BE903128A - BENZIMIDAZOLE DERIVATIVES PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THEM - Google Patents

BENZIMIDAZOLE DERIVATIVES PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THEM

Info

Publication number
BE903128A
BE903128A BE0/215506A BE215506A BE903128A BE 903128 A BE903128 A BE 903128A BE 0/215506 A BE0/215506 A BE 0/215506A BE 215506 A BE215506 A BE 215506A BE 903128 A BE903128 A BE 903128A
Authority
BE
Belgium
Prior art keywords
group
preparation
agents containing
benzimidazole derivatives
hydrogen atom
Prior art date
Application number
BE0/215506A
Other languages
French (fr)
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59182400A external-priority patent/JPS6160660A/en
Priority claimed from JP60061194A external-priority patent/JPH068283B2/en
Priority claimed from JP60061195A external-priority patent/JPH0764826B2/en
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Publication of BE903128A publication Critical patent/BE903128A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Des dérives de benzimodazole de formule (I) dans laquelle R1 représente un atome d'hydrogène, un groupe alkyle en C1-C8, un groupe cycloalkyle, un groupe phényle ou un groupe aralkyle, R2 représente un atome d'hydrogène ou un groupe alkyle en C1-C8, ou encore R1 et R2 forment un noyau ensemble avec l'atome d'azote adjacent, tandis que R3 et R4 représentent chacun un atome d'hydrogène, un atome d'halogène, un groupe trifluorométhyle, un groupe alkyle inférieur, un groupe alcoxy inférieur, un groupe alcoxy inférieur-carbonyle ou un groupe amino, ces dérivés étant efficaces contre les ulcères.Benzimodazole derivatives of formula (I) in which R1 represents a hydrogen atom, a C1-C8 alkyl group, a cycloalkyl group, a phenyl group or an aralkyl group, R2 represents a hydrogen atom or an alkyl group in C1-C8, or R1 and R2 form a nucleus together with the adjacent nitrogen atom, while R3 and R4 each represent a hydrogen atom, a halogen atom, a trifluoromethyl group, a lower alkyl group , a lower alkoxy group, a lower alkoxy-carbonyl group or an amino group, these derivatives being effective against ulcers.

BE0/215506A 1984-08-31 1985-08-27 BENZIMIDAZOLE DERIVATIVES PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THEM BE903128A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59182400A JPS6160660A (en) 1984-08-31 1984-08-31 Benzimidazole derivative, its preparation, and antitumor agent containing it
JP60061194A JPH068283B2 (en) 1985-03-26 1985-03-26 Benzimidazole derivative, method for producing the same, and antiulcer agent containing the same
JP60061195A JPH0764826B2 (en) 1985-03-26 1985-03-26 Benzimidazole derivative

Publications (1)

Publication Number Publication Date
BE903128A true BE903128A (en) 1985-12-16

Family

ID=27297422

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215506A BE903128A (en) 1984-08-31 1985-08-27 BENZIMIDAZOLE DERIVATIVES PROCESS FOR THEIR PREPARATION AND ANTI-ULCER AGENTS CONTAINING THEM

Country Status (14)

Country Link
KR (1) KR920004936B1 (en)
AR (1) AR242195A1 (en)
AU (3) AU4640985A (en)
BE (1) BE903128A (en)
BR (1) BR8504252A (en)
CH (1) CH665417A5 (en)
DE (1) DE3531487C2 (en)
ES (1) ES8703142A1 (en)
FR (1) FR2569691B1 (en)
GB (1) GB2163747B (en)
IT (1) IT1189601B (en)
MX (1) MX159807A (en)
NL (1) NL8502384A (en)
SE (1) SE500669C2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines

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GB8417194D0 (en) * 1984-07-05 1984-08-08 Boots Co Plc Therapeutic agents
EP0174717B1 (en) 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors
GB2161160B (en) * 1984-07-06 1989-05-24 Fisons Plc Heterocyclic sulphinyl compounds
US5869513A (en) * 1985-05-24 1999-02-09 G. D. Searle & Co. 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines
AU5768886A (en) * 1985-05-24 1986-11-27 G.D. Searle & Co. 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines
US4824856A (en) * 1985-08-14 1989-04-25 Nippon Chemiphar Co., Ltd. Method of protecting gastrointestinal tract
EP0232399A1 (en) * 1985-08-21 1987-08-19 Byk Gulden Lomberg Chemische Fabrik GmbH New amines, process for their manufacture, their use and medicines containing them
AR243167A1 (en) 1985-08-24 1993-07-30 Hoechst Ag Substituted toluidines, process for their preparation, pharmaceutical compositions containing them and their use as gastric secretion inhibitors
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
DE3639926A1 (en) * 1986-11-22 1988-06-01 Hoechst Ag SUBSTITUTED THIENOIMIDAZOLTOLUIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS CONTAINING IT AND THEIR USE AS AN INGESTIC ACID INHIBITOR
IT1222412B (en) * 1987-07-31 1990-09-05 Chiesi Farma Spa THYOMETHYL AND SULFINYL METHYL DERIVED WITH ANTI-SECRET ACID GASTRIC ACTION, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
JP2614756B2 (en) * 1988-08-10 1997-05-28 日本ケミファ株式会社 Imidazole derivative, method for producing the same, and anti-ulcer agent containing the same
JPH06298611A (en) * 1993-04-16 1994-10-25 Nippon Chemiphar Co Ltd Antibacterial agent
SE9301489D0 (en) 1993-04-30 1993-04-30 Ab Astra VETERINARY COMPOSITION
SE9402431D0 (en) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
SE9500422D0 (en) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (en) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
HRP960232A2 (en) * 1995-07-03 1998-02-28 Astra Ab A process for the optical purification of compounds
CN1093855C (en) * 1995-09-21 2002-11-06 帕斯医药股份有限公司 Novel compositions containing acid-labile omeprazole and processes for their preparation
SE9600070D0 (en) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
US6380222B2 (en) 1996-10-11 2002-04-30 Astrazeneca Ab Use of an H+, K+-atpase inhibitor in the treatment of nasal polyps
US6303644B1 (en) 1997-07-25 2001-10-16 Byk Gulden Lomberg Chemische Fabrik Gmbh Proton pump inhibitor in therapeutic combination with antibacterial substances
SE9704870D0 (en) 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulation I
SE9704869D0 (en) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
WO2000009092A1 (en) 1998-08-12 2000-02-24 Byk Gulden Lomberg Chemische Fabrik Gmbh Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles
WO2000027841A1 (en) * 1998-11-06 2000-05-18 Dong-A Pharmaceutical Co., Ltd. Method of preparing sulfide derivatives
TWI243672B (en) 1999-06-01 2005-11-21 Astrazeneca Ab New use of compounds as antibacterial agents
JP4980527B2 (en) 1999-06-07 2012-07-18 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel formulations and dosage forms containing acid labile active compounds
SE9903831D0 (en) 1999-10-22 1999-10-22 Astra Ab Formulation of substituted benzimidazoles
SE0000774D0 (en) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
US6544556B1 (en) 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
SE0101379D0 (en) 2001-04-18 2001-04-18 Diabact Ab Composition that inhibits gastric acid secretion
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
SE0102993D0 (en) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
MXPA04009968A (en) 2002-04-09 2004-12-13 Flamel Tech Sa Oral suspension of active principle microcapsules.
DE60323474D1 (en) 2002-04-09 2008-10-23 Flamel Tech Sa ORAL PHARMACEUTICAL FORMULATION IN THE FORM OF AQUEOUS SUSPENSION OF MICRO-CAPSULES FOR THE MODIFIED RELEASE OF AMOXICILLIN
SE0203065D0 (en) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
US8246986B2 (en) 2003-09-26 2012-08-21 Alza Corporation Drug coating providing high drug loading
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
WO2007112581A1 (en) 2006-04-03 2007-10-11 Isa Odidi Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US9233092B2 (en) 2006-07-25 2016-01-12 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI
NZ598728A (en) 2006-12-22 2013-09-27 Ironwood Pharmaceuticals Inc Compositions comprising bile acid sequestrants for treating esophageal disorders
EA201100313A1 (en) 2008-09-09 2011-10-31 Астразенека Аб METHOD OF DELIVERY OF THE PHARMACEUTICAL COMPOSITION TO THE PATIENT NEEDING THIS
CA2764963C (en) 2009-06-25 2016-11-01 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080501A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
BR112014016085A8 (en) 2011-12-28 2017-07-04 Pozen Inc Enhanced compositions and methods for delivery of omeprazole plus acetylsalicylic acid
CA2898362C (en) 2013-01-15 2020-09-01 Ironwood Pharmaceuticals, Inc. Gastro-retentive sustained-release oral dosage form of a bile acid sequestrant
EP2801565B1 (en) 2013-05-06 2015-07-22 King Saud University Compounds for use as anti-ulcer agent and/or anti-Helicobacter pylori agent and pharmaceutical compositions thereof
US20180015118A1 (en) 2015-02-03 2018-01-18 Ironwood Pharmaceuticals, Inc. Methods of treating upper gastrointestinal disorders in ppi refractory gerd

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
EP0174717B1 (en) * 1984-07-06 1992-01-22 FISONS plc Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687775A (en) * 1986-07-17 1987-08-18 G. D. Searle & Co. 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles
US4772619A (en) * 1986-07-17 1988-09-20 G. D. Searle & Co. [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines
US4721718A (en) * 1986-08-18 1988-01-26 G. D. Searle & Co. 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers

Also Published As

Publication number Publication date
AU2975092A (en) 1993-01-28
GB2163747A (en) 1986-03-05
FR2569691A1 (en) 1986-03-07
GB8521493D0 (en) 1985-10-02
BR8504252A (en) 1986-06-17
AU4640985A (en) 1986-03-06
GB2163747B (en) 1989-02-08
AU4127189A (en) 1989-12-21
DE3531487C2 (en) 1995-08-17
SE8504048L (en) 1986-03-01
KR860001793A (en) 1986-03-22
ES546445A0 (en) 1986-11-16
AR242195A1 (en) 1993-03-31
KR920004936B1 (en) 1992-06-22
IT8567743A0 (en) 1985-08-30
FR2569691B1 (en) 1989-08-04
NL8502384A (en) 1986-03-17
AU647978B2 (en) 1994-03-31
SE8504048D0 (en) 1985-08-30
SE500669C2 (en) 1994-08-08
MX159807A (en) 1989-08-31
ES8703142A1 (en) 1986-11-16
CH665417A5 (en) 1988-05-13
IT1189601B (en) 1988-02-04
DE3531487A1 (en) 1986-03-13

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NIPPON CHEMIPHAR CO. LTD

Effective date: 20000831