BG104338A - Състав от понижаващи липидите средства - Google Patents

Състав от понижаващи липидите средства

Info

Publication number
BG104338A
BG104338A BG104338A BG10433800A BG104338A BG 104338 A BG104338 A BG 104338A BG 104338 A BG104338 A BG 104338A BG 10433800 A BG10433800 A BG 10433800A BG 104338 A BG104338 A BG 104338A
Authority
BG
Bulgaria
Prior art keywords
lipid
reducing
composition
smelt
time
Prior art date
Application number
BG104338A
Other languages
English (en)
Inventor
Lieven Baert
Geert Verreck
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG104338A publication Critical patent/BG104338A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до нови фармацевтични състави от понижаващи липидите средства, които могат да се прилагат на бозайници, страдащи от хиперлипидемия, затлъстяване или атеросклероза. Дозиращата форма се прилага веднъж на ден и по всяко време наденя, независимо от приема на храна. Новите състави включват частички, които се получават чрез екструдиране на стопилка на смес, включваща понижаващолипидите средство и подходящ водноразтворим полимер, и последващо смилане на екструдираната като стопилка смес.
BG104338A 1997-11-03 2000-04-14 Състав от понижаващи липидите средства BG104338A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203407 1997-11-03
PCT/EP1998/006998 WO1999022738A1 (en) 1997-11-03 1998-10-27 Compositions of lipid lowering agents

Publications (1)

Publication Number Publication Date
BG104338A true BG104338A (bg) 2000-12-29

Family

ID=8228898

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104338A BG104338A (bg) 1997-11-03 2000-04-14 Състав от понижаващи липидите средства

Country Status (20)

Country Link
US (1) US6342245B1 (bg)
EP (1) EP1028730B1 (bg)
JP (1) JP2001521899A (bg)
KR (2) KR20010023661A (bg)
CN (1) CN1278175A (bg)
AR (1) AR013739A1 (bg)
AT (1) ATE216238T1 (bg)
AU (1) AU746890B2 (bg)
BG (1) BG104338A (bg)
BR (1) BR9814109A (bg)
CA (1) CA2307097A1 (bg)
DE (1) DE69804994D1 (bg)
EE (1) EE200000186A (bg)
HU (1) HUP0004139A3 (bg)
NO (1) NO20002279L (bg)
NZ (1) NZ503413A (bg)
PL (1) PL340305A1 (bg)
SK (1) SK5972000A3 (bg)
WO (1) WO1999022738A1 (bg)
ZA (1) ZA989997B (bg)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011784A (es) 2001-06-22 2004-04-02 Pfizer Prod Inc Composiciones farmaceuticas de dispersiones de farmacos y polimeros neutros.
US20030059487A1 (en) * 2001-09-21 2003-03-27 Niazi Sarfaraz K. Composition and method for the treatment of hypercholesterolemia and hyperlipidemia in mammals
US20040220240A1 (en) * 2001-11-28 2004-11-04 Pellegrini Cara A. Method of increasing the extent of absorption of tizanidine
US6455557B1 (en) 2001-11-28 2002-09-24 Elan Pharmaceuticals, Inc. Method of reducing somnolence in patients treated with tizanidine
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
NZ546182A (en) * 2003-09-26 2009-08-28 Alza Corp Controlled release formulations of opioid and nonopioid analgesics such as hydrocodone and acetaminophen
DE602004032149D1 (de) * 2003-09-26 2011-05-19 Alza Corp Oros-push-stick für die kontrollierte abgabe von wirkstoffen
NZ546183A (en) * 2003-09-26 2011-04-29 Alza Corp Controlled release formulations exhibiting an ascending rate of release
CN100563658C (zh) 2003-11-14 2009-12-02 味之素株式会社 苯丙氨酸衍生物的固体分散体或固体分散体医药制剂
EP1737460A2 (en) * 2004-04-09 2007-01-03 Janssen Pharmaceutica N.V. Intermittent dosing regimen for the treatment of overweight with mtp-inhibitors
WO2005117834A1 (en) * 2004-05-27 2005-12-15 Janssen Pharmaceutica N.V. Solid dispersions of a basic drug compound and a polymer containing acidic groups
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
KR100582347B1 (ko) * 2004-12-30 2006-05-22 한미약품 주식회사 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법
WO2006129193A2 (en) * 2005-05-27 2006-12-07 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
CA2618264C (en) * 2005-08-08 2015-11-24 Abbott Gmbh & Co. Kg Dosage forms with improved bioavailability
EP1938804A1 (en) * 2006-12-22 2008-07-02 Novartis AG Pharmaceutical formulation comprising neurokinin antagonist
DE102008047910A1 (de) 2008-09-19 2010-03-25 Molkerei Meggle Wasserburg Gmbh & Co. Kg Tablettierhilfsstoff auf Laktose- und Cellulosebasis
WO2010143199A1 (en) 2009-06-11 2010-12-16 Suven Nishtaa Pharma Private Limited Solid lipid dispersion for aqueous solubility enhancement of poorly water soluble drugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU697744C (en) * 1994-10-27 2002-08-22 Elanco Animal Health Ireland Limited Apolipoprotein-B synthesis inhibitors
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Also Published As

Publication number Publication date
EP1028730B1 (en) 2002-04-17
EP1028730A1 (en) 2000-08-23
NO20002279D0 (no) 2000-04-28
SK5972000A3 (en) 2000-12-11
HUP0004139A3 (en) 2002-03-28
BR9814109A (pt) 2000-10-03
JP2001521899A (ja) 2001-11-13
AU746890B2 (en) 2002-05-02
US6342245B1 (en) 2002-01-29
EE200000186A (et) 2001-04-16
AR013739A1 (es) 2001-01-10
KR20010023729A (ko) 2001-03-26
CN1278175A (zh) 2000-12-27
WO1999022738A1 (en) 1999-05-14
CA2307097A1 (en) 1999-05-14
AU1157699A (en) 1999-05-24
ATE216238T1 (de) 2002-05-15
DE69804994D1 (de) 2002-05-23
NZ503413A (en) 2001-06-29
PL340305A1 (en) 2001-01-29
NO20002279L (no) 2000-04-28
ZA989997B (en) 2000-05-02
HUP0004139A2 (hu) 2002-02-28
KR20010023661A (ko) 2001-03-26

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