BG102708A - 4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation - Google Patents

4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation

Info

Publication number
BG102708A
BG102708A BG102708A BG10270898A BG102708A BG 102708 A BG102708 A BG 102708A BG 102708 A BG102708 A BG 102708A BG 10270898 A BG10270898 A BG 10270898A BG 102708 A BG102708 A BG 102708A
Authority
BG
Bulgaria
Prior art keywords
preparation
application
medicamentous
preparations containing
aminopyrimidine derivatives
Prior art date
Application number
BG102708A
Other languages
Bulgarian (bg)
Inventor
Frank Himmelsbach
Georg Dahmann
Rueden Thomas Von
Thomas Metz
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996108631 external-priority patent/DE19608631A1/en
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG102708A publication Critical patent/BG102708A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The 4-aminopyramidine derivatives have valuavlepharmacological properties, in particular they show suppressiveeffect on the signal transmission by tyrosikinases. They have thegeneral formulawhere the meanings of Ra, Rb and B are shown in claim 1 in thedescription. The invention also relates to their tautomers,stereoisomers and salts, in particular their pharmaceuticallyacceptable salts with inorganic or organic acids of bases, as wellas to their application for the treatment of diseases, inparticular of tumours, as well as to their preparation.9 claims
BG102708A 1996-03-06 1998-08-20 4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation BG102708A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1996108631 DE19608631A1 (en) 1996-03-06 1996-03-06 New (heterocyclyl- pyrimidino or -pyrido)fused pyrimidine derivatives
DE19629652A DE19629652A1 (en) 1996-03-06 1996-07-23 4-Amino-pyrimidine derivatives, medicaments containing these compounds, their use and processes for their preparation
PCT/EP1997/001057 WO1997032881A1 (en) 1996-03-06 1997-03-03 4-amino pyrimidine derivates, medicaments containing these compounds, their use and process for their production

Publications (1)

Publication Number Publication Date
BG102708A true BG102708A (en) 1999-09-30

Family

ID=26023531

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102708A BG102708A (en) 1996-03-06 1998-08-20 4-aminopyrimidine derivatives, medicamentous preparations containing them, their application and method for their preparation

Country Status (19)

Country Link
EP (1) EP0885226A1 (en)
JP (1) JP2000506847A (en)
KR (1) KR19990087550A (en)
CN (1) CN1212695A (en)
AU (1) AU710274B2 (en)
BG (1) BG102708A (en)
BR (1) BR9708312A (en)
CA (1) CA2243994A1 (en)
CZ (1) CZ281798A3 (en)
DE (1) DE19629652A1 (en)
EE (1) EE9800277A (en)
HU (1) HUP9901820A3 (en)
IL (1) IL125404A0 (en)
NO (1) NO984084L (en)
NZ (1) NZ331546A (en)
PL (1) PL328771A1 (en)
SK (1) SK120598A3 (en)
TR (1) TR199801749T2 (en)
WO (1) WO1997032881A1 (en)

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Also Published As

Publication number Publication date
EP0885226A1 (en) 1998-12-23
NO984084D0 (en) 1998-09-04
EE9800277A (en) 1999-02-15
HUP9901820A3 (en) 2001-10-29
PL328771A1 (en) 1999-02-15
SK120598A3 (en) 1999-06-11
NO984084L (en) 1998-09-04
TR199801749T2 (en) 1998-12-21
WO1997032881A1 (en) 1997-09-12
DE19629652A1 (en) 1998-01-29
BR9708312A (en) 1999-08-03
AU710274B2 (en) 1999-09-16
IL125404A0 (en) 1999-03-12
KR19990087550A (en) 1999-12-27
JP2000506847A (en) 2000-06-06
CA2243994A1 (en) 1997-09-12
NZ331546A (en) 2000-03-27
CZ281798A3 (en) 1999-02-17
HUP9901820A2 (en) 1999-09-28
CN1212695A (en) 1999-03-31
AU1925197A (en) 1997-09-22

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