BG105178A - Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства - Google Patents

Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства

Info

Publication number
BG105178A
BG105178A BG105178A BG10517801A BG105178A BG 105178 A BG105178 A BG 105178A BG 105178 A BG105178 A BG 105178A BG 10517801 A BG10517801 A BG 10517801A BG 105178 A BG105178 A BG 105178A
Authority
BG
Bulgaria
Prior art keywords
preparation
indole
hexahydro
benzene
hydroxy
Prior art date
Application number
BG105178A
Other languages
English (en)
Inventor
Matthias Grauert
Christoph Hoenke
Adrian Carter
Wolf-Dietrich Bechtel
Thomas Weiser
Rainer Palluk
Uwe Pschorn
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of BG105178A publication Critical patent/BG105178A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретението се отнася до индолови производни с обща формула, както и до метод за тяхното получаване и приложението им като лекарствени средства.
BG105178A 1998-07-31 2001-01-24 Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства BG105178A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19834714A DE19834714A1 (de) 1998-07-31 1998-07-31 Neue 2,3,3a,4,9,9a-Hexahydro-8-hydroxy-1H-ben[f]indole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/005222 WO2000007986A1 (de) 1998-07-31 1999-07-22 Neue 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1h-benz[f]indole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
BG105178A true BG105178A (bg) 2001-12-29

Family

ID=7876092

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105178A BG105178A (bg) 1998-07-31 2001-01-24 Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства

Country Status (29)

Country Link
US (1) US6051583A (bg)
EP (1) EP1100780B1 (bg)
JP (1) JP2002522418A (bg)
KR (1) KR20010072142A (bg)
CN (1) CN1147470C (bg)
AT (1) ATE360611T1 (bg)
AU (1) AU763834B2 (bg)
BG (1) BG105178A (bg)
BR (1) BR9912605A (bg)
CA (1) CA2336783C (bg)
CO (1) CO5080748A1 (bg)
DE (2) DE19834714A1 (bg)
EA (1) EA003370B1 (bg)
EE (1) EE200100062A (bg)
ES (1) ES2285851T3 (bg)
HU (1) HUP0103518A3 (bg)
ID (1) ID28292A (bg)
IL (1) IL140863A0 (bg)
MY (1) MY133085A (bg)
NO (1) NO20010513D0 (bg)
NZ (1) NZ510246A (bg)
PL (1) PL345808A1 (bg)
SK (1) SK1502001A3 (bg)
TR (1) TR200100316T2 (bg)
TW (1) TW464643B (bg)
UA (1) UA68388C2 (bg)
WO (1) WO2000007986A1 (bg)
YU (1) YU5501A (bg)
ZA (1) ZA200007770B (bg)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002666D0 (en) 2000-02-04 2000-03-29 Univ London Blockade of voltage dependent sodium channels
JP2005514412A (ja) * 2001-12-27 2005-05-19 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 中枢神経系疾患を処置するために有用なアロイルピロールヘテロアリールおよびメタノール類

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU648032B2 (en) * 1989-07-13 1994-04-14 Pharmacia & Upjohn Company (1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives
AU2153592A (en) * 1991-05-20 1993-01-08 Upjohn Company, The Carboxamido-(3,2n)-carbocyclic-2-aminotetralin derivatives
GB9612153D0 (en) * 1996-06-11 1996-08-14 Smithkline Beecham Plc Compounds

Also Published As

Publication number Publication date
HUP0103518A2 (hu) 2002-01-28
HK1038017A1 (en) 2002-03-01
EE200100062A (et) 2002-06-17
CN1310707A (zh) 2001-08-29
PL345808A1 (en) 2002-01-02
KR20010072142A (ko) 2001-07-31
ID28292A (id) 2001-05-10
EP1100780A1 (de) 2001-05-23
TW464643B (en) 2001-11-21
BR9912605A (pt) 2001-05-02
CA2336783A1 (en) 2000-02-17
DE19834714A1 (de) 2000-02-03
CN1147470C (zh) 2004-04-28
ATE360611T1 (de) 2007-05-15
US6051583A (en) 2000-04-18
AU5162699A (en) 2000-02-28
JP2002522418A (ja) 2002-07-23
NO20010513L (no) 2001-01-30
ES2285851T3 (es) 2007-11-16
TR200100316T2 (tr) 2001-07-23
EP1100780B1 (de) 2007-04-25
IL140863A0 (en) 2002-02-10
UA68388C2 (en) 2004-08-16
AU763834B2 (en) 2003-07-31
YU5501A (sh) 2003-04-30
NZ510246A (en) 2003-08-29
DE59914314D1 (de) 2007-06-06
SK1502001A3 (en) 2001-09-11
EA003370B1 (ru) 2003-04-24
EA200100107A1 (ru) 2001-08-27
CA2336783C (en) 2009-04-28
MY133085A (en) 2007-10-31
HUP0103518A3 (en) 2002-12-28
CO5080748A1 (es) 2001-09-25
WO2000007986A1 (de) 2000-02-17
ZA200007770B (en) 2002-01-17
NO20010513D0 (no) 2001-01-30

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