BG105355A - 4-aminopyrrolopyrimidines as kinase inhibitors - Google Patents
4-aminopyrrolopyrimidines as kinase inhibitorsInfo
- Publication number
- BG105355A BG105355A BG105355A BG10535501A BG105355A BG 105355 A BG105355 A BG 105355A BG 105355 A BG105355 A BG 105355A BG 10535501 A BG10535501 A BG 10535501A BG 105355 A BG105355 A BG 105355A
- Authority
- BG
- Bulgaria
- Prior art keywords
- compounds
- disorders
- hyperproliferative
- aminopyrrolopyrimidines
- kinase inhibitors
- Prior art date
Links
- BCEMGRPBGIVPSD-UHFFFAOYSA-N N1=CNC2=CC=NC2=C1N Chemical class N1=CNC2=CC=NC2=C1N BCEMGRPBGIVPSD-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 230000003463 hyperproliferative effect Effects 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 abstract 1
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Chemical compounds having the structural formula and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferative is a factor. These compounds can be used to treat cancer, hyperproliferation disorders, rheumatoid arthritis, disorders of the immune system, transplant rejection, and inflammatory disorders. 45 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10095498P | 1998-09-18 | 1998-09-18 | |
| PCT/US1999/021536 WO2000017202A1 (en) | 1998-09-18 | 1999-09-17 | 4-aminopyrrolopyrimidines as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG105355A true BG105355A (en) | 2001-11-30 |
Family
ID=26795786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105355A BG105355A (en) | 1998-09-18 | 2001-03-16 | 4-aminopyrrolopyrimidines as kinase inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| BG (1) | BG105355A (en) |
-
2001
- 2001-03-16 BG BG105355A patent/BG105355A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL141867A0 (en) | 4-aminopyrrolopyrimidines as kinase inhibitors | |
| BG105346A (en) | Pyrolopyrimidines as protein kinase inhibitors | |
| WO2001009121A3 (en) | 2-pyrazolin-5-ones_as tyrosine kinase inhibitors | |
| WO2000075139A3 (en) | Benzothiazinone and benzoxazinone compounds | |
| DE60015594D1 (en) | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | |
| DE60006541D1 (en) | SRC-KINASE INHIBITING COMPOUNDS | |
| NZ508268A (en) | Bicyclic pyrimidines and bicyclic 3,4- dihydropyrimidines as inhibitors of cellular proliferation | |
| DK0585328T3 (en) | Substituted 3-aminoquinuclidines | |
| NO986090L (en) | Phenylalanine derivatives as integrin inhibitors | |
| TR199900048T2 (en) | Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors | |
| ID28276A (en) | HETEROLINGKAR NITROGEN BISIKLIK | |
| NO984718D0 (en) | Irreversible inhibitors of tyrosine kinases | |
| MX9605915A (en) | Piperazine derivatives as 5ht1a antagonists. | |
| NO20002702L (en) | thienopyrimidine | |
| GR81887B (en) | ||
| HK107591A (en) | 4-nitrogen substituted isoquinolinol compounds having cardiotonic,phosphodiesterase fraction iii inhibiting properties and/or renal vasodilating properties | |
| GB9814414D0 (en) | Chemical compounds | |
| NO20026246D0 (en) | 2-amino-thieno [2,3-d] pyrimidines | |
| IL89257A0 (en) | Antiulcer pyrimidine derivatives | |
| DK177191D0 (en) | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | |
| DK1005471T3 (en) | Anti-convulsive and anti-allergic / anti-asthmatic pyrazolo (3,4-D) pyrimidines | |
| UA31788A (en) | METHOD OF TREATMENT OF MYCOSIS WITH EXPRESSED MANIFESTATIONS OF HYPERKERATOSIS |