BE898307A - Nouvelle composition dentifrice. - Google Patents

Nouvelle composition dentifrice. Download PDF

Info

Publication number: BE898307A
Authority: BE; Belgium
Prior art keywords: sep; fluorine; silica; fluoride; toothpaste
Prior art date: 1982-11-26

Application number

BE2/60269A

Other languages

English (en)

French (fr)

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-26

Filing date

1983-11-25

Publication date

1984-03-16

1983-11-25 Application filed by Pierrel Spa filed Critical Pierrel Spa

1984-03-16 Publication of BE898307A publication Critical patent/BE898307A/fr

Links

239000000203 mixture Substances 0.000 title claims abstract description 49
239000000606 toothpaste Substances 0.000 title claims abstract description 33
229940034610 toothpaste Drugs 0.000 title claims description 27
229910052731 fluorine Inorganic materials 0.000 claims abstract description 33
239000011737 fluorine Substances 0.000 claims abstract description 32
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims abstract description 26
239000011775 sodium fluoride Substances 0.000 claims abstract description 13
235000013024 sodium fluoride Nutrition 0.000 claims abstract description 13
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 3
229960004029 silicic acid Drugs 0.000 claims abstract description 3
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 2
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 29
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 22
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
208000002925 dental caries Diseases 0.000 claims description 14
239000000377 silicon dioxide Substances 0.000 claims description 9
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
239000011734 sodium Substances 0.000 claims description 6
229910052708 sodium Inorganic materials 0.000 claims description 6
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 5
239000000796 flavoring agent Substances 0.000 claims description 5
235000019634 flavors Nutrition 0.000 claims description 5
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 5
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 5
239000000600 sorbitol Substances 0.000 claims description 5
239000000811 xylitol Substances 0.000 claims description 5
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 5
235000010447 xylitol Nutrition 0.000 claims description 5
229960002675 xylitol Drugs 0.000 claims description 5
239000008119 colloidal silica Substances 0.000 claims description 4
239000008213 purified water Substances 0.000 claims description 4
WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 claims description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
239000000975 dye Substances 0.000 claims description 3
239000011591 potassium Substances 0.000 claims description 3
229910052700 potassium Inorganic materials 0.000 claims description 3
229940081974 saccharin Drugs 0.000 claims description 3
235000019204 saccharin Nutrition 0.000 claims description 3
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 3
229940075554 sorbate Drugs 0.000 claims description 3
239000011230 binding agent Substances 0.000 claims description 2
235000003599 food sweetener Nutrition 0.000 claims description 2
239000003755 preservative agent Substances 0.000 claims description 2
239000004094 surface-active agent Substances 0.000 claims description 2
239000003765 sweetening agent Substances 0.000 claims description 2
239000000080 wetting agent Substances 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims 1
230000003449 preventive effect Effects 0.000 claims 1
YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 31
230000000694 effects Effects 0.000 description 17
229940091249 fluoride supplement Drugs 0.000 description 13
239000012153 distilled water Substances 0.000 description 12
210000003298 dental enamel Anatomy 0.000 description 9
150000002222 fluorine compounds Chemical class 0.000 description 7
OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 6
239000002253 acid Substances 0.000 description 6
238000000034 method Methods 0.000 description 6
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
229960000414 sodium fluoride Drugs 0.000 description 5
238000012360 testing method Methods 0.000 description 5
IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 4
239000000470 constituent Substances 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
-1 ion fluoride Chemical class 0.000 description 3
150000002500 ions Chemical class 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
239000006072 paste Substances 0.000 description 3
239000000047 product Substances 0.000 description 3
238000012546 transfer Methods 0.000 description 3
238000005406 washing Methods 0.000 description 3
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
230000009471 action Effects 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000000675 anti-caries Effects 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000000551 dentifrice Substances 0.000 description 2
238000011161 development Methods 0.000 description 2
230000018109 developmental process Effects 0.000 description 2
238000004817 gas chromatography Methods 0.000 description 2
230000002779 inactivation Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
230000003902 lesion Effects 0.000 description 2
238000005259 measurement Methods 0.000 description 2
NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
239000011698 potassium fluoride Substances 0.000 description 2
235000010241 potassium sorbate Nutrition 0.000 description 2
239000004302 potassium sorbate Substances 0.000 description 2
229940069338 potassium sorbate Drugs 0.000 description 2
230000002265 prevention Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
239000005051 trimethylchlorosilane Substances 0.000 description 2
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical class OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
102000035183 Clathrin adaptor proteins Human genes 0.000 description 1
108091005769 Clathrin adaptor proteins Proteins 0.000 description 1
235000009854 Cucurbita moschata Nutrition 0.000 description 1
240000001980 Cucurbita pepo Species 0.000 description 1
235000009852 Cucurbita pepo Nutrition 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
239000004141 Sodium laurylsulphate Substances 0.000 description 1
239000003082 abrasive agent Substances 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
230000032683 aging Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical class [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
229910001424 calcium ion Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
238000011088 calibration curve Methods 0.000 description 1
229940075397 calomel Drugs 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
238000004040 coloring Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
XPBBUZJBQWWFFJ-UHFFFAOYSA-N fluorosilane Chemical compound [SiH3]F XPBBUZJBQWWFFJ-UHFFFAOYSA-N 0.000 description 1
239000007789 gas Substances 0.000 description 1
230000008570 general process Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000010410 layer Substances 0.000 description 1
238000003760 magnetic stirring Methods 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
235000003270 potassium fluoride Nutrition 0.000 description 1
238000004313 potentiometry Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
238000000926 separation method Methods 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000020354 squash Nutrition 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
239000002344 surface layer Substances 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Birds (AREA)
Epidemiology (AREA)
Cosmetics (AREA)

BE2/60269A 1982-11-26 1983-11-25 Nouvelle composition dentifrice. BE898307A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8224467A IT1206105B (it)	1982-11-26	1982-11-26	Nuova composizione dentifricia.

Publications (1)

Publication Number	Publication Date
BE898307A true BE898307A (fr)	1984-03-16

Family

ID=11213638

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE2/60269A BE898307A (fr)	1982-11-26	1983-11-25	Nouvelle composition dentifrice.

Country Status (4)

Country	Link
BE (1)	BE898307A (it)
CH (1)	CH661658A5 (it)
FR (1)	FR2536657A1 (it)
IT (1)	IT1206105B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5094841A (en) *	1988-07-05	1992-03-10	The Trustees Of Columbia University In The City Of New York	Gel for optimum release of fluoride with antibacterial capability for use in the prevention of caries of root surface
JP2008533183A (ja) *	2005-03-21	2008-08-21	グラクソグループリミテッド	フッ化物源およびシリカ歯研磨剤を含む、アルキル硫酸塩およびオルトリン酸塩無配合の歯磨剤組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU514418B2 (en) *	1976-02-05	1981-02-12	W.R. Grace & Co.	Dentifrice
AR228368A1 (es) *	1981-01-09	1983-02-28	Grace W R & Co	Pasta dental

1982
- 1982-11-26 IT IT8224467A patent/IT1206105B/it active
1983
- 1983-11-09 CH CH6031/83A patent/CH661658A5/it not_active IP Right Cessation
- 1983-11-22 FR FR8318545A patent/FR2536657A1/fr active Pending
- 1983-11-25 BE BE2/60269A patent/BE898307A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT8224467A0 (it)	1982-11-26
FR2536657A1 (fr)	1984-06-01
CH661658A5 (it)	1987-08-14
IT1206105B (it)	1989-04-14

Legal Events

Date

Code

Title

Description

1993-05-31

RE

Patent lapsed

Owner name: R-V CHEMICALS LTD

Effective date: 19921130

Publication	Publication Date	Title
Duckworth et al.	1987	Fluoride in saliva and plaque following use of fluoride-containing mouthwashes
Birkeland	1970	Direct potentiometric determination of fluoride in soft tooth deposits
Hashizume et al.	2003	Fluoride availability and stability of Japanese dentifrices
EP0748591B1 (fr)	2001-10-17	Caséines micellaires fluorées
FR2508796A1 (fr)	1983-01-07	Composition dentifrice ayant une activite contre la carie et susceptible de reconstituer au moins partiellement les parties cariees des dents
JP2017510618A (ja)	2017-04-13	エナメル質の保護及び修復方法
FR2474862A1 (fr)	1981-08-07	Composition buccale prophylactique a base d'acide trans-4-(aminomethyl)cyclohexane-1-carboxylique
FR2474864A1 (fr)	1981-08-07	Composition buccale utilisable pour le traitement de la gingivite, a base d'acide trans-4-(aminomethyl)-cyclohexane-1-carboxylique
EP0317378B1 (fr)	1992-03-25	Silice pour compositions dentifrices compatible notamment avec le zinc
Birkeland et al.	1976	Effect of pH on the fluoride ion activity of plaque
CA1340770C (fr)	1999-09-28	Silice pour compositions dentifrices compatible notamment avec la chlorhexidine
WO2022160718A1 (zh)	2022-08-04	一种增强氟活性的抗敏感牙膏
FR2475899A1 (fr)	1981-08-21	Composition antigingivite non colorante a base d'acide trans-4-(aminomethyl) cyclohexane-1-carboxylique
US4702904A (en)	1987-10-27	Oral composition containing zirconium-bonded synthetic amorphous silicate
Forss et al.	1995	Fluoride Concentration, Mutans Streptococci and Lactobacilli in Plaque from Old Glass lonomer Fillings
US4415550A (en)	1983-11-15	Treatment-and-prophylactic tooth paste possessing anticarious effect
US20110117033A1 (en)	2011-05-19	Therapeutic and prophylactic formulation for oral care
BE897502A (fr)	1984-02-10	Pate dentifrice opaque
US5788951A (en)	1998-08-04	Dual component dentifrice composition for fluoridating teeth containing compatible silica abrasive
Vogel et al.	2001	Effect of a water rinse on ‘labile’fluoride and other ions in plaque and saliva before and after conventional and experimental fluoride rinses
BE898307A (fr)	1984-03-16	Nouvelle composition dentifrice.
US20130022554A1 (en)	2013-01-24	Oral care formulations
BE1030310B1 (fr)	2024-07-10	Pâte dentifrice anti-sensible capable de renforcer l'activité du fluor
Eggert et al.	1999	In vitro investigation of the liberation of fluoride ions from toothpaste compounds in a permeation model
KR0180119B1 (ko)	1999-03-20	안정한 과산화물 함유 치약 조성물