BG102771A - Diarylmethylidenfuran derivatives, method for their preparation and utilization as medicamentous forms - Google Patents

Diarylmethylidenfuran derivatives, method for their preparation and utilization as medicamentous forms

Info

Publication number
BG102771A
BG102771A BG102771A BG10277198A BG102771A BG 102771 A BG102771 A BG 102771A BG 102771 A BG102771 A BG 102771A BG 10277198 A BG10277198 A BG 10277198A BG 102771 A BG102771 A BG 102771A
Authority
BG
Bulgaria
Prior art keywords
diarylmethylidenfuran
utilization
derivatives
preparation
medicamentous forms
Prior art date
Application number
BG102771A
Other languages
Bulgarian (bg)
Other versions
BG62808B1 (en
Inventor
Eric Nicolai
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa filed Critical Laboratoires Upsa
Publication of BG102771A publication Critical patent/BG102771A/en
Publication of BG62808B1 publication Critical patent/BG62808B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The invention relates to diarylmethildenfuran derivativeswith the formulawhere the meanings of the substitutents are listed in thedescription, and to their usage as medicamentous forms, inparticular as antiphlogistic and analgetic means.13 claims
BG102771A 1996-04-04 1998-09-16 New diarylmethylidenfuran derivatives, method for their preparation and utilization as medicamentous forms BG62808B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9604236A FR2747123B1 (en) 1996-04-04 1996-04-04 NOVEL DIARYLMETHYLIDENE TETRAHYDROFURANE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THERAPEUTIC USES
FR9607922A FR2747124B1 (en) 1996-04-04 1996-06-26 NOVEL FURANIC DIARYLMETHYLIDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
PCT/FR1997/000602 WO1997037984A1 (en) 1996-04-04 1997-04-03 Novel furan diarylmethylidene derivatives, method for their preparation and therapeutical uses thereof

Publications (2)

Publication Number Publication Date
BG102771A true BG102771A (en) 1999-06-30
BG62808B1 BG62808B1 (en) 2000-08-31

Family

ID=9490907

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102771A BG62808B1 (en) 1996-04-04 1998-09-16 New diarylmethylidenfuran derivatives, method for their preparation and utilization as medicamentous forms

Country Status (28)

Country Link
EP (1) EP0891345B1 (en)
JP (1) JP2000508638A (en)
KR (1) KR20000005146A (en)
CN (1) CN1215396A (en)
AR (1) AR006539A1 (en)
AT (1) ATE204268T1 (en)
AU (1) AU717146B2 (en)
BG (1) BG62808B1 (en)
BR (1) BR9708510A (en)
CA (1) CA2248949A1 (en)
CZ (1) CZ318898A3 (en)
DE (1) DE69706157T2 (en)
DK (1) DK0891345T3 (en)
EE (1) EE03687B1 (en)
ES (1) ES2162678T3 (en)
FR (2) FR2747123B1 (en)
GE (1) GEP20032924B (en)
IL (1) IL126105A (en)
NO (1) NO984624L (en)
NZ (1) NZ331672A (en)
PL (1) PL329213A1 (en)
PT (1) PT891345E (en)
RU (1) RU2189979C2 (en)
SI (1) SI0891345T1 (en)
SK (1) SK283292B6 (en)
TW (1) TW353660B (en)
WO (1) WO1997037984A1 (en)
ZA (1) ZA972894B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180651B1 (en) * 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
US6026814A (en) 1997-03-06 2000-02-22 Scimed Life Systems, Inc. System and method for percutaneous coronary artery bypass
JP2001518087A (en) * 1997-04-02 2001-10-09 メルク フロスト カナダ アンド カンパニー Α-Methylene-γ-lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (en) * 1998-02-27 2000-05-19 Union Pharma Scient Appl NOVEL HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
CN1106392C (en) * 2000-10-24 2003-04-23 中国科学院上海有机化学研究所 Butenolide containing no substituent at beta position and its synthesis process
AR038957A1 (en) 2001-08-15 2005-02-02 Pharmacia Corp COMBINATION THERAPY FOR CANCER TREATMENT
WO2004041217A2 (en) * 2002-11-05 2004-05-21 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
ATE515493T1 (en) * 2003-03-31 2011-07-15 Council Scient Ind Res MERCAPTOPHENYLNAPHTHYLMETHANE DERIVATIVES AND THEIR PRODUCTION
PT1534305E (en) 2003-05-07 2007-02-28 Osteologix As Treating cartilage / bone conditions with water-soluble strontium salts
US8779168B2 (en) * 2010-12-16 2014-07-15 Transitions Optical, Inc. Lactone compounds and materials made therefrom
IL305573A (en) 2021-03-15 2023-10-01 Saul Yedgar Hyaluronic acid conjugated with dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment or suppression of inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6027694A (en) * 1993-01-15 1994-08-15 G.D. Searle & Co. Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge

Also Published As

Publication number Publication date
EP0891345B1 (en) 2001-08-16
PT891345E (en) 2002-02-28
SK283292B6 (en) 2003-05-02
AU2393397A (en) 1997-10-29
AR006539A1 (en) 1999-09-08
CN1215396A (en) 1999-04-28
SK137598A3 (en) 1999-02-11
ZA972894B (en) 1997-11-04
FR2747123B1 (en) 1998-06-26
EP0891345A1 (en) 1999-01-20
NO984624L (en) 1998-11-30
SI0891345T1 (en) 2002-02-28
EE03687B1 (en) 2002-04-15
FR2747124B1 (en) 1998-06-26
CZ318898A3 (en) 1999-01-13
NZ331672A (en) 2000-02-28
IL126105A0 (en) 1999-05-09
AU717146B2 (en) 2000-03-16
DE69706157D1 (en) 2001-09-20
NO984624D0 (en) 1998-10-02
ES2162678T3 (en) 2002-01-01
BR9708510A (en) 1999-08-03
PL329213A1 (en) 1999-03-15
ATE204268T1 (en) 2001-09-15
RU2189979C2 (en) 2002-09-27
WO1997037984A1 (en) 1997-10-16
KR20000005146A (en) 2000-01-25
DK0891345T3 (en) 2001-12-03
FR2747124A1 (en) 1997-10-10
GEP20032924B (en) 2003-03-25
BG62808B1 (en) 2000-08-31
EE9800333A (en) 1999-04-15
FR2747123A1 (en) 1997-10-10
TW353660B (en) 1999-03-01
DE69706157T2 (en) 2002-04-11
CA2248949A1 (en) 1997-10-16
JP2000508638A (en) 2000-07-11
IL126105A (en) 2001-08-26

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