BG101647A - Бициклени тромбинови инхибитори с ниско молекулно тегло - Google Patents
Бициклени тромбинови инхибитори с ниско молекулно теглоInfo
- Publication number
- BG101647A BG101647A BG101647A BG10164797A BG101647A BG 101647 A BG101647 A BG 101647A BG 101647 A BG101647 A BG 101647A BG 10164797 A BG10164797 A BG 10164797A BG 101647 A BG101647 A BG 101647A
- Authority
- BG
- Bulgaria
- Prior art keywords
- thrombine
- bicyclic
- molecular weight
- low molecular
- treatment
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 208000005189 Embolism Diseases 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 206010047249 Venous thrombosis Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 abstract 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 210000004165 myocardium Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426038.7A GB9426038D0 (en) | 1994-12-22 | 1994-12-22 | Low molecular weight bicyclic thrombin inhibitors |
| GBGB9503136.5A GB9503136D0 (en) | 1994-12-22 | 1995-02-17 | Low molecular weight bicyclic thrombin inhibitors |
| GBGB9510266.1A GB9510266D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight bicyclic thrombin inhibitors |
| GBGB9510267.9A GB9510267D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight thiobicyclic thrombin inhibitors |
| GBGB9510265.3A GB9510265D0 (en) | 1995-05-22 | 1995-05-22 | Low molecular weight diaminobicyclic thrombin inhibitors |
| PCT/CA1995/000708 WO1996019483A1 (en) | 1994-12-22 | 1995-12-21 | Low molecular weight bicyclic thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG101647A true BG101647A (bg) | 1998-03-31 |
Family
ID=27517273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG101647A BG101647A (bg) | 1994-12-22 | 1997-06-20 | Бициклени тромбинови инхибитори с ниско молекулно тегло |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0802916A1 (ru) |
| JP (1) | JPH11508535A (ru) |
| CN (1) | CN1175259A (ru) |
| AP (1) | AP9701004A0 (ru) |
| AU (2) | AU4250596A (ru) |
| BG (1) | BG101647A (ru) |
| CA (1) | CA2208772A1 (ru) |
| CZ (1) | CZ189997A3 (ru) |
| EE (1) | EE9700113A (ru) |
| FI (1) | FI972466A7 (ru) |
| HU (1) | HUT77651A (ru) |
| IL (1) | IL116503A0 (ru) |
| IS (1) | IS4504A (ru) |
| LV (1) | LV12019B (ru) |
| MD (1) | MD970253A (ru) |
| MX (1) | MX9704718A (ru) |
| NO (1) | NO972892L (ru) |
| NZ (1) | NZ297360A (ru) |
| OA (1) | OA10493A (ru) |
| PL (1) | PL320965A1 (ru) |
| SK (1) | SK83897A3 (ru) |
| WO (1) | WO1996019483A1 (ru) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
| US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
| IL119466A (en) | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
| AU719216B2 (en) * | 1996-02-13 | 2000-05-04 | Akzo Nobel N.V. | Serine protease inhibitors |
| IL120310A (en) | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
| TW523513B (en) * | 1996-03-01 | 2003-03-11 | Akzo Nobel Nv | Serine protease inhibitors |
| US6124291A (en) * | 1996-06-18 | 2000-09-26 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
| EP1661566A3 (en) * | 1996-08-05 | 2008-04-16 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| ES2262184T3 (es) * | 1996-08-05 | 2006-11-16 | Myriad Genetics, Inc. | Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion. |
| US6117896A (en) * | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
| WO1998009987A1 (en) * | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| WO1998028326A1 (en) * | 1996-12-23 | 1998-07-02 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
| NZ500353A (en) | 1997-04-14 | 2002-02-01 | Cor Therapeutics Inc | Cyclic diaza compounds that are selective inhibitors of factor Xa |
| AU741099B2 (en) * | 1997-04-14 | 2001-11-22 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
| AU6896398A (en) | 1997-04-14 | 1998-11-11 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| WO1999015169A1 (en) * | 1997-09-23 | 1999-04-01 | Merck & Co., Inc. | Thrombin inhibitors |
| ATE230414T1 (de) * | 1998-02-12 | 2003-01-15 | Molecumetics Ltd | Mimetika von beta-faltblatt und verfahren zur verwendung davon |
| US6323219B1 (en) | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
| US8106094B2 (en) | 1998-07-06 | 2012-01-31 | Johnson & Johnson Consumer Companies, Inc. | Compositions and methods for treating skin conditions |
| US8093293B2 (en) | 1998-07-06 | 2012-01-10 | Johnson & Johnson Consumer Companies, Inc. | Methods for treating skin conditions |
| CA2348740A1 (en) | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Thrombin or factor xa inhibitors |
| HUP0201295A3 (en) | 1999-01-27 | 2002-10-28 | Ortho Mcneil Pharm Inc | Peptidyl heterocyclic ketones useful as tryptase inhibitors |
| FR2795072B1 (fr) * | 1999-06-15 | 2001-07-27 | Adir | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7309688B2 (en) | 2000-10-27 | 2007-12-18 | Johnson & Johnson Consumer Companies | Topical anti-cancer compositions and methods of use thereof |
| JP2003528071A (ja) * | 2000-03-23 | 2003-09-24 | エラン ファーマスーティカルズ インコーポレイテッド | アルツハイマー病治療用組成物および方法 |
| AU2001275857A1 (en) * | 2000-06-29 | 2002-01-14 | Bristol-Myers Squibb Pharma Company | Thrombin or factor xa inhibitors |
| US8431550B2 (en) | 2000-10-27 | 2013-04-30 | Johnson & Johnson Consumer Companies, Inc. | Topical anti-cancer compositions and methods of use thereof |
| FR2818277B1 (fr) * | 2000-12-14 | 2003-01-24 | Servier Lab | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7192615B2 (en) | 2001-02-28 | 2007-03-20 | J&J Consumer Companies, Inc. | Compositions containing legume products |
| AU2003219809A1 (en) | 2002-02-14 | 2003-09-04 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
| MXPA04009228A (es) | 2002-03-22 | 2005-08-16 | Gpc Biotech Ag | Compuestos inmunosupresores, metodos y usos relacionados con los mismos. |
| ES2819218T3 (es) | 2014-10-06 | 2021-04-15 | Cortexyme Inc | Inhibidores de lisina gingipaína |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| WO2017083433A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| KR102780603B1 (ko) | 2016-09-16 | 2025-03-12 | 라이트하우스 파마슈티컬스, 인코포레이티드 | 리신 진지파인의 케톤 억제제 |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| AU2019216260B2 (en) | 2018-01-31 | 2023-03-02 | Janssen Sciences Ireland Unlimited Company | Cycloalkyl substituted pyrazolopyrimidines having activity against RSV |
| CA3095277A1 (en) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Heteroaromatic compounds having activity against rsv |
-
1995
- 1995-12-21 JP JP8519383A patent/JPH11508535A/ja active Pending
- 1995-12-21 NZ NZ297360A patent/NZ297360A/xx unknown
- 1995-12-21 CN CN95197614A patent/CN1175259A/zh active Pending
- 1995-12-21 FI FI972466A patent/FI972466A7/fi unknown
- 1995-12-21 MD MD97-0253A patent/MD970253A/ru unknown
- 1995-12-21 AP APAP/P/1997/001004A patent/AP9701004A0/en unknown
- 1995-12-21 SK SK838-97A patent/SK83897A3/sk unknown
- 1995-12-21 PL PL95320965A patent/PL320965A1/xx unknown
- 1995-12-21 CA CA002208772A patent/CA2208772A1/en not_active Abandoned
- 1995-12-21 CZ CZ971899A patent/CZ189997A3/cs unknown
- 1995-12-21 EE EE9700113A patent/EE9700113A/xx unknown
- 1995-12-21 AU AU42505/96A patent/AU4250596A/en not_active Abandoned
- 1995-12-21 HU HU9800216A patent/HUT77651A/hu unknown
- 1995-12-21 WO PCT/CA1995/000708 patent/WO1996019483A1/en not_active Ceased
- 1995-12-21 EP EP95940923A patent/EP0802916A1/en not_active Ceased
- 1995-12-22 IL IL11650395D patent/IL116503A0/xx unknown
- 1995-12-22 AU AU40628/95A patent/AU715378B2/en not_active Ceased
-
1997
- 1997-06-11 IS IS4504A patent/IS4504A/is unknown
- 1997-06-18 OA OA70029A patent/OA10493A/en unknown
- 1997-06-20 BG BG101647A patent/BG101647A/xx unknown
- 1997-06-20 NO NO972892A patent/NO972892L/no unknown
- 1997-06-23 MX MX9704718A patent/MX9704718A/es unknown
- 1997-07-15 LV LVP-97-141A patent/LV12019B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LV12019B (en) | 1998-07-20 |
| IS4504A (is) | 1997-06-11 |
| MX9704718A (es) | 1998-06-28 |
| NO972892D0 (no) | 1997-06-20 |
| EP0802916A1 (en) | 1997-10-29 |
| NO972892L (no) | 1997-08-20 |
| FI972466L (fi) | 1997-08-19 |
| WO1996019483A1 (en) | 1996-06-27 |
| FI972466A7 (fi) | 1997-08-19 |
| NZ297360A (en) | 2000-03-27 |
| CZ189997A3 (cs) | 1998-09-16 |
| CN1175259A (zh) | 1998-03-04 |
| MD970253A (ru) | 1999-05-31 |
| PL320965A1 (en) | 1997-11-24 |
| AU4062895A (en) | 1996-07-04 |
| AU715378B2 (en) | 2000-02-03 |
| SK83897A3 (en) | 1998-05-06 |
| AU4250596A (en) | 1996-07-10 |
| EE9700113A (et) | 1997-12-15 |
| AP9701004A0 (en) | 1997-07-31 |
| HUT77651A (hu) | 1998-07-28 |
| CA2208772A1 (en) | 1996-06-27 |
| IL116503A0 (en) | 1996-03-31 |
| FI972466A0 (fi) | 1997-06-11 |
| OA10493A (en) | 2002-04-10 |
| JPH11508535A (ja) | 1999-07-27 |
| LV12019A (lv) | 1998-04-20 |
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