BE880662A - Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio) -alkyle) de n"-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant - Google Patents

Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio) -alkyle) de n"-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant

Info

Publication number
BE880662A
BE880662A BE0/198600A BE198600A BE880662A BE 880662 A BE880662 A BE 880662A BE 0/198600 A BE0/198600 A BE 0/198600A BE 198600 A BE198600 A BE 198600A BE 880662 A BE880662 A BE 880662A
Authority
BE
Belgium
Prior art keywords
alcynyl
thiazolyle
cyanoguanidine
diamino
methylthio
Prior art date
Application number
BE0/198600A
Other languages
English (en)
Inventor
R Crenshaw
A Algieri
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE880662A publication Critical patent/BE880662A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
BE0/198600A 1978-12-18 1979-12-17 Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio) -alkyle) de n"-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant BE880662A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/970,517 US4200578A (en) 1978-12-18 1978-12-18 Thiazole derivatives

Publications (1)

Publication Number Publication Date
BE880662A true BE880662A (fr) 1980-06-17

Family

ID=25517073

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/198600A BE880662A (fr) 1978-12-18 1979-12-17 Derives de n-alcynyl-n'-(omega-((thiazolyle eventuellement substitue)-methylthio) -alkyle) de n"-cyanoguanidine et d'ethylene 1,1-diamino-2-substitue, leur procede de production et medicament les contenant

Country Status (24)

Country Link
US (1) US4200578A (fr)
JP (1) JPS5583768A (fr)
KR (3) KR830001920B1 (fr)
AT (1) AT375354B (fr)
AU (1) AU533014B2 (fr)
BE (1) BE880662A (fr)
CA (1) CA1133909A (fr)
CH (1) CH642956A5 (fr)
DE (1) DE2950838A1 (fr)
DK (1) DK533979A (fr)
ES (2) ES487035A0 (fr)
FI (1) FI793904A7 (fr)
FR (1) FR2444674B1 (fr)
GB (1) GB2038822B (fr)
GR (1) GR73586B (fr)
HU (1) HU182461B (fr)
IE (1) IE49320B1 (fr)
IL (1) IL58960A (fr)
IT (1) IT1164076B (fr)
LU (1) LU82000A1 (fr)
NL (1) NL7909054A (fr)
SE (1) SE444680B (fr)
YU (3) YU292179A (fr)
ZA (1) ZA796814B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31588E (en) * 1977-06-03 1984-05-22 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines
GR71929B (fr) * 1979-11-13 1983-08-19 Ici Ltd
US4904792A (en) * 1980-10-02 1990-02-27 Eli Lilly And Company N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine
US4760075A (en) * 1980-10-02 1988-07-26 Eli Lilly And Company N-thiazolylmethylthioalkyl-N-alkyl-amidines and related compounds
US4382090A (en) * 1980-10-02 1983-05-03 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N'alkylamidines and related compounds
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
US4474794A (en) * 1982-03-19 1984-10-02 Eli Lilly And Company N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds
US4458077A (en) * 1982-11-22 1984-07-03 American Home Products Corporation Heterocyclic anti-ulcer agents
JPS59104370A (ja) * 1982-12-03 1984-06-16 Kotobuki Seiyaku Kk チアゾ−ル誘導体及びその製造方法
ES8601941A1 (es) * 1983-02-07 1985-11-01 Lilly Co Eli Un procedimiento para la preparacion de nizatidina
IL80961A0 (en) * 1985-12-18 1987-03-31 Lilly Co Eli Synthesis of nizatidine
JPH0247453U (fr) * 1988-09-29 1990-03-30
WO2022034121A1 (fr) 2020-08-11 2022-02-17 Université De Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer
CN111974333B (zh) * 2020-08-19 2023-06-09 宁夏亚东化工有限公司 噻唑生产线及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4083988A (en) * 1972-09-05 1978-04-11 Smith Kline & French Laboratories Limited Pharmacologically active compounds
BE804144A (fr) 1972-09-05 1974-02-28 Smith Kline French Lab Cyanoguanidines
GB1421792A (en) 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1553070A (en) 1975-05-21 1979-09-19 Smith Kline French Lab Thiourea guanidine and 1-nitro-2,2-diaminoethylene derivatives
NZ186965A (en) 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
GB2038822B (en) 1983-01-19
YU259482A (en) 1983-02-28
AU533014B2 (en) 1983-10-27
IE792436L (en) 1980-06-18
YU292179A (en) 1983-02-28
FR2444674B1 (fr) 1986-03-28
ES8106715A1 (es) 1981-09-01
GR73586B (fr) 1984-03-26
ES8101569A1 (es) 1980-12-16
HU182461B (en) 1984-01-30
GB2038822A (en) 1980-07-30
ES487035A0 (es) 1980-12-16
NL7909054A (nl) 1980-06-20
CH642956A5 (fr) 1984-05-15
US4200578A (en) 1980-04-29
KR840001075B1 (ko) 1984-07-31
KR840001074B1 (ko) 1984-07-31
KR830001263A (ko) 1983-04-29
ATA793779A (de) 1983-12-15
ES493718A0 (es) 1981-09-01
CA1133909A (fr) 1982-10-19
IT7950977A0 (it) 1979-12-04
IL58960A (en) 1983-06-15
IT1164076B (it) 1987-04-08
SE444680B (sv) 1986-04-28
LU82000A1 (de) 1980-07-21
FI793904A7 (fi) 1980-06-19
AT375354B (de) 1984-07-25
FR2444674A1 (fr) 1980-07-18
ZA796814B (en) 1980-11-26
IL58960A0 (en) 1980-03-31
KR830001920B1 (ko) 1983-09-23
JPS5583768A (en) 1980-06-24
IE49320B1 (en) 1985-09-18
DK533979A (da) 1980-06-19
AU5371679A (en) 1980-06-26
JPS639512B2 (fr) 1988-02-29
KR840004685A (ko) 1984-10-22
KR840004686A (ko) 1984-10-22
SE7910392L (sv) 1980-06-19
YU259382A (en) 1983-02-28
DE2950838A1 (de) 1980-07-03

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19861231