BG104059A - Diabetes treatment with rosiglytazone and insulin - Google Patents

Diabetes treatment with rosiglytazone and insulin

Info

Publication number: BG104059A
Authority: BG; Bulgaria
Prior art keywords: rosiglytazone; insulin; diabetes treatment; treatment; nontoxic
Prior art date: 1997-06-18

Application number

BG104059A

Other languages

Bulgarian (bg)

English (en)

Inventor

Stephen Smith

Original Assignee

Smithkline Beecham P.L.C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-18

Filing date

2000-01-06

Publication date

2000-10-31

2000-01-06 Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.

2000-10-31 Publication of BG104059A publication Critical patent/BG104059A/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
206010012601 diabetes mellitus Diseases 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
241000124008 Mammalia Species 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Emergency Medicine (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)

BG104059A 1997-06-18 2000-01-06 Diabetes treatment with rosiglytazone and insulin BG104059A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9712866.4A GB9712866D0 (en)	1997-06-18	1997-06-18	Novel method of treatment
PCT/EP1998/003692 WO1998057636A1 (en)	1997-06-18	1998-06-15	Treatment of diabetes with rosiglitazone and insulin

Publications (1)

Publication Number	Publication Date
BG104059A true BG104059A (en)	2000-10-31

Family

ID=10814527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104059A BG104059A (en)	1997-06-18	2000-01-06	Diabetes treatment with rosiglytazone and insulin

Country Status (30)

Country	Link
EP (1)	EP0999837A1 (it)
JP (1)	JP2002504138A (it)
KR (1)	KR20010013843A (it)
CN (1)	CN1133431C (it)
AP (1)	AP1287A (it)
AR (2)	AR012997A1 (it)
AU (1)	AU8216398A (it)
BG (1)	BG104059A (it)
BR (1)	BR9810444A (it)
CA (1)	CA2294141A1 (it)
CO (1)	CO4940454A1 (it)
DZ (1)	DZ2521A1 (it)
EA (1)	EA004800B1 (it)
GB (1)	GB9712866D0 (it)
HU (1)	HUP0003260A3 (it)
ID (1)	ID23951A (it)
IL (1)	IL133143A0 (it)
IN (1)	IN189723B (it)
MA (1)	MA26511A1 (it)
NO (1)	NO996265L (it)
OA (1)	OA11517A (it)
PE (1)	PE104499A1 (it)
PL (1)	PL343123A1 (it)
SK (1)	SK179399A3 (it)
TR (1)	TR199903095T2 (it)
TW (1)	TW587937B (it)
UA (1)	UA70299C2 (it)
UY (1)	UY25050A1 (it)
WO (1)	WO1998057636A1 (it)
ZA (1)	ZA985237B (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6291495B1 (en) *	1997-02-24	2001-09-18	Robert B. Rieveley	Method and composition for the treatment of diabetes
US7045519B2 (en)	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
TWI249401B (en)	1999-04-14	2006-02-21	Takeda Chemical Industries Ltd	Agent for improving ketosis
HRP20010773B1 (en)	1999-04-23	2005-06-30	Smithkline Beecham P.L.C.	Thiazolidinedione derivative and its use as antidiabetic
SI1133312T1 (sl) *	1999-06-21	2008-02-29	Lilly Co Eli	Uporaba tiazolidindionov v kombinaciji z glukagonu podobnim peptidom-1 in njegovimi agonisti za zdravljenje sladkorne bolezni, neodvisne od inzulina
EP1196189A2 (en)	1999-06-25	2002-04-17	Medtronic MiniMed, Inc.	Multiple agent diabetes therapy
US6468507B1 (en) *	2000-05-01	2002-10-22	Aeropharm Technology, Inc.	Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer
GB0023970D0 (en) *	2000-09-29	2000-11-15	Smithkline Beecham Plc	Novel pharmaceutical
WO2002067969A2 (en)	2001-02-21	2002-09-06	Medtronic Minimed, Inc.	Stabilized insulin formulations
US6531461B1 (en)	2001-06-04	2003-03-11	Louis Obyo Obyo Nelson	Medicament for the treatment of diabetes
WO2002100396A1 (en) *	2001-06-07	2002-12-19	Wyeth	COMBINATION OF A PTPase INHIBITOR AND A THIAZOLIDINEDIONE AGENT
US6737401B2 (en)	2001-06-28	2004-05-18	Metronic Minimed, Inc.	Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom
CA2503117C (en)	2002-11-08	2010-12-21	F. Hoffmann-La Roche Ag	Substituted 4-alkoxyoxazol derivatives as ppar agonists
US7264813B2 (en)	2003-09-24	2007-09-04	Nikken Sohonsha Corporation	Therapeutic uses of Dunaliella powder
CN102389427A (zh) *	2011-10-10	2012-03-28	成都恒瑞制药有限公司	含有罗格列酮和盐酸西替利嗪的固体口服制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1103590C (zh) *	1993-09-15	2003-03-26	三共株式会社	使用噻唑烷二酮防止或延缓非胰岛素依赖性糖尿病(niddm)的发作
JPH11510508A (ja) *	1995-08-10	1999-09-14	ワーナー−ランバート・コンパニー	インシュリン非依存性真性糖尿病患者に投与される外来インシュリンの量を減らす方法
PT859608E (pt) *	1995-09-18	2004-06-30	Ligand Pharm Inc	Tratamento de niddm com agonistas de rxr

1997
- 1997-06-18 GB GBGB9712866.4A patent/GB9712866D0/en active Pending
1998
- 1998-06-15 UA UA99126881A patent/UA70299C2/uk unknown
- 1998-06-15 EA EA200000042A patent/EA004800B1/ru not_active IP Right Cessation
- 1998-06-15 HU HU0003260A patent/HUP0003260A3/hu unknown
- 1998-06-15 IL IL13314398A patent/IL133143A0/xx unknown
- 1998-06-15 PL PL98343123A patent/PL343123A1/xx unknown
- 1998-06-15 AU AU82163/98A patent/AU8216398A/en not_active Abandoned
- 1998-06-15 AP APAP/P/1999/001718A patent/AP1287A/en active
- 1998-06-15 CN CNB988062232A patent/CN1133431C/zh not_active Expired - Fee Related
- 1998-06-15 BR BR9810444-6A patent/BR9810444A/pt not_active IP Right Cessation
- 1998-06-15 TR TR1999/03095T patent/TR199903095T2/xx unknown
- 1998-06-15 CA CA002294141A patent/CA2294141A1/en not_active Abandoned
- 1998-06-15 JP JP50375799A patent/JP2002504138A/ja not_active Ceased
- 1998-06-15 WO PCT/EP1998/003692 patent/WO1998057636A1/en not_active Ceased
- 1998-06-15 KR KR1019997011864A patent/KR20010013843A/ko not_active Ceased
- 1998-06-15 ID IDW991627A patent/ID23951A/id unknown
- 1998-06-15 SK SK1793-99A patent/SK179399A3/sk unknown
- 1998-06-15 EP EP98932169A patent/EP0999837A1/en not_active Withdrawn
- 1998-06-17 ZA ZA9805237A patent/ZA985237B/xx unknown
- 1998-06-17 DZ DZ980131A patent/DZ2521A1/xx active
- 1998-06-17 AR ARP980102883A patent/AR012997A1/es not_active Application Discontinuation
- 1998-06-17 MA MA25122A patent/MA26511A1/fr unknown
- 1998-06-17 AR ARP980102886A patent/AR015894A1/es not_active Application Discontinuation
- 1998-06-17 TW TW087109619A patent/TW587937B/zh not_active IP Right Cessation
- 1998-06-18 IN IN1698DE1998 patent/IN189723B/en unknown
- 1998-06-18 UY UY25050A patent/UY25050A1/es unknown
- 1998-06-18 CO CO98034654A patent/CO4940454A1/es unknown
- 1998-06-18 PE PE1998000535A patent/PE104499A1/es not_active Application Discontinuation
1999
- 1999-12-17 NO NO996265A patent/NO996265L/no not_active Application Discontinuation
- 1999-12-17 OA OA9900296A patent/OA11517A/en unknown
2000
- 2000-01-06 BG BG104059A patent/BG104059A/xx unknown

Also Published As

Publication number	Publication date
PL343123A1 (en)	2001-07-30
NO996265D0 (no)	1999-12-17
AR015894A1 (es)	2001-05-30
PE104499A1 (es)	2000-01-13
EA004800B1 (ru)	2004-08-26
SK179399A3 (en)	2000-11-07
TW587937B (en)	2004-05-21
DZ2521A1 (fr)	2003-02-08
HUP0003260A3 (en)	2001-12-28
HUP0003260A2 (hu)	2001-05-28
CN1133431C (zh)	2004-01-07
WO1998057636A1 (en)	1998-12-23
CA2294141A1 (en)	1998-12-23
IL133143A0 (en)	2001-03-19
ID23951A (id)	2000-06-08
CN1260715A (zh)	2000-07-19
KR20010013843A (ko)	2001-02-26
AR012997A1 (es)	2000-11-22
TR199903095T2 (xx)	2000-08-21
NO996265L (no)	1999-12-17
OA11517A (en)	2004-02-04
AU8216398A (en)	1999-01-04
AP1287A (en)	2004-06-26
AP9901718A0 (en)	1999-12-31
IN189723B (it)	2003-04-19
MA26511A1 (fr)	2004-12-20
JP2002504138A (ja)	2002-02-05
EA200000042A1 (ru)	2000-08-28
BR9810444A (pt)	2000-09-05
UY25050A1 (es)	2000-09-29
ZA985237B (en)	2000-02-17
CO4940454A1 (es)	2000-07-24
EP0999837A1 (en)	2000-05-17
GB9712866D0 (en)	1997-08-20
UA70299C2 (en)	2004-10-15

Publication	Publication Date	Title
BG104060A (en)	2000-10-31	Diabetes treatment with thiazolyidindion and methformine
ZA977783B (en)	1999-03-01	Method of inhibiting fibrosis with a somatostatin agonist
AU2373400A (en)	2000-07-12	Shelf-stable formulation of glucagon-like peptide-1
AU5456598A (en)	1998-06-10	Insulin delivery enhanced by coached breathing
WO2000057900A3 (en)	2001-02-15	Factor for regulation of neurite growth
AU2272097A (en)	1997-09-10	Drug delivery compositions suitable for intravenous injection
ZA94878B (en)	1995-08-10	Prolonged delivery of peptides
EP0767687A4 (en)	1998-10-07	IMPLANTABLE PUMP FOR THE ADMINISTRATION OF A MEDICINE
MY129220A (en)	2007-03-30	"use of glp-1 analogs and derivatives administered peripherally in regulation of obesity"
IL160983A0 (en)	2004-08-31	Use of pyy for preparation of a medicament for modification of feeding behavior
BG103740A (en)	2000-05-31	Phytostyrene composition for the prevention of the alzheimer's disease
BG104135A (en)	2000-10-31	Diabetes treatment with thiazolydindion, a form increasing the insulin and biguanide secretion
WO2000016797A3 (en)	2000-05-25	Use of glp-1 or analogs in treatment of stroke
ZA967502B (en)	1997-09-19	Medicament delivery device.
WO2003018516A3 (en)	2004-02-26	Glucagon-like peptide-1 analogs
ZA99104B (en)	2000-07-07	Method for administering ASPB28-human insulin.
AU4714393A (en)	1994-02-14	Use of 1,3-dicyclopropymethyl-8-amino-xanthine for the treatment and prevention of type ii diabetes mellitus and obesity
ZA953537B (en)	1995-11-06	Use of certain methanebisphosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration
BG104062A (en)	2000-11-30	Treatment of diabetes with thiazolidindion, stimulant of insulin secretion and alpha-glucosidase inhibitor
BG104058A (en)	2000-10-31	Diabetes treatment with thiazolydindion and sulphonylurea
BG104139A (en)	2000-11-30	Diabetes treatment with thizolidindion and sulphonylurea
WO1999053064A3 (en)	2000-03-16	Methods of delivering glp-1
AU8019898A (en)	1998-12-08	Somatostatin and somatostatin agonists for treating insulin insensitivity and syndrome
NZ332688A (en)	2000-07-28	Stimulation of host defence mechanisms against tumors using interferon
WO1997005875A3 (en)	1997-03-27	A method of reducing the amount of exogenous insulin administered to a patient having noninsulin-dependent diabetes mellitus