BG104243A - Method for the synthesis of quinoline derivatives - Google Patents

Method for the synthesis of quinoline derivatives

Info

Publication number: BG104243A
Authority: BG; Bulgaria
Prior art keywords: synthesis; quinoline derivatives; phenylquinoline; ethylbenzyl; alpha
Prior art date: 1997-09-17

Application number

BG104243A

Other languages

Bulgarian (bg)

English (en)

Inventor

Joseph Sisko

Mark Mellinger

Conrad Kowalski

Original Assignee

Smithkline Beecham Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-17

Filing date

2000-03-15

Publication date

2001-05-31

2000-03-15 Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation

2001-05-31 Publication of BG104243A publication Critical patent/BG104243A/xx

Links

238000000034 method Methods 0.000 title abstract 2
229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
BIAVGWDGIJKWRM-FQEVSTJZSA-N 3-hydroxy-2-phenyl-n-[(1s)-1-phenylpropyl]quinoline-4-carboxamide Chemical compound N([C@@H](CC)C=1C=CC=CC=1)C(=O)C(C1=CC=CC=C1N=1)=C(O)C=1C1=CC=CC=C1 BIAVGWDGIJKWRM-FQEVSTJZSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003248 quinolines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
- C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

BG104243A 1997-09-17 2000-03-15 Method for the synthesis of quinoline derivatives BG104243A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5930397P	1997-09-17	1997-09-17
PCT/US1998/019434 WO1999014196A1 (fr)	1997-09-17	1998-09-17	Procede de synthese de derives de quinoleine

Publications (1)

Publication Number	Publication Date
BG104243A true BG104243A (en)	2001-05-31

Family

ID=22022126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104243A BG104243A (en)	1997-09-17	2000-03-15	Method for the synthesis of quinoline derivatives

Country Status (32)

Country	Link
US (6)	US6335448B1 (fr)
EP (1)	EP1017676B1 (fr)
JP (1)	JP2001516744A (fr)
KR (1)	KR20010024031A (fr)
CN (1)	CN1125815C (fr)
AP (1)	AP1201A (fr)
AR (1)	AR015445A1 (fr)
AT (1)	ATE353879T1 (fr)
AU (1)	AU744538B2 (fr)
BG (1)	BG104243A (fr)
BR (1)	BR9812085A (fr)
CA (1)	CA2303026A1 (fr)
DE (1)	DE69837100T2 (fr)
DZ (1)	DZ2607A1 (fr)
EA (1)	EA002633B1 (fr)
ES (1)	ES2283072T3 (fr)
HU (1)	HUP0004855A3 (fr)
ID (1)	ID24140A (fr)
IL (1)	IL134991A0 (fr)
MA (1)	MA24644A1 (fr)
MY (1)	MY120237A (fr)
NO (1)	NO314303B1 (fr)
NZ (1)	NZ503307A (fr)
OA (1)	OA11340A (fr)
PE (1)	PE129299A1 (fr)
PL (1)	PL339340A1 (fr)
SK (1)	SK3672000A3 (fr)
TR (1)	TR200000720T2 (fr)
TW (1)	TW509678B (fr)
UY (2)	UY25174A1 (fr)
WO (1)	WO1999014196A1 (fr)
ZA (1)	ZA988455B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP1201A (en) *	1997-09-17	2003-09-01	Smithkline Beecham Corp	Method for the synthesis of quinoline derivatives.
ATE247652T1 (de)	1999-03-29	2003-09-15	Neurogen Corp	4-substituierte chinolinderivate als nk-3 und/oder gaba(a) rezeptor liganden
KR100799802B1 (ko)	2004-02-04	2008-01-31	화이자 프로덕츠 인크.	치환된 퀴놀린 화합물
CA2611060A1 (fr) *	2005-06-03	2006-12-07	R. Thomas Simpson	Derives de quinoline utilises comme antagonistes de nk3
US20080194623A1 (en) *	2005-08-02	2008-08-14	Labaw Clifford S	Method for the Synthesis of Quinoline Derivatives
US20080280949A1 (en) *	2005-08-11	2008-11-13	Astrazeneca Ab	Oxopyridyl Quinoline Amides as Nk3 Receptor Modulators
AR057130A1 (es) *	2005-09-21	2007-11-14	Astrazeneca Ab	Quinolinas de alquilsulfoxido y una composicion farmaceutica
JP2009508944A (ja) *	2005-09-21	2009-03-05	アストラゼネカ・アクチエボラーグ	Ｎｋ−３受容体リガンドとしてのｎ−オキソ複素環及びｎ−オキソ−アルキルキノリン−４−カルボキシアミド類
US20090054445A1 (en) *	2006-01-27	2009-02-26	Astrazeneca Ab	Amide Substituted Quinolines
CN102702099A (zh) *	2012-06-21	2012-10-03	江苏恩华药业股份有限公司	(s)-3-羟基-2-苯基-n-(1-苯基丙基)喹啉-4-甲酰胺的制备方法
CN102924375B (zh) *	2012-06-21	2015-02-18	江苏恩华药业股份有限公司	Talnetant中间体及其制备方法和应用
CN103214416A (zh) *	2013-04-26	2013-07-24	扬州大学	一种合成多取代喹啉类化合物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2776290A (en) *		1957-01-01		Hydroxy cevchoninates and carboxylic
DE69531458T2 (de) *	1994-05-27	2004-08-05	Glaxosmithkline S.P.A.	Chinolinderivate als tachykinin nk3 rezeptor antagonisten
US5627193A (en) *	1995-02-09	1997-05-06	Mitsui Toatsu Chemicals, Inc.	Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
AP1201A (en) *	1997-09-17	2003-09-01	Smithkline Beecham Corp	Method for the synthesis of quinoline derivatives.

1998
- 1998-05-08 AP APAP/P/2000/001767A patent/AP1201A/en active
- 1998-09-08 UY UY25174A patent/UY25174A1/es not_active Application Discontinuation
- 1998-09-08 MA MA25246A patent/MA24644A1/fr unknown
- 1998-09-11 PE PE1998000868A patent/PE129299A1/es not_active Application Discontinuation
- 1998-09-14 DZ DZ980217A patent/DZ2607A1/fr active
- 1998-09-15 MY MYPI98004207A patent/MY120237A/en unknown
- 1998-09-16 ZA ZA988455A patent/ZA988455B/xx unknown
- 1998-09-16 AR ARP980104603A patent/AR015445A1/es not_active Application Discontinuation
- 1998-09-17 EP EP98947099A patent/EP1017676B1/fr not_active Expired - Lifetime
- 1998-09-17 JP JP2000511747A patent/JP2001516744A/ja active Pending
- 1998-09-17 NZ NZ503307A patent/NZ503307A/en unknown
- 1998-09-17 CA CA002303026A patent/CA2303026A1/fr not_active Abandoned
- 1998-09-17 AU AU93958/98A patent/AU744538B2/en not_active Ceased
- 1998-09-17 US US09/508,358 patent/US6335448B1/en not_active Expired - Fee Related
- 1998-09-17 TR TR2000/00720T patent/TR200000720T2/xx unknown
- 1998-09-17 PL PL98339340A patent/PL339340A1/xx unknown
- 1998-09-17 IL IL13499198A patent/IL134991A0/xx unknown
- 1998-09-17 HU HU0004855A patent/HUP0004855A3/hu unknown
- 1998-09-17 CN CN98810978A patent/CN1125815C/zh not_active Expired - Fee Related
- 1998-09-17 KR KR1020007002766A patent/KR20010024031A/ko not_active Ceased
- 1998-09-17 DE DE69837100T patent/DE69837100T2/de not_active Expired - Lifetime
- 1998-09-17 ES ES98947099T patent/ES2283072T3/es not_active Expired - Lifetime
- 1998-09-17 AT AT98947099T patent/ATE353879T1/de not_active IP Right Cessation
- 1998-09-17 WO PCT/US1998/019434 patent/WO1999014196A1/fr not_active Ceased
- 1998-09-17 ID IDW20000498A patent/ID24140A/id unknown
- 1998-09-17 EA EA200000322A patent/EA002633B1/ru not_active IP Right Cessation
- 1998-09-17 BR BR9812085-9A patent/BR9812085A/pt not_active IP Right Cessation
- 1998-09-17 SK SK367-2000A patent/SK3672000A3/sk unknown
- 1998-09-29 TW TW087114858A patent/TW509678B/zh not_active IP Right Cessation
1999
- 1999-02-26 UY UY25407A patent/UY25407A1/es unknown
2000
- 2000-03-15 BG BG104243A patent/BG104243A/xx unknown
- 2000-03-16 NO NO20001387A patent/NO314303B1/no not_active IP Right Cessation
- 2000-03-16 OA OA1200000078A patent/OA11340A/en unknown
2001
- 2001-10-17 US US09/981,185 patent/US20020038029A1/en not_active Abandoned
2002
- 2002-06-17 US US10/174,458 patent/US20020173657A1/en not_active Abandoned
2003
- 2003-05-20 US US10/441,708 patent/US20040049031A1/en not_active Abandoned
2005
- 2005-03-30 US US11/093,701 patent/US20050171152A1/en not_active Abandoned
2006
- 2006-04-28 US US11/413,932 patent/US20060189809A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1017676B1 (fr)	2007-02-14
MY120237A (en)	2005-09-30
UY25174A1 (es)	2001-07-31
NO20001387L (no)	2000-03-16
EP1017676A4 (fr)	2002-12-04
AP2000001767A0 (en)	2000-03-31
ATE353879T1 (de)	2007-03-15
HUP0004855A2 (hu)	2001-06-28
EA200000322A1 (ru)	2000-10-30
US20020173657A1 (en)	2002-11-21
AR015445A1 (es)	2001-05-02
UY25407A1 (es)	1999-11-17
TW509678B (en)	2002-11-11
SK3672000A3 (en)	2000-09-12
ES2283072T3 (es)	2007-10-16
IL134991A0 (en)	2001-05-20
CN1125815C (zh)	2003-10-29
MA24644A1 (fr)	1999-04-01
KR20010024031A (ko)	2001-03-26
US20020038029A1 (en)	2002-03-28
PL339340A1 (en)	2000-12-18
PE129299A1 (es)	2000-02-19
CA2303026A1 (fr)	1999-03-25
NZ503307A (en)	2002-04-26
HUP0004855A3 (en)	2001-08-28
US20060189809A1 (en)	2006-08-24
ID24140A (id)	2000-07-06
DZ2607A1 (fr)	2003-03-01
US20050171152A1 (en)	2005-08-04
AU744538B2 (en)	2002-02-28
ZA988455B (en)	1999-02-17
CN1278796A (zh)	2001-01-03
US6335448B1 (en)	2002-01-01
NO20001387D0 (no)	2000-03-16
EA002633B1 (ru)	2002-08-29
WO1999014196A1 (fr)	1999-03-25
AP1201A (en)	2003-09-01
TR200000720T2 (tr)	2000-08-21
AU9395898A (en)	1999-04-05
US20040049031A1 (en)	2004-03-11
BR9812085A (pt)	2000-09-26
OA11340A (en)	2003-12-09
DE69837100D1 (de)	2007-03-29
JP2001516744A (ja)	2001-10-02
EP1017676A1 (fr)	2000-07-12
NO314303B1 (no)	2003-03-03
DE69837100T2 (de)	2007-11-22

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MY120237A (en)	2005-09-30	Method for the synthesis of quinoline derivatives
PL327171A1 (en)	1998-11-23	Novel derivatives of phenyl amine, method of obtaining them and their application as therapeutic agents
PL350568A1 (en)	2002-12-16	N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
BG105766A (en)	2002-03-29	New process for preparing pesticidal intermediates
RU94046144A (ru)	1996-09-27	Замещенные (арилалкиламинобензил) аминопропионамидные производные, их применение, способы их получения, фармкомпозиция
CA2214072A1 (fr)	1998-02-28	Benzo [b] thiophenes, intermediaires, procedes, compositions et methodes
EG24052A (en)	2008-04-13	Novel processes for the preparation of (r)-a (2,3-demethoxyphenyl-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethapnol
MXPA03006057A (es)	2004-01-26	Proceso para preparar (+) trans-4-p-fluorofenil -3 hidroximetil.
TR199900480T2 (xx)	1999-06-21	Kristalin farmas�tik �r�n.
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MXPA03009723A (es)	2004-03-16	Procedimientos e intermediarios para preparar epoxidos substituidos de bencilo.
PL343629A1 (en)	2001-08-27	Improved process for the manufacture of n-(1-cyanoalkyl)-2-phenoxypropionamide derivatives
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WO2001083423A3 (fr)	2002-02-21	Acide 2,6-diamino-6-methyl-heptanoique et derives, procede de preparation et utilisation correspondants
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WO2003045909A3 (fr)	2003-12-11	Procedes et produits intermediaires pour la synthese d'azepines