BG102707A - NEW TRIAZOLOPURINES, METHOD FOR THEIR RECOVERY AND THEIR APPLICATION AS MEDICINES - Google Patents

NEW TRIAZOLOPURINES, METHOD FOR THEIR RECOVERY AND THEIR APPLICATION AS MEDICINES

Info

Publication number
BG102707A
BG102707A BG102707A BG10270798A BG102707A BG 102707 A BG102707 A BG 102707A BG 102707 A BG102707 A BG 102707A BG 10270798 A BG10270798 A BG 10270798A BG 102707 A BG102707 A BG 102707A
Authority
BG
Bulgaria
Prior art keywords
new
triazolopurines
medicines
recovery
application
Prior art date
Application number
BG102707A
Other languages
Bulgarian (bg)
Inventor
Ulrike Kuefner-Muehl
Werner Kummer
Gerald Pohl
Wolfram Gaida
Erich Lehr
Joachim Mierau
Thomas Weiser
Original Assignee
Boehringer Ingelheim Pharma Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002242097A external-priority patent/CA2242097C/en
Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of BG102707A publication Critical patent/BG102707A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретението се отнася до нови триазолопуринови производни с формула, както и до метод за тяхното получаване и приложението им като лекарствени средства. Съединенията проявяват афинитет спрямо аденозин-рецептори и представляват нов клас аденозин-антагонисти. Последните могат да имат лечебно действие в случаите, когато болести или патологични състояния са свързани с активиране на аденозин-рецептори.The invention relates to novel triazolo-purine derivatives of the formula, as well as to a process for their preparation and their use as medicaments. The compounds exhibit affinity for adenosine receptors and represent a new class of adenosine-antagonists. The latter may have a healing effect in cases where diseases or pathological conditions are associated with activation of adenosine receptors.

BG102707A 1996-07-20 1998-08-20 NEW TRIAZOLOPURINES, METHOD FOR THEIR RECOVERY AND THEIR APPLICATION AS MEDICINES BG102707A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19629378A DE19629378A1 (en) 1996-07-20 1996-07-20 New triazolopurines, process for their preparation and their use as medicaments
PCT/EP1997/003841 WO1998003511A1 (en) 1996-07-20 1997-07-17 New triazolopurines, method of preparing them and their use as drugs
CA002242097A CA2242097C (en) 1996-07-20 1998-06-26 Imidazotriazolopyrimidines, process for preparing them and their use as pharmaceutical compositions

Publications (1)

Publication Number Publication Date
BG102707A true BG102707A (en) 1999-09-30

Family

ID=32963000

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102707A BG102707A (en) 1996-07-20 1998-08-20 NEW TRIAZOLOPURINES, METHOD FOR THEIR RECOVERY AND THEIR APPLICATION AS MEDICINES

Country Status (25)

Country Link
EP (2) EP0978517A3 (en)
JP (1) JP3020281B2 (en)
CN (1) CN1219936A (en)
AT (1) ATE191913T1 (en)
AU (1) AU3695597A (en)
BG (1) BG102707A (en)
BR (1) BR9710747A (en)
CA (1) CA2256736A1 (en)
CZ (1) CZ265498A3 (en)
DE (2) DE19629378A1 (en)
DK (1) DK0880524T3 (en)
EE (1) EE9800451A (en)
ES (1) ES2147453T3 (en)
GR (1) GR3033842T3 (en)
HR (1) HRP970395A2 (en)
HU (1) HUP9902311A3 (en)
ID (1) ID19106A (en)
IL (1) IL126453A0 (en)
NO (1) NO983860L (en)
PL (1) PL328824A1 (en)
PT (1) PT880524E (en)
SK (1) SK114498A3 (en)
TR (1) TR199801659T2 (en)
WO (1) WO1998003511A1 (en)
ZA (1) ZA976331B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826843A1 (en) * 1998-06-16 1999-12-23 Boehringer Ingelheim Pharma Novel imidazotriazolopyrimidines, process for their preparation and their use as medicaments
US6492377B1 (en) 1998-06-25 2002-12-10 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines with adenosine-antagonistic activity
AU9347498A (en) * 1998-08-27 2000-03-21 Boehringer Ingelheim Pharma Kg Imidazotriazolopyrimidines
US7329668B2 (en) 2003-02-25 2008-02-12 Bristol-Myers Squibb Company Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7071333B2 (en) 2003-07-30 2006-07-04 Bristol-Myers Squibb Company Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
US7511050B2 (en) * 2006-06-23 2009-03-31 Incyte Corporation Purinone derivatives as HM74A agonists
AU2019227607C1 (en) 2018-02-27 2023-07-20 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
EP3810610A1 (en) 2018-05-18 2021-04-28 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
CN117304191A (en) 2018-07-05 2023-12-29 因赛特公司 Fused pyrazine derivatives as A2A/A2B inhibitors
AR117164A1 (en) 2018-11-30 2021-07-14 Merck Sharp & Dohme DERIVATIVES OF AMINO-TRIAZOLOQUINAZOLINE 9-SUBSTITUTED AS ANTAGONISTS OF THE ADENOSINE RECEPTOR, PHARMACEUTICAL COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF VARIOUS TYPES OF CANCER
TWI829857B (en) 2019-01-29 2024-01-21 美商英塞特公司 Pyrazolopyridines and triazolopyridines as a2a / a2b inhibitors
CN112778311B (en) * 2019-11-01 2024-06-04 上海翰森生物医药科技有限公司 Nitrogen-containing fused ring derivative inhibitor, preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623755B2 (en) * 1989-03-29 1992-05-21 Merrell Pharmaceuticals Inc. Selective adenosine receptor compounds
IT1264901B1 (en) * 1993-06-29 1996-10-17 Schering Plough S P A HETEROCYCLIC ANALOGUES OF 1,2,4-TRIAZOLE(15-C)PYRIMIDINES WITH ANTAGONIST ACTIVITY FOR THE ADENOSINE A2 RECEPTOR
JPH083169A (en) * 1994-06-15 1996-01-09 Yamasa Shoyu Co Ltd 4-Methyl-1H- [1,2,4] triazolo [1,5-a] purin-9 (4H) -ones

Also Published As

Publication number Publication date
PT880524E (en) 2000-07-31
WO1998003511A1 (en) 1998-01-29
ID19106A (en) 1998-06-18
DE59701467D1 (en) 2000-05-25
CA2256736A1 (en) 1998-01-29
GR3033842T3 (en) 2000-10-31
IL126453A0 (en) 1999-08-17
ATE191913T1 (en) 2000-05-15
EP0978517A2 (en) 2000-02-09
DK0880524T3 (en) 2000-07-17
DE19629378A1 (en) 1998-01-29
ES2147453T3 (en) 2000-09-01
NO983860L (en) 1998-10-21
BR9710747A (en) 1999-08-17
EP0978517A3 (en) 2003-11-12
CZ265498A3 (en) 1998-12-16
CN1219936A (en) 1999-06-16
EP0880524B1 (en) 2000-04-19
PL328824A1 (en) 1999-02-15
JP3020281B2 (en) 2000-03-15
HUP9902311A2 (en) 1999-10-28
ZA976331B (en) 1999-01-25
HUP9902311A3 (en) 2000-06-28
AU3695597A (en) 1998-02-10
SK114498A3 (en) 1999-02-11
EE9800451A (en) 1999-06-15
HRP970395A2 (en) 1998-08-31
EP0880524A1 (en) 1998-12-02
JP2000501420A (en) 2000-02-08
TR199801659T2 (en) 1998-12-21
NO983860D0 (en) 1998-08-21

Similar Documents

Publication Publication Date Title
FI20105844L (en) Pharmaceutical compositions for the treatment of diseases caused by IL-6 production
BG101715A (en) TETRACYCLE COMPOUNDS, THE METHOD FOR THEIR PREPARATION, AND THE APPLICATION THEREOF AS 5TH LOW 1D RECEPTOR ANTAGONISTS
BR0214870A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and application thereof
TR199901174T2 (en) New heterocyclylmethyl-substituted pyrazole derivatives.
EA200000723A1 (en) DERIVATIVES 2- (PURIN-9-IL) -TETRAHYDROFURAN-3,4-DIOLA
YU56995A (en) ONLY DERIVED INDOLA
EA200001223A1 (en) DERIVATIVES 2- (PURIN-9-IL) -TETRAHYDROFURAN-3,4-DIOLA
BR9502707A (en) Compound pharmaceutical composition and method for treating a condition
ATE201203T1 (en) CHIRAL METHYLPHENYLOXAZOLIDINONE
ATE182333T1 (en) HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE
BR0013311A (en) Substituted 1,5-dihydropyrrol-2-one derivatives effective as nmda receptor antagonists for the treatment of pain states
PT77898A (en) Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
FI931332A0 (en) Novel alkylenediammonium diclavulanate derivatives, process for their preparation as well as their use for the purification of calvulanic acid
YU63696A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals
ATE231849T1 (en) CYCLOPENTABENZOFURAN DERIVATIVES AND THEIR USE
BG101605A (en) ENTEROQUINETIC BENSAMIDES
BR9809637A (en) Glycoconjugates of 20 (s) -camptothecin
MX9700807A (en) DERIVATIVES OF 3-AZABICICLO (3.2.0) N-SUBSTITUTED HEPTANE USEFUL AS NEUROLEPTICOS.
BG104232A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ol, a method for their preparation and their use as medicaments
NO983860L (en) Novel triazolopurins, their method of preparation and their use as drugs
ATE149507T1 (en) SOLUBLE, NON-TOXIC DERIVATIVES OF BASIC POLYEN MACROLIDS, THEIR PREPARATION AND USE
ES2128313T3 (en) N-SUBSTITUTED NAFTALIMIDES, THEIR OBTAINING AND EMPLOYMENT.
BR9610175A (en) Compound preparation process of the pharmaceutical composition and use of the compound
ES2188909T3 (en) NEW DERIVATIVES OF CIS-3,4-CHROMANE USEFUL FOR THE PREVENTION OR TREATMENT OF SYNDROMES OR ILLNESS RELATED TO THE ESTROGEN. YOU
FI952203L (en) Cyclohexane derivatives, process for their preparation and use of the compounds for treating diseases