BG104604A - Process for the preparation of paroxetin hydrochloride - Google Patents
Process for the preparation of paroxetin hydrochlorideInfo
- Publication number
- BG104604A BG104604A BG104604A BG10460400A BG104604A BG 104604 A BG104604 A BG 104604A BG 104604 A BG104604 A BG 104604A BG 10460400 A BG10460400 A BG 10460400A BG 104604 A BG104604 A BG 104604A
- Authority
- BG
- Bulgaria
- Prior art keywords
- preparation
- hydrochloride
- propan
- paroxetin
- paroxetine hydrochloride
- Prior art date
Links
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 abstract 6
- 229960005183 paroxetine hydrochloride Drugs 0.000 abstract 3
- 239000012453 solvate Substances 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726907.0A GB9726907D0 (en) | 1997-12-19 | 1997-12-19 | Novel compounds |
| PCT/GB1998/003836 WO1999032484A1 (en) | 1997-12-19 | 1998-12-18 | Process for the preparation of paroxetine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104604A true BG104604A (en) | 2001-03-30 |
Family
ID=10823933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104604A BG104604A (en) | 1997-12-19 | 2000-07-13 | Process for the preparation of paroxetin hydrochloride |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1042318A1 (id) |
| JP (1) | JP2001526288A (id) |
| KR (1) | KR20010033317A (id) |
| CN (1) | CN1281448A (id) |
| AP (1) | AP2000001836A0 (id) |
| AU (1) | AU1769899A (id) |
| BG (1) | BG104604A (id) |
| BR (1) | BR9813638A (id) |
| CA (1) | CA2315066A1 (id) |
| EA (1) | EA200000689A1 (id) |
| GB (1) | GB9726907D0 (id) |
| HU (1) | HUP0004503A3 (id) |
| ID (1) | ID24733A (id) |
| IL (1) | IL136590A0 (id) |
| NO (1) | NO20003145D0 (id) |
| OA (1) | OA11635A (id) |
| PL (1) | PL341358A1 (id) |
| SK (1) | SK9242000A3 (id) |
| TR (1) | TR200001933T2 (id) |
| WO (1) | WO1999032484A1 (id) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919001D0 (en) * | 1999-08-12 | 1999-10-13 | Smithkline Beecham Plc | Novel process |
| GB9923439D0 (en) * | 1999-10-04 | 1999-12-08 | Smithkline Beecham Plc | Novel process |
| NL1017421C2 (nl) | 2001-02-21 | 2002-01-15 | Synthon Bv | Werkwijze voor het vervaardigen van paroxetine. |
| IL163593A0 (en) * | 2002-02-22 | 2005-12-18 | Teva Pharma | Preparation of paroxetine involving novel intermediates |
| KR100672184B1 (ko) | 2004-09-21 | 2007-01-19 | 주식회사종근당 | 파록세틴의 콜린산 또는 콜린산 유도체 염 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0223403B1 (en) * | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
| SK283608B6 (sk) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
| CA2187128A1 (en) * | 1996-10-04 | 1997-06-26 | K. S. Keshava Murthy | New and useful polymorph of anhydrous paroxetine hydrochloride |
-
1997
- 1997-12-19 GB GBGB9726907.0A patent/GB9726907D0/en not_active Ceased
-
1998
- 1998-12-18 JP JP2000525421A patent/JP2001526288A/ja active Pending
- 1998-12-18 TR TR2000/01933T patent/TR200001933T2/xx unknown
- 1998-12-18 IL IL13659098A patent/IL136590A0/xx unknown
- 1998-12-18 HU HU0004503A patent/HUP0004503A3/hu unknown
- 1998-12-18 SK SK924-2000A patent/SK9242000A3/sk unknown
- 1998-12-18 CN CN98811920A patent/CN1281448A/zh active Pending
- 1998-12-18 AU AU17698/99A patent/AU1769899A/en not_active Abandoned
- 1998-12-18 CA CA002315066A patent/CA2315066A1/en not_active Abandoned
- 1998-12-18 OA OA1200000182A patent/OA11635A/en unknown
- 1998-12-18 PL PL98341358A patent/PL341358A1/xx unknown
- 1998-12-18 EA EA200000689A patent/EA200000689A1/ru unknown
- 1998-12-18 AP APAP/P/2000/001836A patent/AP2000001836A0/en unknown
- 1998-12-18 KR KR1020007006764A patent/KR20010033317A/ko not_active Withdrawn
- 1998-12-18 ID IDW20001158A patent/ID24733A/id unknown
- 1998-12-18 EP EP98962563A patent/EP1042318A1/en not_active Withdrawn
- 1998-12-18 BR BR9813638-0A patent/BR9813638A/pt not_active Application Discontinuation
- 1998-12-18 WO PCT/GB1998/003836 patent/WO1999032484A1/en not_active Ceased
-
2000
- 2000-06-16 NO NO20003145A patent/NO20003145D0/no not_active Application Discontinuation
- 2000-07-13 BG BG104604A patent/BG104604A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010033317A (ko) | 2001-04-25 |
| GB9726907D0 (en) | 1998-02-18 |
| TR200001933T2 (tr) | 2000-12-21 |
| AP2000001836A0 (en) | 2000-06-30 |
| IL136590A0 (en) | 2001-06-14 |
| JP2001526288A (ja) | 2001-12-18 |
| AU1769899A (en) | 1999-07-12 |
| HUP0004503A2 (hu) | 2002-03-28 |
| SK9242000A3 (en) | 2001-01-18 |
| CA2315066A1 (en) | 1999-07-01 |
| WO1999032484A1 (en) | 1999-07-01 |
| EA200000689A1 (ru) | 2000-12-25 |
| OA11635A (en) | 2004-11-22 |
| BR9813638A (pt) | 2000-10-17 |
| PL341358A1 (en) | 2001-04-09 |
| ID24733A (id) | 2000-08-03 |
| HUP0004503A3 (en) | 2002-04-29 |
| CN1281448A (zh) | 2001-01-24 |
| EP1042318A1 (en) | 2000-10-11 |
| NO20003145L (no) | 2000-06-16 |
| NO20003145D0 (no) | 2000-06-16 |
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