BE899059A - BENZAMIDE DERIVATIVES - Google Patents
BENZAMIDE DERIVATIVESInfo
- Publication number
- BE899059A BE899059A BE0/212488A BE212488A BE899059A BE 899059 A BE899059 A BE 899059A BE 0/212488 A BE0/212488 A BE 0/212488A BE 212488 A BE212488 A BE 212488A BE 899059 A BE899059 A BE 899059A
- Authority
- BE
- Belgium
- Prior art keywords
- compounds
- dichloro
- benzamide derivatives
- new
- methylenedioxy
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 3,4-methylenedioxy Chemical group 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Parmi les composés de formule (I), sont nouveaux ceux où R1 représente un halogène, un cyano ou un trifluorométhyle en position para et R2 représente un hydrogène, ou bien où R1 et R2 représentent ensemble un 2,4-dichloro-, un 3,4-dichloro ou un 3,4-méthylènedioxy ; les composés encore nouveaux peuvent etre préparés par des procédés connus. Ces composés ainsi que leurs sels d'addition d'acides pharmaceutiquement applicables présentent, ayant une faible toxicité, des propriétés intéressantes d'inhibition de la monoamine oxydase et peuvent etre utilisés pour traiter les états dépressifs et la maladie de Parkinson.Among the compounds of formula (I), are new those where R1 represents a halogen, a cyano or a trifluoromethyl in the para position and R2 represents a hydrogen, or else where R1 and R2 together represent a 2,4-dichloro-, a 3 , 4-dichloro or 3,4-methylenedioxy; the still new compounds can be prepared by known methods. These compounds as well as their pharmaceutically applicable acid addition salts have, having a low toxicity, advantageous properties of inhibition of monoamine oxidase and can be used to treat depressive states and Parkinson's disease.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1150/83A CH653670A5 (en) | 1983-03-03 | 1983-03-03 | BENZAMIDE DERIVATIVES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE899059A true BE899059A (en) | 1984-09-03 |
Family
ID=4203649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/212488A BE899059A (en) | 1983-03-03 | 1984-03-02 | BENZAMIDE DERIVATIVES |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS59167552A (en) |
| KR (1) | KR910008202B1 (en) |
| AR (1) | AR243155A1 (en) |
| AT (1) | AT390948B (en) |
| AU (2) | AU570431B2 (en) |
| BE (1) | BE899059A (en) |
| CA (1) | CA1252794A (en) |
| CH (1) | CH653670A5 (en) |
| DE (1) | DE3407654C2 (en) |
| DK (1) | DK166382C (en) |
| ES (3) | ES8504680A1 (en) |
| FI (1) | FI79297C (en) |
| FR (1) | FR2541996B1 (en) |
| GB (1) | GB2135998B (en) |
| GR (1) | GR81866B (en) |
| HU (1) | HU193556B (en) |
| IE (1) | IE57004B1 (en) |
| IL (1) | IL71078A (en) |
| IT (1) | IT1173365B (en) |
| LU (1) | LU85231A1 (en) |
| MC (1) | MC1568A1 (en) |
| NL (1) | NL8400459A (en) |
| NO (1) | NO165999C (en) |
| NZ (1) | NZ207272A (en) |
| PH (1) | PH19623A (en) |
| PT (1) | PT78187B (en) |
| SE (1) | SE466447B (en) |
| ZA (1) | ZA841394B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1261335A (en) * | 1984-08-29 | 1989-09-26 | Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee | Ethylenediamine monoamide derivatives |
| US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
| NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
| FR2642972B1 (en) * | 1989-02-14 | 1994-08-05 | Inst Nat Sante Rech Med | AGENTS FOR THE DIAGNOSIS AND TREATMENT OF MELANOMAS, HALOGENATED AROMATIC DERIVATIVES SUITABLE FOR USE AS SUCH AGENTS AND THEIR PREPARATION |
| WO2014155184A1 (en) * | 2013-03-28 | 2014-10-02 | Rhenovia Pharma | Treatment for parkinson's disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342679A (en) * | 1967-09-19 | Parts by weight of acid chloride to react with parts of amine in | ||
| FR6557M (en) * | 1967-06-20 | 1968-12-23 | Ile De France | |
| GB1455116A (en) * | 1972-12-15 | 1976-11-10 | Ici Ltd | Pharmaceutical compositions |
| GB1520584A (en) * | 1975-04-02 | 1978-08-09 | Yamanouchi Pharma Co Ltd | 2 - alkoxy - 5 substituted benzamide derivatives and their use in pharmaceutical compositions |
| DE2616486A1 (en) * | 1976-04-14 | 1977-11-03 | Basf Ag | Perylene tetracarboxylic acid diimide pigments - for use in paints, thermoplastics, etc. and as vat dyes |
| CA1206964A (en) * | 1980-11-12 | 1986-07-02 | Nobuo Shinma | Tetra-substituted benzene derivatives |
| DE3200258A1 (en) * | 1982-01-07 | 1983-07-21 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | SUBSTITUTED 1-BENZOYL-2-PHENYLIMINO IMIDAZOLIDINE, THE ACID ADDITION SALTS THEREOF, METHOD FOR THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING THE SAME |
| IL69997A0 (en) * | 1983-01-03 | 1984-01-31 | Miles Lab | Procainamide and n-acetylprocainamide immunogens,antibodies prepared therefrom,labeled conjugates,and the use of such antibodies and labeled conjugates in immunoassays |
| US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
-
1983
- 1983-03-03 CH CH1150/83A patent/CH653670A5/en not_active IP Right Cessation
-
1984
- 1984-01-13 CA CA000445296A patent/CA1252794A/en not_active Expired
- 1984-02-13 NL NL8400459A patent/NL8400459A/en not_active Application Discontinuation
- 1984-02-22 FI FI840734A patent/FI79297C/en not_active IP Right Cessation
- 1984-02-23 IT IT19778/84A patent/IT1173365B/en active
- 1984-02-24 ZA ZA841394A patent/ZA841394B/en unknown
- 1984-02-24 NZ NZ207272A patent/NZ207272A/en unknown
- 1984-02-27 IL IL71078A patent/IL71078A/en not_active IP Right Cessation
- 1984-02-27 HU HU84767A patent/HU193556B/en not_active IP Right Cessation
- 1984-02-27 AU AU25066/84A patent/AU570431B2/en not_active Ceased
- 1984-02-29 LU LU85231A patent/LU85231A1/en unknown
- 1984-02-29 DK DK147584A patent/DK166382C/en not_active IP Right Cessation
- 1984-02-29 PH PH30315A patent/PH19623A/en unknown
- 1984-03-01 MC MC841696A patent/MC1568A1/en unknown
- 1984-03-01 DE DE3407654A patent/DE3407654C2/en not_active Expired - Fee Related
- 1984-03-01 FR FR8403219A patent/FR2541996B1/en not_active Expired
- 1984-03-01 GR GR73975A patent/GR81866B/el unknown
- 1984-03-01 JP JP59037410A patent/JPS59167552A/en active Granted
- 1984-03-02 AT AT0072484A patent/AT390948B/en not_active IP Right Cessation
- 1984-03-02 AR AR84295901A patent/AR243155A1/en active
- 1984-03-02 BE BE0/212488A patent/BE899059A/en not_active IP Right Cessation
- 1984-03-02 PT PT78187A patent/PT78187B/en not_active IP Right Cessation
- 1984-03-02 SE SE8401190A patent/SE466447B/en not_active IP Right Cessation
- 1984-03-02 IE IE512/84A patent/IE57004B1/en not_active IP Right Cessation
- 1984-03-02 ES ES530230A patent/ES8504680A1/en not_active Expired
- 1984-03-02 NO NO840797A patent/NO165999C/en unknown
- 1984-03-02 GB GB08405486A patent/GB2135998B/en not_active Expired
- 1984-03-03 KR KR1019840001083A patent/KR910008202B1/en not_active Expired
- 1984-10-25 ES ES537046A patent/ES8506601A1/en not_active Expired
- 1984-10-25 ES ES537045A patent/ES8506600A1/en not_active Expired
-
1987
- 1987-12-24 AU AU83079/87A patent/AU609758B2/en not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GEP19960313B (en) | Method for Production of Pyridin Derivatives | |
| ATE36149T1 (en) | ANTICONVULSIVE SULFAMATE DERIVATIVES. | |
| CA2164638A1 (en) | Novel erythromycin derivatives, method for preparing same and use thereof as drugs | |
| BE903110A (en) | ETHYLENEDIAMINEMONOAMIDE DERIVATIVES | |
| BR9307387A (en) | Therapeutic agents | |
| PL254121A1 (en) | A method of pyrazole analogs of mevalonolactone and their derivatives production | |
| KR960000861A (en) | Phenyl-substituted alkenylcarboguanides having perfluoroalkyl groups, methods for their preparation, their use as medicaments or diagnostic agents and medicaments containing them | |
| FR2426694A1 (en) | ADVANCED CEPHALOSPORINS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION | |
| HUT46658A (en) | Process for producing pharmaceutical compositions with lincotriene antagonist effect, comprising aromatic thioether derivatives as active ingredient | |
| BE899059A (en) | BENZAMIDE DERIVATIVES | |
| JPS54160740A (en) | Anti-fibrotic agent | |
| ATE59632T1 (en) | DIHYDRODIBENZOCYCLOHEPTYLIDENETHYLAMINE DERIVATIVES | |
| MX2025010256A (en) | Hydroquinazoline derivatives for the treatment of a disease or disorder | |
| PT82032B (en) | PROCESS FOR THE PREPARATION OF AMINO ACID DERIVATIVES WITH ANTICONVULSIVE ACA AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM | |
| DK562488D0 (en) | PHARMACEUTICAL PREPARATION CONTAINING POLYMINE DERIVATIVES, AND SOME OF THESE POLYAMINE DERIVATIVES | |
| KR910019964A (en) | Hydrazone | |
| IE42218L (en) | Pyrazinoisoquinoline derivatives | |
| BE905601A (en) | DICHLOROANILINE DERIVATIVES. | |
| Lippmann et al. | Effects of the administration of epsilon amino caproic acid on catecholamine and serotonin levels in the rat and dog | |
| PT77666A (en) | PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF NITROSOUREE | |
| CA2282666A1 (en) | Novel erythromycin derivatives, method of preparation and application as medicines | |
| EA200400470A1 (en) | SUBSTITUTED DERIVATIVES ALKYLAMINOPIRIDAZINONE, METHOD OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS | |
| LU83713A1 (en) | PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| US4579870A (en) | Aminoalkyl phenyl selenides for the treatment of hypertension and nervous system dysfunctions | |
| CA2119661A1 (en) | New n-benzylpiperazine compounds, their preparation process and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE A.G. Effective date: 19950331 |