584789A (ja) * 1981-04-03 1983-01-11 Fujisawa Pharmaceut Co Ltd 新規セフエム化合物およびその製造法
DE3279470D1 (en) * 1981-04-03 1989-04-06 Fujisawa Pharmaceutical Co New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds

Also Published As

Publication number Publication date
ZA795738B (en) 1980-10-29
JPS5559197A (en) 1980-05-02
AU5223979A (en) 1980-05-01
AU529338B2 (en) 1983-06-02

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19851031