BE904476A - Solutions a base de phenytoine, leur procede de preparation et leur application pharmaceutique. - Google Patents

Solutions a base de phenytoine, leur procede de preparation et leur application pharmaceutique.

Info

Publication number
BE904476A
BE904476A BE6/48212A BE6048212A BE904476A BE 904476 A BE904476 A BE 904476A BE 6/48212 A BE6/48212 A BE 6/48212A BE 6048212 A BE6048212 A BE 6048212A BE 904476 A BE904476 A BE 904476A
Authority
BE
Belgium
Prior art keywords
phenytoin
preparation process
pharmaceutical application
based solutions
group
Prior art date
Application number
BE6/48212A
Other languages
English (en)
Inventor
M Fawzi
A Taylor
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BE904476A publication Critical patent/BE904476A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Solution formée par mise au contact d'au moins un principe actif choisi dans le groupe consistant en phénytoine et phénytoine sodium de formule empirique C15H11N2NaO2, et un réactif complexant choisi dans le groupe comprenant amines, amino-acides, sels d'amines et leurs mélanges. Elle est caractérisée en ce que la phénytoine sodium est le principe actif employé. Elle se rapporte à des solutions à base de phénytoine, leur procédé de préparation et leur application pharmaceutique.
BE6/48212A 1985-05-20 1986-03-24 Solutions a base de phenytoine, leur procede de preparation et leur application pharmaceutique. BE904476A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/735,932 US4642316A (en) 1985-05-20 1985-05-20 Parenteral phenytoin preparations

Publications (1)

Publication Number Publication Date
BE904476A true BE904476A (fr) 1986-09-24

Family

ID=24957819

Family Applications (1)

Application Number Title Priority Date Filing Date
BE6/48212A BE904476A (fr) 1985-05-20 1986-03-24 Solutions a base de phenytoine, leur procede de preparation et leur application pharmaceutique.

Country Status (18)

Country Link
US (1) US4642316A (fr)
JP (1) JPS61268618A (fr)
AU (1) AU595790B2 (fr)
BE (1) BE904476A (fr)
CA (1) CA1268119A (fr)
CH (1) CH668594A5 (fr)
DE (1) DE3610330A1 (fr)
DK (1) DK100786A (fr)
ES (1) ES8707195A1 (fr)
FR (1) FR2581871B1 (fr)
GB (1) GB2175203B (fr)
IT (1) IT1190282B (fr)
LU (1) LU86383A1 (fr)
NL (1) NL8600899A (fr)
NZ (1) NZ215783A (fr)
PH (1) PH22922A (fr)
SE (1) SE8600998L (fr)
ZA (1) ZA862094B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3828156A1 (de) * 1988-08-19 1990-02-22 Astrapin Pharmazeutische Praep Stabile waessrige loesung von fluorouracil
WO1999004798A1 (fr) * 1997-07-22 1999-02-04 Warner-Lambert Company Fosphenytoine sodium lyophilise a usage parenteral
US6245917B1 (en) 1998-03-20 2001-06-12 Warner-Lambert Company Crystalline sodium phenytoin monohydrate
US6274168B1 (en) 1999-02-23 2001-08-14 Mylan Pharmaceuticals Inc. Phenytoin sodium pharmaceutical compositions
WO2004058152A2 (fr) * 2002-12-16 2004-07-15 Ranbaxy Pharmaceuticals Inc. Composition pharmaceutique a liberation prolongee de phenytoine sodique
EP2946810A1 (fr) 2005-02-03 2015-11-25 TopoTarget UK Limited Polythérapie à base d'un inhibiteur d'HDAC et de vincristine pour le traitement du cancer
DE102005019393A1 (de) * 2005-04-25 2006-10-26 Basell Polyolefine Gmbh Polyethylenformmassen für Spritzgussanwendungen
AU2012213940B2 (en) * 2005-05-13 2015-03-26 Topotarget Uk Limited Pharmaceutical formulations of HDAC inhibitors
CN102579417B (zh) * 2005-05-13 2014-11-26 托波塔吉特英国有限公司 Hdac抑制剂的药物制剂
EP2361619A1 (fr) 2005-11-10 2011-08-31 TopoTarget UK Limited Inhibiteurs d'histone deacetylase (hdac) (pxd-101) pour le traitement du cancer hématologique
CA2632198C (fr) * 2005-12-05 2013-10-01 Taro Pharmaceuticals North America, Inc. Preparation pharmaceutique contenant de la phenytoine sodium et du stearate de magnesium
CA2700173C (fr) * 2007-09-25 2016-10-11 Topotarget Uk Limited Procedes de synthese de certains composes d'acide hydroxamique
WO2009109861A1 (fr) * 2008-03-07 2009-09-11 Topotarget A/S Procédés de traitement employant une perfusion continue prolongée de belinostat
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
RU2559083C9 (ru) 2009-05-19 2016-01-20 Неуродерм Лтд Композиции для непрерывного введения ингибиторов допа-декарбоксилазы
CN110123743A (zh) 2010-11-15 2019-08-16 纽罗德姆有限公司 L-多巴、多巴脱羧酶抑制剂、儿茶酚-o-甲基转移酶抑制剂及其组合物的连续施用
WO2012082995A1 (fr) 2010-12-15 2012-06-21 Nektar Therapeutics Composés d'hydantoïne contenant un oligomère
WO2013183055A1 (fr) 2012-06-05 2013-12-12 Neuroderm Ltd Compositions comprenant de l'apomorphine et des acides organiques, et leurs utilisations
EP3116475B1 (fr) 2014-03-13 2020-11-04 Neuroderm Ltd Compositions d'inhibiteurs de dopa-décarboxylase
US10258585B2 (en) 2014-03-13 2019-04-16 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
WO2023205615A1 (fr) * 2022-04-18 2023-10-26 ISHA Therapeutics LLC Compositions de film antimicrobien à dissolution orale et leurs méthodes d'utilisation
US12109303B2 (en) 2022-04-18 2024-10-08 ISHA Therapeutics LLC Orally dissolving antimicrobial film compositions and methods of their use
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3749779A (en) * 1970-08-27 1973-07-31 American Home Prod Stable solutions of sodium diphenylhydantoin
JPS5221575B2 (fr) * 1972-03-18 1977-06-11
US4260769A (en) * 1977-04-22 1981-04-07 Interx Research Corporation 5,5-Diphenylhydantoins
US4163058A (en) * 1977-04-22 1979-07-31 Interx Research Corporation Derivatives of 5,5-diphenylhydantoin exhibiting enhanced solubility and the therapeutic use thereof

Also Published As

Publication number Publication date
IT1190282B (it) 1988-02-16
CH668594A5 (fr) 1989-01-13
AU5441286A (en) 1986-11-27
DE3610330A1 (de) 1986-11-20
CA1268119A (fr) 1990-04-24
GB8607383D0 (en) 1986-04-30
PH22922A (en) 1989-01-24
ZA862094B (en) 1986-11-26
IT8647936A1 (it) 1987-10-24
SE8600998L (sv) 1986-11-21
LU86383A1 (fr) 1986-09-02
FR2581871A1 (fr) 1986-11-21
IT8647936A0 (it) 1986-04-24
FR2581871B1 (fr) 1990-05-11
GB2175203A (en) 1986-11-26
DK100786D0 (da) 1986-03-05
JPS61268618A (ja) 1986-11-28
NZ215783A (en) 1989-01-27
GB2175203B (en) 1988-09-14
NL8600899A (nl) 1986-12-16
ES555143A0 (es) 1987-07-16
US4642316A (en) 1987-02-10
AU595790B2 (en) 1990-04-12
ES8707195A1 (es) 1987-07-16
SE8600998D0 (sv) 1986-03-05
DK100786A (da) 1986-11-21

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: WARNER-LAMBERT CY

Effective date: 19920331